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马尔尼菲青霉病的血清学诊断

广西医学院学报 1988年第4期 23-27页

作者：邓卓霖马韵李山叶琼玉广西医学院

本文通过对3例马尔尼菲青霉患者及其他各类病例2370例的血清免疫扩散试验,证明马尔尼菲青霉具有免疫原性.人感染马尔尼菲青霉后能产生特异性抗体,病变明显者抗体效价高,病变消退后抗体效价下降,不出现病变者血清中不出现抗体.抵抗力太... 详细信息

本文通过对3例马尔尼菲青霉患者及其他各类病例2370例的血清免疫扩散试验,证明马尔尼菲青霉具有免疫原性.人感染马尔尼菲青霉后能产生特异性抗体,病变明显者抗体效价高,病变消退后抗体效价下降,不出现病变者血清中不出现抗体.抵抗力太差的全身性广泛播散病例无抗体产生,其预后不良.非马尔尼菲青霉病患者,其中包括隐球菌、孢子丝菌和着色霉菌等深部真菌感染病例,其血清与马尔尼菲青霉抗原无交叉反应.应用免疫扩散试验对马尔尼菲青霉病有诊断和估计预后的价值.

关键词：马尔尼菲青霉抗原特异性抗体免疫扩散试验

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酷似组织胞浆菌病的马尔尼菲青霉病

中华病理学杂志 1999年第5期28卷 384-386页

作者：邓卓霖马韵广西医科大学病理学教研室南宁530021

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ΔNp63在鼻咽癌组织中的表达及意义

癌症 2004年第3期23卷 288-291页

作者：廖芝玲邓卓霖张斌谢凯圣广西柳州市肿瘤医院病理科广西柳州545006 广西医科大学病理学教研室广西南宁530000

背景与目的:鼻咽癌致病的分子机理至今仍不清楚。有研究表明ΔNp63以显性失活的方式抑制p53的反式激活,并与鳞状细胞的恶性增生与失分化有关。本研究旨在探讨ΔNp63蛋白在鼻咽癌组织中的表达及意义。方法:采用免疫组织化学方法检测60例... 详细信息

背景与目的:鼻咽癌致病的分子机理至今仍不清楚。有研究表明ΔNp63以显性失活的方式抑制p53的反式激活,并与鳞状细胞的恶性增生与失分化有关。本研究旨在探讨ΔNp63蛋白在鼻咽癌组织中的表达及意义。方法:采用免疫组织化学方法检测60例鼻咽癌组织、37例癌旁粘膜及30例鼻咽粘膜慢性炎症组织中ΔNp63蛋白的表达。60例鼻咽癌的类型为角化性鳞癌3例,非角化性癌57例,其中后者包括未分化癌12例。结果:全部60例鼻咽癌组织ΔNp63染色呈阳性表达。角化性鳞癌均呈弱阳性表达,非角化性癌的强阳性表达率为66.67%(38/57),未分化癌的强阳性表达率为83.33%(10/12)。慢性炎症组织及癌旁粘膜仅基底层及上基层细胞阳性。结论:ΔNp63蛋白与细胞的恶性增生密切相关;ΔNp63蛋白表达在幼稚或间变鳞状细胞中有明显的倾向性,是诊断间变鳞状细胞有价值的标志物。

关键词： ΔNp63 鼻咽癌基因表达肿瘤

Clinical blood routine and bone marrow smear manifestations of disseminated penicilliosis marneffei

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Chinese Medical Journal 2002年第12期115卷 1892-1894,157页

作者：莫武宁邓卓霖李山广西医科大学第一附属医院中心实验室南宁530021 广西医科大学第一附属医院病理科南宁530021

OBJECTIVE: To investigate the manifestation of clinical, blood routine and bone marrow smear of disseminated penicilliosis marneffei. METHODS: There were 13 cases of penicilliosis marneffei whose peripheral blood had been drawn for routine tests, as well as blood and bone marrow aspiration for smears. Wright's-Giemsa stain, Gomori's methenamine-silver stain (GMS) and periodic acid Schiff's reaction (PAS) were performed for light microscopy in consultation with pathologic diagnosis and fungi culture for precise diagnosis. RESULTS: Seven cases of bone marrow and 2 peripheral blood smears were found positive for penicillium marneffei in the test group. The morphology of penicillium marneffei was extremely similar to that of histoplasma capsulatum. However, the observation of sausage cells and central cross wall, which are signs of dividing by fission and not by budding, aided in differential diagnosis. CONCLUSION: Bone marrow smear or occasional blood smear examination play an important role in the diagnosis of disseminated penicilliosis marneffei.

关键词： Bone Marrow Examination Penicillium Adolescent Adult Child Child, Preschool Female Humans Infant Male Middle Aged Mycoses

肝细胞癌患者的谷胱甘肽硫转移酶基因缺失的研究

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肿瘤 2003年第6期23卷 464-466页

作者：韦义萍马韵邓卓霖广西医科大学护理学院病理学教研室南宁530021 广西医科大学病理学教研室

目的　研究广西黄曲霉毒素B1(AFB1)高污染区人群谷胱甘肽硫转移酶GSTM 1和GSTT1基因缺失多态性与肝细胞癌高发的相关性。方法　采用聚合酶链反应 (PCR)方法检测 110例高污染区肝细胞癌患者和 135例无癌健康对照者的GSTM1和GSTT1基因型... 详细信息

目的　研究广西黄曲霉毒素B1(AFB1)高污染区人群谷胱甘肽硫转移酶GSTM 1和GSTT1基因缺失多态性与肝细胞癌高发的相关性。方法　采用聚合酶链反应 (PCR)方法检测 110例高污染区肝细胞癌患者和 135例无癌健康对照者的GSTM1和GSTT1基因型分布。结果　正常对照组GSTM 1和GSTT1基因缺失率分别为 4 7.4 %和 4 0 .7% ,肝细胞癌组GSTM 1和GSTT1基因缺失率分别为 6 3.6 %和 6 0 .0 % ;GSTM 1基因缺失在肝细胞癌组和正常对照组之间 ,差异具有显著性意义 (P <0 .0 5 ) ;GSTT1基因缺失在肝细胞癌组和正常对照组之间差异具有非常显著性意义 (P <0 .0 1)。结论　肝细胞癌患者GSTM1和GSTT1基因缺失水平偏高可能是易感的原因之一。

关键词：肝细胞癌谷胱甘肽硫转移酶基因缺失黄曲霉毒素B1

X-RAY REPAIR CROSS-COMPLEMENTING GROUP 1 (XRCC1) Arg 399 Gln POLYMORPHISM AND AFLATOXIN B1 (AFB1)-RELATED HEPATOCELLULAR CARCINOMA (HCC) IN GUANGXI POPULATION

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Chinese Journal of Cancer Research 2005年第1期17卷 17-21页

作者：龙喜带马韵韦义萍邓卓霖 Department of Path1ology Guangxi Medical University Nanning 530021

Objective: To explore the relationship of XRCC1 Arg 399 Gln polymorphism and AFB1-related hepatocellular carcinoma (HCC) risk in Guangxi population. Methods: The DNA samples from peripheral blood white blood cells were obtained from subjects including 140 HCC and 536 controls. The XRCC1 gene 399 codon polymorphism was detected by PCR-RFLP technique. Results: The frequency of XRCC1 399 Arg/Gln & Gln/Gln genotype in HCC patients (48.57%) was significantly higher that in normal controls (32.46%), and XRCC1 399 Arg/Gln & Gln/Gln genotype was associated with increased risk of HCC (adjusted odds ratios (OR)=2.18, 95% confidence interval (CI) 1.27～3.74). In addition, in the cohort of low/median level of AFB1 exposure, the codon 399 Gln allele was associated with a conspicuous significantly increasing risk for HCC (adjusted OR=2.06, 95% CI=1.01～4.20). Conclusion: The results indicate that the XRCC1 399 Gln allele is a potentially important determinant of susceptibility to AFB1-related HCC.

关键词： XRCC1 Polymorphism AFB1 DNA damage HCC

南宁地区中青年动脉粥样硬化在冠状动脉与主动脉的对比研究

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中华病理学杂志 1993年第6期22卷 365-366页

作者：吴成志邓卓霖广西医学院病理教研室 530027

一、材料和方法收集南宁地区1988～1992年本地人158例15～39岁非正常死亡(自杀与他杀等)的冠脉和主动脉。男123例,女35例,平均年龄25岁,这些病例均无心血管病史。组织学标本的制备是按WHO1986年的标准,

关键词：动脉粥样硬化冠状动脉主动脉

Glutathione S-transferase M1 and T1 Gene Deletion Associated with Increased Susceptibility to Nasopharyngeal Carcinoma

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The Chinese-German Journal of Clinical Oncology 2005年第5期4卷 276-278,324页

作者：邓卓霖韦义萍马韵广西医科大学病理学教研室 530021

Objective： To evaluate the association of Glutathione S-transferase （GST） M1 and T1 genetic polymorphisms and susceptibility to nasopharyngeal carcinoma （NPC） in a high risk area of Guangxi Zhuang Autonomous Region （province）, Southwest of China. Methods： A case-control study was conducted to investigate the genetic polymorphisms of these enzymes （GSTM1 and GSTT1 null genotypes）. A total of 127 NPC cases and 207 controls were recruited. Results： GSTM1 and GSTT1 null genotype frequencies were higher among NPC patients at a level of statistical significance （P〈0.005; P〈0.001 respectively）, and both GSTM1 and GSTT1 null genotype were even more significant （P〈0.001）. Conclusion： NPC is the most common cancer in Guangxi. GST enzymes are involved in the detoxification of many environmental carcinogens. Homozygous deletions of GSTM1 and GSTT1 have been associated with several types of cancer. The risk to develop NPC has been associated with environmental factors such as cigarette smoking and EB virus infection. The present results indicate that the GSTM1 and GSTT1 deletion polymorphisms are associated with an increase risk of susceptibility to NPC, and both detoxific enzyme genes deletion is more important than a single gene deletion for the susceptibility to NPC.

关键词： carcinoma nasopharyngeal glutathione S-transferase M1 glutathione S-transferase T1

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艾滋病合并马尔尼菲青霉菌感染一例

中华内科杂志 2000年第5期39卷 348-348,I009页

作者：邓卓霖刘新民广西医科大学病理学教研室南宁530021 广东省深圳市红十字会医院消化科

患者女性，28岁，已婚，无业。曾以发热20d，伴咳嗽、腹胀及头晕入院。

关键词：艾滋病并发症马尔尼菲青霉菌感染诊断治疗