检索结果-南通市图书馆

Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Shan Lu Chenxi Cao Wenjia zhang Jiayi Li jingli Yang Zisheng Huang zhijun Wu Baitao liu Hongjie Huang Haijun Wang Yongjian Wang Dingge liu Zhihua zhang Kaiping liu Gang Yang Xi Gong Hui Dai Yingjia Li Erdan Dong Xin zhang Yan zhang Haihe Laboratory of Cell Ecosystem Institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University Institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Sports Medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering Research Center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

关键词：

Activity of Silica-Rich Hydrothermal Fluid and Its Impact on Deep Dolomite Reservoirs in the Sichuan Basin, Southern China

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2017年第6期91卷 2214-2229页

作者： ZHU Dongya zhang Dianwei liu Quanyou jin zhijun HE Zhiliang State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Petroleum Exploration and Production Research Institute of SINOPEC Laboratory of Structural and Sedimentological Reservoir Geology

Well-developed dissolution pores occur in the dolomites of the Sinian Dengying Formation, which is an important oil and gas reservoir layer in the Sichuan Basin and adjacent areas in southern China. The pores are often filled with quartz, and some dolomites have been metasomatically altered to siliceous chert. Few studies have documented the characteristics, source or origin of silica-rich fluids and their effects on the dolomite reservoir. The peak homogenisation temperatures （Th） of fluid inclusions in pore-filling quartz are between 150~C and 190~C, with an average of 173.7~C. Gases in the inclusions are mainly composed of CO2, CH4 and N2. Compared with host dolomite, pore-filling quartz and metasomatic chert contain higher amounts of Cr, Co, Mo, W and Fe, with average concentrations of 461.58, 3.99, 5.05, 31.43 and 6666.83 ppm in quartz and 308.98, 0.99, 1.04, 13.81 and 4703.50 ppm in chert, respectively. Strontium levels are lower than that in the host dolomite, with average concentrations in quartz and chert of 4.81 and 11.06 ppm, respectively. Rare earth element compositions in quartz and chert display positive Eu anomalies with a maximum δEu of 5.72. The δDsMow values of hydrogen isotopes in water from quartz inclusions vary from -85.1‰ to -53.1‰ with an average of-64.3‰, whereas the δ18OsMow values range from 7.2‰ to 8.5‰ with an average of 8.2‰. The average 87Sr/86Sr ratios in quartz and chert are 0.711586 and 0.709917, respectively, which are higher than that in the host dolomite. The fluid inclusions, elemental and isotopic compositions demonstrate that the formation of quartz and chert was related to silica-rich hydrothermal fluid and that the fluid was the deep circulation of meteoric water along basement faults. Interactions with silica-rich hydrothermal fluids resulted in densification of dolomite reservoirs in the Dengying Formation through quartz precipitation and siliceous metasomatism. However, it increased the resistance of the host dolomite to

关键词： Dengying Formation dolomite silica-rich hydrothermal fluid quartz rare earth element,Sichuan Basin

Kinetic Model of Gaseous Alkanes Formed from Coal in a Confined System and Its Application to Gas Filling History in Kuqa Depression,Tarim Basin,Northwest China

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2011年第4期85卷 911-922页

作者： liu Quanyou zhang Tongwei jin zhijun QIN Shengfei TANG Yongchun liu Wenhui Exploration and Production Research Institute SINOPECBeijing 100083China Bureau of Economic Geology The University of Texas at Austin University StationAustinTexas 78713- 8924USA Power Environmental and Energy Research InstituteCalifornia 91722USA Research Institute of Petroleum Exploration and Development PetroChinaBeijing 100083China

Based on the pyrolysis products for the Jurassic low-mature coal under programmed temperature,and chemical and carbon isotopic compositions of natural gas from the Kuqa Depression, the genetic origin of natural gas was determined,and then a gas filling model was established,in combination with the geological background of the Kuqa *** active energy of CH_4,C_2H_6 and C_3H_8 was gotten after the data of pyrolysis gas products under different heating rates（2℃/h and 20℃/h）were fitted by the Gas Oil Ratio（GOR）Isotope Model *** the frequency factor（Af）was chosen as 1×10^（14）,the active energy of CH_4,C_2H_6 and C_3H_8 was 58 kcal/mol,57 kcal/mol and 54 kcal/ mol,*** distributive ranges of theδ^（13）C_1,δ^（13）C_2 andδ^（13）C_3 values for the pyrolysis gas products are-35.9‰to-30.7‰,-26.2‰to-21.3‰and-26.4‰to-22.7‰,*** of the natural gases from the Kuqa Depression are dominated by hydrocarbon gases,with the high gas dryness（C_1/C_（1-4））at the middle and northern parts of the depression and the low values at both east and west sides and the southern *** carbon isotopes of methane and its homologs as a typical coal-type gas are enriched in ^（13）C,and the distributive range of theδ^（13）C_1,δ^（13）C_2 andδ^（13）C_3 value is-32‰to -38‰,-22‰to-24‰and-20‰to-22‰,respectively,with the carbon isotopes of gaseous alkanes being less negative with the carbon *** the ethane being enriched in ^（13）C the increasing tendency of the geological reserve of natural gas in the Kuqa Depression is *** observed change is consistent with the results of pyrolysate gas yield of coal as a potential gas source in the Kuqa Depression,suggesting natural gas was thermally derived from the humic organic matters and the carbon isotopes of gaseous alkanes would coarsely predict the geological reserve of gas in the Kuqa *** the simulation of kinetic processes of gas generation for the Jurassic coal in the Kuqa Depression,the gas in th

关键词： natural gas gas kinetic carbon isotope gas-filling history Kuqa Depression

Multi-spheric interactions driven differential formation and accumulation of hydrocarbon resources in the North Sea Basin

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第11期67卷 3397-3420页

作者： Rixiang ZHU Shuichang zhang Huajian WANG Xiaomei WANG Yuke liu Wang zhang Fang HAO zhijun jin Key Laboratory of Deep Petroleum Intelligent Exploration and Development Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Enhanced Oil&Gas Recovery Research Institute of Petroleum Exploration and DevelopmentChina National Petroleum CorporationBeijing 100083China State Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580China Institute of Energy Peking UniversityBeijing 100871China

The North Sea Basin is the most important oil and gas producing area in Europe and the birthplace of many classic petroleum geological theories. From the perspective of multi-spheric interactions in the Earth, this study investigated the riftforeland-rift evolution process of the North Sea Basin, which was controlled by the deep dynamic driving forces of the continental collision orogeny, mantle plume uplift, and intraplate deformation. The North Sea Basin was found to have drifted northward since the Carboniferous and passed through the low-latitude Hadley and the mid-latitude Ferrel cells. Two sets of main hydrocarbon source rocks have formed, the coals and coal measures of the Upper Carboniferous Westphalian and the marine shale of the Upper Jurassic Kimmeridge Clay Formation. We propose that the deep processes, tectonic activity, and transgression-climate evolution jointly controlled the types and horizons of the source rocks, reservoirs, and seals in different regions of the North Sea Basin. In the southern North Sea Basin, a Carboniferous-Lower Triassic gas-rich petroleum system was formed,which is characterized by transitional coal measure source rocks, desert aeolian sandstone reservoirs, and evaporite cap rocks. In the northern North Sea Basin, an Upper Triassic-Paleogene oil-rich petroleum system was formed, which is characterized by marine graben-type source rocks, deltaic sandstone and marine limestone reservoirs, and marine tight marl and shale cap *** late tectonic burial and uplift in the North Sea Basin further controlled the processes of oil and gas generation and accumulation, ultimately leading to a differential distribution pattern which is oil rich in the northern part and gas rich in the southern part of the basin. In the future, there is an urgent need to re-examine the mechanisms for the petroleum generation and accumulation in large mature exploration areas(e.g., super basins such as the North Sea) and low exploration areas(e.g., the O

关键词： North Sea Basin Multi-spheric interactions Petroleum system Okhotsk Sea region

Process and Mechanisms of Deep Fluid Effects on Hydrocarbon Generation and Pore Space in Shale:A Case Study from the Mesoproterozoic Xiamaling Formation in the Zhaojiashan Section

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2022年第4期96卷 1342-1352页

作者： MENG Qingqiang PANG Qian HU Guang jin zhijun ZHU Dongya liu Jiayi zhang Chuanwen State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development SINOPECBeijing 100083China Petroleum Exploration and Product Research Institute SinopecBeijing 102206China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 637001China Institute of Energy Peking UniversityBeijing 100871China School of Energy Chinese University of Geosciences(Beijing)Beijing 100083China

Heat carried by deep fluid might greatly affect hydrocarbon generation and pore space in *** intrusion carrying high levels of heat may be a means by which to explore the influence of deep fluid on shale *** study evaluates hydrocarbon generation and analyzed the evolution of shale storage space in the third member of the Xiamaling Formation in the Zhaojiashan section,Hebei Province,based on experimental data such as TOC,SEM,VRo,low-temperature N_(2)adsorption and high-pressure mercury *** results show that the dyke intrusion reduced the shale TOC content drastically―by up to 77%―and also induced instantaneous hydrocarbon generation over a range about 1.4 times the thickness of the ***,the dyke intrusion might transform organic pores in surrounding shales into inorganic *** were two shale porosity peaks:one appeared when VRo=2.0%,caused by the increase of organic pores as thermal maturity increased,the other occurred when the VRo value was between 3%and 4%,caused by the increase of inorganic mineral *** can be concluded that dyke intrusion can be an effective tool with which to study how deep fluid affects instantaneous hydrocarbon generation and pore space in shale.

关键词： deep fluid hydrocarbon generation thermal effect pore Xiamaling Formation

Organic-rich formation and hydrocarbon enrichment of lacustrine shale strata:A case study of Chang 7 Member

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2022年第1期65卷 118-138页

作者： Quanyou liu Peng LI zhijun jin Yuewu SUN Guang HU Dongya ZHU Zhenkai HUANG Xinping LIANG Rui zhang Jiayi liu State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development SINOPECBeijing 102206China Petroleum Exploration and Production Research Institute S1NOPECBeijing 102206China Institute of Energy Peking UniversityBeijing 100871China Research Center of Palaeontology and Stratigraphy Jilin UniversityChangchun 130026China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China

Lacustrine shale is an important target for the exploration of unconventional oil and gas in China beyond marine shale ***,the formation environment of lacustrine shale differs from that of marine shale,resulting in a different reservoir composition,organic matter,oil and gas content,and hydrocarbon *** this study,the Chang 7 shale of the Yanchang Formation in the Ordos Basin was used to analyze the effect of volcanic activity on the paleoproductivity and preservation conditions during the formation of lacustrine *** results show that algae and bacteria were developed before the *** the eruption,the number of bacteria declined,but the increased prosperity of algae reflects that the volcanic activity enhanced ancient *** sulfate generated by volcanic activity promotes bacterial sulfate reduction,and the produced H_(2)S leads to a strong reducing environment in the waterbody,which is conducive to the preservation of organic *** geochemical analysis shows that the black shale in the shale strata has a high total organic carbon(TOC)content and strong hydrocarbon generation potential,whereas the tuff has a low TOC content and can scarcely generate hydrocarbons,indicating that the tuff deposited by volcanic activity cannot be considered as effective source *** terms of storage space,shale is mainly laminar and dispersed,and it includes organic and inorganic *** development of organic pores is affected by thermal maturity,whereas inorganic pores mainly occur between detrital particles and *** is mainly supported by heterogeneous matrix and associated with *** pores include inter-and intragranular mineral *** development of tight sandstone pores is affected by compaction,cementation,and dissolution,which mainly consist of intra-and intergranular *** Chang 7 lacustrine shale generally contains oil,but different lithologies have different oil drainage *** and

关键词： Lacustrine shale Organic-rich Volcanic activity Pore structure Oiliness

Methods for monitoring cancer cell pyroptosis

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第4期19卷 398-414页

作者： Shuo Wang Yuantong liu Lu zhang zhijun Sun The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of EducationSchool and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral Maxillofacial-Head Neck Oncology School and Hospital of StomatologyWuhan UniversityWuhan 430079China

Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of *** main features of pyroptosis are altered membrane permeability,cell swelling,membrane rupture,and the ability to mobilize a strong immune *** relationship between pyroptosis and cancer has become a popular topic in immunological *** strategies for inducing pyroptosis in cancer cells have been developed for cancer therapy,including chemotherapy,small molecule drugs,and *** this review,we systematically discuss recent advances in research on the mechanisms of pyroptosis,and compare pyroptosis with apoptosis and necroptosis from several *** development of various experimental systems has accompanied rapid progress in this field,but little consensus on monitoring pyroptosis is currently *** focus on techniques commonly used to monitor pyroptosis,and describe future techniques that may be used to increase our knowledge in this ***,the advancement of pyroptosis detection methods will help researchers to better investigate the relationships between pyroptosis and various cancers,and should provide insights into the use of these promising tools for cancer treatments.

关键词： Pyroptosis gasdermin caspase cancer immunotherapy cell death

TESLA-Based Authentication for BeiDou Civil Navigation Message

在线全文

学校读者我要写书评

暂无评论

China Communications 2020年第11期17卷 194-218页

作者： zhijun Wu Yun zhang Liang liu Meng Yue The College of Electronic Information&Automation Civil Aviation University of ChinaTianjin 300300China

Due to the civil BeiDou navigation system is open,unauthenticated,and non-encrypted,civilian BeiDou navigation signals may have great security loopholes during transmission or *** main security loophole here is spoofing *** attacks make the positioning or timing results of BeiDou civilian receivers *** errors may cause a series of security problems,which lays a serious hidden danger for Bei-Dou satellite information *** article proposes an anti-spoofing method for BeiDou navigation system based on the combination of SM commercial cryptographic algorithm and Timed Efficient Stream Loss-tolerant Authentication(TESLA)for spoofing *** this solution,we use the SM3 algorithm to generate a TESLA key chain with time information,and then use the key in the key chain to generate the message authentication code for the BeiDou D2 navigation *** message authentication code is inserted into a reserved bit of the D2 navigation *** addition,this solution uses the SM2 algorithm to protect and encrypt time information in the TESLA key chain to prevent key replay attacks in *** experimental results tested on the experimental platform built in this paper show that this scheme reduces the possibility of the BeiDou navigation system being deceived and enhances the safety of the BeiDou navigation system.

关键词： BeiDou navigation system SM commercial cryptographic algorithm TESLA message authentication code D2 navigation message

Selectively Fluorescent Sensing Behavior of Phenylaza-15-crown-5-triazolyl Coumarin for Hg2＋ and Fe3＋ in Alcohol and Aqueous Media Respectively

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2013年第5期31卷 598-602页

作者： zhijun zhang Hui Wang Hengyi zhang Yu liu Department of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China

A n-conjugated phenylaza-15-crown-5-triazol-substituted coumarin fluoroionophore 1 was synthesized by cop- per（I）-catalyzed Huisgen alkyne-azide 1,3-dipolar cycloaddition （CuAAC ＂click＂ reaction）. 1 can display selective fluorescence enhancement toward Fe3＋ over Hg2＋, Cr3＋ and the other metal ions in aqueous solution. In sharp con- trast, the fluorescence behavior between Fe3＋ and Hg2＋ is completely reversed in EtOH. That is, Hg2＋ gives the largest fluorescence enhancement over Cr3＋, Fe3＋ and the other metal ions.

关键词： coumarin sensors crown compounds metal ions fluorescence