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Female indris determine the rhythmic structure of the song and sustain a higher cost when the chorus size increases

Current Zoology 2019年第1期65卷 89-97页

作者： Chiara De Gregorio Anna Zanoli Daria Valente Valeria Torti Giovanna Bonadonna rose marie Randrianarison Cristina Giacoma Marco Gamba Dipartimento di Scienze della Vita e Biologia dei Sistemi Universita di Torino via Accademia Albertina Torino Italia Dipartimento di Scienze Chimiche della Vita e della Sostenibilita Ambientale Universita di Parma Parma Italia Group d'Ttude et de Recherche sur les Primates de Madagascar (GERP) Antananarivo Madagascar Departement de Anthropobiologie et Developpement Durable Universite d'Antananarivo Faculte des Sciences Antananarivo Madagascar

Among the behavioral traits shared by some nonhuman primate species and humans there is singing. Unfortunately, our understanding of animals' rhythmic abilities is still in its infancy. Indris are the only lemurs who sing and live in monogamous pairs, usually forming a group with their offspri ng. All adult members of a group usually participate in choruses that are emitted regularly and play a role in advertising territorial occupa ncy and in tergroup spaci ng. Males and females emit phrases that have similar frequency ranges but may differ in their temporal structure. We examined whether the individuals' contribution to the song may change according to chorus size, the total duration of the song or the duration of the individual con tribution using the in ter-on set intervals within a phrase and between phrases. We found that the rhythmic structure of indri's songs depends on factors that are different for males and females. We showed that females have sigrdficantly higher variation in the rhythm of their contribution to the song and that, changes according to chorus size. Our findings indicate that female indris sustain a higher cost of singing than males whe n the nu mber of singers in creases. These results suggest that cross-species investigatio ns will be crucial to un derstanding the evoluti on ary frame in which such sexually dimorphic traits occurred.

关键词： chorus coordination duets lemurs singing synchrony

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Egypt

Egypt

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作者： (author.)Hagen rose-marie (author..1928-)Hagen Rainer

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Francisco Goya, 1746-1828

Francisco Goya, 1746-1828

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作者： Hagen rose-marie. (1928-)Hagen Rainer (1746-1828.)Goya Francisco

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大跨径钢混组合连续梁桥力学性能研究

大跨径钢混组合连续梁桥力学性能研究

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作者： UKWIZABIGIRA marie rose 哈尔滨工业大学

学位级别：硕士

钢-混凝土组合梁桥结构充分发挥了钢材良好的抗拉性能和混凝土良好的抗压性能,增大了桥梁的跨越能力,同时具有跨高比大、挠度小、刚度大等优点,在桥梁工程结构中得到了广泛的应用。然而该类桥梁也存在一些问题,特别是在连续钢-混凝土组... 详细信息

钢-混凝土组合梁桥结构充分发挥了钢材良好的抗拉性能和混凝土良好的抗压性能,增大了桥梁的跨越能力,同时具有跨高比大、挠度小、刚度大等优点,在桥梁工程结构中得到了广泛的应用。然而该类桥梁也存在一些问题,特别是在连续钢-混凝土组合桥的负弯矩区,混凝土板会产生拉应力,导致桥面开裂,造成防水层失效,桥面铺装层易损。混凝土板通常处于受拉状态,梁底翼缘处于受压状态,这在结构的耐久性、承载能力和使用寿命方面普遍存在不足。因此,本文依托哈尔滨长江路立交桥工程,对连续组合梁桥的力学性能进行研究,分析连续组合梁桥优化施工技术及施工影响因素,研究改善中支点负弯矩区受力的工程措施,降低负弯矩区混凝土板的开裂风险。首先总结分析了钢混土组合梁桥的受力特点及相关计算理论,对剪力滞影响以及界面剪切滑移对承载力的影响进行了分析。其次利用Midas土木有限元软件对钢-混凝土组合梁桥进行了有限元建模。在建模过程中,考虑施工过程影响,分析支座顶升、温度、混凝土徐变和收缩等因素对钢混凝土组合梁桥力学性能的影响。重点分析了不同顶升高度对组合梁负弯矩的调整效应,得到了桥梁内力变化与中支点顶升位移量的关系,为施工顶升提供了理论依据。论文同时分析了收缩徐变对组合梁长期性能的影响,探讨了混凝土徐变收缩对中支点顶升量效应的影响。研究结果表明:合理的支座顶升高度可以通控制负弯矩区的混凝土裂缝,显著提高大跨度连续钢-混凝土组合梁桥的力学性能,混凝土桥面板可以保留一定的压应力,同时可以降低钢梁底翼缘处的压应力。论文最后重点分析了高寒地区温度变化对钢混组合梁连续结构的影响。通过布设的健康监测系统采集的长期数据,给出了桥梁整体温度变化规律以及沿梁高的温度梯度监测结果,并与设计规范给出的温度模式进行了对比,为寒区桥梁温度荷载模式提供了参考。

关键词：连续组合梁桥负弯矩区支座顶升温度监测温度效应

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TNFR1 Deficiency Protects Mice from Colitis-Associated Colorectal Cancer Coupled with a Decreased Level of Oxidative Damage in the Colon: Implications for Anti-TNF Therapy of Unremitting Colitis

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Journal of Cancer Therapy 2012年第6期3卷 926-940页

作者： rose marie Stillie Heidi L. Sapp Andrew W. Stadnyk Department of Microbiology & Immunology Dalhousie University Halifax Canada Department of Pediatrics Dalhousie University Halifax Canada. Division of Anatomical Pathology Queen Elizabeth II Health Sciences Centre Halifax Canada

It has long been appreciated that there is a direct relationship between the intensity and duration of inflammatory bowel diseases (IBD) and increasing intestinal cancer risk but which elements of the inflammatory response are responsible have not been identified. Anti-TNF drugs have been successful at treating IBD but considering the presumed anti-tumor activity of TNF, it is important to understand whether the treatment impacts on the patients’ intestinal cancer risk. We modeled this relationship by “treating mice lacking TNF receptors with a colon cancer causing combination of azoxymethane followed by repeated dextran sulphate sodium exposures (AOM + DSS regime). TNF receptor type1 gene deficient (TNFR1-/-) and TNFR2-/- mice experienced similar clinical illnesses and colonic inflammation as C57BL/6 wildtype controls during the AOM + DSS regime. Despite the inflammation, TNFR1-/- mice developed significantly fewer colon tumors than the other strains. The reduced tumor incidence was a product of the combined lack of receptor expression on hematopoietic and nonhematopoietic cells, shown using bone marrow cell chimeras of wildtype and TNFR1-/- mice. As oxidative damage is a potent contributing factor to tumorigenesis and inflammatory leukocytes make copious amounts of reactive oxygen radicals, we measured oxidative damage in the animals’ colons. TNFR1-/- mice showed less damage compared to the other strains. We subsequently examined mice deficient in their leukocyte NADPH oxidative pathway (Nox2-/-) for their cancer incidence using the AOM + DSS regime. Nox2-/- mice became inflamed but had fewer tumors than wildtype mice. We conclude that TNF promotes colon cancer including through promoting oxidative processes utilizing TNFR1 in leukocytes. Moreover, the C57BL/6 strain can be used to dissociate mechanisms of colon inflammation from tumorigenic processes. We interpret our results to mean that IBD patients on TNF antagonist therapies will potentially benefit with redu

关键词： TNF Receptor Colitis Associated Cancer Colorectal Cancer Azoxymethane

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Castleman’s Disease of the Pleura: Case Presentation and Review of Literature

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International Journal of Clinical Medicine 2012年第4期3卷 311-317页

作者： Pablo Loarte Nayle Araguez rose marie Flores Li-The Wu Ronny Cohen North Shore University Hospital Forest Hills NY Woodhull Medical Center Brooklyn NY Woodhull Medical Center Brooklyn NY 2NYU School of Medicine New York NY

Purpose. Castleman’s Disease is a very rare medical disease and the presence of this condition in the pleura is even rarer and there are only few reported cases. The presence of symptoms is also unusual and has been mostly described in multicentric cases of castleman’s disease instead of solitary lesions (unicentric castleman). We report a case of unicentric pleural castlema’s disease with presence of constitutional symptoms. Methods. A 36-year-old male without any significant past medical history who presented to the emergency due to an incidental large pleural effusion seen in chest radiograph, but referring chronic constitutional symptoms consistent of significant weight loss and chronic cough. Results. Chest computed tomography revealed a mass and several attemps with minimally invase approach failed to identify the lesion. The mass was excised through VATS but due to its significant vascularity, it had to be converted to open thoracotomy. Conclusion. The treatment of unicentric lesions is mainly complete surgical excision and the prognosis is excellent with some chances of recurrence. There are less than one dozen of reported pleural castleman reported in the literature. This case evidence than unicentric lesion may exhibit constitutional symptoms and confirmed than lesions above 5 cm can be removed by VATS but the chances for conversion to an open thoracotomy are high.

关键词： UCD: Unicentric Castleman's Disease MCD: Multicentric Castleman's Disease Pleural Effusion VATS: Video Assisted Thoracoscopy HIV: Human Immunodeficiency Virus

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1例中国被收养女性罹患神经性贪食症的案例：跨文化研究

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上海精神医学 2017年第4期29卷 243-246页

作者： Marion Vu-Augier de MONTGREMIER Liangliang CHEN Jue CHEN marie rose MORO MDA Cochin AP-HP Paris Descartes University CESP Inserm 1178 Paris France Shanghai Changning Mental Health Center {SCMHC) Shanghai Jiao Tong University Shanghai China Psychosomatic Unit Clinical psychology Department of Shanghai Mental Health Center (SMHC) Shanghai Jiao Tong University Shanghai China

概述:一直以来,饮食障碍被认为是西方国家特有的与文化相关的综合症。因为神经性厌食症,这个理论似乎已被打破,但仍少有关于神经性贪食症的跨文化研究,故这方面文献有限。在本临床病例中,我们试图探讨文化因素对这一疾病的影响。我们研... 详细信息

概述:一直以来,饮食障碍被认为是西方国家特有的与文化相关的综合症。因为神经性厌食症,这个理论似乎已被打破,但仍少有关于神经性贪食症的跨文化研究,故这方面文献有限。在本临床病例中,我们试图探讨文化因素对这一疾病的影响。我们研究了此病例中的非典型特征,特别关注到容易被忽略的患者的外表容貌和收养隐秘被揭晓所诱发的心理冲击。神经性贪食症触发了一种亲子关系和自我认同的重新寻找,以期日后再度恢复良好家庭关系并最终获得自我。同样我们也研究本病例中的中国收养状况。本病例提示文化因素影响的重要性,跨文化研究可以帮助我们更好的理解神经性贪食症,并提示了有效治疗手段。

关键词：神经性贪食症跨文化精神病学收养家庭关系个体化

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CD70 defines a subset of proinflammatory and CNSpathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis

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Cellular & Molecular Immunology 2019年第7期16卷 652-665页

作者： Tessa Dhaeze Laurence Tremblay Catherine Lachance Evelyn Peelen Stephanie Zandee Camille Grasmuck Lyne Bourbonnière Sandra Larouche Xavier Ayrignac rose-marie Rébillard Josée Poirier Boaz Lahav Pierre Duquette Marc Girard Robert Moumdjian Alain Bouthillier Catherine Larochelle Alexandre Prat Department of Neuroscience Faculty of MedicineUniversitéde Montréaland Centre de Recherche du CHUM(CRCHUM)MontréalQC H2X0A9Canada Multiple Sclerosis Clinic Division of NeurologyCHUMMontréalQC H2X0A9Canada Division of Neurosurgery CHUMMontréalQC H2X0A9Canada CD70 is the unique ligand of CD27 and is expressed on immune cells only upon

***,engagement of the costimulatory CD27/CD70 pathway is solely dependent on upregulation of ***,the T cell-intrinsic effect and function of human CD70 remain ***,we describe that CD70 expression distinguishes proinflammatory CD4^(+)T lymphocytes that display an increased potential to migrate into the central nervous system(CNS).Upregulation of CD70 on CD4^(+)T lymphocytes is induced by TGF-β1 and TGF-β3,which promote a pathogenic *** addition,CD70 is associated with a TH1 and TH17 profile of lymphocytes and is important for T-bet and IFN-γexpression by both T helper ***,adoptive transfer of CD70−/−CD4^(+)T lymphocytes induced less severe experimental autoimmune encephalomyelitis(EAE)disease than transfer of WT CD4^(+)T ***70+CD4^(+)T lymphocytes are found in the CNS during acute autoimmune inflammation in humans and mice,highlighting CD70 as both an immune marker and an important costimulator of highly pathogenic proinflammatory TH1/TH17 lymphocytes infiltrating the CNS.

关键词： CD70+CD4^(+)T lymphocytes multiple sclerosis CD27/CD70 pathway TGF-β1 TGF-β3 soluble CD70 blood-brain barrier endothelial cells experimental autoimmune encephalitis TCR1640 transgene mouse model

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蝙蝠侠出没美国马肉黑市

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商业周刊（中文版） 2021年第9期 80-85页

作者： David Gauvey Herbert rose marie(摄影) 不详

在佛罗里达州打击地下屠宰黑市的斗争中,说起那位“黑暗骑士”蝙蝠侠式的人物,你不用去寻找他;你只要发出信号,他会找到你。2020年3月,我搭乘飞机来到佛罗里达州西棕榈滩市,然后租车朝里面开,住进理查德·库托(Richard Couto)帮我选的... 详细信息

在佛罗里达州打击地下屠宰黑市的斗争中,说起那位“黑暗骑士”蝙蝠侠式的人物,你不用去寻找他;你只要发出信号,他会找到你。2020年3月,我搭乘飞机来到佛罗里达州西棕榈滩市,然后租车朝里面开,住进理查德·库托(Richard Couto)帮我选的一家连锁酒店。随后我收到他短信发来的一个地址。我开车朝他的秘密领地驶去,一路经过柑橘园、轰隆隆喷着烟的拖拉机,还有各种自制的支持特朗普的标语牌。最后,沿着一条两边长满高大的澳洲松的土路,来到一连串远程控制的大门前,有闭路电视监控系统和啸叫老鹰形象的装饰护卫着。

关键词：闭路电视监控系统特朗普棕榈滩佛罗里达州柑橘园连锁酒店

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酶对葡萄酒澄清和过滤的增效作用

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中外葡萄与葡萄酒 2007年第4期 58-59页

作者： rose marie Canal Liauberes 潘婧法国诺盟公司上海200135

葡萄皮和果肉细胞壁释放出的多糖，以及来自酵母细胞的多糖（甘露聚糖）和来源于感染灰葡萄孢属菌的葡萄多糖容易与其它不溶颗粒相互作用，重新聚合成难溶物质，从而造成过滤、澄清的困难。

关键词：葡萄酒增效作用过滤澄清颗粒相互作用葡萄孢属甘露聚糖酵母细胞

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