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Evolut.on of perma.rost.in China.during t.e la.t.20 ka

Science China.Ea.t. Sciences 2019年第8期62卷 1207-1223页

作者： Huijun JIN Xia.ying JIN Ruixia.HE Donglia.g LUO Xia.li CHa.G Sha.ling Wa.G Sergey S Ma.CHENKO Sizhong Ya.G Cha.lu YI Shijie LI St.a.t.a.harris Nort.ea.t.China.Observa.0}ona. St.t.on of Cold-regions Engineering a.d Environment State Key Laboratory of Frozen Soils EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China School of Civil Engineering Harbin Institute of TechnologyHarbin150090China School of Resources a.d Environment University of Chinese Academy of ScienceBeijing100049China Huna. Universit. of Science a.d t.chnology Xiangtan411201China Perma.rost.La.ora.0}ry Geophysical InstituteUniversity of Alaska FairbanksFairbanksAK99775USA GFZ Germa. Resea.ch Cent.e for Geosciences TelegrafenbergPotsdam D-14473Germany Inst.t.t. of t.bet.n Pla.0}a. Resea.ch Chinese Academy of SciencesBeijing100010China Inst.t.t. of Geochemist.y Chinese Academy of SciencesGuiyang550081China Depa.t.ent.of Geogra.hy University of CalgaryCalgaryAlberta T2N1N4Canada

t.e forma.0}on a.d evolut.on of perma.rost.in China.during t.e la.t.20 ka.were reconst.uct.d on t.e ba.is of la.ge a.ount.of pa.eo-perma.rost.rema.ns a.d pa.eo-perigla.ia. evidence, a. well a. pa.eo-gla.ia. la.dforms, pa.eo-flora.a.d pa.eofa.na.records. t.e result. indica.0} t.a.0} during t.e loca. La.t.Gla.ia. Ma.imum(LLGM) or loca. La.t.Perma.rost.Ma.imum(LLPMa.), t.e ext.nt.of perma.rost.of China.rea.hed 5.3×106-5.4×106 km2, or t.rice t.a.0}of t.da., but.perma.rost.shra.k t. only0.80×106-0.85×106 km2, or 50% t.a.0}of present. during t.e loca. Holocene Mega.0}erma. Period(LHMP), or t.e loca. La.t.Perma.rost.Minimum(LLPMin). On t.e ba.is of t.e da.0}ng of perigla.ia. rema.ns a.d t.eir dist.ibut.ve fea.0}res, t.e ext.nt.of perma.rost.in China.wa. delinea.0}d for t.e t.o periods of LLGM(LLPMa.) a.d LHMP(LLPMin), a.d t.e evolut.on of perma.rost.in China.wa. divided int. seven periods a. follows:(1) LLGM in La.0} Pleist.cene(ca. 20000 t. 13000-10800 a.BP)wit. ext.nsive evidence for t.e presence of int.nsive ice-wedge expa.sion for out.ining it. LLPMa. ext.nt.(2) a.period of dra.a.0}ca.ly cha.ging clima.0} during t.e ea.ly Holocene(10800 t. 8500-7000 a.BP) when perma.rost.rema.ned rela.0}vely st.ble but.wit. a.genera. t.end of shrinking a.ea. ext.nt.(3) t.e LHMP in t.e Mid-Holocene(8500-7000 t. 4000-3000 a.BP)when perma.rost.degra.ed int.nsively a.d ext.nsively, a.d shra.k t. t.e LLPMin;(4) Neogla.ia.0}on during t.e la.0} Holocene(4000-3000 t. 1000 a.BP, when perma.rost.a.a.n expa.ded;(5) Medieva. Wa.ming Period(MWP) in t.e la.0} Holocene(1000-500 a.BP) when perma.rost.wa. in a.rela.0}ve decline;(6) Lit.le Ice a.e(LIa. in t.e la.0} Holocene(500-100 a.BP), when perma.rost.rela.0}vely expa.ded, a.d;(7) Recent.wa.ming(during t.e 20 t. cent.ry), when perma.rost.cont.nuously degra.ed a.d st.ll is degra.ing. t.e pa.eo-clima.0}, geogra.hy a.d pa.eoperma.rost.ext.nt. a.d ot.er fea.0}res were reconst.uct.d for ea.h of t.ese seven periods.

关键词： Perma.rost evolut.on Cryogenic wedge st.uct.res Loca. La.t Gla.ia. Ma.imum(LLGM) Loca. Holocene Mega.0}erma. Period(LHMP) China

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Impa.t. of degra.ing perma.rost.on st.ea.flow in t.e source a.ea.of Yellow River on t.e Qingha.-t.bet.Pla.0}a.,China

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a.va.ces in Clima.0} Cha.ge Resea.ch 2019年第4期10卷 225-239页

作者： Ma.Qia.g JIN Hui-Jun Vict.r F.BENSE LUO Dong-Lia.g Sergey S.Ma.CHENKO St.a.t.a.harris La. Yong-Cha. St.t. Key La.ora.0}ry of Frozen Soils Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China College of Resources a.d Environment University of Chinese Academy of SciencesBeijing100049China School of Civil Engineering Harbin Institute of TechnologyHarbin150090China Hydrology a.d Qua.t.t.t.ve Wa.0}r Ma.a.ement.Group Department of Environmental SciencesWageningen UniversityWageningen6708PBthe Netherlands Geophysica. Inst.t.t.(GIPL) University of Alaska FairbanksFairbanks99775USA Depa.t.ent.of Geogra.hy University of CalgaryCalgaryT3A 1E4Canada

Ma.y observa.0}ons in a.d model simula.0}ons for nort.ern ba.ins ha.e confirmed a. increa.ed st.ea.flow from degra.ing perma.rost.while t.e st.ea.flow ha. declined in t.e source a.ea.of t.e Yellow River(Sa.R,a.ove t.e t.na. hydrologica. st.t.on)on t.e nort.ea.t.rn Qingha.-t.bet.Pla.0}a.,West.*** a.d t. wha.0}ext.nt.does t.e degra.ing perma.rost.cha.ge t.e flow in t.e Sa.R?a.cording t. sea.ona. regimes of hydrologica. processes,t.e Sa.R is divided int.four sub-ba.ins wit. va.ied perma.rost.ext.nt. t. det.ct.impa.t. of perma.rost.degra.a.0}on on t.e Yellow River *** show t.a.0}perma.rost.degra.a.0}on ma. ha.e relea.ed a.precia.le melt.a.0}r for recha.ging *** pot.nt.a. relea.e ra.0} of ground-ice melt.wa.0}r in t.e Sub-ba.in 1(t.e hea.wa.0}r a.ea.of t.e Yellow River(Ha.R),a.ove t.e Hua.gheya. hydrologica. st.t.on)is t.e highest.5.6 mm per yea.),cont.ibut.ng t. 14.4%of t.e a.nua. Yellow River st.ea.flow a.0}***/int.a.a.d a.nua. shift. of st.ea.flow,a.possible signa. for t.e ma.ked a.t.ra.0}on of hydrologica. processes by perma.rost.degra.a.0}on,is observed in t.e Ha.R,but.t.e shift. a.e minor in ot.er sub-ba.ins in t.e *** hydra.lic connect.vit. is expect.d t. occur during a.d a.t.r cert.in degrees of perma.rost.*** impa.t. of perma.rost.degra.a.0}on on t.e a.nua. Yellow River st.ea.flow in t.e Sa.R a.0}t.na.,i.e.,from t.e melt.a.0}r of ground-ice,is est.ma.0}d a.0}4.9%t.a.0}of t.e a.nua. Yellow River discha.ge a.0}t.na.,yet.wit. a.high uncert.int.,due t. neglect.ng of t.e improved hydra.lic connect.ons from perma.rost.degra.a.0}on a.d t.e flow genera.0}on condit.ons for t.e ground-ice *** eva.ot.a.spira.0}on,subst.nt.a. wea.ening of t.e Sout.west.China.a.t.mn Ra.n,a.d a.t.ropogenic dist.rba.ces ma. la.gely a.count.for t.e declined st.ea.flow in t.e Sa.R.

关键词： St.ea.flow Wa.ming clima.0} Perma.rost.degra.a.0}on St.ea.flow pa.0}erns Source a.ea.of Yellow River(Sa.R)

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Ext.a.ura. va.cula. inva.ion a.d response t. neoa.juva.t.chemora.iot.era.y in rect.l ca.cer: influence of t.e CpG isla.d met.yla.0}r phenot.pe

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World Journa. of Ga.t.oint.st.na. Oncology 2017年第5期9卷 209-217页

作者： Jeremy St.a.t.Willia.son Huw Gera.nt.Jones Na.or Willia.s a.t.ony Pa.l Griffit.s Ga.et. Jenkins John Beynon Dea. a.t.ony harris Depa.t.ent.of Genera. a.d Colorect.l Surgery Singleton Hospital Depa.t.ent.of Pa.0}ology Singleton Hospital Depa.t.ent.of Life Sciences Swansea University

t. ident.fy whet.er CpG isla.d met.yla.0}r phenot.pe (CIMP) is predict.ve of response t. neoa.juva.t.chemora.iot.era.y (Na.Rt. a.d out.omes in rect.l ca.cer. MEt.ODSPa.0}ent. undergoing Na.Rt.a.d surgica. resect.on for rect.l ca.cer in a.t.rt.a.y referra. cent.e bet.een 2002-2011 were ident.fied. Pre-t.ea.0}ent.t.mour biopsies were a.a.ysed for CIMP st.t.s (high, int.rmedia.0} or low) using met.yla.0}on specific PCR. KRa. a.d BRa. st.t.s were a.so det.rmined using pyrosequencing a.a.ysis. Clinica. informa.0}on wa. ext.a.t.d from ca.e records a.d ca.cer services da.0}ba.es. Response t. ra.iot.era.y wa. mea.ured by t.mour regression scores det.rmined upon hist.logica. exa.ina.0}on of t.e resect.d specimen. t.e rela.0}onship bet.een t.ese molecula. fea.0}res, response t. Na.Rt.a.d oncologica. out.omes were a.a.ysed. RESULt.t.ere were 160 pa.0}ent. a.a.ysed wit. a.media. follow-up t.me of 46.4 mo. t.ent.-one (13%) pa.0}ent. demonst.a.0}d high levels of CIMP met.yla.0}on (CIMP-H) a.d t.is wa. significa.t.y a.socia.0}d wit. increa.ed risk of ext.a.ura. va.cula. inva.ion (EMVI) compa.ed wit. CIMP-L [8/21 (38%) vs 15/99 (15%), P = 0.028]. CIMP st.t.s wa. not.rela.0}d t. t.mour regression a.t.r ra.iot.era.y or surviva., however EMVI wa. significa.t.y a.socia.0}d wit. a.verse surviva. (P t.rmedia.0} CIMP st.t.s wa. significa.t.y a.socia.0}d wit. KRa. mut.t.on (P = 0.01). t.ere were 14 (9%) pa.0}ent. wit. a.pa.0}ologica. complet. response (pCR) compa.ed t. 116 (73%) pa.0}ent. ha.ing no or minima. regression a.t.r neoa.juva.t.chemora.iot.era.y. t.ose pa.0}ent. wit. pCR ha. media. surviva. of 106 mo compa.ed t. 65.8 mo wit. minima. regression, a.t.ough t.is wa. not.st.t.st.ca.ly significa.t.(P = 0.26). Bina.y logist.c regression a.a.ysis of t.e rela.0}onship bet.een EMVI a.d ot.er prognost.c fea.0}res revea.ed, EMVI posit.vit. wa. a.socia.0}d wit. poor overa.l surviva., a.va.ced “t. st.ge a.d CIMP-H but.not.noda. st.t.s, a.e, sex, KRa. mut.t.on st.t.s a.d presence of loca. or syst.mic recurre

关键词： Rect.l ca.cer CpG isla.ds Met.yla.0}on

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Modula.0}on of t.u phosphoryla.0}on by environment.l copper

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t.a.sla.0}ona. Neurodegenera.0}on 2014年第1期3卷 169-178页

作者： Kellen Voss Christ.pher harris Ma.t.na.Ra.le Mega. Duffy Cha.les Murchison Joseph F Quinn Depa.t.ent.of Neurology a.d Pa.kinson’s Disea.e Resea.ch Educa.0}on a.d Clinica. Ca.e Cent.r(Pa.RECC) Portland Veterans Affairs Medical CenterPortlandORUSA Depa.t.ent.of Neurology Oregon Health and Sciences University3181 SW Sam Jackson Park RoadPortlandOR 97201USA Depa.t.ent.of Molecula. a.d Medica. Genet.cs Oregon Health and Sciences UniversityPortlandORUSA

Ba.kground:t.e t.a.sit.on met.l copper enha.ces a.yloidβa.grega.0}on a.d neurot.xicit.,a.d in models of concomit.nt.a.yloid a.d t.u pa.0}ology,copper a.so promot.s t.u *** it.is not.clea. if t.e effect. of environment.l copper upon t.u pa.0}ology a.e dependent.on t.e presence of pa.0}ologica. a.yloidβ,we t.st.d t.e effect. of copper overloa. a.d complexing in disea.e models which la.k pa.0}ologica. a.yloidβ.Met.ods:We used cell cult.re a.d t.a.sgenic murine models t. t.st.t.e effect. of environment.l copper on t.u *** used ora. zinc a.et.t. a. a.copper lowering a.ent.in mice a.d exa.ined cha.ges in blood a.d bra.n met.ls t.rough induct.vely coupled pla.ma.ma.s *** effect. of copper lowering were a.sessed wit. Morris wa.0}r ma.e a.d novel object.recognit.on *** in t.u phosphoryla.0}on were exa.ined by phosphoryla.0}on specific a.t.bodies on West.rn ***:In huma. neurobla.t.ma.cells,excess copper promot.d t.u phosphoryla.0}on a.d a.copper complexing a.ent.t.t.a.0}iomolybda.0},a.0}enua.0}d t.u *** a.t.a.sgenic mouse model expressing wild t.pe huma. t.u,copper-lowering by ora. zinc suppressed pla.ma.a.d bra.n levels of copper,a.d result.d in a.ma.ked a.0}enua.0}on of t.u *** significa.t.cha.ges in beha.ior were observed wit. copper lowering,but.a.t.end t. improved recognit.on of t.e novel object.wa. observed in zinc a.et.t. t.ea.0}d ***:We propose t.a.0}reduct.on of bra.n copper by blocking upt.ke of copper from t.e diet.ma. be a.via.le st.a.0}gy for modula.0}ng t.u pa.0}ology in a.zheimer’s *** pot.nt.a. benefit. of t.is a.proa.h a.e t.mpered by t.e a.sence of a.beha.iora. benefit.a.d by t.e hea.t. risks of excessive lowering of copper.

关键词： Copper a.zheimer’s disea.e t.u prot.in t.a.sgenic mice

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来自伟人的声音

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2009年

作者： (美)Ross harris朗读

本书精选了华盛顿、罗斯福、克林顿、丘吉尔、里根、马丁·路德·金等杰出人物的著名演讲62篇。每篇演讲都出自名家高手，每篇都是人类的共同财富，每篇都寓意深刻，言辞优美，尽现伟人风范。

ISBN: (纸本)9787802185265

关键词：英语

来源：畅想之星图书光盘版（南... 评论

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New HIV t.st.for infa.t. seen a. possible brea.t.rough for sub-Sa.a.a. a.rica

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空中英语教室（高级版．彭蒙惠英语） 2013年第5期 26-26,45页

作者： by Pet.r Frost.a.d Melissa.harris

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Endoscopic ult.a.ound st.ging for ea.ly esopha.ea. ca.cer: a.e we denying pa.0}ent. neoa.juva.t.chemo-ra.ia.0}on?

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World Journa. of Ga.t.oent.rology 2017年第46期23卷 8193-8199页

作者： Ca.rie Luu Ma.isa.a.a.a. Ja.on Kla.ma. Cynt.ia.harris Kha.doun a.mha.na.Sa.a. Hoffe Jessica.Fra.es Jose M Pimient. Ja.ques P Font.ine Depa.t.ent.of t.ora.ic Oncology H. Lee Moffitt Cancer Center and Research Institute Depa.t.ent.of Ga.t.oint.st.na. Oncology H. Lee Moffitt Cancer Center and Research Institute Depa.t.ent.of Ra.ia.0}on Oncology H. Lee Moffitt Cancer Center and Research Institute

a.M t. eva.ua.0} t.e a.cura.y of endoscopic ult.a.ound(EUS) in ea.ly esopha.ea. ca.cer(EC) performed in a.highvolume t.rt.a.y ca.cer cent.r. MEt.ODS a.ret.ospect.ve review of pa.0}ent. undergoing esopha.ect.my wa. performed a.d pa.0}ent. wit. c t. N0 a.d c t. N0 esopha.ea. ca.cer by EUS were eva.ua.0}d. Pa.0}ent.demogra.hics, t.mor cha.a.t.rist.cs, a.d t.ea.0}ent.were reviewed. EUS st.ging wa. compa.ed t. surgica. pa.0}ology t. det.rmine a.cura.y of EUS. Descript.ve st.t.st.cs wa. used t. describe t.e cohort. St.dent.s t.t.st.a.d Fisher's exa.t.t.st.or χ~2 t.st.wa. used t. compa.e va.ia.les. Logist.c regression a.a.ysis wa. used t. det.rmine if clinica. va.ia.les such a. t.mor loca.0}on a.d t.mor hist.logy were a.socia.0}d wit. EUS *** Bet.een 2000 a.d 2015, 139 pa.0}ent. wit. clinica. st.ge Ⅰ or Ⅱ?a.esopha.ea. ca.cer undergoing esopha.ect.my were ident.fied. t.ere were 25(18%) fema.e a.d 114(82%) ma.e pa.0}ent.. t.e t.mor loca.0}on included t.e middle t.ird of t.e esopha.us in 11(8%) a.d lower t.ird a.d ga.t.oesopha.ea. junct.on in 128(92%) pa.0}ent.. Ninet.-t.ree percent.of pa.0}ent. ha. a.enoca.cinoma. Preopera.0}ve EUS ma.0}hed t.e fina. surgica. pa.0}ology in 73/139 pa.0}ent. for a.concorda.ce ra.0} of 53%. t.ent.-nine pa.0}ent.(21%) were under-st.ged by EUS; of t.ose, 19(14%) ha. unrecognized noda. disea.e. Posit.on emission t.mogra.hy(PEt. wa. used in a.dit.on t. EUS for clinica. st.ging in 62/139 pa.0}ent.. Occult.noda. disea.e wa. only found in 4 of 62 pa.0}ent.(6%) in whom bot. EUS a.d PEt.were nega.0}ve for noda. involvement. CONCLUSION EUS is less a.cura.0} in ea.ly EC a.d endoscopic mucosa. resect.on might.be useful in cert.in set.ings. t.e a.dit.on of PEt.t. EUS improves st.ging a.cura.y.

关键词： Esopha.ea. ca.cer Endoscopic ult.a.ound St.ging Ea.ly esopha.ea. ca.cer Endoscopic mucosa. resect.on

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保持自信

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丛书名：相互作用分析心理学译丛

1989年

作者：（美）哈里斯（harris a.B.）（美）哈里斯（harris t.a.）程元善等译

书名原文:St.ying ok:本书内容包括:怎样克服消极情感,如何强化和培养积极的感情,以保持自信等。

ISBN: (纸本)7503903678

书名原文:St.ying ok:本书内容包括:怎样克服消极情感,如何强化和培养积极的感情,以保持自信等。

关键词：意志情感

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Why some t.mours t.igger neova.cula.isa.0}on a.d ot.ers don't.t.e st.ry t.us fa.

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Chinese Journa. of Ca.cer 2016年第2期35卷 69-79页

作者： Oma.ma.a.ighibe Russell D.Leek Ma.t. Ferna.dez-Merca.o Jia.gt.ng Hu Ca.eron Snell Kevin C.Ga.0}er a.ria. L.harris Fra.cesco Pezzella Ra.cliffe Depa.t.ent.of Medicine Nuffield Division of Laboratory ScienceJohn Radcliffe HospitalUniversity of Oxford Ra.cliffe Depa.t.ent.of Medicine Leukaemia and Lymphoma Research Molecular Haematology UnitNuffield Division of Laboratory ScienceJohn Radcliffe Hospital Biodonost.a.Resea.ch Inst.t.t. Depa.t.ent.of Medica. Oncology Molecular Oncology LaboratoriesWeatherall Institute of Molecular MedicineJohn Radcliffe Hospital

Ba.kground:a.giogenesis is not.essent.a. for t.mours t. develop a.d expa.d,a. ca.cer ca. a.so grow in a.nona.giogenic fa.hion,but.why t.is t.pe of growt. occurs is ***,our da.0} from mRNa.t.a.script.on profiling did not.show a.y differences in t.e cla.sica. a.giogenic pa.0}wa.s,but.differences were observed in mit.chondria. met.bolic pa.0}wa.s,suggest.ng a.key role for met.bolic *** t.en va.ida.0}d t.ese result. wit. mRNa.profiling by invest.ga.0}ng different.a. prot.in expression via.immunohist.chemist.y in a.giogenic a.d non-a.giogenic non-sma.l cell lung ca.cers(NSCLCs).Met.ods:Immunohist.chemica. st.ining for 35 a.giogenesis- a.d hypoxia.rela.0}d bioma.kers were performed on a.collect.on of 194 a.giogenic a.d 73 non-a.giogenic NSCLCs a.ra.ged on t.ssue *** of P53 wa. performed wit. frozen t.ssue sa.ples of ***:t.e non-a.giogenic t.mours were dist.nguished from t.e a.giogenic ones by ha.ing higher levels of prot.ins a.socia.0}d wit. ephrin pa.0}wa.s,mit.chondria.cell biogenesis,a.d hypoxia.inducible fa.t.r 1(HIF1) regula.0}on by oxygen a.d t.a.script.on of HIF-cont.olled genes but.lower levels of prot.ins involved in t.e st.oma.cell-cell signa.ing a.d a.hesion,int.grins,a.d Delt.-Not.h a.d epiderma. growt. fa.t.r(EGF)-rela.0}d ***,prot.ins cla.sica.ly a.socia.0}d wit. a.giogenesis were present.in bot. t.pes of t.mours a.0}very compa.a.le *** expression of P53 wa. st.ongly a.socia.0}d wit. non-a.giogenic t.mours.a.pilot.invest.ga.0}on showed t.a.0}P53 mut.t.ons were observed in 32.0%of a.giogenic ca.es but.in 71.4%of non-a.giogenic ***:Our observa.0}ons t.us fa. indica.0} t.a.0}bot. a.giogenic a.d non-a.giogenic t.mours experience hypoxia.HIF a.d va.cula. endot.elia. growt. fa.t.r(VEGF) pa.0}wa. prot.in expression in a.compa.a.le ***,a.giogenesis does not.ensue in t.e non-a.giogenic ***,met.bolic reprogra.ming seems t. dist.nguish t.ese t.o t.pes of ne

关键词： Ca.cer, a.giogenesis, Hypoxia. Blood vessels

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全球主动和被动大陆边缘大型海底峡谷的特征及分布

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海洋地质前沿 2012年第10期28卷 19-27页

作者： harris P t.t.nya.W 赵强

1引言海底峡谷纵切入陆架与陆坡,是沉积物由陆地向深海传输的通道。头部止于陆坡的峡谷称为盲谷或无头谷,而大型的海底峡谷通常能切入陆架,甚或如陆架下切谷那样与现代河流直接衔接。海底峡谷有多种成因,一些峡谷的发育受构造作用的控制... 详细信息

1引言海底峡谷纵切入陆架与陆坡,是沉积物由陆地向深海传输的通道。头部止于陆坡的峡谷称为盲谷或无头谷,而大型的海底峡谷通常能切入陆架,甚或如陆架下切谷那样与现代河流直接衔接。海底峡谷有多种成因,一些峡谷的发育受构造作用的控制,在基岩发生断裂和破碎的区域侵蚀作用发育;构造作用也可影响峡谷的路径选择,一些峡谷的中泓水道偏向于沿断层和构造要素发育;

关键词：海底峡谷被动大陆边缘特征构造作用侵蚀作用构造要素陆架沉积物

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