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视功能降低与用γ-乙烯氨基丁酸治疗婴儿性痉挛有关

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 25-26页

作者： Hammoudi D.S. Lee S.S.F. madison A. C. A. Westall 王大江 Dept. of Ophthalmol. and Vis. Sci. Hospital for Sick Children555 University Avenue Toronto Ont. M5G 1X8 Canada

PURPOSE. To use visual evoked potential (VEP) testing to determine whether visual deficits are present in children with a history of vigabatrin use. METHODS. Contrast sensitivity and visual acuity were assessed by visual evoked potential testing and compared between 28 children (mean age,4.90± 4.92 years) with seizure disorders who had taken vigabatrin and 14 typically developing children (mean age, 3.14± 1.70 years). Exclusion criteria were heritable eye disease, suspected cortical visual impairment, nystagmus, and prematurity>2 weeks. The effects of the following factors on contrast sensitivity and visual acuity were examined: type of seizure (infantile spasms versus other), ERG result, duration of vigabatrin therapy, cumulative dosage of vigabatrin, and other seizure medications (other versus no other medication). RESULTS. Contrast sensitivity and visual acuity were reduced in vigabatrin- treated children with infantile spasms compared with vigabatrin- treated childrenwith other seizure disorders and typically developing control subjects. The other factors examined had no significant effect on contrast sensitivity or visual acuity, with adjustment for seizure type. CONCLUSIONS. Children with infantile spasms on vigabatrin may have compromised visual function, even in the absence of suspected cortical visual impairment. The children tested in the present study have reduced vision, probably associated with infantile spasms rather than vigabatrin.

关键词：氨基丁酸视功能癫痫发作类型眼球震颤对比敏感度视觉诱发电位视敏度发作史视网膜电图用药史

Functional remodeling of Ca^(2+)-activated Cl^-channel in pacing induced canine failing heart

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Journal of Geriatric Cardiology 2008年第3期5卷 169-174页

作者： Ning Li,~1 Kejuan Ma,~2 Siyong Teng,~2 Jonathan C.Makielski,~3 Jielin Pu~(1,2) 1. Research Center for Pathology and Physiology, Fu Wai Cardiovascular Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China 2. Center for Arrhythmia Diagnosis and Treatment, Fu Wai Cardiovascular Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China 3. Department of Cardiology, University of wisconsin, madison 53706, USA Research Center for Pathology and Physiology Fu Wai Cardiovascular Hospital Chinese Academy of Medical Sciences Beijing 100037 China Center for Arrhythmia Diagnosis and Treatment Fu Wai Cardiovascular Hospital Chinese Academy of Medical Sciences Beijing 100037 China Department of Cardiology University of Wisconsin Madison WI 53706 United States

Objective To determine whether Ca2+ activated Cl- current(Icl(Ca)) contributes to the functional remodeling of the failing *** Whole cell patch-clamp recording technique was employed to record the Icl(Ca) in cardiac myocytes enzymatically isolatedfrom rapidly pacing induced canine failing hearts at room temperature and compared that of the normal hearts (Nor).Results Thecurrent density of DIDS(200M)sensitive Icl(Ca) induced by intracellular Ca2+ release trigged by L-type Ca2+ current(Ica,L)wassignificantly decreased in heart failare(HE)cells compared to Nor *** membrane voltage of 20mV,the Icl(Ca) density was 3.02±0.54 pA/pF in Nor(n=6)vs.1.31±0.25 pA/pF in HF(n=8)cells,(P＜0.01),while the averaged Ica,L density did not show differencebetween two *** time constant of current decay of Icl(Ca) was similar in both types of *** the other hand,in intra cellularCa2+ clamped mode,where the[Ca2+];was maintained at 100nmol/L,Icl(Ca) density be increased significantly in HF cells when themembrane voltage at+30mV or *** Our results suggest that Icl(Ca) density was decreased in pacing induced failingheart but the channel function be *** Ca2+ handing in HF cells rather than reduced,Icl(Ca) channel function itself may havecaused this *** Icl(Ca) density reduction might contribute to the prolongation of action potential in failing *** Icl(Ca)channel function up-rugulation is likely to cause cardiac arrhythmia by inducing a delayed after depolarization,when Ca2+ overloadoccurred in diastolic failing heart cells.

关键词： heart failure cardiac arrhythmia Ca^(2+)-activated Cl^-channel

Understanding the effects of radiative preheat and self-emission from shock heating on equation of state measurement at 100s of Mbar using spherically converging shock waves in a NIF hohlraum

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Matter and Radiation at Extremes 2020年第1期5卷 16-22页

作者： Joseph Nilsen Andrea L.Kritcher madison EMartin Robert E.Tipton Heather D.Whitley Damian C.Swift Tilo Doppner Benjamin L.Bachmann Amy E.Lazicki Natalie B.Kostinski Brian R.Maddox Gilbert W.Collins Siegfried H.Glenzer Roger W.Falcone Lawrence Livermore National Laboratory LivermoreCalifornia 94551USA University of Rochester RochesterNew York 14627USA SLAC National Accelerator Menlo ParkCalifornia 94025USA University of California Berkeley BerkeleyCalifornia 94720USA

Over the last six years many experiments have been done at the National Ignition Facility to measure the Hugoniot of materials,such asCHplastic at extreme pressures,up to 800 ***“Gbar”design employs a strong spherically converging shock launched through a solid ball of material using a hohlraum radiation *** shock front conditions are characterized using x-ray *** this paper we examine the role of radiation in heating the unshocked material in front of the shock to understand the impact it has on equation of state measurements and how it drives the measured data off the theoretical Hugoniot *** particular,the two main sources of radiation heating are the preheating of the unshocked material by the high-energy kilo-electron-volt x-rays in the hohlraum and the heating of the material in front of the shock,as the shocked material becomes hot enough to radiate *** our model,we estimate that preheating can reach 4 eV in unshocked material,and that radiation heating can begin to drive data off the Hugoniot significantly,as pressures reach above 400 Mb.

关键词： spherical equation radiative

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联邦党人文集

Polycyclic Aromatic Hydrocarbons in Agricultural Soils of the Southern Subtropics,China

作者： (美)亚历山大·汉密尔顿(Alexander Hamilton) (美)詹姆斯·麦迪逊(James madison) (美)约翰·杰伊(John Jay

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Pedosphere 2007年第5期17卷 673-680页

作者： HAO Rong WAN Hong-Fu SONG Yan-Tun JIANG Hong PENG Shao-Lin South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 （China） Guangdong Key Laboratory of Agricultural Environment Pollution Integrated Control Guangdong Institute of Eco- Environment and Soil Sciences Guangzhou 510650 （China） School of Life Science Sun Yat-Sen University Guangzhou 510275 （China） Conservation Biology Institute 260 SW Madison Ave. Suite 106 Corvallis OR 97333 （USA）

The contributions of persistent organic pollutants （POPs） from the subtropical regions of China to pollution of the global environment have been paid great attention; however, little is known about the state of POPs in agricultural ecosystems within these regions of China. This study primarily revealed the state of the contamination and distribution of polycyclic aromatic hydrocarbons （PAH） in agricultural soils in the subtropical regions. 115 surface soils （0-20 cm） were sampled in the breadbaskets of these regions. The concentrations and types of PAH were determined using gas chromatography linked to mass spectrometry （GC-MS）. The total PAH concentrations ranged from 22.1 to 1 256.9 ng g^-1 with a mean of 318.2 ± 148.2 ng g^-1. In general terms, the current PAH concentrations were lower than most PAH levels reported in a number of investigations from different countries and regions. PAH isomer ratios indicated that pyrolytic origins, such as fossil fuel combustion related to vehicle tail gas and industrial emissions, were the dominant sources of PAH in the southern subtropical areas of China. Although PAH concentrations decreased with decreasing pollution, population, and traffic density, to a great extent PAH compositions were similar throughout subtropical soils, with naphthalene, phenanthrene, fluoranthene, and benzo（b）fluoranthene being dominant.

关键词： agricultural soils polycyclic aromatic hydrocarbons subtropical region

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家具与风景

现代装饰（家居） 2016年第2期 114-120页

作者： Bina Baitel Demeter Fogarasi Kazuya Koike Nicholas Baker madison Heim Soojin Kang Alessandra Baldereschi Elissa Lacoste Beatrice Cordara Valentin Garal Caterina Moretti 李薇范嘉苑 FφLSOM Studio SoRa studio

法国画家皮埃尔·奥古斯特·雷诺阿在他的油画《乡村之舞》中描绘了这样的一幅画面：一对共舞的男妇,男子身穿蓝色外套,脚穿皮鞋,左手握住舞伴的右腕,右手搂住舞伴的腰肢;画面中的女子左手绕过男子的右臂搂在男子的右肩上,右手拿着一把... 详细信息

法国画家皮埃尔·奥古斯特·雷诺阿在他的油画《乡村之舞》中描绘了这样的一幅画面：一对共舞的男妇,男子身穿蓝色外套,脚穿皮鞋,左手握住舞伴的右腕,右手搂住舞伴的腰肢;画面中的女子左手绕过男子的右臂搂在男子的右肩上,右手拿着一把折扇,面部向外,脸上充满幸福的表情。《乡村之舞》整幅画面以暖色调为主,共舞的男妇几乎占据了油画的整个画面,当观赏这幅画作时,观赏者首先关注的应该会是这对共舞的男女,感受到欢快愉悦的氛围;而如果细心地去观赏寻觅,就会发现在这幅画的左边角落里其实还藏着一位＂偷看的女孩儿＂,

关键词：雷诺阿整幅画面奥古斯特埃尔画中古斯手工编织小王子灵感来源童话世界

维普期刊数据库博看期刊

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作为和平教育政策的多语主义研究（英文）

语言政策与语言教育 2015年第2期 43-67页

作者：弗朗索瓦·维克多·涂尚 University of Wisconsin-madison

本文从语言教育政策的视角回顾了和平与全球化的利益得失,其中包括:1.语言多样性在获取和平的世界公民身份时所起的作用;2.多语教育与和平的关系;3.英语和各种'杀手语言';4.语言教育政策与和平的关系。相关语言政策无法根据不同环境调适... 详细信息

本文从语言教育政策的视角回顾了和平与全球化的利益得失,其中包括:1.语言多样性在获取和平的世界公民身份时所起的作用;2.多语教育与和平的关系;3.英语和各种'杀手语言';4.语言教育政策与和平的关系。相关语言政策无法根据不同环境调适,往往会提出过度概括性的解决方案。全球制度性的暴力仅由海市蜃楼般的问责制和对数字非人性化的使用来管理,这种情况对和平的实现造成了系统性干扰。语言规划需要去中心化,能够灵活适应不同人类生活环境。本文指出以上讨论的这些问题有助于增进全球理解,多语能力与跨文化沟通能力应成为和平教育的战略目标之一。

关键词：多语主义语言教育教育政策和平教育

墨西哥随机盲法复检抗酸杆菌涂片新的外部质量评价指南实验项目结果报告

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结核与肺部疾病杂志 2005年第4期8卷 158-161页

作者： A. Martinez S. Balandrano A. Parissi A. Zuniga M. Sanchez J. Ridderhof H. B. Lipman B. madison 张宗德 Institute de Diagnostico y Referenda Epidemiológicos Mexico DF Laboratorio Estatal de Salud Pública Veracruz Laboratorio Estatal de Salud Publica Pachuca Hidalgo Mexico Centers for Disease Control and Prevention Atlanta Georgia USA

地点:实施国家结核病控制规划中的抗酸菌镜检外部质量保证的墨西哥实验室。包括对本地实验室报告的 100%抗酸菌阳性涂片和 10%阴性涂片的复检。在墨西哥使用非随机和非盲法重检时很少发现错误。目的:对墨西哥两个州的当地结核病实验室... 详细信息

地点:实施国家结核病控制规划中的抗酸菌镜检外部质量保证的墨西哥实验室。包括对本地实验室报告的 100%抗酸菌阳性涂片和 10%阴性涂片的复检。在墨西哥使用非随机和非盲法重检时很少发现错误。目的:对墨西哥两个州的当地结核病实验室一年的实验项目抗酸菌痰涂片随机盲法重检结果进行评价,决定这种方法在以后实施的可行性。设计:为减少误差,来自流行病学诊断与参比研究所国家结核病实验室(InDRE)的工作人员对每个州的当地实验室抗酸菌涂片进行每季度一次的统计学抽样及现场评价。抗酸菌涂片复检在本州的实验室进行,如遇结果不符时上交 InDRE 解决。结果:对抗酸菌涂片进行随机盲法复检比非随机、非盲法重检时发现错误的概率大得多。结论:随机盲法重检可以更加准确地估计抗酸菌涂片镜检的结果,提高诊断及对治疗效果的监测。

关键词：质量保证实验室检查 AFB镜检结核病随机盲法阳性涂片实验项目墨西哥复检结果报告

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新碳纤维艺术

Design（产品设计） 2008年第7期 14-14页

作者：露西·麦迪逊（Lucy madison）

随着碳纤维系列的推出，设计师达利欧（Dario Antonioni）向我们重新定义了价签，洞察力以及设计和艺术的分水龄。

关键词：纤维艺术碳纤维设计师洞察力