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Asian Journal of Andrology 2017年第6期19卷 625-632页

作者： Lea LB Lauridsen Linn H Arendt henrik Stovring Jorn Olsen Cecilia H Ramlau-Hansen 1Department of Public Health Section for Epidemiology Aarhus University 8000 Aarhus C Denmark Department of Public Health Section for 8iostatistics Aarhus University 8000 Aarhus C Denmark Department of Clinical Epidemiology Aarhus University Hospital 8200 Aarhus N Denmark

The evidence is scarce on the association between age at puberty and semen quality. A cohort of 320 Danish men aged 18-21 years enrolled in the ＂Healthy Habits for Two＂ birth cohort provided self-reported data on pubertal indicators and delivered semen and blood samples. The results indicated an association between older age at pubertal development and lower semen quality and altered reproductive hormones concentrations as measured in young adult life. Men who had their first nocturnal emission, start of pubic hair growth and first voice break episode when older than 15 years had 37.0%, 45.0% and 32.7% lower sperm concentration; 37.8%, 44.2% and 29.1% lower total sperm count; 7.4%, 13.4% and 15.3% lower testosterone concentration; and 21.3%, 1.5% and 3.7% lower inhibin B concentration, respectively, compared with the men who were younger than 13 years at their first pubertal indicators. Only few of the results were statistically significant, but similar tendencies were seen in several of the reproductive parameters suggesting an association between the timing of pubertal development and reproductive health later in life.

关键词： pubertal development puberty reproductive health reproductive hormones semen quality

Nutritional value of high fiber co-products from the copra,palm kernel,and rice industries in diets fed to pigs

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Journal of Animal Science and Biotechnology 2016年第2期7卷 125-133页

作者： Hans henrik Stein Gloria Amparo Casas Jerubella Jerusalem Abelilla Yanhong Liu Rommel Casilda Sulabo Department of Animal Science University of IllinoisUrbana 61801USA Departamento de Produccion Animal Facultad de Medicina Veterinariay deZootecniaUniversidad Nacional de ColombiaBogotaColombia. University of California Davis 95616USA. University of the Philippines Los BanosPhilippines.

High fiber co-products from the copra and palm kernel industries are by-products of the production of coconut oil and palm kernel oil. The co-products include copra meal, copra expellers, palm kernel meal, and palm kernel expellers. All 4 ingredients are very high in fiber and the energy value is relatively low when fed to pigs. The protein concentration is between 14 and 22 % and the protein has a low biological value and a very high Arg：Lys ratio. Digestibility of most amino acids is less than in soybean meal but close to that in corn. However, the digestibility of Lys is sometimes low due to Maillard reactions that are initiated due to overheating during *** and palm kernel ingredients contain 0.5 to 0.6 % P. Most of the P in palm kernel meal and palm kernel expellers is bound to phytate, but in copra products less than one third of the P is bound to phytate. The digestibility of P is, therefore, greater in copra meal and copra expellers than in palm kernel ingredients. Inclusion of copra meal should be less than 15 % in diets fed to weanling pigs and less than 25 % in diets for growing-finishing pigs. Palm kernel meal may be included by 15 % in diets for weanling pigs and 25 % in diets for growing and finishing *** bran contains the pericarp and aleurone layers of brown rice that is removed before polished rice is *** bran contains approximately 25 % neutral detergent fiber and 25 to 30 % starch. Rice bran has a greater concentration of P than most other plant ingredients, but 75 to 90 % of the P is bound in phytate. Inclusion of microbial phytase in the diets is, therefore, necessary if rice bran is used. Rice bran may contain 15 to 24 % fat, but it may also have been defatted in which case the fat concentration is less than 5 %. Concentrations of digestible energy（DE） and metabolizable energy（ME） are slightly less in full fat rice bran than in corn, but defatted rice bran contains less than 75 % of the DE and ME in corn. The concentrat

关键词： Copra expellers Copra meal Palm kernel expellers Palm kernel meal Rice bran

Nanostructure and mechanical properties of the osteocyte lacunar-canalicular network-associated bone matrix revealed by quantitative nanomechanical mapping

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Nano Research 2015年第10期8卷 3250-3260页

作者： Shuai Zhang Fiona Linnea Bach-Gansmo Dan Xia Flemming Besenbacher henrik Birkedal Mingdong Dong TheInterdisciplinaryNanoscienceCenter AarhusUniversityAarhusC8000Denmark DepartmentofChemistry AarhusUniversityAarhusC8000Denmark

Osteocytes are the main bone cells embedded in the bone matrix where they form a large surface-area network called the lacunar-canalicular network （LCN）, interconnecting their resident spaces with the lacunae by the canaliculi. Increasing evidence points toward osteocytes playing a pivotal role in maintaining bone quality. On the one hand, osteocytes transmit mechanical strain and microenvironmental signals through the LCN to regulate the activity of osteoblasts and osteoclasts; on the other hand, osteocytes are suggested to be able to remodel the LCN-associated bone matrix. However, due to the challenges involved in the assessment and characterization of the LCN-associated bone matrix, little is known about its structure and the corresponding mechanical properties. In this work, we used quantitative nanomechanical mapping, backscattered electron imaging, and nanoindentation to characterize the LCN-associated bone matrix. The results show that the techniques can be used to probe the LCN-associated bone matrix. Nanoindentation and quantitative mechanical mapping reveal spatially inhomogeneous mechanical properties of the bone matrix associated with the osteocyte lacunae and canaliculi. The obtained nano-topography and corresponding nano-mechanical maps reveal altered mechanical properties in the immediate vicinity of the osteocyte lacunae and canaliculi, which cannot be explained solely by the topographic change.

关键词： lacunar-canalicularnetwork osteocyte perilacunar bone matrix pericanalicular bone matrix reduced modulus mechanical properties

Myxomycetes from Papua New Guinea and New Caledonia

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Fungal Diversity 2013年第2期59卷 33-44页

作者： henrik Kylin David W.Mitchell El-Hacène Seraoui Bart Buyck Department of Water and Environmental Studies Linköping UniversitySE-58183 LinköpingSweden Walton Cottage Upper HartfieldEast SussexTN74ANEnglandUK 11 rue Louis Armand74100 AmbillyFrance Department of Systematics and Evolution CP39 UMR7205Muséum national d’Histoire naturelle75005 ParisFrance

We present a compilation of all myxomycetes recorded from Papua New Guinea(PNG)and New Caledonia(NC).Specimens were collected during field trips in September 1983–January 1984 to both territories and in August 1991,October 2007,and April 2009 to *** and dung samples for moist chamber cultures were collected during the field trips in September 1983–January 1984(PNG and NC)and in August 1991 and October 2007(NC).In addition,information from previous publications and unpublished specimens in the herbarium at the Plant Protection Instituted in Port Moresby,PNG,are included.A total of 180 species are *** the 63 species from PNG 51 are new to the country,and 123 of the 149 species from NC are new to the territory.

关键词： Mycetozoa Myxomycota Amoebozoa Slime moulds Southwest Pacific

Immune checkpoint therapy for pancreatic cancer

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World Journal of Gastroenterology 2016年第43期22卷 9457-9476页

作者： henrik Johansson Roland Andersson Monika Bauden Sarah Hammes Stefan Holdenrieder Daniel Ansari Department of Surgery Clinical Sciences Lund Lund University and Sk?ne University Hospital Institute of Laboratory Medicine German Heart Center at the Technical University Munich

Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has shown effect in other solid tumors, and could have a place in pancreatic cancer treatment. Most available clinical studies on immune checkpoint inhibitors for pancreatic cancer are not yet completed and are still recruiting patients. Among the completed trials, there have been findings of a preliminary nature such as delayed disease progression and enhanced overall survival after treatment with immune checkpoint inhibitors in mono- or combination therapy. However, due to small sample sizes, major results are not yet identifiable. The present article provides a clinical overview of immune checkpoint inhibition in pancreatic cancer. Pub Med, Clinical *** and American Society of Clinical Oncology's meeting abstracts were systematically searched for relevant clinical studies. Four articles, five abstracts and 25 clinical trials were identified and analyzed in detail.

关键词： Pancreatic cancer Immune checkpoint inhibitors Clinical trials

Advanced control and modeling of deposition processes

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Chinese Optics Letters 2013年第13期11卷 30-35页

作者： Detlev Ristau henrik Ehlers Centre of Quantum Engineering and Space-Time Research Hannover Germany Department of Laser Components Laser Zentrum Hannover e.V. Hannover Germany

During the last decade, striking improvements could be achieved for the precise control of deposition processes in optical coating technology. For example, as a consequence of enormous progresses in measure- ment and computer technology, direct optical monitoring in a broad spectral range can be considered as a common tool in many production environments nowadays. Besides the development of the corresponding hardware and measurement channels, advanced approaches for the evaluation of the acquired data and new multiple sensor monitoring strategies moved into the focus of modern research on the way towards de- terministic deposition techniques. In this context, also innovative concepts for the simulation of deposition processes to forecast the result for a specified coating design and automatic online correction algorithms gained of importance to reduce the risk of failure in coating production. The present contribution will be dedicated to selected aspects in this field, especially addressing broad band optical monitoring systems. A short review on examples for existing hardware configurations and software tools will be presented illus- trating the advantages of modern process control techniques. Novel approaches based on the modeling of thin film growth are discussed as an additional strategy to improve the predictability of coating processes.

关键词： 310.1860 Deposition and fabrication 310.6845 Thin film devices and applications 280.4788 Optical sensing and sensors

Sensor Selection and Routing Design for State Estimation over Wireless Sensor Networks

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Sensor Selection and Routing Design for State Estimation ove...

Long-term survival after pancreaticoduodenectomy in patients with ductal adenocarcinoma of the pancreatic head

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作者： Yuchi Wu Takuya Iwaki Junfeng Wu Karl henrik Johansson Ling Shi Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology KTH Royal Institute of Technology

ISBN: (纸本)9781538629185

In this paper,we consider a wireless sensor network that consists of a group of sensor nodes estimating multiple independent LTI *** point-to-point link between the sensor nodes is a slow frequency-flat fading channel and the states of the channel are described by a finite-state Markov channel（FSMC） *** propose a transmission schedule of the sensors such that the overall estimation error at the remote estimator is ***,we present an event-based routing scheme with respect to channel state,i.e.,online routing among the selected sensors to ensure the zero outage-probability at a constant transmission rate with the least transmission *** channel inversion,we separate the sensor scheduling and routing as two independent *** results for a simple wireless sensor network is presented to compare the energy cost with and without event-based routing.

关键词： sensor network routing slow fading channel inversion networked control state estimation

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Hepatobiliary & Pancreatic Diseases International 2021年第3期20卷 271-278页

作者： Andreas Minh Luu Chris Braumann Orlin Belyaev Monika Janot-Matuschek henrik Rudolf Michael Praktiknjo Waldemar Uhl Department of General and Visceral Surgery St.Josef HospitalRuhr University BochumGudrunstrasse 56Bochum 44791Germany Department of Medical Informatics Biometry and EpidemiologyRuhr University BochumUniversitaetsstrasse 105Bochum 44789Germany Department of Internal Medicine University of BonnVenusberg-Campus 1Bonn 53127Germany

Background: Pancreatic ductal adenocarcinoma(PDAC) has the worst prognosis of all malignant tumors due to unavailable screening methods, late diagnosis with a low proportion of resectable tumors and resistance to systemic treatment. Complete tumor resection remains the cornerstone of modern multimodal strategies aiming at long-term survival. This study was performed to investigate the overall rate of long-term survival(LTS) and its contributing factors. Methods: This was a retrospective single-center analysis of consecutive patients undergoing pancreaticoduodenectomy(PD) for PDAC between 2007 and 2014 at the St. Josef Hospital, Ruhr University Bochum, Germany. Clinical and laboratory parameters were assessed and evaluated for prediction of LTS with Cox regression analysis. Results: The overall rate of LTS after PD for PDAC was 20.4%(34/167). Median survival was 24 months regardless of adjuvant treatment. Carbohydrate antigen 19-9 levels, tumor grade, lymph vessel invasion, perineural invasion and reduced general condition were significantly associated with LTS in univariate analysis( P<0.05). Serum levels of carbohydrate antigen 19-9, American Joint Committee on Cancer stage, tumor grade, abdominal pain, male, exocrine pancreatic insufficiency and duration of postoperative hospital stay were independent predictors of cancer survival in multivariable analysis. Conclusions: Cancer related characteristics are associated with LTS in multimodally treated patients after curative PDAC surgery.

关键词： Pancreaticoduodenectomy Whipple’s procedure Pancreatic cancer survival Ductal adenocarcinoma Pancreas Pancreatic surgery

Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy

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World Journal of Psychiatry 2021年第12期11卷 1177-1190页

作者： Hans-Gert Bernstein Gerburg Keilhoff Gregor Laube henrik Dobrowolny Johann Steiner Department of Psychiatry University of MagdeburgMagdeburg D-39116Saxony-AnhaltGermany Institute of Biochemistry and Cell Biology University of MagdeburgMagdeburg D-39116Saxony-AnhaltGermany Department of Anatomy ChariteBerlin D-10117Germany

Polyamines play preeminent roles in a variety of cellular functions in the central nervous system and other organs.A large body of evidence suggests that the polyamine pathway is prominently involved in the etiology and pathology of *** in the expression and activity of polyamine metabolizing enzymes,as well as changes in the levels of the individual polyamines,their precursors and derivatives,have been measured in schizophrenia and animal models of the ***,neuroleptic treatment has been shown to influence polyamine concentrations in brain and blood of individuals with ***,the polyamine system may appear to be a promising target for neuropharmacological treatment of ***,for a number of practical reasons there is currently only limited hope for a polyamine-based schizophrenia therapy.

关键词： Polyamines Spermidine Spermine Schizophrenia Animal models Therapy