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Microglia out of place—mapping macrophages across the developing human body

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cellular & Molecular Immunology 2024年第3期21卷 210-212页

作者： roman Sankowski Marco prinz Institute of Neuropathology Faculty of MedicineUniversity of FreiburgFreiburgGermany Signalling research centres BIOsS and cIBSs University of FreiburgFreiburgGermany

Macrophages(MΦs)are versatile cells found in every *** the body,they work tirelessly to maintain *** this end,they are instructed by their respective niches to express organ-specific genes and proteins,resulting in a variety of cell morphologies and highly specialized functions across different tissues[1].A recent study by Wang et *** single-cell rNA sequencing to comprehensively profile human MΦphenotypes across 19 organs between postconception weeks(PcW)4 and 26[2].This study revealed a surprising diversity of these cells and suggests new avenues of research.

关键词： organs instru

EXPErIMENTAL STUDY OF FATIGUE DAMAGE DEVELOPMENT IN NOTchED cOMPOSITE LAMINATES

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chinese Journal of Aeronautics 1989年第4期 261-270页

作者： r.prinz h.c.goetting Institute for Structural Mechanics DFVLr

The damage development of notched graphite/epoxy laminates during tension-compression loading has been investigated. The laminates with a multidirectionalstacking sequence were fabricated with T300/914c prepregs. The variation ofthe laminate stiffness with the number of cycles, the stress-strain response prior tofailure, and the damage distribution were obtained. The failure mechanisms of thelaminates and some characteristics of damage development are described in thispaper.

关键词： load EXPErIMENTAL STUDY OF FATIGUE DAMAGE DEVELOPMENT IN NOTchED cOMPOSITE LAMINATES 羹羹

cultural tightness,trust,and power in enforcing tax compliance

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Economic and Political Studies 2024年第2期12卷 143-170页

作者： Aloys prinz Institute of Public Economics M€unster Centre for Economic PolicyUniversity of M€unsterM€unsterGermany

The so-called cultural Tightness–Looseness(cTL)concept intends to describe the socio-cultural foundation of societies by the strictness of social *** this paper,cTL is used to investigate its relevance to enforcing tax *** cTL concept is formalised by structural payoff matrices for the confrontation between citizens and *** norms and their impacts on the behaviour of the parties in a conflict are used to define several variants of tight and loose *** payoff matrices are employed to classify respective forms of *** a dynamic analysis,‘power’and‘trust’,as policy measures of behaviour control,are introduced to determine which instrument or combination of instruments emerges as the most relevant and effective option in the respective societal *** result is that‘trust’emerges in tight societies as the more important instrument of behaviour control,whereas‘power’appears as the more crucial tool in loose ***,it is concluded that power or the‘cops and robbers’approach is usually applied in loose societies to enforce tax *** contrast,‘trust’via the provision of information and support for paying taxes can be more often used in tight societies.

关键词： cultural tightness cultural looseness social norms behaviour control trust and power tax compliance

Evaluation of disease burden and symptom scores in patients with acute atrial fi brillation in the emergency department

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World Journal of Emergency Medicine 2024年第5期15卷 397-400页

作者： Nikola Schütz Dominik roth Michael prinz Filippo cacioppo Sebastian Schnaubelt Alexander O.Spiel hans Domanovits harald herkner Department of Emergency Medicine Medical University of ViennaVienna 1090Austria Department of Emergency Medicine Clinic OttakringVienna 1160Austria

Atrial fibrillation(AF)is a major public health problem and poses a substantial economic burden on healthcare systems worldwide.[1-4]The emergency department(ED)serves as the first point of contact with the healthcare system and plays a key role in the management of patients with AF,which accounts for 3%-10%of all hospital admissions.[5]Treatment plans are often discussed and initiated at the ED.

关键词： patients atrial acute

“畸变工程”:从系统的角度探讨零件的畸变现象

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金属热处理 2004年第11期29卷 43-50页

作者： Klaus-DieterThoben DieterKlein Th.Luebben B.clausen chr.prinz A.Schulz r.rentsch r.Kusmierz L.Nowag h.Surm F.Frerichs M.hunkel P.Mayr BremenInstituteofIndustrialTechnologyandAppliedWorkScience（BIBA） BremenGermany InstituteforMaterialScience（IWT） BremenGermany

在产品的最终加工过程中用精磨去除零件中的畸变是一个既费钱又费时的事情。例如 ,仅在 (车辆 )传动技术领域 ,1995年德国用于最后精磨以消除工件的畸变而增加的成本已达 8 5亿欧元。迄今为止 ,行业人士认为在最后的产品加工过程中导致... 详细信息

在产品的最终加工过程中用精磨去除零件中的畸变是一个既费钱又费时的事情。例如 ,仅在 (车辆 )传动技术领域 ,1995年德国用于最后精磨以消除工件的畸变而增加的成本已达 8 5亿欧元。迄今为止 ,行业人士认为在最后的产品加工过程中导致零件产生畸变的主要原因在于淬火过程 ,而今大家普遍认为这个观点不是很对 ,认为淬火过程只是释放了在各个加工环节中积累在工件中的畸变潜能 ,如铸造、车削加工、铣削、淬火、磨削。由不来梅大学创立及DeutscheForschungsgemeinschaft资助的合作研究中心SFB 5 70“畸变工程”的研究方针是从系统导向着手 ,分析零件的畸变。合作研究中心由 12个子项目组成 ,涉及 2 0多位来自材料科学、制造技术、数学及过程控制工程的研究人员。根据系统导向的方法 ,合作研究中心SFB 5 70“畸变工程”认为 ,与优化零件整个生产过程 (工序链 )相比 ,对零件生产过程中的单个过程的优化是第二位的。为了推广系统导向的方法 ,保证SFB 5 70“畸变工程”中集中在不同工序和技术的这 12个子项目间的一个连续、协调的知识和信息交换 ,已成立了一个系统模式工作组。这个工作组的焦点在于详细阐述和进一步发展系统导向的方法以及协调应用于这些子项目中的工序和方法。和其它方法相比较 ,整体方法包?

关键词：变现工程项目系统欧元协调行业导向潜能数学

New insights on murineγδT cells from single-cell multi-omics

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Science Bulletin 2022年第11期67卷 1102-1104页

作者： Likai Tan Daniel Inácio Immo prinz Bruno Silva-Santos Institute of Systems Immunology University Medical Center Hamburg EppendorfHamburg 20251Germany Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisbon 1649-028Portugal

γδT cells are a second T cell lineage conserved throughout evolution and across animal species that express aγδT-cell receptor(Tcr)consisting of a Tcrγand a Tcrδchain.γδT cells develop in the murine thymus into various subsets with distinct functional potential that preferentially home to specific peripheral tissues,rather than lymphoid organs[1].

关键词： organs γδT细胞多组学研究

The roles of microglia in viral encephalitis:from sensome to therapeutic targeting

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cellular & Molecular Immunology 2021年第2期18卷 250-258页

作者： chintan chhatbar Marco prinz Institute of Neuropathology Medical FacultyUniversity of FreiburgFreiburgGermany center for Basics in NeuroModulation(NeuroModulBasics) Faculty of MedicineUniversity of FreiburgFreiburgGermany Signalling research centres BIOSS and cIBSS University of FreiburgFreiburgGermany

Viral encephalitis is a devastating disease with high mortality,and survivors often suffer from severe neurological *** are innate immune cells of the central nervous system(cNS)parenchyma whose turnover is reliant on local *** express a diverse range of proteins,which allows them to continuously sense the environment and quickly react to *** inflammatory conditions such as cNS viral infection,microglia promote innate and adaptive immune responses to protect the ***,during viral infection,a dysregulated microglia-T-cell interplay may result in altered phagocytosis of neuronal synapses by microglia that causes neurocognitive *** this review,we summarize the current knowledge on the role of microglia in viral encephalitis,propose questions to be answered in the future and suggest possible therapeutic targets.

关键词： microglial activation viral encephalitis neurocognitive issues purinergic signaling Prr signaling

一例右心房肿瘤的鉴别诊断:血栓抑或粘液瘤?

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德国医学 1994年第1期11卷 13-14页

作者： c.Müller h.-J.prinz W.-W.hpker 阮幼冰 Abteilung fr Pathologie des Allgemeinen Krankenhauses Barmbek HamburgD-22307 HamburgGermany I.Medizinische Abteilung des Allgemeinen Krankenhauses Barmbek HamburgD-22307 HamburgGermany 同济医科大学

一位78岁高龄妇女因心绞痛住院,临床、心电图和实验室检查诊断为急性心肌梗塞。住院时诊断:新鲜心肌梗塞、Ⅱ型真性糖尿病、动脉高压、两心室心肌功能不全。随后数日内患者迅速恢复,急性肺瘀血消失,除有新出现的房颤时绝对心律失常外,... 详细信息

一位78岁高龄妇女因心绞痛住院,临床、心电图和实验室检查诊断为急性心肌梗塞。住院时诊断:新鲜心肌梗塞、Ⅱ型真性糖尿病、动脉高压、两心室心肌功能不全。随后数日内患者迅速恢复,急性肺瘀血消失,除有新出现的房颤时绝对心律失常外,无任何并发症、心酶减退、心电图改变消退。住院第23天午休时,患者突然虚脱。

关键词：心脏肿瘤心房血栓粘液瘤

contemporary climate infuence on variability patterns of Anadenanthera colubrina ***,a key species in seasonally dry tropical forests

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Journal of Forestry research 2022年第1期33卷 89-101页

作者： María Victoria García María Eugenia Barrandeguy Kathleen prinz Genética de Poblaciones y cuantitativa-Departamento de Genética-Facultad de ciencias Exactas Químicas y Naturales-Universidad Nacional deMisionesInstituto de Biología Subtropical(UNaM-CONICET)Nodo PosadasFélix de Azara 15523300 PosadasArgentina consejo Nacional de Investigaciones científicas Y Técnicas(cONIcET) PosadasMisionesArgentina Institute of Systematic Botany With herbarium haussknecht and Botanical Gardens Friedrich-Schiller-University Jena07743 JenaGermany

The distribution of many plant species has been shaped by climate changes,and their current phenotypic and genetic variability refect microclimatically suitable *** study relates contemporary climate to variability patterns of phenotypic traits and molecular markers in the Argentinean distribution of Anadenanthera colubrina ***,as well as to identify the most relevant phenotypic trait or molecular marker associated with those *** from four populations in both biogeographic provinces,Paranaense and Yungas,were *** analyses and multiple linear regressions were carried out to determine relationships among phenotypic traits and nuclear microsatellites,respectively,to climatic variables,and to identify the phenotypic traits as well as nuclear microsatellite loci most sensitive to *** and three clusters of individuals were detected based on genetic and phenotypic data,*** clusters based on genetic data refected the biogeographic origin of *** traits were the most relevant indicators of climatic *** microsatellite locus Ac41.1 appeared to be non-neutral presenting a strong correlation with climate variable temperature *** findings show complex patterns of genetic and phenotypic variability in the Argentinean distribution of *** *** related to the present or contemporary climate,and provides an example for an integrative approach to better understand climate impact on contemporary genetic and phenotypic variability in light of global climate change.

关键词： contemporary climate curupay Genetic variability Phenotypic variability Seasonally dry tropical forests