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第六届海峡两岸心血管科学研讨会

作者：黄戊田台湾台南致远管理学院医学管理学科

＜正＞热卒中时会表现下列的脑血管功能异常：颅内压升高、脑灌注压下降,以及脑炎症反应。本研究旨在于探讨静脉内给予 L-arginine 是否经由抑制这些脑血管功能异常而增进大白鼠热卒中之存活。全身麻醉的大白鼠,经暴置于43℃之环境中七...

＜正＞热卒中时会表现下列的脑血管功能异常：颅内压升高、脑灌注压下降,以及脑炎症反应。本研究旨在于探讨静脉内给予 L-arginine 是否经由抑制这些脑血管功能异常而增进大白鼠热卒中之存活。全身麻醉的大白鼠,经暴置于43℃之环境中七十分钟后,分为二大组。一组是在热卒中后立即给予 L-arginine,而一组是在热卒中后立即给予生理食盐水。我们发现热中风大白鼠接受生理食盐水处理的存活时间为20～26 min。

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Inducible and Neuronal Nitric Oxide Synthase Inhibitors Protect Against Experimental Heatstroke-induced Circulatory Shock and Cerebral Ischemic Injury

Inducible and Neuronal Nitric Oxide Synthase Inhibitors Prot...

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第八届海峡两岸心血管科学研讨会

作者：黄戊田张菁萍张明温郑伯智许淑芬林茂村 Department of Recreation and Health-Care Management Chia-Nan University of Pharmacy and Science Department of Biotechnology Southern Taiwan University Department of Electrical Engineering Southern Taiwan University Department of Surgery Chi Mei Medical Center Department of Physical Therapy Shu-Zen College of Medicine and Management Department of Medical Research Chi Mei Medical Center

＜正＞Background Circulatory shock as well as cerebral ischemia results in neuronal injury and death in animals suffering from *** levels of nitric oxide（NO） have also been associated with a number of models of circulatory shock or cerebral *** This study attempted to determine whether NO contributes to the hypotensive state and cerebral ischemic insults induced by prolonged environmental heat stress（ES）.Methods Urethane - anesthetized rats were instrumented for the measurement of mean arterial pressure（MAP）,cerebral blood flow（CBF） and neuronal damage score（NDS）,and colonic temperature （Tco）.Rats were exposed to ES（ambient temperature,43 oC） until MAP and CBF began to decrease from their peak levels,which was arbitrarily defined as the onset of *** time to death（TTD,interval between the start of ES and cardiac arrest） was also *** addition to these parameter measurements, the inducible NO synthase（iNOS）,neuronal NOS（nNOS） and endothelial NOS（eNOS） protein expression in different brain structures were assessed during *** The values of MAP,CBF and TTD after heatstroke onset were all significantly lower than those in control ***,the values of Tco and NDS were *** addition,after the onset of heatstroke,the protein expression of iNOS,nNOS and eNOS were all significantly elevated in the cortex,hypothalamus and hippocampus of rat *** pretreatment with aminoguanidine（an iNOS inhibitor） or 7 - nitro - indazole（a nNOS inhibitor）,but not L - NAME（an eNOS inhibitor）,at the start of ES,did attenuate the heatstroke - induced arterial hypotension,cerebral ischemia and neuronal damage and result in prolongation of *** Taken together,these results indicate that NO mediate the circulatory shock and cerebral ischemic injury associated with heatstroke.

关键词： cerebral ischemia neuronal damage heat stress circulatory shock

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Attenuating Heat-induced Apoptosis,Autophagy and Necrosis in Cardiac H9C2 Cells by Preinduction of Heat Shock Protein 70

Attenuating Heat-induced Apoptosis,Autophagy and Necrosis in...

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第八届海峡两岸心血管科学研讨会

作者：许淑芬郑伯智张菁萍黄戊田王英娟林茂村 Department of Physical Therapy Shu-Zen College of Medicine and Management Department of Surgery Chi Mei Medical Center Department of Biotechnology Southern Taiwan University Department of Recreation and Health-Care Management Chia-Nan University of Pharmacy and Science Department of Nursing Shu-Zen College of Medicine and Management Department of Medical Research Chi Mei Medical Center

＜正＞Preinduction of heat shock protein（HSP） 70 plays a protective effect against various circumstances;however,its effect on cell loss caused by heat exposure remains *** deal with the question,in this study,the cell viabilitywas significantly reduced by heat exposure in a temperature（40℃-44℃） - dependent and time（90 min - 180 min） - dependent manner in H9C2 *** exposure caused apoptosis（evidenced by flow cytometry[Annexin - V positive and porpidium iodide negative]and caspase 3 activation - increased apoptotic cells）,autophagy（evidenced by increased LC3 - 11 expression and lysosomal activity）, and necrosis（evidenced by increased lactate dehydrogenase activity in the medium） in H9C2 *** shock preconditioning,in addition to inducing overexpression of HSP70 in HPC2 cells,significantly protected against the heat - induced cell loss and H9C2 cells apoptosis,autophagy,and *** beneficial effects of heat shock preconditioning in preventing the occurrence of heat - induced cell loss,apoptosis,autophagy, and necrosis could be significantiy attenuated by inhibition of HSP - 70 overexpression with *** data indicate that Preinduction of HSP - 70 with heat shock preconditioning attenuates cell loss in the heat via inhibiting H9C2 cells apoptosis autophagy,and necrosis.

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Hypobaric hypoxia preconditioning attenuates acute lung injury during high-altitude exposure in rats via up-regulating heat-shock protein 70

Hypobaric hypoxia preconditioning attenuates acute lung inju...

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第八届海峡两岸心血管科学研讨会

作者：林宏荣王嘉地牛柯琪林茂村黄戊田许淑芬张菁萍 Department of Emergency Medicine Chi Mei Medical Center Department of Biotechnology Southern Taiwan University Department of Hyperbaric Oxygen Chi Mei Medical Center Department of Medical Research Chi Mei medical Center Department of Recreation and Health-Care Management Chia-Nan University of Pharmacy and Science Department of Physical Therapy Shu-Zen College of Medicine and Management

＜正＞Objective HHP（hypobaric hypoxia preconditioning） induces the overexpression of HSP70（heat -shock protein 70）,as well as tolerance to cerebral *** the present study,we hypothesized that HHP would protect against HAE（high - altitude exposure） - induced acute lung injury and edema via promoting the expression of HSP70 in lungs prior to the onset of *** At 2 weeks after the start of HHP, animals were exposed to a simulated HAE of 6000 m in a hypobaric chamber for 24 *** after being returned to ambient pressure,the non - HHP animals had higher scores of alveolar edema,neutrophil infiltration and hemorrhage,acute pleurisy（*** exudate volume,increased numbers of polymorphonuclear cells and increased lung myeloperoxidase activity）,increased pro - inflammatory cytokines[*** -α（tumor necrosis factor -α）,IL（interleukin） - 1 β and IL - 6],and increased cellular ischemia（*** and lactate/ pyruvate ratio） and oxidative damage[glycerol,NOx（combined nitrate + nitrite） and 2,3 - dihydroxybenzoic acid]markers in the BALF（bronchoalveolar fluid）.Results HHP,in addition to inducing overexpression of HSP70 in the lungs,significantly attenuated HAE - induced pulmonary edema,inflammation, and ischemic and oxidative damage in the *** beneficial effects of HHP in preventing the occurrence of HAE - induced pulmonary edema,inflammation,and ischemic and oxidative damage was reduced significantly by pretreatment with a neutralizing anti - HSP70 *** In conclusion,HHP may attenuate the occurrence of pulmonary edema,inflammation,and ischemic and oxidative damage caused by HAE in part via up - regulating HSP70 in the lungs.

关键词： hypobaric hypoxia preconditioning heat-shock protein 70 acute lung injury

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Effects of Body Cooling on Myocardial Protein Expression during Experimental Heatstroke:the Heart Tissue Proteomic Study

Effects of Body Cooling on Myocardial Protein Expression dur...

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第八届海峡两岸心血管科学研讨会

作者：许传智吴南均张菁萍许琼月黄戊田张明温许淑芬郑伯智 Department of Surgery Chi Mei Medical Center Institute of Clinical Medicine School of MedicineNational Cheng-Kung University Department of Biotechnology Southern Taiwan University Department of Recreation and Health-Care Management Chia-Nan University of Pharmacy and Science Department of Electrical Engineering Southern Taiwan University Department of Physical Therapy Shu-Zen College of Medicine and Management

＜正＞Objective Whole body cooling（WBC） is the current therapy of choice for heatstroke because no pharmacologic agent is *** the true mechanism of protection exerted by WBC during heatstroke remains unclear,ample evidence has accumulated to indicate that cardiac dysfunction is an attractive target for the therapy of *** The current study attempted to compare both the cardiac function and the 2 - dimensional electrophoresis protein patterns of myocardium samples from the normothermic controls with those from the untreated heatstroke *** The cardiac dysfunction that occurred during heatstroke were associated with altered cardiac *** increased spots during heart stroke were identified by using mass spectrometry as NADH dehydrogenase 1 alpha subcomplex 10 - like protein（NDUFA10） and phosphorylated alpha B *** decreased spots during heatstroke were identified as annexinⅢ,heat shock protein（HSP） 27,adenine phosphoribosyl transferase（APRTase）,HSP20,cytochrome C oxidase polypeptide Vb mitochondrial precursor（MTCO1）,NADH:ubiquinone oxidoreductase（NDUFA5）,MYH6 RAT myosin heavy chain cardiac muscled a isoform（MYHC - alpha）,and *** cooling,in addition to restoring the appropriate levels of HSP27,HSP20,APRTase,MTCO1,annexinⅢ,NDUFA5,and MYHC -alpha, enhances preservation of alpha B crystalline and maintains appropriate cardiac function during heatstroke. Conclusions This study demonstrated that the failing hearts during heatstroke were characterized by reduced mitochondrial activity,disruption of energy production,and loss of the structural integrity of the cardiomyocytes, and reduced anticoagulation,which can be improved by body cooling.

关键词： heatstroke heat shock protein stroke volume myocardium hypotension proteomic

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Protective effects of hypothermia therapy in ischemia ypoxia-induced cardiomyocyte cell death model:the role of autophagy

Protective effects of hypothermia therapy in ischemia ypoxia...

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第八届海峡两岸心血管科学研讨会

作者：邱碧莹许尧钦张菁萍陈佳莹许传智黄戊田许淑芬张明温郑伯智 Department of Chinese Medicine Chi Mei Medical Center Department of Biotechnology Southern Taiwan University Department of Surgery Chi Mei Medical Center Department of Recreation and Health-Care Management Chia-Nan University of Pharmacy and Science Department of Nursing Shu-Zen College of Medicine and Management Department of Electrical Engineering Southern Taiwan University

Objective Therapeutic hypothermia has been associated as a potential treatment for a number of medical conditions including head injury and cerebral vascular *** the past decade,there have been numerous studies focusing upon the resuscitation following cardiac *** addition,the mechanism of therapeutic hypothermia protection is not completely ***,this cardiomyocyte ischemia reperfusion (I/R) model does demonstrate significant anti - apoptosis and anti - autophage - mediated cardioprotective *** we hypothesized that therapeutic hypothermia would be significantly protected in this model of I/R when induced at start - ischemia or endischemia and maintained into *** H9c2 cells are divided into four groups:Control,Ischemia Reperfusion(I/R),Cooling at Reperfusion(PostTreat) and Cooling at Ischemia(PreTreat).H9c2 cardiomyocytes simulated ischemia/hypoxia by incubation serum and glucose deprived medium and transferred into 0.2%O hypoxia chamber,and then reperfusion replaced into 21%*** H9c2 cells apoptosis was evidenced by flow cytometry -,DNA fragmentation -,and caspase 3 activation - increased apoptotic cells(Annexin -V positive and propidium iodide negative).The H9c2 cells autophagy was evidenced by double immunofluresence stain for lysosome activity,western blot for LC3II protein *** The cell viability was serum deprivation - hypoxia reperfusion reduced significantly and time *** viability loss in the hypoxic serum - starved H9c2 cells was due to apoptosis and *** the 24 - hour I/R injury,the DNA strand breaks and fragmentation occurred in the I/R group,whereas coincidently,the caspase -3,lysosome activity,and LC3II were ***, the percentage of apoptotic cells(flow cytometryanalyzed annexin - V positive and PI negative) significantly increased in I/R *** temperature,especially in PreTreat group,significantly reduced the simulated ischemia - induced cell

关键词： hypothermia autophagy myocardium infarction cardiomyocyte ischemia-reperfusion

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Neuroprotection of Agmatine Against Neuronal Death via Attenuating of Blood Flow and Inhibiting the Increase of Aquaporine-4 Induced by Cerebral Ischemia/Reperfusion:the MRI Study

Neuroprotection of Agmatine Against Neuronal Death via Atten...

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第八届海峡两岸心血管科学研讨会

作者：王哲川黄怡静郭进荣张菁萍郑伯智张丞圭林茂村张明温黄戊田邱仲庆 Department of Neurosurgery Chi Mei Medical Center Department of Radiology Chi Mei Medical CenterLiouying Department of Biotechnology Southern Taiwan University Graduate Institute of Injury Prevention and Control Taipei Medical University and Municipal Wan-Fan Hospital Department of Medical Research Chi Mei Medical Center Department of Electrical Engineering National Cheng Kung University Department of Recreation and Health-Care Management Chia-Nan University of Pharmacy and Science

＜正＞Objective Agmatine formed by the decarboxylation of L - arginine by arginine decarboxylase in mammalian *** purpose of this study was to evaluate the neuroprotective effect of agmatine in a transient focal ischemia in adult rat,and to evaluate effects on aquaporin -4（AQP -4） expression and cell death. Methods Immunofluorescence double stain of AQP -4 and glial fibrillary acidic protein（GFAP） were performed at 1,3,24,48,and 72 hours after *** - deoxynucleotidyl transferase mediated nick and end - labeling（TUNEL） with neuron - specific nuclear protein（Neu - N） and 2,3,7 - Triphenyltetrazolium chloride（TTC） stainings were performed at the corresponding *** transient focal cerebral ischemia combined with agmatine treatment,and using clinical 1.5 T MRI equipment to assess temporal evolution of cerebral infarct and doing comparative analysis of pathological *** Our results showed that the use of T2WT and DWI could appropriately assess the infarct size and treatment *** use of CE - T1WI also helped to evaluate the extent of blood - brain barrier damage,especially for patients with thrombolytic therapy to predict the occurrence of hemorrhagic *** addition,the neuroprotective effect of agmatine on cerebral edema seemed to attenuate cytotoxic *** the control ischemia group,the number of Neu - N TUNEL - positive cells,AQP -4 expression in astrocyte,and gliosis were significantly increased in the cortex（P＜0.05）.Neuronal death was reduced when agmatine was present start of reperfusion, and this protection was associated with a reduction of inducible nitric oxide synthase（iNOS）.Total number of TUNEL - positive cells,AQP-4 positive astrocytes,and brain damage on TTC stain were significantly attenuated in the agmatine - treated rats compared with the ischemia rats（P＜0.05）.Diffusion-weighted MRI（DWI） is a sensitive and reliable marker of cerebral *** minutes of an ischemic event in the brain,the mi

关键词： ischemia reperfusion apoptosis blood flow MRI

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职业本科专业建设：类型特征、实践误区与未来路向

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黑龙江高教研究 2025年第2期 1-7页

作者：黄守峰贵州开放大学(贵州职业技术学院) 华南师范大学

职业本科专业为新时代高素质技术技能人才培养提供了全新路径。在开展职业本科专业建设时，既要把握其高适应性、高融合性、高技能性、高特殊性等类型特征，也要规避陷入办学惯性、走入浅层合作、步入办学重复、坠入“普本复制”等发展... 详细信息

职业本科专业为新时代高素质技术技能人才培养提供了全新路径。在开展职业本科专业建设时，既要把握其高适应性、高融合性、高技能性、高特殊性等类型特征，也要规避陷入办学惯性、走入浅层合作、步入办学重复、坠入“普本复制”等发展误区。推进我国职业本科专业高质量发展，需要紧跟产业发展脉搏，明确专业崭新航向；扣住产教融合内涵，凸显专业固有特征；紧抓“三教”改革根本，提升专业内在质量；改革人才培养模式，塑造专业特色品牌。

关键词：职业本科教育专业建设类型特征误区防范未来路向

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高速电磁能推进装置枢轨接触特性分析及实验研究

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西安交通大学学报 2025年第1期59卷 28-36页

作者：祝丽花刘平谷雨茜郝建英田子豪杨庆新天津理工大学新能源电力变换传输与智能控制天津市重点实验室天津300384

为准确分析高速增强型电磁能推进装置枢轨接触特性,提出了一种数值计算与实验测量相结合的方法,对推进装置枢轨接触特性进行动态分析。首先,建立接触电阻与膛口电压、轨道电流、磁场等物理量之间的数学模型,并设计实验对膛口电压、轨道... 详细信息

为准确分析高速增强型电磁能推进装置枢轨接触特性,提出了一种数值计算与实验测量相结合的方法,对推进装置枢轨接触特性进行动态分析。首先,建立接触电阻与膛口电压、轨道电流、磁场等物理量之间的数学模型,并设计实验对膛口电压、轨道电流、电枢速度以及空间磁场等装置参数进行测量;其次,通过膛口电压与轨道电流等实验测量数据和有限元数值计算结果,对增强型电磁能推进装置枢轨接触电阻进行计算;进一步根据接触电阻计算结果与电枢速度特性曲线,对不同阶段下推进装置枢轨接触特性进行分析;最后,将服役后的导轨进行拆解和形貌扫描,通过样貌图侧面验证了不同阶段接触特性分析的可靠性。研究结果表明:初始阶段枢轨接触电阻最大可达8.5 mΩ,且轨道在此阶段损伤较为严重;在加速至中高速阶段,接触电阻基本平稳在0.78 mΩ左右,枢轨接触状态较为稳定;在高速运动至出口阶段,接触电阻波动幅度较大,电接触稳定性差。研究内容可为轨道磨损以及提高系统性能等提供基础数据和新的可靠参考。

关键词：电磁能推进装置高速状态接触电阻轨道形貌枢轨接触

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基于改进DeblurGAN-v2的运动模糊农作物害虫图像复原方法

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光电子·激光 2025年第1期36卷 46-52页

作者：赵辉黄镖王红君岳有军天津理工大学电气工程与自动化学院天津市复杂系统控制理论与应用重点实验室

为对巡检机器人在巡检过程中产生的运动模糊图像进行高效精准识别，提出了一种基于改进DeblurGAN-v2的运动模糊农作物害虫图像复原方法。为有效提取图像重要特征，该方法将通道注意力(channel attention, CA)机制集成到DeblurGAN-v2主... 详细信息

为对巡检机器人在巡检过程中产生的运动模糊图像进行高效精准识别，提出了一种基于改进DeblurGAN-v2的运动模糊农作物害虫图像复原方法。为有效提取图像重要特征，该方法将通道注意力(channel attention, CA)机制集成到DeblurGAN-v2主干网格中，使模型更加关注细节特征，提高对运动模糊图像的复原能力；此外，在原模型特征提取网络顶层引入空间金字塔池化(spatial pryamid pooling, SPP)缓解图像多尺度变化造成对图像复原的负面影响，提高模型对图像复原的性能。基于实际农田环境建立的数据集所做的实验结果表明，改进后算法的PSNR、SSIM指标分别为26.281 8 dB、0.947 3,较原模型提升了8、7.2个百分点。与其他主流模型的对比实验结果表明，本文方法对模糊图像的实际复原效果更优，对解决运动模糊农作物害虫的图像复原问题具有实际应用价值。

关键词：运动模糊深度学习图像复原 DeblurGAN-v2 通道注意力(CA)机制空间金字塔池化(SPP)模块

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