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Journal of Clinical and Translational Hepatology 2022年第2期10卷 356-362页

作者： Ángela rojas María Rosario García-Lozano Antonio Gil-Gómez Manuel Romero-Gómez Javier Ampuero Department of Unit of Digestive Diseases Virgen del Rocío University HospitalSevilleSpain SeLiver group at the Insti-tute of Biomedicine of Seville(IBIS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Center for the Study of Liver and Gastrointestinal Diseases(CIBERehd) Carlos III National Institute of HealthMadridSpain De-partment of Organic and Medicinal Chemistry Faculty of PharmacyUniversity of SevilleE-41071SevilleSpain

The prevalence of non-alcoholic fatty liver disease(NAFLD)is increasing worldwide,reflecting the current epidemics of obesity,insulin resistance,type 2 diabetes mellitus,and metabolic *** is characterized by the accumulation of fat in the liver,and is known to be a cause of *** many pathways have been proposed,the cause of NAFLD-linked fibrosis progression is still unclear,which posed challenges for the development of new therapies to prevent NASH-related cirrhosis and hepatocellular *** is associated with activation of hepatic stellate cells(HSC)and accumulation of excess extracellular matrix proteins,and inhibiting the activation of HSCs would be expected to slow the progression of *** molecular signals and pathways such as oxidative stress and glutaminolysis have been reported to promote HSC *** mechanisms are plausible antifibrotic targets in NASH,as the activation of HSCs the proliferation of myofibroblasts depend on those *** review summarizes the role of the glutaminolysis-ammonia-urea cycle axis in the context of NAFLD progression,and shows how the axis could be a novel therapeutic target.

关键词： Non-alcoholic fatty liver disease Cirrhosis Fibrosis Glutaminoly-sis Ammonia Urea

Entry of hepatitis C virus into the cell: A therapeutic target

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World Journal of Gastroenterology 2012年第33期18卷 4481-4485页

作者： José Antonio Del Campo ngela rojas Manuel Romero-Gómez Unit for Medical and Surgical Management of Digestive Diseases Center for Biomedical Research in Digestive and Liver Diseases Network (CIBERehd) Valme University Hospital University of Seville E-41014 Sevilla Spain

Several receptors have been identified as implicated on viral entry into the hepatocyte; and, this interaction between the virus and potential receptors could modulate infection, spontaneous viral clearance, persistence of the infection and the widespread of the virus as outbreak. Nevertheless, the playing role of each of them remains controversial. The NiemannPick type C1 like 1 gene (NPC1L1) receptor has been recently implicated on hepatitis C virus (HCV) entry into the cell and ezetimibe, an anti-cholesterol drug seems to block that, emerging the idea to control hepatitis C outbreak modulating lipid-related receptors. Hepatitis C infection seems to modulate lipid metabolism according to host genetic background. Indeed, it circulates like a lipoviroparticle. The main aim of this field of vision would be to discuss the role of hepatocyte receptors implicated on virus entry, especially NPC1L1 and the therapeutic options derived from the better knowledge about HCV-lipidsreceptors interaction.

关键词： Hepatitis C virus entry Niemann-Pick type C1 like 1 gene Lipid metabolism Ezetimibe

Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid-and long-term prediction of hepatocellular carcinoma among cirrhotic patients

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World Journal of Gastroenterology 2021年第48期27卷 8343-8356页

作者： Antonio Gil-Gómez Ángela rojas Chang-Hai Liu Rocio Gallego-Duran Rocio Muñoz-Hernandez Giorgio Fassina Patrizia Pontisso Javier Ampuero Manuel Romero-Gómez SeLiver Group Institute of Biomedicine of SevilleSeville 41013Spain CIBERehd Instituto de Salud Carlos IIIMadrid 28029Spain Mucosal Immunity Lab IRCCS Humanitas Research HospitalMilan 20089Italy Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610017Sichuan ProvinceChina State Key Laboratory of Biotherapy and Center of Infectious Diseases West China HospitalChengdu 610017Sichuan ProvinceChina Life Biotechnology Padua UniversityVenice 30175Italy Department of Clinical and Experimental Medicine University of PadovaPadova 35123Italy UCM Digestive Diseases Virgen del Rocío University HospitalSeville 41014Spain

BACKGROUND The combination of alpha-fetoprotein(AFP)and squamous cell carcinoma antigen immunocomplex(SCCA-IgM)have been proposed for its use in the screening of hepatocellular carcinoma(HCC).Current screening programs for all cirrhotic patients are controversial and a personalized screening is an unmet need in the precision medicine *** To determine the role of the combination of SCCA-IgM and AFP in predicting mid-and long-term appearance of *** Two-hundred and three cirrhotic patients(Child A 74.9%,B 21.2%,C 3.9%)were followed-up prospectively every six months to screen HCC by ultrasound and AFP according to European Association for the Study of the Liver *** estimation cohort was recruited in Italy(30.5%;62/203)and validation cohort from Spain(69.5%;141/203).Patients underwent to evaluate SCCA-IgM by enzyme-linked immunosorbent assay(Hepa-IC,Xeptagen,Italy)and AFP levels at *** were followed-up for 60 mo,being censored at the time of the appearance of *** There were 10.8%and 23.1%of HCC development at two-and five-years *** with HCC showed higher levels of SCCA-IgM than those without it(425.72±568.33 AU/mL vs 195.93±188.40 AU/mL,P=0.009)during the fiveyear *** multivariate analysis,after adjusting by age,sex,aspartate transaminase and Child-Pugh,the following factors were independently associated with HCC:SCCA-IgM[Hazard ratio(HR)=1.001,95%CI:1.000-1.002;P=0.003],AFP(HR=1.028,95%CI:1.009-1.046;P=0.003)and creatinine(HR=1.56495%CI:1.151-2.124;P=0.004).The log-rank test of the combination resulted in 7.488(P=0.024)in estimation cohort and 11.061(P=0.004)in the validation cohort,and a 100%of correctly classified rate identifying a low-risk group in both cohorts in the two-year *** We have constructed a predictive model based on the combination of SCCA-IgM and AFP that provides a new HCC screening method,which could be followed by tailored HCC surveillance for individual patients,esp

关键词： Squamous cell carcinoma antigen Hepatocellular carcinoma prediction Precision medicine Stratification of cirrhotic patient

An Approach to Design MIMO FO Controllers for Unstable Nonlinear Plants

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IEEE/CAA Journal of Automatica Sinica 2016年第3期3卷 338-344页

作者： Arturo rojas-Moreno IEEE Department of Electrical Engineering Universidad de Ingenieriay Tecnologia (www.utec.edu.pe)

This paper develops an approach to control unstable nonlinear multi-inputs multi-output(MIMO) square plants using MIMO fractional order(FO) controllers. The controller design uses the linear time invariant(LTI) state space representation of the nonlinear model of the plant and the diagonal closedloop transfer matrix(TM) function to ensure decoupling between inputs. Each element of the obtained MIMO controller could be either a transfer function(TF) or a gain. A TF is associated in turn with its corresponding FO TF. For example, a D(Derivative) TF is related to a FO TF of the form Dδ, δ =[0, 1]. Two applications were performed to validate the developed approach via experimentation: control of the angular positions of a manipulator, and control of the car and arm positions of a translational manipulator.

关键词： Fractional calculus modeling of nonlinear sys-tem control of manipulator multivariable decoupling multivari-able nonlinear system

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Physicochemical properties of Li_(3)Ba_(2)La_(3)(MoO_(4))_(8):Eu,Tb red-emitting phosphor for solid state white lamps

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Journal of Rare Earths 2023年第9期41卷 1279-1287,I0001页

作者： Kora Lu rojas Baldivia Gustavo A.Hirata Center for Scientific Research and Higher Education of Ensenada Ensenada Baja California 22860Mexico Center for Nanoscience and Nanotechnology National Autonomous University of Mexico EnsenadaBaja Califomia 22860Mex

In this work,combustion synthesis was used for the first time to fabricate a phosphor material with red emission for applications in solid-state white-light *** synthesized a material with emission wavelength at λ_(em)=617 nm,excited under long UV-blue wavelength based on Eu^(3+),Tb^(3+)-activated molybdates Li_(3)Ba_(2)(La_(1-x-y)Eu_(x)Tb_(y))_(3)(MoO_(4))_(8) with 0 ≤ x ≤1 and 0 ≤ y ≤ 1.A series of powder samples were produced by the combustion method and post-annealed at 800℃ in *** crystalline phase formation was investigated by X-ray diffraction,which reveals the monoclinic C2/c(15) space *** is observed that crystalline structure and morphology are preserved when the host lattice is doped with Eu^(3+) or Tb^(3+) single ions and co-doped with both ions at different doping concentrations.A detailed characterization by scanning electron microscopy(SEM) and transmission electron microscopy(TEM)shows a similar morphology in all samples:rather large(1-7 μm) agglomerate particles with irregular shapes and surrounded by smaller nanoparticles of 50 nm in ***-visible absorption spectra confirm the presence of Eu^(3+) and Tb^(3+) *** luminescent properties of the obtained phosphors were studied in *** measurements indicate that the best emission intensity is for Eu^(3+):Tb^(3+)doping ratios of 80:0,90:0 and 20:*** the other hand,samples with 80:0,60:40,and 20:80 doping ratios show the highest intensity in a detailed photoluminescence analysis and they exhibit the highest quantum yield values.A complete and efficient energy transfer from the sensitizer Tb^(3+) to the activator Eu^(3+) is observed in all co-doped phosphors post-annealed at 800℃ for 4 ***,the Li_(3)Ba_(2)La_(3)(MaO_(4))_(8):Eu^(3+),Tb^(3+) materials fabricated by combustion synthesis are excellent phosphors for being applied as red-emitting component in solid-state white-light lamps due to an improved color rendering index(CRI) that can be obtained under lo

关键词： Molybdate Europium Terbium Luminescence Phosphor-converted LED Rare earths

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The endophytic mycobiota of Arabidopsis thaliana

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Fungal Diversity 2013年第3期60卷 71-89页

作者： Elena García Ángela Alonso Gonzalo Platas Soledad Sacristán Centro de Biotecnología y Genómica de Plantas(UPM-INIA)and E.T.S.I.Agrónomos Universidad Politécnica de MadridCampus de MontegancedoAutopista M40(Km.38)28223 Pozuelo de Alarcón MadridSpain Departamento de Biotecnología E.T.S.I.AgrónomosUniversidad Politécnica de MadridAvda.Complutense s/n28040 MadridSpain Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía MEDINA Parque Tecnológico de las Ciencias de la Salud de GranadaAvda del Conocimiento 318100 ArmillaGranadaSpain Instituto de Recursos Naturales y Agrobiología Consejo Superior de Investigaciones CientíficasAvenida Reina Mercedes 1041012 SevillaSpain

Fungal endophytes are receiving increasing attention as resources to improve crop production and ecosystem ***,the biology and ecological significance of these symbionts remains poorly understood,due to a lack of model systems for more efficient *** this work,we have analyzed the culturable endophytic mycobiota associated,in the wild,with leaves and siliques of the model plant *** have studied the effect of biotic and abiotic factors in the frequency of fungal endophytes in plant specimens,and in the species composition of the endophytic *** results indicate that the frequency of Arabidopsis plants hosting endophytes depends on the time of the year and the phenological stage of the plant,and that the probability of endophyte colonization increases as the life cycle of the plant *** diversity of the endophytic assemblages of natural *** populations was high,and precipitation and temperature were the two main factors determining the diversity and species composition of the *** propose *** and its endophytes as a model system for an integral approach to the principles governing the endophytic lifestyle,taking advantage of the molecular tools and the abundant knowledge accessible from the host plant.

关键词： Endophyte Mycobiota Arabidopsis Wild populations Ecology

The versatility of mesenchymal stem cells:From regenerative medicine to COVID,what is next?

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BIOCELL 2022年第4期46卷 913-922页

作者： THAÍS CASAGRANDE PAIM MÁRCIA ROSÂngela WINK Laboratório de Biologia Celular Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre90050-170Brazil

Mesenchymal stem cells(MSCs)play key roles in regenerative medicine by promoting tissue *** can be isolated from different adult tissues and they are able to differentiate into several *** to their antiinflammatory,angiogenic and immune-modulatory properties,MSCs are suitable for tissue engineering applications and,when associated with biomaterials,their benefits can be ***,recently,MSCs have been studied for new clinical applications,such as in the treatment of patients with *** regenerative potential has been attributed to their secretome,which comprises extracellular matrix,soluble proteins and several elements,including the release of extracellular *** though,in order to explore all their therapeutic potential,it is still necessary to advance in the investigation of their basic cell biology characteristics.

关键词： Mesenchymal stem cells Regenerative medicine Secretome Biomaterials Extracellular vesicles

Potential use of magnesium industrial waste for synthesis of Li and Mg co-doped LiMn_(2)O_(4)nanoparticles as cathode material for Li-ion batteries:Effect of sintering temperature

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Nano Research 2022年第5期15卷 4500-4516页

作者： Aleksei Llusco Luis rojas Svetlana Ushak Mario Grageda Department of Chemical Engineering and Mineral Processing and Center for Advanced Study of Lithium and Industrial Minerals(CELiMIN) Universidad de AntofagastaAntofagasta 1270300Chile

Potential advantages of active electrode nanomaterials have led to development of high energy and power density lithium-ion(Li-ion)***,under increasing demand for critical resources such as lithium and cobalt,it is necessary to use abundant raw materials,which can be obtained from industrial *** this work,purified Mg(OH)_(2)from waste generated in the production of Li2CO3 with natural brines from the Salar de Atacama(Chile)is used as a doping agent for synthesis of LiMn_(2)O_(4)(LMO)spinel octahedral nanoparticles co-doped with excess Li and *** of a pure cubic spinel phase(Fd3m)takes place at 500℃and sintering temperature effect at 580 and 750℃,thus the elemental composition and the structural,morphological,and electrochemical properties are studied in *** electrochemical performance at room temperature is obtained for Li_(1.03)Mg_(0.05)Mn_(1.92)O_(4)spinel sintered at 750℃with an initial discharge capacity of 121.3 mAh·g^(-1)and capacity retention of 94.0%after 100 cycles at C/3.A locally ordered spinel structure is obtained at 750℃,and doping with Mg^(2+)improves structural *** between both effects resulted in a high Li^(+)diffusion rate(1.29×10^(-9)cm^(2)·s^(-1))significantly improving cycling performance at elevated C-rates in 50℃.

关键词： LiMn_(2)O_(4)(LMO)spinel Mg doped excess Li octahedral nanoparticle industrial waste lithium-ion(Li-ion)batteries

UPLAND EROSION MODELING WITH CASC2D-SED

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International Journal of Sediment Research 2002年第4期17卷 265-274页

作者： Pierre JULIEN,Rosalía rojas Engineering Research Center Colorado State University Research Associate Civil Engineering Dept. Colorado State University Professor of Civil EngineeringFortCollins CO80523 USA Fort Collins CO80523 USA

Developed at Colorado State University, CASC2D-SED is a physically-based model simulating the hydrologic response of a watershed to a distributed rainfall field. The time-dependent processes include: precipitation, interception, infiltration, surface runoff and channel routing, upland erosion, transport and sedimentation. CASC2D-SED is applied to Goodwin Creek, Mississippi. The watershed covers 21 km2 and has been extensively monitored both at the outlet and at several internal locations by the ARS-NSL at Oxford, MS. The model has been calibrated and validated using rainfall data from 16 meteorological stations, 6 stream gauging stations and 6 sediment gauging stations. Sediment erosion/deposition rates by size fraction are predicted both in space and time. Geovisualization, a powerful data exploration technique based on GIS technology, is used to analyze and display the dynamic output time series generated by the CASC2D-SED model.

关键词： Geographical Information System (GIS) Hydrologic model Soil erosion Watershed

Processing of ingredients and diets and effects on nutritional value for pigs

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Journal of Animal Science and Biotechnology 2017年第4期8卷 751-763页

作者： Oscar Javier rojas Hans Henrik Stein Devenish Nutrition Fairmont MN 56031 USA Department of Animal Sciences University of Illinois Urbana IL 61801 USA.

A conventional diet based on corn and soybean meal fed to pigs is usually provided in a mash form and in most cases, processing other than grinding and mixing is not used. However, due to the high cost of energy in pig diets,use of high fiber ingredients such as soybean hulls, distillers dried grains with solubles, and wheat middlings has increased. High fiber concentrations in the diet usually results in reduced energy and nutrient digestibility due to the low capacity of pigs to digest fiber, which negatively impacts growth performance and carcass composition of the pigs. Feed processing technologies such as changes in grinding procedures, expansion, extrusion, pelleting, use of enzymes or chemical treatments may, however, be used to solubilize some of the cel ulose and hemicel ulose fractions that form the cel wal of plants in the ingredients, and therefore, increase nutrient availability. This may have a positive effect on energy digestibility, and therefore, also on pig growth performance and carcass composition, but effects of different feed technologies on the nutritional value of feed ingredients and diets fed to pigs are not fully understood. It has however, been demonstrated that reduced particle size of cereal grains usually results in increased digestibility of energy, primarily due to increased digestibility of starch. Extrusion or expansion of ingredients or diets may also increase energy digestibility and it appears that the increase is greater in high fiber diets than in diets with lower concentrations of fiber. Chemical treatments have not consistently improved energy or nutrient digestibility, but a number of different enzymes may be used to increase the digestibility of phosphorus, calcium, or energy. Thus, there are several opportunities for using feed technology to improve the nutritional value of diets fed to pigs.

关键词： Chemical treatments Enzymes Particle size Pig Processing Starch

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