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Development of functional connectome gradients during childhood and adolescence

Science Bulletin 2022年第10期67卷 1049-1061,M0004页

作者： Yunman Xia Mingrui Xia Jin Liu Xuhong Liao Tianyuan Lei Xinyu Liang Tengda Zhao Ziyi Shi Lianglong Sun Xiaodan Chen Weiwei Men Yanpei Wang Zhiying Pan Jie Luo Siya Peng Menglu Chen Lei Hao Shuping Tan Jia-Hong Gao Shaozheng Qin Gaolang Gong Sha Tao Qi Dong Yong He State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Beijing Key Laboratory of Brain Imaging and Connectomics Beijing Normal UniversityBeijing 100875China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Systems Science Beijing Normal UniversityBeijing 100875China Center for MRI Research Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Beijing City Key Laboratory for Medical Physics and Engineering Institute of Heavy Ion PhysicsSchool of PhysicsPeking UniversityBeijing 100871China Beijing Huilongguan Hospital Peking University Huilongguan Clinical Medical SchoolBeijing 100096China IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract ***,how this gradient pattern develops and whether its development is linked to cognitive growth,topological reorganization,and gene expression profiles remain largely *** longitudinal resting-state functional magnetic resonance imaging data from 305 children(aged 6-14 years),we describe substantial changes in the primary-to-transmodal gradient between childhood and adolescence,including emergence as the principal gradient,expansion of global topography,and focal tuning in primary and default-mode *** gradient changes are mediated by developmental changes in network integration and segregation,and are associated with abstract processing functions such as working memory and expression levels of calcium ion regulated exocytosis and synaptic transmission-related *** findings have implications for understanding connectome maturation principles in normal development and developmental disorders.

关键词： Brain development Functional connectome gradient Primary-to-transmodal Working memory Transcriptome

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