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Acute liver failure with hemolytic anemia in children with Wilson’s disease:Genotype-phenotype correlations?

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World Journal of Hepatology 2021年第10期13卷 1428-1438页

作者： Tudor lucian Pop Alina Grama Ana Cristina Stefanescu Claudia Willheim Peter Ferenci 2^(nd) Pediatric Discipline Department of Mother and ChildIuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 400177Romania 2^(nd) Pediatric Clinic Center of Expertise in Pediatric Liver Rare DisordersEmergency Clinical Hospital for ChildrenCluj-Napoca 400177Romania Department of Internal Medicine Ⅲ Gastroenterology and HepatologyMedical University of ViennaWien A-1090Austria

BACKGROUND Wilson’s disease(WD)is a rare autosomal recessive inherited disorder of copper *** liver failure(ALF)and hemolytic anemia represent the most severe presentation of WD in *** clear genotype-phenotype correlations exist in ***-truncating nonsense,frame-shift,or splice-site variants may be associated with more severe *** contrast,missense variants may be associated with late-onset,less severe disease,and more neurological ***,a gene variant(HSD17B13:TA,rs72613567)with a possible hepatic protective role against toxins was associated with a less severe hepatic phenotype in *** To analyze the possible genotype-phenotype correlations in children with WD presented with ALF and non-immune hemolytic *** The medical records of children with WD diagnosed and treated in our hospital from January 2006 to December 2020 were retrospectively *** clinical manifestations(ALF with non-immune hemolytic anemia or other less severe forms),laboratory parameters,copper metabolism,ATP7B variants,and the HSD17B13:TA(rs72613567)variant were reviewed to analyze the possible genotype-phenotype *** We analyzed the data of 51 patients with WD,26 females(50.98%),with the mean age at the diagnosis of 12.36±3.74 *** and Coombs-negative hemolytic anemia was present in 8 children(15.67%),all adolescent *** Kayser-Fleisher ring was present in 9 children(17.65%).The most frequent variants of the ATP7B gene were ***1069Gln(c.3207A>G)in 38.24% of all alleles,***1341Asp(c.4021G>A)in 26.47%,***939Cys(c.2817G>T)in 9.80%,and ***844Ter(c.2530A>T)in 4.90%.In ALF with hemolytic anemia,***939Cys(c.2817G>T)and ***844Ter(c.2530A>T)variants were more frequent than in other less severe forms,in which ***1069Gln(c.3207A>G)was more ***1341Asp(c.4021G>A)has a similar frequency in all hepatic *** 33 of the patients,the HSD17B13 genotype was *** overall HSD17B13:TA a

关键词： Wilson’s disease Children Acute liver failure Hemolytic anemia ATP7B variant Genotype-phenotype correlation

What Is a Muon Anyways: Meson or Lepton!?

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Journal of High Energy Physics, Gravitation and Cosmology 2020年第2期6卷 244-250页

作者： lucian M. Ionescu Department of Mathematics Illinois State University IL USA

Understanding the role of muons in Particle Physics is an important step understanding generations and the origin of mass as an expression of “internal structure”. A possible connection between muonic atoms and cycl... 详细信息

关键词： Standard Model Cycloatoms Elementary Particles Muons

From Periods to Anabelian Geometry and Quantum Amplitudes

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Advances in Pure Mathematics 2020年第5期10卷 229-244页

作者： lucian M. Ionescu Department of Mathematics Illinois State University Normal IL USA

Periods are algebraic integrals, extending the class of algebraic numbers, and playing a central, dual role in modern Mathematical-Physics: scattering amplitudes and coefficients of de Rham isomorphism. The Theory of Periods in Mathematics, with their appearance as scattering amplitudes in Physics, is discussed in connection with the Theory of Motives, which in turn is related to Conformal Field Theory (CFT) and Topological Quantum Field Theory (TQFT), on the physics side. There are three main contributions. First, building a bridge between the Theory of Algebraic Numbers and Theory of Periods, will help guide the developments of the later. This suggests a relation between the Betti-de Rham theory of periods and Grothendieck’s Anabelian Geometry, towards perhaps an algebraic analog of Hurwitz Theorem, relating the algebraic de Rham cohomology and algebraic fundamental group, both pioneered by A. Grothendieck. Second, a homotopy-homology refinement of the Theory of Periods will help explain the connections with quantum amplitudes. The novel approach of Yves Andre to Motives via representations of categories of diagrams, relates from a physical point of view to generalized TQFTs. Finally, the known “universality” of Galois Theory, as how symmetries “grow”, controlling the structure of the objects of study, is discussed, in relation to the above several areas of research, together with ensuing further insight into the Mathematical-Physics symbiosis. To better understand and investigate Kontsevich-Zagier conjecture on abstract periods, the article ponders on the case of algebraic Riemann Surfaces representable by Belyi maps. Reformulation of cohomology of cyclic groups as a discrete analog of de Rham cohomology and the Arithmetic Galois Theory will provide a purely algebraic toy-model of the said algebraic homology/homotopy group theory of Grothendieck as part of Anabelian Geometry. The corresponding Platonic Trinity 5,7,11/TOI/E678 leads to connections with ADE-corresp

关键词： Periods Anabelian Geometry Motives Quantum Physics

A Study of the p-Adic Frobenius Lifts and p-Adic Periods, from a Deformation Theory Viewpoint

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Advances in Pure Mathematics 2018年第4期8卷 408-418页

作者： lucian M. Ionescu Mathematics Department Illinois State University Normal IL USA

A canonical p-adic Frobenius lift is defined in the context of p-adic numbers, viewed as deformations of the corresponding finite field. Applications to p-adic periods are considered, including to the classical Euler gamma and beta functions and their p-adic analogues, from a cohomological point of view. Connections between various methods for computing scattering amplitudes are related to the moduli space problem and period domains.

关键词： p-Adic Numbers Frobenius Lift Periods Feynman Integrals Deformation Theory

Wear and Contact Temperature on Steel Surface in Linear Dry Friction Contact with Polimers with SGF

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Journal of Mechanics Engineering and Automation 2015年第10期5卷 554-566页

作者： Dorin Rus lucian Capitanu Mechanical Department Technical University of Civil Engineering Bucharest 050153 Romania Tribology Department Institute of Solid Mechanics of the Romanian Bucharest 010141 Romania

In this paper, we tried to present a qualitative correlation, based on extensive experimental trials between the value and the evolution of the friction coefficient, wear and contact temperature in the case of linear dry contact, thermoplastic material reinforced with SGF （short glass fibres） and various steel surfaces. We tried, believing successfully, the graphic illustration of the evolution of the steel surface wear and of the contact temperature, depending on the friction coefficient. It was analyzed in detail the influence of the normal load and sliding speed, but also of the metallic surface roughness on the friction coefficient.

关键词： Friction coefficient evolution wear of steel surface contact temperature plastic material transfer hardness of steel surface influence

Collecting a comprehensive evidence base to monitor fracture rehabilitation: A case study

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World Journal of Orthopedics 2013年第4期4卷 259-266页

作者： Stuart A Callary Dominic Thewlis Alex V Rowlands David M Findlay lucian B Solomon Centre for Orthopaedic and Trauma Research The University of Adelaide Department of Orthopaedics and Trauma Royal Adelaide Hospital School of Health Sciences University of South Australia

AIM: To determine the feasibility and potential role of combining radiostereometric analysis(RSA), gait analysis and activity monitoring in the follow-up of fracture ***: Two patients with similar 41B3 tibial plateau fractures were treated by open reduction internal fixation augmented with impaction bone grafting and were instructed to partial weight bear to 10 kg for the first six postoperative weeks. Fracture reduction and fixation were assessed by postoperative computer tomographic(CT) scanning. Both patients had tantalum markers inserted intra-operatively to monitor their fracture stability during healing using RSA and differentially loaded RSA(DLRSA) at 6 and 12 wk postoperatively. Gait analyses were performed at 1, 2, 6, and 12 wk postoperatively. Activity monitors were worn for 4 wk between the 2 and 6 wk appointments. In addition to gait analysis, knee function was assessed using the patient reported Lysholm scores, and doctor reported knee range of motion and stability, at 6 and 12 wk ***: There were no complications. CT demonstrated that both fractures were reduced anatomically. Gait analysis indicated that Patient 1 bore weight to 60% of body weight at 2 wk postoperative and 100% at 6 wk. Patient 2 bore weight at 10% of body weight to 6 wk and had very low joint contact forces to that time. At 12 wk however, there was no difference between the gait patterns in the two patients. Patient 1 increased activities of moderate-vigorous intensity from 20 to 60 min/d between 2 and 6 postoperative weeks, whereas Patient 2 remained more stable at 20-30 min/d. The Lysholm scores were similar for both patients and did not improve between 6 and 12 wk postoperatively. DLRSA examination at 12 wk showed that both patients were comfortable to weight bear to 80 kg and under this weight the fractures displaced less than 0.4 mm. RSA measurements demonstrated over time fracture migrations of less than 2 mm in both cases. However, Patient 2, who

关键词： Radiostereometric analysis Gait analysis Activity monitoring Rehabilitation protocols Lower

Investments of Milk Processing Capacities from Romania, through the Funds Provided by the ＂NPRD 2014-2020＂

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Journal of Agricultural Science and Technology(A) 2017年第8期7卷 577-584页

作者： Vladu Marius Panzaru Radu lucian Department of Agricultural and Forestry Technology Faculty of Agronomy University of Craiova Craiova 200421 Romania Department of Land Management Measurements and Mechanization University of Craiova Craiova 200421 Romania

In this paper, an analysis of the possibilities of development of milk processing activity was made, using as financing source the public funds provided by the Common Agricultural Policy and the distribution of the investments in Romania. All the EU member states gain 99.6 billion through the European Agricultural Fund for Rural Development, the period 2014-2020, of which Romania has received the total of 8.128 billion euros. Through the 2014-2020 National Rural Development Program （NRDP 2014-2020）, sub-measure 4.2 ＂Support for investment in processing/marketing of agricultural products＂（2014）, Romania is falling Regulation （EC） 1305/2013 in measure 4 ＂Investments in physical assets＂（2013） and contributes to increasing the value added of products on local markets and inter-professional organizations, the establishment and development of small businesses and job creation. Until now, in the milk processing sector, investments of 93,918,043 euros were made, about 50% （47,667.41 euros） of which from public funds.

关键词： Public funds investment processing milk.

Real-time sono-elastography in the diagnosis of diffuse liver diseases

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World Journal of Gastroenterology 2010年第14期16卷 1720-1726页

作者： Dan Ionut Gheonea Adrian S ǎftoiu Tudorel Ciurea Florin Gorunescu Sevastita Iordache Gabriel lucian Popescu Smaranda Belciug Marina Gorunescu Larisa Sǎndulescu Research Center of Gastroenterology and Hepatology University of Medicine and Pharmacy Craiova 200349 Romania Department of Biostatistics and Informatics University of Medicine and Pharmacy Craiova 200349 Romania IT Department University of Medicine and Pharmacy Craiova 200349 Romania Faculty of Mathematics of Computer Science University of Craiova Craiova 200585 Romania

AIM: To analyze whether computer-enhanced dynamic analysis of elastography movies is able to better characterize and differentiate between different degrees of liver fibrosis. METHODS: The study design was prospective. A total of 132 consecutive patients with chronic liver diseases and healthy volunteers were examined by transabdominal ultrasound elastography. All examinations were done by two ***: Due to the limitations of the method, we obtained high-quality elastography information in only 73.48% of the patients. The κ-means clustering method was applied to assess the inter-observer diagnosis varia- bility, which showed good variability values in accordance with the experience of ultrasound examination of every observer. Cohen’sκ test indicated a moderate agreement between the study observers (κ = 0.4728). Furthermore, we compared the way the two observers clustered the patients, using the test for comparing two proportions (t value, two-sided test). There was no statistically significant difference between the two physicians, regardless of the patients’ real status. CONCLUSION: Transabdominal real-time elastography is certainly a very useful method in depicting liver hard- ness, although it is incompletely tested in large multicenter studies.

关键词： Elastography Ultrasonography Liver steato- sis Viral hepatitis Liver cirrhosis

氢醌化合物对针叶木硫酸盐纸浆氧脱木素的影响

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中国造纸学报 2004年第2期19卷 32-36页

作者：付时雨 Lucia A.lucian 柴欣生詹怀宇华南理工大学制浆造纸工程国家重点实验室广州510641 乔治亚理工大学造纸研究所亚特兰大乔治亚美国GA30332

研究了具有氧化还原性的氢醌类化合物作为氧脱木素过程的添加物。结果表明 ,氢醌的加入可以降低纸浆的卡伯值 ,提高氧脱木素的选择性。其原因是氢醌的存在可以提高O2 转化成为含氧的活性反应产物 ,加速木素中甲氧基的脱除 ,有利于破坏... 详细信息

研究了具有氧化还原性的氢醌类化合物作为氧脱木素过程的添加物。结果表明 ,氢醌的加入可以降低纸浆的卡伯值 ,提高氧脱木素的选择性。其原因是氢醌的存在可以提高O2 转化成为含氧的活性反应产物 ,加速木素中甲氧基的脱除 ,有利于破坏木素的结构和脱除木素。

关键词：氧脱木素纸浆针叶木卡伯值醌类脱除氢醌含氧类化合物硫酸盐