Objective\ To evaluate the response to antiandrogen withdrawal in patients with advanced prostate cancer treated with combined androgen blockade. Methods\ Twenty four cases of advanced prostate cancer (10 in stage C ...
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Objective\ To evaluate the response to antiandrogen withdrawal in patients with advanced prostate cancer treated with combined androgen blockade. Methods\ Twenty four cases of advanced prostate cancer (10 in stage C and 14 in stage D) were retrospectively studied. All the patients were treated with combined androgen blockade (bilateral orchiectomy and flutamide). After initial response to hormone therapy for 7 to 36 months, flutamide was discontinued because of deterioration of the disease. Serum prostate specific antigen (PSA) levels were checked every 2 to 4 weeks and symptoms observed. Results\ The results following withdrawal of flutamide were as follows: 8 patients showed a decline in PSA (mean 74.8%), of whom 6 cases had the PSA decline greater than 50%. Clinical symptoms improved in 4 cases. The nodules of the prostate were smaller than before in cases. The mean duration of response was 4.3 ***\ In patients with hormone refractory advanced prostate cancer after initial combined androgen blockade therapy, a trial of 'antiandrogen withdrawal' is a reasonable choice of therapeutic maneuver.
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