检索结果-南通市图书馆

Intramuscular delivery of rAAV-mediated kallikrein gene reduces hypertension and prevents cardiovascular injuries in model rats

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第12期28卷 1898-1906页

作者： Yao WANG~(2,3),Ling-bo HOU~(2,3),Zhen-jun LIU~2,Yan WANG~2,Chun-lian CHEN~2,Xiao XIAO~(2,4),Dao-wen WANG~(2,5)~2 Institute of Hypertension and Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science andTechnology,Wuhan 430030,China ~4 Departments of Molecular Genetics and Biochentistry and Gene Therapy Center University of Pittsburgh,Pittsburgh,PA 15261,USA InstituteofHypertensionandDepartmentofInternalMedicine TongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030China UniversityofPittsburgh PittsburghPA15261USA

Aim:The overexpression of the human tissue kallikrein （HK） gene can reduceblood pressure and ameliorate the secondary syndromes associated with hyper-tension in animal *** current study was designed to investigate hy-potensive effect of intramuscular delivery of HK ***:We generatedan recombinant adeno-associated virus （rAAV） vector expressing human tissuekallikrein under the control of a cytomegalovirus promoter and administered therAAV-HK vector to a spontaneously hypertensive rat model at a dose of 1×1010virons/rat through intramuscular ***:A persistent,high-level ex-pression of HK post-gene delivery was confirmed by *** systolic bloodpressure in the rats receiving rAAV-LacZ and saline increased from 171.3 mmHg to182.3 mmHg 28 weeks' post *** contrast,the delivery of the HK gene byAAV vectors attenuated the increase of the systolic blood pressure in the *** systolic blood pressure was only slightly lowered （from a level of 174mmHg to 170.5 mmHg） post-vector *** difference in blood pres-sure between the treated group and the control groups is statistically significantat 12.6 *** hypotensive effect of rAAV-HK persisted until the end of thetesting *** addition,a significant amelioration of cardiovascularhypertrophy,renal injury,and collagen depositions in the rAAV-HK-treated ani-mals were also ***:All the effects are comparable with thoseof intravenous ***,the intramuscular administration of rAAV-HKmay be used in gene therapy for hypertension.

关键词： recombinant adeno-associated virus vector human tissue kallikrein intramuscular administration hypertension gene therapy cardiovascular remodeling spontaneously hypertensive rat

Possibility and limitation of chemotherapy for metastatic breast cancerIsamu Adachi

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Possibility and limitation of chemotherapy for metastatic br...

2000全国肿瘤学术大会

作者： MD(Medical Oncology Division,National Cancer Center,Hospital,1-1,Tsukiji5-chome,Chuo-ku,Tokyo) MD（Medical Oncology Division National Cancer CenterHospital1-1Tsukiji 5-chomeChuo-kuTokyo）

＜正＞We established chemo-endocrine therapy using anticancer agents suchasadriamycin（ADM）mitomycin C,and cy- clophosphamide（CPA）and hormone preparations such as tamoxifen（T）and medroxyprogesterone acetate（MPA）in var- ious combinatiom through a randomized clinical trial conducted in 923cases between 1985 and 1997 for the development of a standard treatment for metastatic breast *** 1995,we have alsoattempted to develop new chemotherapy us- ing taxanes such as docetaxeland *** symposium,the results of these evaluations are presented,and recom-

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Aims and Scope

Theoretical & Applied Mechanics Letters 2015年第6期 273-273页

作者： Theoretical&Applied Mechanics Letters5(2015) Theoretical&Applied Mechanics Letters5(2015)

The bimonthly produced journal Theoretical&Applied Mechanics Letters(TAML),founded in 2011,is an international peer-reviewed journal for the purpose of publishing more letter *** intends to publish original,significant but short articles in all aspects of theoretical and applied mechanics,as well as other interdisciplinary areas,such as aerospace and aeronautical engineering,coastal and

关键词： TAML Aims and Scope

Determination of Conversion Coefficient to Evaluate Couple-year of Protection (CYP) for Tubectomy and Vasectomy in Urban and Rural Regions of Iran:IMES Study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Reproduction and Contraception 2009年第2期20卷 81-92页

作者： Farzane Alinejad Abtin Heidarzade Mohammad Eslami Roya Faraji Mohsen Shatti Shervin Ghadarjani Faculty of Medicine Guilan University of Medical Sciences Dept. of Community medicine Faculty of Medicine Guilan University of Medical Sciences Family Planning Office Family Health Department Ministry of Health Central Building Dept. of Obstetrics and GYN Guilan University of Medical Sciences Monitoring and Evaluation Office Family Health Section Ministry of Health and Medical Education

Objective To calculate couple-year of protection （CYP） by conversion coefficient （F） of tubectomy and vasectomy in urban and rural regions of Iran. Methods A total of 103 450 married women aged 10-49 years in 2005 across urban and rural regions of lran were sampled by multi stage cluster sampling. The data were collected by household survey and direct interview and analyzed by STATA8.0 software and survey analysis commands. Results Mean age of the women at the time of tubectomy estimated 31.9 years and conversion coefficient of tubectomy was 17.1 ±0.1. Mean age of women at the time of her husband vasectomy estimated 31.48 years and its conversion coefficient was 17. 5 ± 0. 1. Cluster analysis defined different regions of Iran on the basis of evaluated conversion coefficients of tubectomy and vasectomy which both of them presented seven clusters. Literacy of women and total coverage of family planning in a region had a direct relationship with this conversion coefficient （P〈0.05）. Conclusion The variations observed in the conversion coefficients and their dissimilarity among different regions of Iran may be due to a variety of fundamental factors of which literacy and culture are of important factors.

关键词： family planning contraception vasectomy tubectomy conversion coefficient (F) couple-year of protection (CYP)

在线全文

学校读者我要写书评

暂无评论

足球视频媒体如何多元化创收

中国报业 2018年第13期 79-79页

作者：微信公众号"德外5号"

西班牙队被葡萄牙队逼平,拥有梅西的阿根廷队被冰岛队战平,卫冕冠军德国队被墨西哥队击败,志在世界杯冠军的巴西队在先进一球的情况下被瑞士扳平……2018年的世界杯一开场就冷门不断,吸引了全世界的目光。在关注赛事的同时,你是否思考... 详细信息

西班牙队被葡萄牙队逼平,拥有梅西的阿根廷队被冰岛队战平,卫冕冠军德国队被墨西哥队击败,志在世界杯冠军的巴西队在先进一球的情况下被瑞士扳平……2018年的世界杯一开场就冷门不断,吸引了全世界的目光。在关注赛事的同时,你是否思考过：为广大球迷朋友提供专业视频内容的足球视频媒体到底是怎么盈利的？采取多元化运营模式的Copa90也许可以解答。

关键词：视频媒体多元化足球世界杯葡萄牙队西班牙队视频内容阿根廷

在线全文

学校读者我要写书评

暂无评论

溃疡性结肠炎的病因及相关问题探讨

山东中医杂志 2001年第4期20卷 195-198页

作者：王立春马鑫胡强基吴仕九海军杭州疗养院浙江杭州310002 淄博市淄川中医院山东淄博255100 第一军医大学广东广州510515

溃疡性结肠炎是原因不明的结肠粘膜层和粘膜下层的慢性和非特异性炎症。本文从溃疡性结肠炎病因 ,包括免疫功能紊乱、饮食因素、肠道感染、情志失调、内伤劳倦和他脏影响方面 ,探讨了脾主运化与泄泻的关系 ,脾恶湿与粘膜水肿的关系 ,脾... 详细信息

溃疡性结肠炎是原因不明的结肠粘膜层和粘膜下层的慢性和非特异性炎症。本文从溃疡性结肠炎病因 ,包括免疫功能紊乱、饮食因素、肠道感染、情志失调、内伤劳倦和他脏影响方面 ,探讨了脾主运化与泄泻的关系 ,脾恶湿与粘膜水肿的关系 ,脾主肌肉与肠粘膜溃疡修复的关系 ,脾生血、统血与肠粘膜出血的关系 ,从基础理论与临床实践和中西医结合方面阐明了溃疡性结肠炎的本质及其影响因素 ,为提高临床疗效开辟新的途径。

关键词：溃疡性结肠炎病因免疫功能紊乱饮食因素肠道感染

在线全文

学校读者我要写书评

暂无评论

保存时间对Gress氏固体试剂效果的影响

动物科学与动物医学 2000年第4期17卷 26-27页

作者：刘田生马文芝彭波天津农学院动物科学系天津300381

用保存 1～ 1 2年的格利斯 (Gress)氏固体试剂分别检测亚硝酸盐标准溶液和实验中毒兔的胃内容物提取液 ,结果表明保存 1～ 6年的试剂颜色反应准确稳定 ,灵敏度高 ,随着保存年限的延长 ,灵敏度逐渐降低 ,1 0～ 1 2年者颜色反应阴性。

关键词：亚硝酸盐中毒诊断格利斯法固体试剂保存时间

清心开窍方对APP/PS1双转基因小鼠海马区AKT/GSK3α/βapp/Aβ表达的影响

在线全文

学校读者我要写书评

暂无评论

中华中医药学刊 2018年第6期36卷 1431-1434,I0029页

作者：杨文育李燕林坚炜高诗雨王天琪胡海燕温州医科大学第二临床学院浙江温州325003 温州医科大学附属第二医院中医科浙江温州325003

目的：探讨清心开窍方对APP/PS1双转基因小鼠海马AKT（protein kinase B,PKB,Akt）GSK3α（Glycogen synthase kinase 3α）、βAPP（β-amyloid precursor protein,βAPP）、Aβ（β-amyloid,Aβ）表达的影响。方法：选取60只APP/PS1双转基因小鼠,按随机数字表法随机分为模型组、多奈哌齐组（1.67 mg/kg）、清心开窍方高剂量组（19 mg·kg-1·d-1）,清心开窍方中剂量组（9.5 mg·kg-1·d-1）,清心开窍方低剂量组（4.75 mg·kg-1·d-1）,另选取同背景同性别C57BL/6J小鼠为对照组,对照组、模型组给予等量生理盐水灌胃,各组每天干预1次,连续灌胃12周。RT-PCR检测AKT、GSK3α、βAPP、AβmRNA的表达,Western Blot法检测AKT、GSK3α、βAPP、Aβ蛋白表达量,硫磺素T染色法测定小鼠大脑皮层及海马区老年斑的数量。结果：实时荧光定量PCR和Western Blot结果显示,模型组中GSK3α、βAPP、AβmRNA的表达最高,与对照组及其他各组相比有统计学意义（P〈0.05或P〈0.01）,且其表达量随清心开窍方剂量的增加而减少;模型组中AKT的表达量最低,与对照组及其他各组相比有统计学意义（P〈0.05或P〈0.01）,且其表达量随清心开窍方剂量的增加而增加。硫磺素T染色结果显示,模型组中老年斑数量最多,与对照组及其他各组相比有统计学意义（P〈0.05或P〈0.01）。结论：清心开窍方能够促进APP/PS1双转基因小鼠脑内AKT的表达,并减少GSK3α、βAPP和Aβ的表达,减少APP/PS1双转基因小鼠脑内皮质及海马区的老年斑数量。

关键词：阿尔茨海默病清心开窍方丝氨酸苏氨酸蛋白激酶糖原合成酶激酶-3α 淀粉样前体蛋白 β-淀粉样蛋白

TEMPORAL EIGENVALUE SPECTRA OF BOUNDARY-LAYER FLOW OVER RIGID WALL AND COMPLIANT WALL

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2001年第1期13卷 70-74页

作者： Zhao, H.Z. Yeo, K.S. Dep. of Mechanics Huazhong Univ. of Sci. and Technol. Wuhan 430074 China

The temporal eigenvalue spectra of the equation system for the boundary-layer flows over both rigid wall compliant and viscoelastic compliant wall are numerically studied. In a rigid-wall case only the fluid-based eigenmodes, the Tollmien-Schlichting instability (TSI) mode, exist. In a compliant-wall case, both the TSI and wall-based compliance-induced instability flow instability (CIFI) modes occur. The variations of the two categories of eigenvalues at various wall material stiffness and damping are also displayed.

关键词： Computer simulation Eigenvalues and eigenfunctions Stability