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A large-scale transcriptional study reveals inhibition of COVID-19 related cytokine storm by traditional Chinese medicines

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Science Bulletin 2021年第9期66卷 884-888,M0003页

作者： Yifei Dai Weijie Qiang Yu Gui Xue Tan Tianli Pei Kequan Lin Siwei Cai Liang Sun Guochen Ning Jianxun Wang Hongyan Guo Yimin Sun Jing Cheng Lan Xie Xun Lan Dong Wang State Key Laboratory of Southwestern Chinese Medicine Resources School of Basic Medical SciencesChengdu University of Traditional Chinese MedicineChengdu 611137China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China High Performance Computing Department National Supercomputing Center in ShenzhenShenzhen 518055China Department of Electronic and Computer Engineering College of EngineeringDrexel UniversityPhiladelphia 19104USA Dongli District Jinqiao Street Community Health Service Center Tianjin 300300China Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing 100084China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China National Engineering Research Center for Beijing Biochip Technology Beijing 102206China State Key Laboratory of Membrane Biology School of MedicineTsinghua UniversityBeijing 100084China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003China Medical Systems Biology Research Center School of MedicineTsinghua UniversityBeijing 100084China

The application of traditional Chinese medicine(TCM)has made great contributions to the fight against the epidemic of coronavirus disease-2019(COVID-19).Despite the remarkable therapeutic effects of TCM,the molecular mechanisms of TCM formulae inhibiting COVID-19 are still not fully ***,we cφm-bined the automated high throughput sequencing-based high throughput screening(HTS^(2))assay with bioinformatics and computer-aided drug design(CADD)to investigate the molecular mechanisms of TCM-mediated therapeutic effects on COVID-19-related cytokine storm(Fig.1a).

关键词：细胞因子风暴六君子汤理中汤诊疗方案黄连解毒汤中药提取物肺炎分子机制

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玩具租赁行业的现状分析与对策研究

国际公关 2019年第3期 179-179页

作者：王武刚杨强伟张许霞赵丰福韩钰兰州财经大学陇桥学院

一方面随着人们生活水平的提高以及新生儿数量的急剧增加,玩具市场广阔,另一方面却存在的玩具的大量积压、浪费等现象。本文试图从消费者角度出发,结合营销价值创造的相关理论分析相关问题并提出建设性对策,希望能为玩具租赁商的发展提... 详细信息

一方面随着人们生活水平的提高以及新生儿数量的急剧增加,玩具市场广阔,另一方面却存在的玩具的大量积压、浪费等现象。本文试图从消费者角度出发,结合营销价值创造的相关理论分析相关问题并提出建设性对策,希望能为玩具租赁商的发展提供参考依据。

关键词：智能玩具存在问题解决措施创新

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低分子肝素皮下注射治疗TIA67例

医学理论与实践 2002年第6期15卷 655-655页

作者：安占军强伟晨徐立霞赵慧君武警河北省总队医院石家庄050081 河北医科大学附属第四医院急诊中心

TIA(一过性缺血发作)是脑组织短暂缺血所致的局限性脑功能障碍,常以一过性眩晕、共济失调或肢体及面、舌肌瘫痪为主要表现.TIA为中、老年常见病、多发病,近年有年轻化倾向,如不及时治疗大多发展为脑梗死.笔者1999年9月～2002年2月以低... 详细信息

TIA(一过性缺血发作)是脑组织短暂缺血所致的局限性脑功能障碍,常以一过性眩晕、共济失调或肢体及面、舌肌瘫痪为主要表现.TIA为中、老年常见病、多发病,近年有年轻化倾向,如不及时治疗大多发展为脑梗死.笔者1999年9月～2002年2月以低分子肝素为主治疗TIA67例,疗效较佳.现报告如下.

关键词：低分子肝素皮下注射治疗 TIA 局限性脑功能障碍

Quantitative Comparison of Bile Acid Distribution and Intestinal Transport from Native Cow-bezoar and Artificial and in vitro Cultured Substitutes using Caco-2 Cell Monolayer Model

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Digital Chinese Medicine 2018年第4期1卷 261-271页

作者： Ying CHEN Xiao-Ru HU Xian-Long CHENG Shuang-Cheng MA Qing-Sen RAN Qing YANG Wei-Jie QIANG Zhong DAI Xiao-Xin ZHU Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China National Institutes for Food and Drug Control Beijing 100050China

Objective This study was conducted to examine the absorption and translocation of conjugated bile acids(BAs)in Calculus bovis and its substitutes to detect differences in these *** A Caco-2 monolayer cell model was used to compare the apparent permeability coefficient(Papp)value and efflux ratio(ER)of BAs in natural cow-bezoar(NCB),artificial cow-bezoar(ACB),and in vitro cultured cow-bezoar(Ivt-CCB).Papp and ER values were determined by liquid chromatography-mass *** were separated on an analytical *** The distribution of BAs in NCB was significantly different from that in ACB and *** percentages of conjugated BAs were significantly higher in NCB than in the two *** distribution differences of conjugated and unconjugated BAs can be used to distinguish costly NCB from relatively inexpensive *** The transport characteristics of BAs in Ivt-CCB were more consistent with NCB than with ACB,even when the proportions of BAs in Ivt-CCB were closer to those of ACB.

关键词： Bile acids Cow-bezoar Intestinal transport Caco-2 cell Apparent permeability coefficient value Efflux ratio

First Principle Calculation for the Electronic Bands and Absorption of CdTe_(1-x)Sb_x

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Journal of Southwest Jiaotong University(English Edition) 2010年第4期18卷 340-345页

作者：王龙黄整麻焕峰强伟荣潘敏 School of Physical Science and Technology Southwest Jiaotong University Superconductivity R&D Center (SRDC) Southwest Jiaotong University

The lattice parameters for the derivatives of cadmium telluride,CdTe1-xSbx,with the zinc blend crystal structure are calculated using the generalized gradient approximation method; which is based on the density functional theory （DFT）. The effects of antimony （Sb） on the lattices,electric bands,electronic state density,absorption spectroscopy,and band gap between the valence band maximum （VBM） and the conduction band minimum （CBM） of CdTe1-xSbx are discussed. The results show that the antimonic atoms in the lattice are advantageous in promoting the hole concentration and conductivities of CdTe1-xSbx. The increase of the Sb content in CdTe1-xSbx reduces the interaction among Cd,Te,and Sb; resulting in a decreased binding energy within CdTe1-xSbx as well as an increase in the electronic gap. Also discussed are the mechanics for the lattice phase change of CdTe1-xSbx at x=0.5.

关键词： CdTe1-xSbx DFT Electric band Absorption Spectroscopy

Molecular Biological Mechanisms of Yuan Zhi Powder in the Treatment of Alzheimer's Disease: an Analysis Based on Network Pharmacology

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Digital Chinese Medicine 2018年第1期1卷 90-101页

作者： Wei-Jie QIANG Ying CHEN Fu-Yuan HE Mei-Feng XIAO Wei-Yan CAI Yi-Fei DAI Qing YANG Yu-Jie LI Xiao-Gang WENG Qi LI Ya-Jie WANG Xiao-Xin ZHU Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Anhui University of Chinese Medicine HefeiAnhui 230012China College of Pharmacy Hunan University of Traditional Chinese MedicineChangshaHunan 410208China

Objective To predict the main active ingredients,potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network *** A database of chemical constituents of Yuan Zhi powder was constructed by using databases and *** targets were predicted by reverse molecular docking,and then a component-target network was *** target network of Alzheimer's disease(AD)was mapped and analyzed to obtain the“active ingredient-AD target”*** key targets were screened through network ***,the rationality of the prediction was analyzed by comparing with the target reported in the *** There were180chemical constituents acting on the AD target,and the targets included three key targets(cyclooxygenase-2,muscarinic acetylcholine receptor M1,and muscarinic acetylcholine receptor M2)and an important target(acetylcholine esterase).Alzheimer's disease may be treated by regulating the activity of acetylcholine receptors and the binding toβ-amyloid protein,and its biological process may be concentrated in the acetylcholine receptor signal pathway,negative regulation of synaptic transmission and so *** The fact that Yuan Zhi powder can treat AD is consistent with the characteristics of multi-components-multitargets-multiple pathways of traditional Chinese *** important targets obtained from network analysis have a large proportion in literature research,so network analysis have some rationality.

关键词： Yuan Zhi powder Network pharmacology Active ingredients–AD targets network Network analysis Dementia