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Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats

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World Journal of Gastroenterology 2013年第19期19卷 2894-2903页

作者： Ibrahim Akyazi Evren Eraslan Ahmet Gülubuk Elif Ergül Ekiz Zeynep L rakli Damla Haktanir Deniz Aktaran Bala Mete zkurt Erdal Matur Mukaddes zcan Department of Physiology Veterinary FacultyIstanbul University34320 IstanbulTurkey Department of Pathology Veterinary FacultyIstanbul University34320 IstanbulTurkey Department of Biochemistry Bakirkoy Dr.Sadi Konuk Training and Research Hospital34147 IstanbulTurkey Department of Physiology Faculty of MedicineEski ehir Osmangazi University26480 EskisehirTurkey

AIM:To investigate the effects of long term pretreatment with low-,medium-and high-dose aspirin(acetylsalicylic acid,ASA) on a model of acute pancreatitis(AP) induced in ***:Forty male Wistar rats were *** experimental groups,each consisting of eight animals,received low-(5 mg/kg per day),medium-(150 mg/kg per day) and high-dose(350 mg/kg per day) ASA in supplemented pellet chow for 100 *** animals,serving as the AP-control group,and another eight,serving as reference value(RV) group,were fed with standard pellet chow for the same *** pretreatment,AP was induced in the experimental animals by intraperitoneal administration of cerulein(2 × 50 μg/kg),while the RV group received saline in the same *** hours after the second injection,the animals were *** tissue and plasma samples were *** part of the collected pancreatic tissues was used for histopathological evaluation,and the remaining portion was *** levels [tumor necrosis factor,interleukin(IL)1β,IL-6],hemogram parameters,biochemical parameters(amylase and lipase),nuclear factor-κB,aspirin triggered lipoxins and parameters related to the antioxidant system(malondialdehyde,nitric oxide,hemeoxygenase-1,catalase and superoxide dismutase) were ***:Cerulein administration induced mild pancreatitis,characterized by interstitial edema(total histopathological score of 5.88 ± 0.44vs 0.25 ± 0.16,P < 0.001).Subsequent pancreatic tissue damage resulted in an increase in amylase(2829.71 ± 772.48 vs 984.57 ± 49.22 U/L,P = 0.001) and lipase(110.14 ± 75.84 U/L vs 4.71 ± 0.78 U/L,P < 0.001) in plasma,and leucocytes(6.89 ± 0.48 vs 4.36 ± 0.23,P = 0.001) in peripheral ***,IL-1β(18.81 ± 2.55 pg/μg vs 6.65 ± 0.24 pg/μg,P = 0.002) and IL-6(14.62 ± 1.98 pg/μg vs 9.09 ± 1.36 pg/μg,P = 0.04) in pancreatic tissue also *** pretreatment reduced the increase in the aforementioned parameters to a certain degree and partially i

关键词： Aspirin Acute pancreatitis Cerulein Antioxidant Cytokines

Comparison of 1470 nm Radial Fiber Laser Ablation and Radiofrequency Ablation in Endovascular Treatment of Venous Insufficiency

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World Journal of Cardiovascular Surgery 2016年第9期6卷 117-124页

作者： Havva Nur Alparslan Yümün Özcan Gür Selami Gürkan Department of General Surgery Corlu Devlet Hastanesi Tekirdag Turkey Department of Cardiovascular Surgery Namik Kemal University Tekirdag Turkey

Background: In this study, we aimed to compare the results of endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) in patients with lower extremity venous insufficiency due to great saphenous vein (GSV) reflux on efficiency, patient comfort and postoperative morbidity. Methods: Endovascular approach in treatment of GSV insufficiency was performed in 283 patients between 2011 and 2014 at our clinic. In group 1, EVLA was performed on 149 patients (42 male, 107 female;mean age 46.90 ± 11.43) and in group 2, RFA was performed on 134 patients (41 male, 93 female;mean age 47.02 ± 12.58). The results were compared in terms of local pain, ecchymosis, paresthesia, venous clinic severity score (VCSS), length of GSV that process performed, efficiency and Clinical Etiology Anatomy Pathophysiology (CEAP) classification data. Results: GSV diameter at saphenofemoral junction level was 10.65 ± 3.72 mm and 11.29 ± 3.78 mm in group 1 and 2, respectively. Length of GSV that process performed was 38.97 ± 6.88 cm in group 1 and 41.83 ± 4.82 cm in group 2. Postoperatively burn, pulmonary embolism (PE) and deep venous thrombosis (DVT) were not observed in both groups. Postoperative complications in group 1 were hematoma formation in 2 (1.3%) patients, ecchymosis in 13 (8.7%) patients, edema in 21 (14.1%) patients and paresthesia in 10 (6.7%) patients. Postoperative complications in group 2 were hematoma formation in 1 (0.7%) patient, ecchymosis in 8 (6%) patients, edema in 12 (9%) patients and paresthesia in 6 (4.5%) patients. The efficiency of the process was 96.6% in EVLA group and 98.5% in RFA group. Conclusion: We conclude that both RFA and 1470 nm radial fiber EVLA procedures are effective and reliable techniques in treatment of GSV insufficiency. No significant difference was found between two techniques in terms of efficiency and postoperative morbidity.

关键词： Endovascular Radiofrequency Laser Venous Insufficiency

A MIXED VIRTUAL ELEMENT METHOD FOR THE BOUSSINESQ PROBLEM ON POLYGONAL MESHES

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Journal of Computational Mathematics 2021年第3期39卷 392-427页

作者： Gabriel N.Gatica Mauricio Munar Filander A.Sequeira CI^2 MA and Departamento de Ingenieria Matemitica Universidad de ConcepcionCasilla 160-CConcepcionChile Escuela de Matemaitica Universidad NacionalCampus Omar DengoHerediaCosta Rica

In this work we introduce and analyze a mixed virtual element method(mixed-VEM)for the two-dimensional stationary Boussinesq *** continuous formulation is based on the introduction of a pseudostress tensor depending nonlinearly on the velocity,which allows to obtain an equivalent model in which the main unknowns are given by the aforementioned pseudostress tensor,the velocity and the temperature,whereas the pressure is computed via a postprocessing *** addition,an augmented approach together with a fixed point strategy is used to analyze the well-posedness of the resulting continuous *** the discrete problem,we follow the approach employed in a previous work dealing with the Navier-Stokes equations,and couple it with a VEM for the convection-diffusion equation modelling the *** precisely,we use a mixed-VEM for the scheme associated with the fluid equations in such a way that the pseudostress and the velocity are approximated on virtual element subspaces of H(div)and H^(1),respectively,whereas a VEM is proposed to approximate the temperature on a virtual element subspace of H^(1).In this way,we make use of the L^(2)-orthogonal projectors onto suitable polynomial spaces,which allows the explicit integration of the terms that appear in the bilinear and trilinear forms involved in the scheme for the fluid *** the other hand,in order to manipulate the bilinear form associated to the heat equations,we define a suitable projector onto a space of polynomials to deal with the fact that the diffusion tensor,which represents the thermal conductivity,is ***,the corresponding solvability analysis is performed using again appropriate fixed-point ***,Strang-type estimates are applied to derive the a priori error estimates for the components of the virtual element solution as well as for the fully computable projections of them and the postprocessed *** corresponding rates of convergence are als

关键词： Boussinesq problem Pseudostress-based formulation Augmented formulation Mixed virtual element method.High-order approximations

Age and Gender Dependent Amino Acid Concentrations in the Feather, Feather-Free and Whole Empty Body Protein of Fast Growing Meat-Type Chickens

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Open Journal of Animal Sciences 2018年第3期8卷 223-238页

作者： Christian Wecke Daulat Rehman Khan Angela Sünder Frank Liebert Division Animal Nutrition Physiology Department of Animal Sciences Georg-August-University of Gottingen Gottingen Germany

Two consecutive growth experiments with meat-type chickens (Ross 308) were conducted in order to quantify the age-dependent amino acid (AA) content in the whole body protein of male and female birds based on experimental data of the feather and feather-free body protein fractions. Birds were reared under uniform housing and feeding conditions (floor pens, 15 pens per gender, 5 birds per pen) during the starter (day 1 to 22) and grower period (day 22 to 36). Both the starter and grower diet based on corn, wheat, soybean meal, soybean protein concentrate and feed amino acids was formulated to ensure an equal feed protein quality close to the ideal amino acid ratio by adjusting a constant mixture of the feed proteins. At start of the experiment and further on weekly up to the end of the 5th week, 15 birds per gender (each 3 pens of 5 birds) were selected and fasted for 24 h, to emptying of gastro-intestinal tract, respectively. Subsequently, birds were euthanized and the feathers were manually removed. Nitrogen (N) and AA content were determined both in the feather and feather-free body fraction. The concentration of individual AAs in both of body protein fraction is varying considerably. Explicitly higher Cys, Ser and Pro but importantly lower Met, Lys and His concentrations were found in the feather protein. Furthermore, significant differences (p for nearly all AAs of the studied body protein fractions and the whole empty body protein dependent on age of birds were observed. Especially high deviations were obtained during the first week of age and at the end of the experiment. According to this observed variation of AA concentrations must be concluded that the body AA composition of meat-type chickens during growth is not constant. The detected gender-specific differences for several AAs in the feather and body protein of male and female birds were rather low and with very low variation.

关键词： Growing Chickens Feather Amino Acids Body Amino Acids Age Gender

Age and Gender Depending Growth of Feathers and Feather-Free Body in Modern Fast Growing Meat-Type Chickens

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Open Journal of Animal Sciences 2017年第4期7卷 376-392页

作者： Christian Wecke Daulat Rehman Khan Angela Sünder Frank Liebert Division Animal Nutrition Physiology Department of Animal Sciences Georg-August-University of G&#246 ttingen G&#246 ttingen Germany

Two growth experiments with fast growing meat type chickens (Ross 308) were conducted to assess the growth of feathers and feather-free body dependent on age and gender (male:female ratio = 1:1). Birds were reared under uniform management and feeding conditions (floor pens;15 pens per gender;5 birds per pen) during the starter (day 1 to 22) and grower period (day 22 to 36). Diets were based on corn, wheat, soybean meal, soybean protein concentrate and balanced with feed amino acids to ensure an equal feed protein quality close to the ideal amino acid ratio by a constant mixture of the feed proteins. At start of the experiment and further on weekly up to the end of the 5th week, 15 birds per gender (each 3 pens of 5 birds) were selected and 24 h fasted before quantitative de-feathering. Both feather and feather free body fractions were significantly increased with increasing age of the birds (p nder, respectively.

关键词： Growing Chickens Feather Percentage Feather-Free Body Age Gender

Age and Gender Dependent Nutrient Composition of Feather and Feather-Free Body Fractions in Meat-Type Chickens

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Open Journal of Animal Sciences 2018年第1期8卷 74-86页

作者： Christian Wecke Daulat Rehman Khan Angela Sünder Frank Liebert Division Animal Nutrition Physiology Department of Animal Sciences Georg-August-University of Gottingen Gottingen Germany

The objective of this research was to update current results about the nutrient composition of broiler chickens during the growth period up to market age. Two growth experiments were conducted for assessing the nutrient content of feathers and feather-free body of meat-type chickens (Ross 308). Both male and female birds were reared under uniform management conditions (floor pens;15 pens per gender;5 birds per pen). Experimental diets both for the starter (day 1 to 22) and the grower period (day 22 to 36) were based on corn, wheat, soybean meal, soybean protein concentrate and well balanced with feed amino acids. The feed protein quality was adapted to the ideal amino acid ratio and equated within both of the feeding periods by adjusting a constant mixture of the feed proteins. Each 15 birds per gender (3 pens of 5 birds) were selected and subsequently fasted for 24 h before quantitative de-feathering both at start of the experiment and further on weekly up to the end of the 5th week. Nutrient content was determined in representative samples of the feather and feather-free body fraction. In the feather dry matter (DM) very high crude protein (CP) concentrations (>96%) with low age-dependent and insignificant gender-specific differences were observed. In spite, a relatively high variation of CP content in the DM of feather-free body was found. Depending on age, the body CP significantly decreased with increasing age, but male birds yielded higher (p nder, the crude ash content both in feathers and feather-free body of modern fast-growing chickens was rather low and with very low variation.

关键词： Growing Chickens Feather Composition Body Composition Age Gender

Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

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Cellular & Molecular Immunology 2021年第2期18卷 415-426页

作者： Morten Orebo Holmström Rasmus Erik Johansson Mortensen Angelos Michail Pavlidis Evelina Martinenaite Stine Emilie Weis-Banke Mia Aaboe-Jørgensen Simone Kloch Bendtsen Özcan Met Ayako Wakatsuki Pedersen Marco Donia Inge Marie Svane Mads Hald Andersen Department of Oncology National Center for Cancer Immune TherapyCopenhagen University HospitalHerlevDenmark IO Biotech ApS CopenhagenDenmark Institute for Immunology and Microbiology Copenhagen UniversityCopenhagenDenmark

Transforming growth factor-beta(TGFβ)is a highly potent immunosuppressive *** TGFβis a tumor suppressor in early/premalignant cancer lesions,the cytokine has several tumor-promoting effects in advanced cancer;abrogation of the antitumor immune response is one of the most important tumor-promoting *** several immunoregulatory mechanisms have recently been shown to be targets of specific T cells,we hypothesized that TGFβis targeted by naturally occurring specific T cells and thus could be a potential target for immunomodulatory cancer ***,we tested healthy donor and cancer patient T cells for spontaneous T-cell responses specifically targeting 3820-mer epitopes derived from TGFβ*** identified numerous CD4^(+)and CD8^(+)T-cell responses against several epitopes in TGFβ.Additionally,several ex vivo responses were *** enriching specific T cells from different donors,we produced highly specific cultures specific to several TGFβ-derived *** CD8^(+)T-cell clones specific for both a 20-mer epitope and a 9-mer HLA-A2 restricted killed epitope peptide were pulsed in HLA-A2+target cells and killed the HLA-A2+cancer cell lines THP-1 and ***,stimulation of THP-1 cancer cells with cytokines that increased TGFβexpression increased the fraction of killed *** conclusion,we have shown that healthy donors and cancer patients harbor CD4^(+)and CD8^(+)T cells specific for TGFβ-derived epitopes and that cytotoxic T cells with specificity toward TGFβ-derived epitopes are able to recognize and kill cancer cell lines in a TGFβ-dependent manner.

关键词： Immune regulation TGFbeta cancer T cells adaptive immunity

Local tissue development of type 1 innate lymphoid cells:guided by interferon-gamma

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2282-2283页

作者： Thomas M.Conlon Percy A.Knolle Ali Onder Yildirim Comprehensive Pneumology Center(CPC) Institute of Lung Biology and DiseaseHelmholtz Zentrum MunchenMember of the German Center for Lung Research(DZL)NeuherbergGermany lnstitute of Molecular Immunology and Experimental Oncology Klinikum rechts der IsarTechnical University of MunichMunichGermany

A recent article published in Science by Bai et a I.1 identified interferon-Y(IFN-y)secreted by type 1 innate lymphoid cells(ILCIs)self-perpetuated their own local development from resident hematopoietic stem cells(HS... 详细信息

关键词： interferon lymphoid hematopoietic

Fumarate hydratase:a new checkpoint of metabolic regulation in inflammatory macrophages

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4421-4423页

作者： Aicha Jeridi Theodore S.Kapellos Ali Onder Yildirim Comprehensive Pneumology Center(CPC) Institute of Lung Health and Immunity(LHI)Member of the German Center for Lung Research(DZL)Helmholtz MunichMunichGermany Institute of Experimental Pneumology University HospitalLudwig-Maximilians UniversityMünchenGermany

A recent article published by Hooftman et al.1 in Nature identified a crucial function for fumarate hydratase(FH)in bone marrow-derived macrophages(BMDMs).Pharmacological inhibition or genetic ablation of FH led to increased fumarate levels and downstream suppression of mitochondrial respiration implying the importance of cellular metabolic states and cytokine balance shift in innate immunity.

关键词： al. macrophages respiration