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Pure Diffractive Multicolor Optical Fourier Transform System Design

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Chinese Journal of Lasers 1998年第5期 30-35页

作者： zhao liping wu minxian MAO Wenwei jin guofan YAN Yingbai (State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing 100084, China) Received Dec. 22, 1997 Revise

１ＩｎｔｒｏｄｕｃｔｉｏｎＷｉｔｈｔｈｅｄｅｖｅｌｏｐｍｅｎｔｏｆｔｈｅｉｎｔｅｇｒａｔｅｄｏｐｔｉｃｓａｎｄｆａｂｒｉｃａｔｉｏｎｔｅｃｈｎｏｌｏｇｙｏｆｓｅｍｉｃｏｎｄｕｃｔｏｒ，ｏｐｔｉｃａｌＦｏｕｒｉｅｒｔｒ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＷｉｔｈｔｈｅｄｅｖｅｌｏｐｍｅｎｔｏｆｔｈｅｉｎｔｅｇｒａｔｅｄｏｐｔｉｃｓａｎｄｆａｂｒｉｃａｔｉｏｎｔｅｃｈｎｏｌｏｇｙｏｆｓｅｍｉｃｏｎｄｕｃｔｏｒ，ｏｐｔｉｃａｌＦｏｕｒｉｅｒｔｒａｎｓｆｏｒｍ（ＯＦＴ）ｉｓｂｅｃ...

关键词： space bandwidth product diffractive optical element harmonic diffractive optical element

Modularized viromimetic polymer nanoparticle vaccines(VPNVaxs) to elicit durable and effective humoral immune responses

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National Science Review 2024年第3期11卷 200-214页

作者： Zichao Huang Xinyu Zhuang liping Liu Jiayu zhao Sheng Ma Xinghui Si Zhenyi Zhu Fan wu Ningyi jin Mingyao Tian Wantong Song Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Jilin Biomedical Polymers Engineering Laboratory State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Virus-like particle(VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However,the time-consuming and complicated processes in establishing a current recombinant-protein–based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine(VPNVax), with subunit receptor-binding domain(RBD) proteins conjugated to the surface of polyethylene glycol-b-polylactic acid(PEG-b-PLA) nanoparticles for vaccination against SARS-CoV-2. The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses. Using this modular preparation system, we identified that VPNVax with surface protein coverage of 20%–25% had the best immunostimulatory activity, which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant. Moreover, the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design. This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics.

关键词： vaccine polymer nanomaterials SARS-CoV-2

Metabolomic Analysis of the Anthocyanins Associated with Different Colors of Cymbidium goeringii in Guizhou, China

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1455-1466页

作者： Dongbo wu Shuang Qu Lianwen Shen Shengqun Chen Xia Jiang Ai Rao Yuxue zhao Yueyun Wang College of Pharmacy Guizhou University of Traditional Chines MedicineGuiyang550025China Research Institute of Juglans Regia Guizhou Academy of ForestryGuiyang550005China Guizhou liping Rocky Desertification Ecosystem National Observation and Research Station Qiandongnan Prefecture556200China

Cymbidium goeringii is an economically important ornamental plant,and flower color is one of the main features of *** that contributes to its high economic *** clarify the molecular mechanisms underlying the role of anthocyanins in mediating differences in color among varieties,liquid chromatography–tandem mass spectrometry was used to perform anthocyanin-targeted metabolomics of seven *** varieties,including‘jin Qian Yuan’(JQY),‘jin Xiu Qian Yuan’(JXQY),‘Miao Jiang Su Die’(MJSD),‘Qian Ming Su’(QMS),‘Shi Chan’(SC),and‘Yang Ming Su’(YMS),as well as the *** detected 64 anthocyanins,including cyanidins,delphinidins,malvidins,pelargonidins,peonidins,petunidins,procyanidins,and *** identified six shared differentially accumulated metabolites(DAMs),including cyanidin-3-O-rutinoside,delphinidin-3-Osophoroside,pelargonidin-3-O-rutinoside,peonidin-3-O-(6-O-malonyl-beta-D-glucoside),peonidin-3-Osophoroside,and *** DAMs were enriched in the anthocyanin biosynthesis *** Encyclopedia of Genes and Genomes pathway analysis revealed that the differentially expressed metabolites were significantly enriched in the anthocyanin biosynthesis *** of the content of differentially expressed metabolites indicated that peonidin-3-O-(6-O-malonyl-beta-D-glucoside)was the key metabolite underlying color differences among *** *** B2,pelargonidin-3-O-galactoside,and naringenin might also affect the color formation of JQY and QMS,SC,and MJSD,*** results of this study shed light on the metabolic mechanism underlying flower color differences in *** at the molecular *** findings will aid future studies of the mechanism of flower color regulation in *** and have implications for the breeding of new varieties.

关键词： Cymbidium goeringii ﬂower color anthocyanins metabolomics

Comparing a novel Catfish flow restoration device and the Solitaire stent retriever for thrombectomy revascularisation in emergent largevessel occlusion stroke:a prospective randomised controlled study

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Stroke & Vascular Neurology 2023年第6期8卷 435-443页

作者： Gang Luo Xiaoyan Yan Guodong Xiao liping Wei Ya li kun Nai bi jiang Rongyao Ma Wenhuo Chen Chun Fang Zhiming Zhou Jieqing Wan Ya Peng Guilian Zhang Junfeng zhao Li Li Haicheng Yuan jin wu Bing Li Fan Zhang Yuhong Cheng Feng Gao Zhongrong Miao Department of Intervention Interventional Neuroradiology CenterBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Intervention Interventional Neuroradiology CenterChina National Clinical Research Center for Neurological DiseasesBeijingChina Biostatistics Peking University Clinical Research InstituteBeijingChina Neurology The Second Affiliated Hospital of Suzhou UniversityJiangsuChina Department of Neurology Luoyang Central Hospital Affiliated to Zhengzhou UniversityLuoyangHenanChina Neurosurgery Hotan District People's HospitalHotanChina Neurology Nanshi Hospital of NanyangNanyangChina Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujianChina Department of Intervention Tongji Hospital Affiliated to Tongji UniversityShanghaiShanghaiChina Department of Intervention The First Affiliated Hospital of Wannan Medical CollegeWuhuAnhuiChina Department of Neurosurgery Shanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghaiChina Department of Neurosurgery Changzhou No.1 People's HospitalChangzhouChina Neurology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anChina Neurology Siping Central People’s HospitalSipingChina Department of Intervention Xijing Hospital of Air Force Military Medical UniversityXi'anChina Neurology Qingdao Central Medical GroupQingdaoChina Neurology The Second Affiliated Hospital of Nanjing Medical UniversityNanjingChina Department of Intervention Qindao University Medical College Affiliated Yantai Yuhuangding HospitalYantaiShandongChina Neurology Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical UniversityHainanChina Department of Intervention Linfen Central HospitalLinfenShanxiChina

Background The Catfish stent retriever is a newly developed mechanical thrombectomy device for rapid recanalisation in emergent large vessel occlusion(ELVO)*** current trial aimed to assess whether the Catfish stent retriever is non-inferior to the Solitaire stent retriever in terms of outcomes in ELVO *** This was a randomised,prospective,parallel-group,multicentre,open-label,non-inferiority study conducted at 18 sites in *** primary outcome was the proportion of cases with successful recanalisation(modified thrombolysis in cerebral infarction score of 2b or 3)following the *** efficacy outcomes included the National Institutes of Health Stroke Scale scores at 24 hours and 7 days or discharge if earlier,time from artery puncture to successful recanalisation and good clinical outcome(modified Rankin scale score≤2)at 90 *** outcomes included symptomatic intracranial haemorrhage,all cause-death and severe adverse events at 90 *** Between 3 March 2019 and 5 June 2021,118 and 120 patients were randomly allocated to the Catfish and Solitaire groups,*** primary endpoint after all endovascular procedures was non-inferior in the Catfish group(88.5%,100/113)than in the Solitaire group(87.7%,100/114),with a rate difference(RD)of 0.78%(95%CI-7.64 to-9.20;p=0.001).Sensitivity analysis only considering the per-protocol set also yielded similar results,with an RD of 0.83%(95%CI-7.03 to-8.70;p<0.001).Additionally,the proportions of cases with good clinical outcomes(47.8%vs 50.0%,p=0.739)and all-cause death rates(17.7%vs 18.8%,p=0.700)were similar in both groups at 90 *** The Catfish stent retriever is an effective and safe device for endovascular recanalisation in ELVO stroke..

关键词： Solitaire prospective throm

基于实时荧光环介导等温扩增快速检测鸡肉中的大肠杆菌O157:H

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中国食品学报 2019年第3期19卷 281-288页

作者：赵远洋王瑾林丽萍郜彦彦吴国平江西农业大学食品科学与工程学院南昌市农产品加工与质量控制重点实验室南昌330045

以大肠杆菌O157:H7的VT2基因序列设计特异性引物,利用Midori Green新型核酸荧光染料,建立鸡肉中大肠杆菌O157:H7实时荧光定量环介导等温扩增(Rti-LAMP)检测方法。纯培养大肠杆菌O157:H7检测灵敏度达3.5 CFU/反应,需时45 min。模拟大肠杆... 详细信息

以大肠杆菌O157:H7的VT2基因序列设计特异性引物,利用Midori Green新型核酸荧光染料,建立鸡肉中大肠杆菌O157:H7实时荧光定量环介导等温扩增(Rti-LAMP)检测方法。纯培养大肠杆菌O157:H7检测灵敏度达3.5 CFU/反应,需时45 min。模拟大肠杆菌O157:H7污染鸡肉样品,经37℃增菌4 h,用Whirl-pak无菌袋过滤离心得沉淀,提取样品DNA模板用于Rti-LAMP反应,检测大肠杆菌O157:H7灵敏度达140 CFU/g,整个检测流程约7 h。采用蒙脱石封闭的活性炭前处理污染鸡肉样品,不经增菌过程,结果表明:该Rti-LAMP检测方法灵敏度达12 CFU/g,整个检测耗时约4.5 h。市购鸡肉样品51份,以大肠杆菌国标检测法为对照,研究基于Rti-LAMP联合增菌或封闭活性炭预处理而不经增菌的两种方法,对比检测临床鸡肉样品大肠杆菌O157:H7污染率。结果:国标法和增菌的Rti-LAMP两种方法均检测到同一鸡肉样品为大肠杆菌O157:H7阳性,经封闭活性炭预处理而未经增菌的Rti-LAMP则检测到8份鸡肉样品大肠杆菌O157:H7阳性。研究表明,封闭活性炭预处理的Rti-LAMP检测方法较国标法更灵敏、快速、简便、特异地检测鸡肉中大肠杆菌O157:H7污染。

关键词：大肠杆菌O157:H7 鸡肉实时环介导等温扩增增菌封闭的活性炭

基于多孔介质模型的土壤风蚀风洞湍流涡发生器设计的数值模拟

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农业工程学报 2011年第11期27卷 85-89页

作者：高莹金陶胜赵彦琳姬亚芹徐让书吴丽萍南开大学环境科学与工程学院国家环境保护城市空气颗粒物污染防治重点实验室天津300071 沈阳航空航天大学动力与能源工程学院沈阳110136 天津城市建设学院环境与市政工程系天津300384

该文针对土壤风蚀风洞中设计湍流涡发生器模拟大气边界层的需要,利用计算流体动力学(CFD)软件Fluent对NK-1可移动式风蚀风洞中典型农田风蚀地表风速廓线进行数值模拟,提出引入多孔介质模型的方法将原非规则几何结构的棒栅进行替代计算,... 详细信息

该文针对土壤风蚀风洞中设计湍流涡发生器模拟大气边界层的需要,利用计算流体动力学(CFD)软件Fluent对NK-1可移动式风蚀风洞中典型农田风蚀地表风速廓线进行数值模拟,提出引入多孔介质模型的方法将原非规则几何结构的棒栅进行替代计算,最终得到棒栅加粗糙元的最优分布,并通过室内风洞试验进行验证。结果显示,风洞试验实测与模拟所得廓线的相关系数为0.974,模拟效果较理想。该方法使得计算网格数量减少,网格质量提高,节约了模拟成本,提高了计算的精确度和可信度,并且验证了用棒栅-粗糙元组合作为湍流涡发生器来模拟复现大气边界层是可行的,以期为风洞湍流涡发生装置的设计模拟提供一种新的思路和方法。

关键词：风洞湍流数值方法风蚀湍流涡发生器棒栅-粗糙元多孔介质模型 Fluent软件

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原发肺和气管血管球肿瘤临床病理学分析

中华病理学杂志 2020年第12期49卷 1282-1287页

作者：赵胜男金燕谢惠康武春燕李媛张莉萍同济大学附属上海市肺科医院病理科 200433 复旦大学附属肿瘤医院病理科上海200032

目的探讨发生在肺部和气管的血管球肿瘤的临床病理特点。方法收集2010—2019年同济大学附属上海市肺科医院(4例)和复旦大学附属肿瘤医院(7例)诊断的11例肺部血管球肿瘤的临床资料、影像学特征、组织病理学形态、免疫学表型,并复习相关... 详细信息

目的探讨发生在肺部和气管的血管球肿瘤的临床病理特点。方法收集2010—2019年同济大学附属上海市肺科医院(4例)和复旦大学附属肿瘤医院(7例)诊断的11例肺部血管球肿瘤的临床资料、影像学特征、组织病理学形态、免疫学表型,并复习相关文献。结果患者中男性5例,女性6例,发病年龄29~66岁,中位年龄43岁。6例位于肺内,5例位于气管。肿瘤直径1.0~7.5 cm,平均直径2.6 cm。低倍镜下肿瘤细胞呈弥漫分布,或呈分叶状,由大小相对一致的圆形或短梭形的瘤细胞组成,围绕血管生长。4例为良性血管球瘤,其中1例细胞核深染、退变,为良性奇异性血管球瘤。2例为恶性潜能未定血管球瘤,肿瘤呈浸润性生长,细胞有一定异型性。5例为恶性血管球瘤,见肿瘤性坏死及脉管侵犯,肿瘤细胞异型性显著,核仁明显,可见核分裂象(2~20个/10个HPF),包括病理性核分裂象。免疫组织化学染色显示肿瘤细胞阳性表达平滑肌肌动蛋白(SMA,11/11)、波形蛋白(7/8)、Ⅳ型胶原(4/4)、Caldesmon(5/5),少数病例表达结蛋白(1/7)和突触素(1/7),CD34、广谱细胞角蛋白、S-100蛋白等阴性。8例患者获得随访,时间6~95个月,2例恶性病例死亡,其他6例患者在随访期间均无复发及转移。结论原发性肺和气管血管球肿瘤为罕见病,该组病例恶性血管球瘤较多,其次为良性血管球瘤和恶性潜能未定血管球瘤。形态学瘤细胞呈弥漫分布的圆形上皮样细胞,围绕血管内皮下生长,与类癌等相似,需要结合免疫组织化学染色SMA、Caldesmon、Ⅳ型胶原等阳性予以鉴别。

关键词：血管球瘤肺肿瘤支气管免疫组织化学诊断,鉴别

Performances of a prototype point-contact germanium detector immersed in liquid nitrogen for light dark matter search

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Science China(Physics,Mechanics & Astronomy) 2019年第3期62卷 58-65页

作者： Hao Jiang LiTao Yang Qian Yue KeJun Kang JianPing Cheng Yuanjing Li Henry Tsz-King Wong M.A?artio?lu HaiPeng An JianPing Chang jingHan Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He jin Wei Hu QingDong Hu HanXiong Huang liping Jia HauBin Li Hong Li Jian Min Li jin Li Xia Li XueQian Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu YuanYuan Liu ZhongZhi Liu Hao Ma jingLu Ma Hui Pan Jie Ren XiChao Ruan B.Sevda Vivek Sharma ManBin Shen Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang JiMin Wang Li Wang Qing Wang Yi Wang ShiYong wu YuCheng wu HaoYang Xing Yin Xu Tao Xue SongWei Yang Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue XiongHui Zeng Ming Zeng Zhi Zeng FengShou Zhang YunHua Zhang MingGang zhao JiFang Zhou ZuYing Zhou jingJun Zhu ZhongHua Zhu Key Laboratory of Particle and Radiation Imaging (Ministry of Education)and Department of Engineering Physics Tsinghua University College of Nuclear Science and Technology Beijing Normal University Institute of Physics Academia Sinica Department of Physics Dokuz Eylül University Department of Physics Tsinghua University NUCTECH Company Ya Long River Hydropower Development Company College of Physical Science and Technology Sichuan University Department of Nuclear Physics China Institute of Atomic Energy School of Physics Nankai University Department of Physics Banaras Hindu University Department of Physics Beijing Normal University

The CDEX-10 experiment searches for light weakly interacting massive particles, a form of dark matter, at the China jinping Underground Laboratory, where approximately 10 kg of germanium detectors are arranged in an array and immersed in liquid nitrogen. Herein, we report on the experimental apparatus, detector characterization, and spectrum analysis of one prototype detector. Owing to the higher rise-time resolution of the CDEX-10 prototype detector as compared with CDEX-1 B, we identified the origin of an observed category of extremely fast events. For data analysis of the CDEX-10 prototype detector, we introduced and applied an improved bulk/surface event discrimination method. The results of the new method were compared to those of the CDEX-1 B spectrum. Both sets of results showed good consistency in the 0-12 ke Vee energy range, except for the 8.0 keV K-shell X-ray peak from the external copper.

关键词： WIMP pPCGe liquid nitrogen bulk/surface event discrimination extremely fast events

超声在复发性妇科恶性肿瘤直肠受累评估中的价值

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中国超声医学杂志 2023年第7期39卷 801-804页

作者：李丽萍吴鸣邵华赵进陈楠徐仲煌张昕蒙北京美中爱瑞肿瘤医院超声科北京协和医院妇科北京美中爱瑞肿瘤医院妇科 4. 北京美中爱瑞肿瘤医院康复科芝加哥大学统计系

目的探讨超声在复发性妇科恶性肿瘤直肠受累评估中的价值。方法回顾性分析收治的68例复发性妇科恶性肿瘤患者的临床资料，选取接受再次手术并获得病理资料的26例患者作为研究对象。统计学分析比较超声、增强CT、增强MRI 3种影像学检... 详细信息

目的探讨超声在复发性妇科恶性肿瘤直肠受累评估中的价值。方法回顾性分析收治的68例复发性妇科恶性肿瘤患者的临床资料，选取接受再次手术并获得病理资料的26例患者作为研究对象。统计学分析比较超声、增强CT、增强MRI 3种影像学检查方法术前评估直肠受累的灵敏度、特异度和准确度。结果超声、增强CT及增强MRI诊断直肠壁受侵的准确度分别为80.7%、76.9%、85.7%,灵敏度分别为73.3%、66.7%、72.7%,特异度分别为90.9%、90.9%、100%。3种检查方法间差异均无统计学意义(P>0.05)。增强CT与增强MRI各诊断肠壁全层受侵2例，其余病例均无法分辨侵及肠壁深度，均提示与直肠壁界限不清。超声诊断直肠壁浆膜层受侵的准确度为62.5%,评估直肠壁固有肌层致全层受侵的准确度为85.7%。精准评估病灶侵犯直肠壁层次方面，超声优于增强CT、增强MRI。结论超声对复发性妇科恶性肿瘤进行二次手术前直肠壁受累评估中与增强CT和增强MRI具有良好的一致性，超声对直肠壁的受侵程度精准分层判断更具优势。

关键词：复发性妇科恶性肿瘤超声诊断直肠