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核电子学与探测技术 2016年第3期36卷 316-320页

作者：卢贞瑞黄先超李琳王英杰周魏顾笑悦葛良全章志明成都理工大学核技术与自动化工程学院成都610059 中国科学院高能物理研究所核技术应用研究中心北京100049 北京市射线成像技术与装备工程技术研究中心北京100049

基于单点型硅光电倍增管(Si PM)与LYSO闪烁晶体,研制了一种新型乳腺专用PET探测模块,并对其性能进行研究。该探测模块采用28×28根1.9 mm×1.9 mm×15 mm的LYSO晶体组成阵列,与8×8个单点型Si PM组成的阵列通过光导耦合,所产生的脉冲信... 详细信息

基于单点型硅光电倍增管(Si PM)与LYSO闪烁晶体,研制了一种新型乳腺专用PET探测模块,并对其性能进行研究。该探测模块采用28×28根1.9 mm×1.9 mm×15 mm的LYSO晶体组成阵列,与8×8个单点型Si PM组成的阵列通过光导耦合,所产生的脉冲信号分别经过模拟、定时电路处理后送入高速采样电路完成信号处理。该探测模块能够实现1.9 mm位置分辨,12.73%平均能量分辨以及2.66 ns双探头符合时间分辨,具有较好的分辨性能,能够满足乳腺专用PET成像的设计需求。

关键词：硅光电倍增管(SiPM) 乳腺专用PET 探测器能量分辨符合时间分辨

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维普期刊数据库

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Attenuation correction with region growing method used in the positron emission mammography imaging system

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Chinese Physics C 2015年第10期39卷 131-138页

作者：顾笑悦李琳尹鹏飞负明凯柴培黄先超孙校丽魏龙 Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of Sciences Beijing Engineering Research Center of Radiographic Techniques and Equipment

The Positron Emission Mammography imaging system （PEMi） provides a novel nuclear diagnosis method dedicated for breast imaging. With a better resolution than whole body PET, PEMi can detect millimeter-sized breast tumors. To address the requirement of semi-quantitative analysis with a radiotracer concentration map of the breast, a new attenuation correction method based on a three-dimensional seeded region growing image segmentation （3DSRG-AC） method has been developed. The method gives a 3D connected region as the segmentation result instead of image slices. The continuity property of the segmentation result makes this new method free of activity variation of breast tissues. The threshold value chosen is the key process for the segmentation method. The first valley ill the grey level histogram of the reconstruction image is set as the lower threshold, which works well in clinical application. Results show that attenuation correction for PEMi improves the image quality and the quantitative accuracy of radioactivity distribution determination. Attenuation correction also improves the probability of detecting small and early breast tumors.

关键词： breast PET attenuation correction region growing image segmentation

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维普期刊数据库

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High resolution image reconstruction method for a double-plane PET system with changeable spacing

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Chinese Physics C 2016年第5期40卷 111-120页

作者：顾笑悦周魏李琳魏龙尹鹏飞尚雷敏贠明凯卢贞瑞黄先超 Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Beijing Engineering Research Center of Radiographic Techniques and Equipment Beijing 100049Chiua

Breast-dedicated positroil emission tomography （PET） imaging techniques have been developed ill recent years. Their capacities to detect millimeter-sized breast tumors have been the subject of many studies. Some of them have been confirmed with good results in clinical applications. With regard to biopsy application, a double-plane detector arrangement is practicable, as it offers the convenience of breast immobilization. However, the serious blurring effect of the double-plane PET, with changeable spacing for different breast sizes, should be studied. We investigated a high resolution reconstruction method applicable for a double-plane PET. The distance between the detector planes is changeable. Geometric and blurring components were calculated in real-time for different detector distances, and accurate geometric sensitivity was obtained with a new tube area model. Resolution recovery was achieved by estimating blurring effects derived front simulated single gamma response information. The results showed that tile new geometric modeling gave a more finite and smooth sensitivity weight in the double-plane PET. The blurri,lg component yielded contr^ust recovery levels that could not be reached without blurring modeling, and improved visual recovery of the smallest spheres and better delineation of the structures in the reconstructed images were achieved with tile blurring component. Statistical noise had lower variance at tile voxel level with blurring modeling at matched resolution, compared to without blurring modeling. In distance-changeable double-plane PET, finite resolution modeling during reconstruction achieved resolution recovery, without noise amplification.

关键词： breast PET double-plane PET reconstruction

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