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Acute pancreatitis:pathogenesis and emerging therapies

1996年

作者： fred M. Gottheil.

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Journal of Pancreatology 2024年第1期7卷 10-20页

作者： Saif Zaman fred Gorelick Department of Internal Medicine Yale School of MedicineNew HavenCT 06511 Veteran’s Administration Healthcare System West HavenCT 06516 Department of Cell Biology Yale School of MedicineNew HavenCT 06511

Acute pancreatitis is a severe inflammatory disorder with limited treatment *** understanding of disease mechanisms has led to new and potential *** we summarize what we view as some of the most promising new therapies for treating acute pancreatitis,emphasizing the rationale of specific treatments based on disease *** pharmacologic interventions are *** explore potential treatment benefits and risks concerning reducing acute injury,minimizing complications,and improving long-term *** associated with acute pancreatitis initiation,perpetuation,and reconstitution are highlighted,along with potential therapeutic targets and how these relate to new treatments.

关键词： Acinar cell Acute pancreatitis Calcium signaling Transporters Treatment

Modeling displacement flow inside a full-length casing string for well cementing

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Petroleum Research 2024年第1期9卷 1-16页

作者： Hu Dai Ali Eslami Jason Schneider Gefei Liu fred Schwering Pegasus Vertex Inc.USA Laval University Canada Sanjel Energy Services Canada Athabasca Oil Corporation Canada

While computer modeling of annular displacement efficiency is widely applied in cementing engineering,modeling the displacement flow inside a casing or drill string for cementing operations has received less *** predicting displacement efficiency inside a full-length pipe is desired by cementing engineers,the attempt of developing a model with both efficiency and accuracy faces *** to computer simulators for this purpose is *** with annular flow,the displacement flow inside pipe,although within a simpler geometry and without eccentricity effect,is not simpler in physics,modelling strategy and predictability,because a variety of flow patterns and flow instabilities can develop to create complicated fluid *** this paper,we present an integrated numerical model developed to simulate displacement flows inside a full-length pipe,which connects an existing annulus model to enable complete displacement simulations of cementing *** model uses three-dimensional grid to solve fluid concentrations with degrees of mixing,and incorporates flow instability detection and flow regime *** in cementing,the model accounts for effects of pumping rate,well inclination,pipe rotation,fluid densities,rheological parameters and *** computationally efficient model does not rely on high-resolution mesh as often required by conventional Computational Fluid Dynamics models,thus it is suitable to be implemented in a cementing software for daily use by well cementing *** methodology of the model is discussed in detail in this *** validate the model,we examine simulation results against experimental results obtained in our laboratory tests and CFD simulations;acceptable agreement is found under different testing *** also presented two case studies of real cementing jobs with cement evaluation logs compared to simulation results,showing that the model can predict consistent displacement efficie

关键词： Inside pipe displacement Displacement efficiency Numerical model Primary cementing Displacement flow

Jovian Planet Influence on the Forcing of Sunspot Cycles

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World Journal of Condensed Matter Physics 2024年第1期14卷 1-9页

作者： fred J. Cadieu Physics Department Queens College of CUNY New York USA

The history of our solar system has been greatly influenced by the fact that there is a large gas giant planet, Jupiter that has a nearly circular orbit. This has allowed relics of the early solar system formation to still be observable today. Since Jupiter orbits the Sun with a period of approximately 12 years, it has always been thought that this could be connected to the nearly 11-year periodic peak in the number of sunspots observed. In this paper, the Sun and planets are considered to be moving about a center of mass point as the different planets orbit the Sun. This is the action of gravity that holds the solar system together. The center of mass for the Jupiter-Sun system actually lies outside the Sun. The four gas giant planets dominate such effects and the four gas giant Jovian planets can be projected together to determine an effective distance from the Sun’s center. Taken together these effects do seem to function as a sunspot forcing factor with a periodicity very close to 11 years. These predictions are made without consideration of any details of what is happening in the interior of the Sun. From these estimates, sunspot cycle 25 will be expected to peak in about September-October of 2025. Sunspot cycle 26 should peak in the year March of 2037.

关键词： Sun Cycles Solar System Formation Jupiter

Factors Associated with Antiretroviral Therapy Defaulting among Adult Patients Receiving Care at Chikankata Mission Hospital, Chikankata District, Zambia

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Journal of Biosciences and Medicines 2024年第5期12卷 340-365页

作者： fred Paundi Emmanuel Musenge Namayipo Nankamba Department of Clinical Nursing Sciences School of Nursing Sciences University of Zambia Lusaka Zambia

Background: Defaulting on antiretroviral therapy has been identified as the most important factor contributing to the antiretroviral therapy failure rate. This study aimed to investigate factors associated with defaulting on antiretroviral therapy among adult patients receiving care at Chikankata Mission Hospital antiretroviral therapy clinic. Method: Cross-sectional analytical study on 385 participants selected by a computer generated random numbers technique of simple random sampling from among the patients receiving antiretroviral therapy at Chikankata Mission Hospital. Data collected were processed and analysed using Statistical Package for Social Science version 27. Univariate and backward multivariable logistic regression analysis was performed to identify factors associated with antiretroviral therapy defaulting. The level of significance was set at 5% with a confidence level of 95%. Results: Over half (58.4%) of the study participants defaulted on antiretroviral therapy. About 65.8% of study participants indicated improved health as the reason they defaulted on antiretroviral therapy. Most participants indicated that it was important to always go for antiretroviral therapy services (Adjusted Odds Ratio 1.95;95% Confidence Interval: [1.14 - 3.33], p = 0.015). Very few participants indicated poor family support for antiretroviral therapy services (Adjusted Odds Ratio 4.08;95% Confidence Interval: [2.02 - 8.23], p Conclusion: Defaulting on antiretroviral therapy continues to be a significant problem and needs to be addressed as a matter of priority. More counselling and awareness-raising programmes are required to improve knowledge and understanding on the importance of attending scheduled antiretroviral therapy clinics and services as well as the consequences of defaulting on antiretroviral therapy.

关键词： Defaulting Antiretroviral Therapy Human Immunodeficiency Virus Acquired Immune Deficiency Syndrome

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fred Stein:寻常诗意

读者欣赏 2013年第1期 56-63页

作者：烁朱 fred Stein

摄影作为一门新兴艺术,一直和科技携手并进。尽管有不少"艺术纯粹主义者"不承认这点,科技还是一往无前地开启了艺术的新天地。早期的摄影就是一项冒险,摄影师同时还得是化学家、苦力。照相机又大又笨重,拍照需要长时间曝光,因此。

关键词：电影海报罗伯特·卡帕长时间曝光纯粹主义 fred Stein 个人展览读者欣赏新兴艺术德累斯顿勃兰特

The aerodynamics of heavy vehicles II : +trucks, buses, and trains / +fred Browand, Rose McCallen, James Ross (eds.).

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The aerodynamics of heavy vehicles II : +trucks, buses, and ...

fred Baker:DNS根服务器的事实和传言

1000年

作者： fred Browand Rose McCallen James Ross (eds.).

Includes bibliographical references and index.

ISBN: (纸本)9783540850694 (hbk.);3540850694 (hbk.);9783540850700 (eisbn);3540850708 (eisbn)

Includes bibliographical references and index.

关键词： Motor vehicles Trucks Buses Railroad trains

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中国教育网络 2020年第9期 43-45页

作者： fred Baker 郑艺龙(整理) ICANN根服务器系统咨询委员会不详

根服务器的管理机构可轻易修改根区文件内容甚至可移除特定的顶级域?目前全世界仅有13个根服务器?此类针对根域名服务器的传言一直不休,在日前举行的2020年北京网络安全大会上,根服务器系统咨询委员会(Root Server System Advisory Comm... 详细信息

根服务器的管理机构可轻易修改根区文件内容甚至可移除特定的顶级域?目前全世界仅有13个根服务器?此类针对根域名服务器的传言一直不休,在日前举行的2020年北京网络安全大会上,根服务器系统咨询委员会(Root Server System Advisory Committee,RSSAC)主席fred Baker回应了这些问题。

关键词：网络安全根服务器顶级域 DNS RSS 管理机构根域名服务器

Analysis of the Potential for Tourism Development on Semau Island(Case Study at Liman Beach)

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Economics World 2024年第3期11卷 136-144页

作者： Lukas Hattu fred Dethan Yoseba Pulinggomang Arjuna Purba Junita Cestilia Nenabu Nusa Cendana University KupangEast Nusa TenggaraIndonesia

Semau Island has enormous potential to become a tourist destination in East Nusa *** potential is a variety of resources found in a particular area that can be developed into a tourist *** potential of this island is in the form of natural potential,animal husbandry,maritime culture,and *** research aims to analyze and classify the level of potential of tourist attractions on Semau Island in improving the regional economy at tourist attractions on Semau *** data used is the result of direct interviews with respondents,namely village heads,tourist attraction managers,and local *** analytical method used is descriptive qualitative with the SWOT analysis *** research results concluded that the tourist attraction on Semau Island has the potential to be developed as a superior tourist attraction in Kupang *** or steps that can be taken by managers or local governments to increase tourism development in the form of standard tourism facilities,improving the quality of human resources,and improving infrastructure.

关键词： potential development strategy tourism SWOT

Survival Rate and Factors Influencing It in Triptorelin-Castrated Metastatic Prostate Cancer Patients

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Open Journal of Urology 2024年第3期14卷 160-172页

作者： Sossa Jean Vissoh Gilvias Yevi Dodji Magloire Inès Hodonou fred Avakoudjo Déjinnin Josué Georges Centre National Hospitalier Universitaire Hubert Koutoucou Maga Cotonou Bénin

Background: Most newly diagnosed prostate cancers in Benin are metastatic diseases and patients are reluctant to undergo orchiectomy. Still, chemical androgen deprivation therapy is not always available and not every patient can afford it. Thus, it will be interesting to evaluate the results of that therapy in the country. Objective: To analyze the survival rate and factors influencing it in metastatic prostate cancer patients who underwent triptorelin-based androgen deprivation therapy at the former Military Teaching Hospital of Cotonou from January 1, 2012, to December 31, 2022. Patients and Method: Metastatic prostate cancer patients received intragluteal injections of triptorelin 11.25 mg every 3 months. We retrospectively collected follow-up data from the patients’ medical records. By means of the software StataTM version 15, we performed a descriptive analysis of qualitative data. We used Kaplan-Meir method to estimate the overall survival rate in the whole cohort and in specific subgroups of patients. We compared survival rates by using the log-rank test. Results: 68 metastatic prostate cancer patients aged 47-86 years (mean = 69.9) with initial PSA ranging from 24.25 to 6334 ng/mL (mean = 666.1) started triptorelin-based castration. The tumor grade in 21 (33.3%), 14 (22.2%), 15 (23.8), 8 (12.7%), and 5 (7.9%) patients was respectively ISUP grade groups 5, 4, 3, 2, and 1. 15 (22.1%), 4 (5.9%), 2 (2.9%), 1 (1.5%), 11 (16.2%), and 7 (10.3%) patients respectively had hypertension, diabetes mellitus, peptic ulcer, asthma, unilateral or bilateral hydronephrosis, and paralysis. The mean nadir PSA level was 22.5 ng/mL (range: 0.01-220.25). The mean time to nadir PSA level was 8.9 months (range: 3-57). The overall survival rate was 42.6%. There was no significant survival difference between age groups (p = 0.475), relating to the presence of diabetes or hypertension (p = 0.757) or to the presence of paralysis or hydronephrosis (p = 0.090). The initial PSA level exert

关键词： Metastatic Prostate Cancer Androgen Deprivation Therapy Overall Survival PSA Nadir