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25例艾滋病合并卡波西肉瘤患者临床特征分析

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传染病信息 2021年第6期34卷 507-510,544页

作者：赵涵廖宝林刘波张坚生陈志敏冯理智唐奕周龙涛郭琪李凌华蔡卫平何浩岚广州医科大学附属市八医院感染病中心 510060 广州市皮肤病防治所皮肤科 510095 首都儿科研究所病毒研究室儿童病毒病病原学北京重点实验室 100020

目的对艾滋病合并卡波西肉瘤患者的临床特征、治疗及预后情况等进行探讨。方法收集2012年7月—2020年9月广州医科大学附属市八医院首次诊治的25例艾滋病合并卡波西肉瘤患者的临床资料,对临床特征、不同化疗方案患者的生存及不良反应进... 详细信息

目的对艾滋病合并卡波西肉瘤患者的临床特征、治疗及预后情况等进行探讨。方法收集2012年7月—2020年9月广州医科大学附属市八医院首次诊治的25例艾滋病合并卡波西肉瘤患者的临床资料,对临床特征、不同化疗方案患者的生存及不良反应进行回顾性分析。结果25例艾滋病合并卡波西肉瘤患者中,15例>35岁,16例CD4+T淋巴细胞计数0.05),化疗不良反应稍大。结论艾滋病合并卡波西肉瘤好发于免疫力较差的中青年男性,合并机会性感染可能性大,尽量选择整合酶抑制剂抗反转录病毒治疗,异环磷酰胺+脂质体阿霉素组较单药组可能更早获得完全缓解,但骨髓抑制及脱发不良反应稍高,临床上可根据患者一般情况、疾病进展快慢及要求选择治疗方案。

关键词：艾滋病卡波西肉瘤化疗疗效预后

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叶绿素的提取方法及药理作用进展

科技创新与应用 2016年第24期6卷 14-14页

作者：葛俊珂孙丽娜赵涵白宇峰杨朝富杨思宇金刘洋黑河学院理学院黑龙江黑河164300

文章阐述了叶绿素的多种提取方法,并对近年来叶绿素及其衍生物的药理作用进行了概述,为叶绿素提取以及药理作用的进一步研究提供理论基础。

关键词：叶绿素提取药理作用

玉米单倍型标签多态性标记在种质资源分析和基因组学育种中的应用研究

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玉米单倍型标签多态性标记在种质资源分析和基因组学育种中的应用...

A STUDY OF mRNA EXPRESSION OF GROWTH FACTORS IN FULL-THICKNESS BURNT RATS AFTER INTERMINGLEDTRANSPLANTATION OF AUTO-ALLOGRAFT SKIN

第二十届中国作物学会学术年会

作者：赵怡锟田红丽李春辉易红梅张云龙李晓辉赵涵霍永学王蕊康定明路运才刘志浩梁紫越许理文杨扬周玲王天宇赵久然王凤格北京市农林科学院玉米研究所中国农业科学院作物科学研究所吉林省农业科学院玉米研究所江苏省农业科学院种质资源与生物技术研究所中国农业大学农学院黑龙江大学现代农业与生态环境学院

【研究背景】四十年来,分子检测技术与相关检测设备持续更新换代,分析策略也随着不同领域的应用需求不断改进。传统分子标记在成本及多态性等多方面综合考虑下,一直沿用点标记的分析思路,例如SSR,SNP及In Del标记在品种鉴别及背景选择... 详细信息

【研究背景】四十年来,分子检测技术与相关检测设备持续更新换代,分析策略也随着不同领域的应用需求不断改进。传统分子标记在成本及多态性等多方面综合考虑下,一直沿用点标记的分析思路,例如SSR,SNP及In Del标记在品种鉴别及背景选择的应用。本研究结合种质资源分析及辅助育种等不同类型的检测需求与当前分子标记检测的技术瓶颈,开发了新型单倍型标签多态性标记(HTP,haplotypetagpolymorphisms),建立全基因组首尾无缝衔接区块状标记(单倍型标签)系统,实现从单标记到复合标记,点标记到区块标记的技术升级。【材料与方法】材料选自全球范围内的3587份重要玉米自交系。玉米HTP标记的每个区块内部包含多种变异类型,所有位点均是来自高质量的Maize6H-60K芯片。HTP在线服务平台是使用***框架构建的,前端由基于***的AntDesign组件实现(https://***/)。【结果与分析】相比传统标记以点状分布,HTP标记实现了以区块状覆盖100%基因组;相比点标记只能对遗传相似度大于90%的亲本进行推测,HTP标记对仅传递少量基因组(≤10%)亲本也能系谱溯源和预测;作为高质量的核心位点集,单个区块标记同时还具有超高多态性的特点,与点状标记(SSR,SNP,InDel)相比,HTP标记在品种鉴定应用中具有突出的应用优势。本研究开发了全基因组HTP分析工具包HTPTools,同时建立了3,587份重要玉米自交系的HTP数据库,包括了6163个区块化HTP标记,172,921个非冗余的HTP等位基因变异,为玉米研究人员及育种家提供了丰富的单倍型标签资源。同时,基于HTP标记的特点,在HTPTools中集成了智能区块数据填充算法,当仅需获取少量HTP标记的基因型时,可以通过该功能快速地获取对应区块的完整数据。此外,本研究还开发了一种新的绘图引擎"BCplot",可以实现大批量群体样本的基因组背景快速绘制。【结论】HTP标记为玉米全基因组高通量基因分型、遗传作图、种质资源分析提供了强有力的技术支持,在育种群体精准快速背景评估、种质评估、系谱溯源和基因组信息育种等领域具有巨大的应用潜力。

关键词：单倍型标签玉米数据库系谱重建基因组学育种

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Medical Bulletin of Shanghai Jiaotong University 1998年第Z1期19卷 46-48,55页

作者：赵涵芳徐洪梅文瀚章有章朱德安史济湘

Objective To scrutinize the effect of growth factors resulting from the intermingled skin graft onwound healing. Methods By means of RT-PCR technique, mRNA expressions of TGFα, TGFβ1, PDGF andbFGF of autografts and allografts on burnt rats were quantitatively analysed. Results (1) mRNA expressions ofall the four growth factors mentioned above were found both in allografts and autografts, the expressions beinghigher in autografts than allografts; (2) In autografts, TGFα expression began to rise from second post transplantday (D2), reaching a peak on D18,. TGFβ1 expression gained a high level on D2 and had itS peak on D18; PDGFexpression had its peak on D4, rebounding on D25; bFGF expression, exceedingly high on D2, dropped andrebounded in the same manner as in PDGF; (3) In the early stage of the wound healing, mRNA expression of thefour growth factors was lower in allografts, rising up in varying degrees thereafter. Conclusion (1) Graftsurvival took place both in autografts and allografts, with the former pederming better than the latter; (2) Thecombining action of growth factors that reached the affected area through autosecretion and bysecretion probablypromoted the healing of the burn wound, following signal transmission channels; (3) Rejection, which occurred inallogralts, was responsible for the decreasing viability of allografts and their replacement by the host skin.

关键词： growth factor wound healing intermingled skin transpiantation mRNA RT-PCR

A COMPARISON OF THE PROTOONCOGENES BETWEEN THE HUMAN GASTRIC CANCEROUS AND NORMAL MUCOSAL TISSUES

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Medical Bulletin of Shanghai Jiaotong University 1990年第1期13卷 63-71页

作者：陈诗书钱关祥陈季王敦瑞章有章孔良曼赵涵芳何尧祥 Laboratory of Molecular Biology Department of Biochemistry College of Basic Medical Sciences SSMU Shanghai

The allelic distribution of EcoRI and BamHI fragments of ras family genes between the human primary gastric cancer tissues and the corresponding adjacent normal tissues did not show any differences. Three genotypes of BamHI restriction fragment length polymorphism of c-H-ras were revealed. No significant differences in the RFLPs were observed between normal individuals and gastric cancer patients. Four protooncogenes, c-H-ras, N-ras, c-myc and c-fos, were found to be transcriptionally active in the gastric cancer tissues in some cases examined. The comparison of the expression of these oncogenes between the malignant tissues and the corresponding normal tissues showed differential patterns. The expression of c-H-ras at cellular level was detected by in situ hybridization. The enhanced expression of c-H-ras in the gastric cancer cells was demonstrated, but the degree of the expression among the cancer cells was shown to be heterogeneous. In addition, the enhanced expression of c-H-ras was seen in the inflammatory cells.

关键词： human gastric cancer c-oncogenes RFLPs of c-H-ras structure and expression in situ hybridization

Quantum computational advantage via 60-qubit 24-cycle random circuit sampling

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Science Bulletin 2022年第3期67卷 240-245页

作者： Qingling Zhua Sirui Cao Fusheng Chen Ming-Cheng Chen Xiawei Chen Tung-Hsun Chung Hui Deng Yajie Du Daojin Fan Ming Gong Cheng Guo Chu Guo Shaojun Guo Lianchen Han Linyin Hong He-Liang Huang Yong-Heng Huo Liping Li Na Li Shaowei Li Yuan Li Futian Liang Chun Lin Jin Lin Haoran Qian Dan Qiao Hao Rong Hong Su Lihua Sun Liangyuan Wang Shiyu Wang Dachao Wu Yulin Wu Yu Xu Kai Yan Weifeng Yang Yang Yang Yangsen Ye Jianghan Yin Chong Ying Jiale Yu Chen Zha Cha Zhang Haibin Zhang Kaili Zhang Yiming Zhang Han Zhao Youwei Zhao Liang Zhou Chao-Yang Lu Cheng-Zhi Peng Xiaobo Zhu Jian-Wei Pan Hefei National Laboratory for Physical Sciences at the Microscale and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Shanghai Branch CAS Center for Excellence in Quantum Information and Quantum PhysicsUniversity of Science and Technology of ChinaShanghai 201315China Shanghai Research Center for Quantum Sciences Shanghai 201315China QuantumCTek Co. Ltd.Hefei 230026China Henan Key Laboratory of Quantum Information and Cryptography Zhengzhou 450000China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China

To ensure a long-term quantum computational advantage,the quantum hardware should be upgraded to withstand the competition of continuously improved classical algorithms and ***,we demonstrate a superconducting quantum computing systems Zuchongzhi 2.1,which has 66 qubits in a two-dimensional array in a tunable coupler *** readout fidelity of Zuchongzhi 2.1 is considerably improved to an average of 97.74%.The more powerful quantum processor enables us to achieve larger-scale random quantum circuit sampling,with a system scale of up to 60 qubits and 24 cycles,and fidelity of FXEB=(3·66±0·345)×10^(-4).The achieved sampling task is about 6 orders of magnitude more difficult than that of Sycamore[Nature 574,505(2019)]in the classic simulation,and 3 orders of magnitude more difficult than the sampling task on Zuchongzhi 2.0[arXiv:2106.14734(2021)].The time consumption of classically simulating random circuit sampling experiment using state-of-the-art classical algorithm and supercomputer is extended to tens of thousands of years(about 4·8×104years),while Zuchongzhi 2.1 only takes about 4.2 h,thereby significantly enhancing the quantum computational advantage.

关键词： Quantum physics Quantum computation Quantum information Superconducting quantum computing Superconducting qubit