检索结果-南通市图书馆

graphene-calcium carbonate coating to improve the degradation resistance and mechanical integrity of a biodegradable implant

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

journal of Magnesium and Alloys 2024年第1期12卷 394-404页

作者： Lokesh Choudhary Parama Chakraborty Banerjee R.k.singh Raman Derrek e.Lobo Christopher D.easton Mainak Majumder Frank witte jörg F.Löffler Department of Mechanical and Aerospace engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Department of Chemical and Biological engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale science and engineering Laboratory(NseL) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CsIRO Materials science and engineering Bayview AvenueClaytonVIC 3168Australia julius Wolff Institute and Berlin Brandenburg Center for Regenerative Therapies Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Laboratory of Metal Physics and Technology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body *** necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical *** this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RgO)-calcium carbonate(CaCO_(3))composite *** analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.

关键词： graphene coating Biodegradable implant Hydroxyapatite Corrosion Magnesium alloy

Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第10期17卷 9052-9064页

作者： savannah e.est-witte sydney R.shannon Dennis H.gong kaitlyn g.Calabresi jawaun j.Harris kaitlyn storm edwin j.Yoo Ariel Isser Vivek P.jani Natalie k.Livingston Mary O.Omotoso kelly Rhodes elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh simone sidoli stephany Y.Tzeng jonathan P.schneck jordan j.green Translational Tissue engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

马-普量子光学研究所的高功率碘激光器研究评述

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国激光 1983年第Z1期 506-506页

作者： g.brederlow H.Baumhacker e.fill e.gerck M.A.greiner-Mothes j.gruber g.Linford R.Volk s.witkowski k.j.witte 德意志联邦共和国马-普量子光学研究所德意志联邦共和国马-普量子光学研究所德意志联邦共和国马-普量子光学研究所德意志联邦共和国马-普量子光学研究所德意志联邦共和国马-普量子光学研究所德意志联邦共和国马-普等离子体物理研究所德意志联邦共和国马-普量子光学研究所德意志联邦共和国马-普量子光学研究所德意志联邦共和国马-普量子光学研究所德意志联邦共和国马-普量子光学研究所加欣加欣加欣加欣加欣加欣加欣加欣加欣加欣

MPI量子光学研究所在高功率碘激光器方面的研究包括寻找更有效的碘激光介质,增大目前运转的单束300j Asterix Ⅲ型激光系统的输出及脉宽范围的物理及技术研究,以及频率变换的实验。在本文中论及了上述研究内容,从而对目前的碘激光器的... 详细信息

MPI量子光学研究所在高功率碘激光器方面的研究包括寻找更有效的碘激光介质,增大目前运转的单束300j Asterix Ⅲ型激光系统的输出及脉宽范围的物理及技术研究,以及频率变换的实验。在本文中论及了上述研究内容,从而对目前的碘激光器的重要性能进行了评述。在碘激光器中,最常用的激光介质是i-C3F7I。为了寻找一个具有较宽的泵浦带宽和因而有较高泵浦效率的激光介质,正在进行对新的烷基碘化物的研究。至今已有两种成分被分

关键词：高功率碘激光器激光系统量子光学物理光学研究所

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

肿瘤研究历史回顾(1900～1990)

国外医学（肿瘤学分册） 1991年第4期18卷 193-202页

作者： witkowski j A 刘培楠

在20世纪,肿瘤是许多发达国家的主要死亡原因。因此肿瘤研究在本世纪中成为生物医学研究发展的重要推动力。一般深信对机体的基本过程的阐明将有助于了解正常细胞成为恶性的机制,所以这项研究并未只限于以人类肿瘤为对象,而且采用动物... 详细信息

在20世纪,肿瘤是许多发达国家的主要死亡原因。因此肿瘤研究在本世纪中成为生物医学研究发展的重要推动力。一般深信对机体的基本过程的阐明将有助于了解正常细胞成为恶性的机制,所以这项研究并未只限于以人类肿瘤为对象,而且采用动物实验开展了各学科的研究,包括生物化学、遗传学、分子生物学、细胞生物学、发育生物学和免疫学等各领域的探讨。

关键词：肿瘤研究历史

在线全文

学校读者我要写书评

暂无评论

Temporal Bone 2010

N-末端脑利钠肽作为筛查起搏器患者是否发生心力衰竭的工具

2010年

作者： john I. Lane Robert j. witte

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 52-53页

作者： Thackray s.D.R. witte k. ghosh j. 田志 Department of Academic Cardiology University of Hull Castle Hill Hospital Cottingham East Yorkshire United Kingdom

Aims: Assessment of N- terminal brain natriuretic peptide(NTBNP) as a screening tool for heart failure in patients with a permanent pacemaker. Methods and results: Consecutive patients undergoing a routine permanent pacemaker assessment were enrolled. Patients underwent medical history and examination, echocardiography and blood sampling for NT- BNP. Analysis was performed on 261 patients(132 DDD, 121 VVI, eight others), mean age 73± 12 years, range 34- 99 years. seventy two subjects(27% ) had heart failure as defined by left ventricular ejection fraction(LVeF) ≤ 40% and symptoms of heart failure(NYHA class II, III, or IV). screening with NT- BNP gave a sensitivity of 73% and specificity of 72% for detecting heart failure in all patients [area under the curve(AUC) 0.76, Ps increased in subjects with a DDD type pacemaker(sensitivity 80% , specificity 66% , AUC=0.8, CI 0.7- 0.90) and reduced in subjects with a VVI type pacemaker(sensitivity 66% , specificity 61% , AUC 0.68 CI 0.57- 0.78). Conclusion: symptoms of heart failure are common in patients with pacemakers. screening with NT- BNP is feasible and assists in the detection of important cardiac co- morbidity, particularly in patients with a DDD type pacemaker.

关键词：永久性心脏起搏器植入筛查工具心力衰竭脑利钠肽 N-末端患者 DDD起搏器 VVI起搏器超声心动图检查 NYHA分级

在线全文

学校读者我要写书评

暂无评论

缝合伤口时应用曲马多的术后疗效

中国疼痛医学杂志 2001年第3期7卷 189-192页

作者： j.De witte g.W.Rietman 单位不详

这项前瞻性,随机、双盲的试验旨在研究手术结束时使用大剂量镇痛剂曲马多对拔管时,镇静和麻醉后寒战的效果.40名AsA Ⅰ、Ⅱ级的成年患者接受了约1小时的腹腔镜手术,用含异氟醚的O2/N2O维持标准麻醉.开始缝合伤口时静脉给曲马多3mg/kg(n=... 详细信息

这项前瞻性,随机、双盲的试验旨在研究手术结束时使用大剂量镇痛剂曲马多对拔管时,镇静和麻醉后寒战的效果.40名AsA Ⅰ、Ⅱ级的成年患者接受了约1小时的腹腔镜手术,用含异氟醚的O2/N2O维持标准麻醉.开始缝合伤口时静脉给曲马多3mg/kg(n=20),以盐水做对照(n=20).接受曲马多治疗的患者无一出现麻醉后寒战,而对照组有60%的患者发生麻醉后寒战(P＜0.001).曲马多对于拔管时间和镇静没有不良影响,曲马多组的出院期缩短(与对照组相比P＜0.05).在麻醉后监护病房(PACU)里的两组患者的疼痛评分没有统计学差异,但对照组显然需要使用较多的辅助性措施才能治疗寒战和/或疼痛.结论:手术结束时使用大剂量曲马多可避免麻醉后寒战而不延长拔管时间,并可缩短麻醉后监护病房(PACU)的观察期.

关键词：麻醉曲马多合并症寒战镇静恶心手术后腹腔镜

在线全文

学校读者我要写书评

暂无评论

薛定谔与生物科学

科学技术哲学研究 1988年第1期25卷 75-76,65页

作者： j.A.witkowski 郝军山

欧文·薛定谔的《生命是什么》(英文简称WIL)人们普遍认为该书是本世纪四十年代末五十年代初分子生物学发展过程中的一个重要因素,它强调了遗传的密码传递概念,并提醒物理学家们注意有的问题还得等待从生物学中寻求答案。是什么东西使... 详细信息

欧文·薛定谔的《生命是什么》(英文简称WIL)人们普遍认为该书是本世纪四十年代末五十年代初分子生物学发展过程中的一个重要因素,它强调了遗传的密码传递概念,并提醒物理学家们注意有的问题还得等待从生物学中寻求答案。是什么东西使薛定谔1943年写就的东西在现代生物学中起了如此重要的作用?为什么薛定谔的波动方程引起了生物学家的兴趣?

关键词：分子生物学现代生物学物理学家薛定谔五十年代统计力学基因物理学定律四十年代波动方程

Total pancreatectomy with islet autotransplantation in diabetic and pre-diabetic patients with intractable chronic pancreatitis

在线全文

学校读者我要写书评

暂无评论

journal of Pancreatology 2020年第2期3卷 86-92页

作者： Bachul Piotr j. grybowski Damian j. Anteby Roi Basto Lindsay Perea Laurencia golab karolina Wang Ling-jia Tibudan Martin gutierrez Angelica P. komorniczak Michal Nagpal sajan Lucander Aaron Fung john Matthews jeffrey B. witkowski Piotr Department of surgery University of ChicagoChicagoILUSA Faculty of Medicine Tel Aviv UniversityTel AvivIsrael Department of Nephrology Transplantology and Internal MedicineMedical University of GdańskGdańskPoland Department of Medicine University of ChicagoChicagoILUSA

Total pancreatectomy with islet autotransplantation(TPIAT)is an effective treatment option for non-diabetic patients with intractable chronic *** outcome and potential benefits for pre-diabetic and diabetic patients are less well ***-four patients underwent TPIAT were retrospectively divided into 3 groups according to pre-operative glycemic control:diabetes mellitus(DM)(n=5,15%),pre-DM(n=11,32%)and non-DM(n=18,54%).Pre-operative fasting c-peptide was detectable and similar in all 3 *** yield in the DM group was comparable to pre-DM and non-DM groups(median islet equivalents[IeQ]was 191,800,111,800,and 232,000 IeQ,respectively).Patients received islet mass of over the target level of 2000 IeQ/kg in pre-DM and DM at lower but clinically meaningful rates compared to the non-DM group:45%(5/11)and 60%(3/5)for a combined 50%(8/16)rate,respectively,compared to 83%(15/18)for the non-DM *** 1 year,fasting c-peptide and HbA1c did not differ between DM and pre-DM groups but c-peptide was significantly higher in *** transplantation failed(negative c-peptide)only in 1 ***,all patients experienced pancreatic pain with daily opioid dependence in 60%to 70%.Pancreatic-type pain gradually subsided completely in all groups with no differences in other painful somatic *** patients with measurable pre-operative c-peptide can achieve similar benefit from TPIAT,with comparable outcomes to pre-diabetic and non-diabetic patients including pain relief and the metabolic benefit of transplanted *** surprisingly,endocrine outcomes for diabetic and prediabetics patients are substantially worse than in those with normal pre-operative glucose control.

关键词： Autotransplantation Islets Outcomes Pancreatectomy Pre-diabetes