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Primary sclerosing cholangitis in Turkish patients:characteristic features and prognosis

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Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 312-315页

作者： Hilmi Ataseven Erkan Parlak lhami Yüksel mer ba■ar brahim Ertu■rul Nurgül ■a■maz Burhan ■ahin Department of Gastroenterology Türkiye Yüksek htisas Hospital Department of Gastroenterology Di■kapl Yildirlm Beyazlt Education and Research Hospital

baCKGROUND:Primary sclerosing cholangitis(PSC)is a chronic cholestatic liver disease characterized by destruction and fibrosis of the bile *** study aimed to demonstrate the hepatic and extrahepatic characteristic findings and prognostic outcomes of Turkish patients with PSC. METHODS:The medical records of 35 consecutive patients with PSC from January 1988 to June 2007 were recorded *** the time of diagnosis,clinical features and laboratory data were collected. RESULTS:The mean age of the 35 patients was 41.69 years (range 15-80 years)at the time of diagnosis;14(40%)were female,and 21(60%)were *** mean duration of follow-up was 58.86 months(1-180 months).Twenty(57.1%) of the patients with PSC were asymptomatic and 22(62.9%) had inflammatory bowel *** the time of diagnosis, 20(57.1%)of the patients had both intra-and extra-hepatic ***-one(60%)of the patients,who had undergone ERCP for stent placement,had dominant bile duct stenosis. Cholangiocarcinoma was found in 2(5.7%)of the patients and cirrhosis was detected in 7(20%);5(14.3%)underwent liver *** median follow-up time after liver transplantation was 23 months and all are still *** (17.1%)patients died. CONCLUSIONS:PSC has a clinical course varied from advanced liver disease requiring liver transplantation within a short time to being asymptomatic for decades. The prognosis of Turkish patients with PSC is also disappointing as described in other studies.

关键词： primary sclerosing cholangitis cholestatic liver diseases biliary tree endoscopic retrograde cholangiopancreatography

Levels of evidence and grades of recommendation supporting European society for medical oncology clinical practice guidelines

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Oncology Research 2024年第5期32卷 807-815页

作者： MarKO SKELIN BRUNA PERKOV-STIPIČIN SANJA VUŠKOVIĆ MarINAŠANDRK PLEHAČEK ANE baŠIĆ DAVIDŠarČEVIĆ MAJA ILIĆ IVAN KREČAK Pharmacy Department General Hospital ofŠibenik-Knin CountyŠibenikCroatia Faculty of Medicine University of RijekaRijekaCroatia Undergraduate Study in Nursing University of Applied SciencesŠibenikCroatia Department of Oncology University Hospital Center ZagrebZagrebCroatia Pharmacies Joukhadar Sveta NedeljaCroatia Pharmacies Prima Pharme ZagrebCroatia Pharmacy Department General Hospital ZadarZadarCroatia Pharmacy Department General Hospital PulaPulaCroatia Department of Internal Medicine General Hospital ofŠibenik-Knin CountyŠibenikCroatia

background:The European Society for Medical Oncology(ESMO)guidelines are among the most comprehensive and widely used clinical practice guidelines(CPGs)***,the level of scientific evidence supporting ESMO CPG recommendations has not been systematically *** study assessed ESMO CPG levels of evidence(LOE)and grades of recommendations(GOR),as well as their trends over time across various cancer ***:We manually extracted every recommendation with the Infectious Diseases Society of America(IDSA)classification from each *** examined the distribution of LOE and GOR in all available ESMO CPG guidelines across different topics and cancer ***:Among the 1,823 recommendations in the current CPG,30%were classified as LOEⅠ,and 43%were classified as GOR ***,there was a slight decrease in LOEⅠ(−2%)and an increase in the proportion of GOR A(+1%)in the current CPG compared to previous *** proportion of GOR A recommendations based on higher levels of evidence such as randomized trials(LOEⅠ–Ⅱ)shows a decrease(71%vs.63%,p=0.009)while recommendations based on lower levels of evidence(LOEⅢ–Ⅴ)show an increase(29%vs.37%,p=0.01)between previous and current *** the current versions,the highest proportion of LOEⅠ(42%)was found in recommendations related to pharmacotherapy,while the highest proportion of GOR A recommendations was found in the areas of pathology(50%)and diagnostic(50%)*** variability in LOEⅠand GOR A recommendations and their changes over time was observed across different cancer ***:One-third of the current ESMO CPG recommendations are supported by the highest level of *** well-designed randomized clinical trials are needed to increase the proportion of LOEⅠand GOR A recommendations,ultimately leading to improved outcomes for cancer patients.

关键词： ESMO guidelines Clinical practice guidelines Level of evidence Grade of recommendation

Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 341-349页

作者： Nora A.Elsayed Fatma SM Moawed Esraa SA Ahmed Ahmed Hammad Omayma ar Abo-Zaid Biochemistry and Molecular Biology Department Faculty of Vet.Med.Benha UniversityBenha cityEgypt Health Radiation Research National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt Radiation Biology Department National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt

Objective:To assess the hepatoprotective effects of flavone on nicotine-induced liver ***:Thirty-six rats were allocated into six groups:the control group,the nicotine group,the flavone alone groups(10 and 25 mg/kg/body weight),and the nicotine groups treated with flavone(10 and 25 mg/kg/body weight).Liver function,oxidative stress,Nrf2 pathway(HO-1,Nrf2,and Keap-1),and inflammatory markers(IL-17,TNF-α,and NF-κB)were ***,a histopathological examination of liver tissues was ***:Nicotine increased liver damage,inflammation,and oxidative ***,flavone suppressed nicotine-induced liver enzymes,oxidative stress,and inflammation,as manifested by increased antioxidants and decreased malondialdehyde level,liver enzymatic activities,and inflammatory ***(10 and 25 mg/kg/body weight)also reduced the level of Keap-1 and increased HO-1 and Nrf2 levels in the liver of nicotine-exposed ***:Flavone has hepatoprotective properties and may slow the progression of liver injury by reducing oxidative stress,liver enzymes,and inflammation possibly via the Nrf2 pathway.

关键词： Flavone Nicotine Liver Nrf2 HO-1 NF-κB

基于金属-有机框架同分异构体构建MOFs相结用以增强CO_(2)光还原活性

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Science China Materials 2024年第6期67卷 1839-1845页

作者：黄海波李兰王瑞 ar Mahammed Shaheer 刘天赋刘海雄曹荣 School of Environmental Science and Engineering Qingdao UniversityQingdao 266071China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018China

利用太阳能将CO_(2)光转化为化学燃料是前沿研究的热点.当前,科研的重点在于开发和优化各类光催化材料的性能.异质结构不仅用于增强无机半导体催化剂的活性,而且用于金属-有机框架(MOFs)光催化剂的构建.随着异质结技术的不断进步,新的... 详细信息

利用太阳能将CO_(2)光转化为化学燃料是前沿研究的热点.当前,科研的重点在于开发和优化各类光催化材料的性能.异质结构不仅用于增强无机半导体催化剂的活性,而且用于金属-有机框架(MOFs)光催化剂的构建.随着异质结技术的不断进步,新的相结概念应运而生.尽管关于无机半导体中的相结研究已取得一定进展,但是MOFs相结结构的探索尚处于起步阶段.本文中,我们成功设计并构建了一种具有卓越光催化CO_(2)还原性能的MOFs相结杂化材料.这种材料由具有高度连接性的卟啉配体(TCPP-Ni)与Zr6团簇紧密结合而成,在溶剂热反应条件下,PCN-222-Ni能够快速且均匀地成核.通过精准调控调节剂的用量,我们实现了同分异构体PCN-224-Ni在类似条件下较慢的晶体形成过程.最终制得的P@P杂化材料展现出高表面积、多孔性和卓越的结晶度.由于PCN-222-Ni和PCN-224-Ni之间的带隙匹配,光生载流子的分离和迁移得以促进,从而使P@P杂化材料展现出卓越的光还原CO_(2)性能.这一重大突破不仅标志着MOFs相结结构研究的重大进展,还拓宽了MOFs相结在CO_(2)光转化领域的应用前景.

关键词： MOFs polymorphism phase-junctions photo-catalytic CO_(2)reduction

Decentralized multi-agent reinforcement learning with networked agents: recent advances

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Frontiers of Information Technology & Electronic Engineering 2021年第6期22卷 802-814页

作者： Kaiqing ZHANG Zhuoran YANG Tamer baŞar Coordinated Science Laboratory University of Illinois at Urbana-ChampaignIL 61801USA Department of Operations Research and Financial Engineering Princeton UniversityNJ 08544USA

Multi-agent reinforcement learning(MarL) has long been a significant research topic in both machine learning and control systems. Recent development of(single-agent) deep reinforcement learning has created a resurgence of interest in developing new MarL algorithms, especially those founded on theoretical analysis. In this paper, we review recent advances on a sub-area of this topic: decentralized MarL with networked *** this scenario, multiple agents perform sequential decision-making in a common environment, and without the coordination of any central controller, while being allowed to exchange information with their neighbors over a communication network. Such a setting finds broad applications in the control and operation of robots, unmanned vehicles, mobile sensor networks, and the smart grid. This review covers several of our research endeavors in this direction, as well as progress made by other researchers along the line. We hope that this review promotes additional research efforts in this exciting yet challenging area.

关键词： Reinforcement learning Multi-agent systems Networked systems Consensus optimization Distributed optimization Game theory

Inhibition of Ehrlich ascites carcinoma growth by melatonin:Studies with micro-CT

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Oncology Research 2024年第1期32卷 175-185页

作者： SEHER YILMAZ ZÜLEYHA DOĞANYIĞIT merT OCAK EVRIM SUNA arIKAN SÖYLEMEZ ASLI OKAN OFLAMAZ SÜMEYYE UÇar ŞÜKRÜATEŞ AMMAD AHMAD FarOOQI Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecular Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mTOR)signaling pathway and the argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed Tomography(Micro CT).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the IHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8(F8)expression were compared with the control *** was determined that there was a significant decrease(parea/nuclear area(TAA/NA)ratio in the treatment groups(paracterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： Signaling pathway Apoptosis Real-time PCR AgNOR

Twenty-nine million intrinsic Q-factor monolithic microresonators on thin-film lithium niobate

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Photonics Research 2024年第8期12卷 1587-1592页

作者： XINRUI ZHU YAOWEN HU SHENGYUAN LU HANA K.WarNER XUDONG LI YUNXIANG SONG LETíCIA MAGALH?ES AMIRHASSAN SHAMS-ANSarI ANDREA CORDarO NEIL SINCLAIR MarKO LON?ar John A.Paulson School for Engineering and Applied Sciences Harvard University State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of Physics Peking University DRS Daylight Solutions

The recent emergence of thin-film lithium niobate(TFLN) has extended the landscape of integrated *** has been enabled by the commercialization of TFLN wafers and advanced nanofabrication of TFLN such as high-quality dry etching. However, fabrication imperfections still limit the propagation loss to a few dB/m, restricting the impact of this platform. Here, we demonstrate TFLN microresonators with a record-high intrinsic quality(Q) factor of twenty-nine million, corresponding to an ultra-low propagation loss of 1.3 dB/m. We present spectral analysis and the statistical distribution of Q factors across different resonator geometries. Our work pushes the fabrication limits of TFLN photonics to achieve a Q factor within 1 order of magnitude of the material limit. ? 2024 Chinese Laser Press

关键词： Coupled resonators Integrated photonics Lithium niobate Q factor Ring resonators Scanning electron microscopy

On the Space bv_p(F) of Sequences of p-bounded Variation of Fuzzy Numbers

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Acta Mathematica Sinica,English Series 2008年第7期24卷 1205-1212页

作者： zer TALO Feyzi ba■ar Fatih niversitesi Fen-Edebiyat FakltesiMatematik BlmBykekmece Kamps 34500-stanbulTrkiye

Recently, the space bvp of real or complex numbers consisting of all sequences whose differences are in the space lp has been studied by basar, Altay [Ukrainian Math. J. 55（1）（2003）, 136-147], where 1 ≤ p ≤ ∞. The main purpose of the present paper is to introduce the space bvp（F） of sequences of p-bounded variation of fuzzy numbers. Moreover, it is proved that the space bvp（F） includes the space lp（F） and also shown that the spaces bvp（F） and lp（F） axe isomorphic for 1 ≤ p ≤∞. Furthermore, some inclusion relations have been given.

关键词： sequence of fuzzy numbers space of difference sequences isomorphic spaces and inclusion relations

Robust Designs Through Risk Sensitivity:An Overview

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Journal of Systems Science & Complexity 2021年第5期34卷 1634-1665页

作者： baSar Tamer Coordinated Science Laboratory University of Illinois1308 West MainUrbanaIL 61801USA.

This is an overview paper on the relationship between risk-averse designs based on exponential loss functions with or without an additional unknown(adversarial)term and some classes of stochastic *** particular,the paper discusses the equivalences between risk-averse controller and filter designs and saddle-point solutions of some corresponding risk-neutral stochastic differential games with different information structures for the *** of the by-products of these analyses is that risk-averse controllers and filters(or estimators)for control and signal-measurement models are robust,through stochastic dissipation inequalities,to unmodeled perturbations in controlled system dynamics as well as signal and the measurement *** paper also discusses equivalences between risk-sensitive stochastic zero-sum differential games and some corresponding risk-neutral three-player stochastic zero-sum differential games,as well as robustness issues in stochastic nonzero-sum differential games with finite and infinite populations of players,with the latter belonging to the domain of mean-field games.

关键词： Mean-field games risk-sensitive control risk-sensitive filtering risk-sensitive games risk sensitivity robustness