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输血对于癌症手术病人是弊大于利吗?

国外医学.输血及血液学分册 1988年第4期 305-306页

作者： Roger s foster jr.吴洪斌

输血广泛应用于较大的癌症手术,其提高了大面积切除的安全性。但是,随着输血量的增大,危险性也在增加。输血潜在的有害作用,包括由于血型不相容导致的输血反应和由于输入带有细菌、病毒或原生物的血液引起传染性疾病的传播。输入大量... 详细信息

输血广泛应用于较大的癌症手术,其提高了大面积切除的安全性。但是,随着输血量的增大,危险性也在增加。输血潜在的有害作用,包括由于血型不相容导致的输血反应和由于输入带有细菌、病毒或原生物的血液引起传染性疾病的传播。输入大量血液可以导致代谢失调和凝血紊乱。输血也会引起受血者免疫应

关键词：受血者输血反应原生物免疫调节作用异体移植肾移植病人微小转移灶动脉血氧含量红细胞比积免疫应答

Robotic pendant drop:containerless liquid for μs-resolved,AI-executable XPCs

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Light(science & Applications) 2023年第9期12卷 1857-1866页

作者： Doga Yamac Ozgulbas Don Jensen jr. Rory Butler Rafael Vescovi Ian T.foster Michael Irvin Yasukazu Nakaye Miaoqi Chu Eric M.Dufresne soenke seifert Gyorgy Babnigg Arvind Ramanathan Qingteng Zhang Data science and Learning Division Argonne National LaboratoryLemontIL 60439USA X-ray science Division Argonne National LaboratoryLemontIL 60439USA Departement of Computer science University of Chicago5801 S Ellis AveChicagoIL 60637USA XRD Design and Engineering Department Rigaku Corporation 3-9-12 Matsubara-choAkishima-shiTokyo 196-8666Japan Bioscience Division Argonne National LaboratoryLemontIL 60439USA

The dynamics and structure of mixed phases in a complex fluid can significantly impact its material properties,such as ***-angle X-ray Photon Correlation spectroscopy(sA-XPCs)can probe the spontaneous spatial fluctuations of the mixed phases under various in situ environments over wide spatiotemporal ranges(10−6–103 s/10−10–10−6 m).Tailored material design,however,requires searching through a massive number of sample compositions and experimental parameters,which is beyond the bandwidth of the current coherent X-ray *** 3.7-μs-resolved XPCs synchronized with the clock frequency at the Advanced Photon source,we demonstrated the consistency between the Brownian dynamics of~100 nm diameter colloidal silica nanoparticles measured from an enclosed pendant drop and a sealed *** electronic pipette can also be mounted on a robotic arm to access different stock solutions and create complex fluids with highly-repeatable and precisely controlled composition *** closed-loop,AI-executable protocol is applicable to light scattering techniques regardless of the light wavelength and optical coherence,and is a first step towards high-throughput,autonomous material discovery.

关键词： resolved sealed mounted

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冰晶石——氧化铝熔体结构

轻金属 1964年第3期 29-35页

作者： P.A.foster jr.W.B.Frank 沈时英

利用冰点下降的积分式,切姆金的离子熔体公式和有关熔融冰晶石结构的最新发现,对氧化铝在冰晶石中溶解的几个反应机构进行了分析。根据-logα0对1/T的图来看,如下反应机构的可能性最大:3F-+Al-2O3=3/2AlO2-+1/2AlF63-。氧化铝含量高时,... 详细信息

利用冰点下降的积分式,切姆金的离子熔体公式和有关熔融冰晶石结构的最新发现,对氧化铝在冰晶石中溶解的几个反应机构进行了分析。根据-logα0对1/T的图来看,如下反应机构的可能性最大:3F-+Al-2O3=3/2AlO2-+1/2AlF63-。氧化铝含量高时,这个反应与图中直线的偏差,可能是由于AlO2-离子的某种复合作用生成Al2O42-所造成。

关键词：冰晶石离子分数阴离子熔体氟铝酸钠铝矿物电器构件摩尔分数克分子分数分解常数铝化合物氧化铝

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质量工作的十个基本点

中国认证认可 2008年第2期 47-57页

作者：达菲（Grace L．Duffy）巴拉夫斯基（PAUL E．BORAWsKI）福斯特（s.tom.foster jr. 格特曼（HOWARD M．GUTTMAN）黑尔（LYNNE B．HARE）欧克斯（DUKE OKEs）佩恩（GRAEME C．PAYNE）鲁尼（JAMEs J．ROONEY）韦斯特（JOHN E．“JACK” WEsT）韦斯科特（RUss WEsTCOTT）李伟（译）佛罗里达州塔瓦雷斯市管理与绩效部主任美国质量学会（AsQ）执行董事兼首席战略执行官杨百翰大学质量与供应链管理教授格特曼发展战略公司负责人新泽西州东汉诺威市卡夫食品开发研究院应用统计指导主任 AsQ的特别会员 GK咨询公司董事长田纳西州肯农维利市美国船级社公众部风险与可靠性高级工程师 AsQ特别会员康涅狄格州老塞布卢克城R．T．韦斯科特合伙有限公司董事长不详

“没有人逼你学习……也没有人逼你活着。”这句话出自戴明（*** Deming）的《转危为安》一书，它提醒我们每天都应该在工作和生活中努力地吸收知识、强化专业。

关键词：质量工作知识生活质量管理

Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis

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International Journal of Oral science 2015年第1期7卷 27-41页

作者： Laura E Zweifler Mudita K Patel Francisco H Nociti jr.Helen F Wimer Jose L Milln Martha J somerman Brian L foster National Institute of Arthritis and Musculoskeletal and skin Diseases (NIAMs) National Institutes of Health (NIH) Department of Prosthodontics and Periodontics Division of Periodontics School of Dentistry Campinas State University Department of Vertebrate Zoology National Museum of Natural History Smithsonian Institution sanford Children’s Health Research Center Sanford-Burnham Medical Research Institute

Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone. Biomineralization is regulated by the ratio of inorganic phosphate （Pi） to mineral inhibitor pyrophosphate （PPi）, where local Pi and PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase （TNAP） and ectonucleotide pyrophosphatase/phosphodiesterase 1 （NPP1）. The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enppl null mouse increased acellular cementum, with little effect on cellular cementum. Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enppl gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPi environment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPi have little effect on cellular cementum formation, though matrix mineralization is affected.

关键词： cementum bone ectonucleotide pyrophosphatase phosphodiesterase 1 periodontal ligament progressive ankylosis protein tissue-nonspecific aJkalJne phosphatase

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Human photosynthesis, the ultimate answer to the long term mystery of Kleiber’s law or E = M<sup>3/4</sup>: Implication in the context of gerontology and neurodegenerative diseases

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Open Journal of Psychiatry 2013年第4期3卷 408-421页

作者： Gjumrakch Aliev Arturo solís-Herrera Yi Li Yury G. Kaminsky Nikolay N. Yakhno Vladimir N. Nikolenko Andrey A. Zamyatnin jr. Valery V. Benberin sergey O. Bachurin Department of Anatomy First Moscow State Medical University Moscow Russian Federation Department of Neurological Disorders First Moscow State Medical University Moscow Russian Federation Institute of Physiologically Active Compounds Russian Academy of Sciences Chernogolovka Russian Federation Medical Center of the Administration of the President of the Republic of Kazakhstan Astana Kazakhstan Russian Academy of sciences Institute of Theoretical and Experimental Biophysics Pushchino Russian Federation “GALLY” International Biomedical Research Consulting LLC San Antonio USA Human Photosynthesis study Center Pulgas Pandas Sur México Institute of Molecular Medicine First Moscow State Medical University Moscow Russian Federation Department of Human sciences Texas A&M University-Kingsville Kingsville USA

Kleiber’s Law or E = M3/4 is a mathematical expression known since 1932 that outlines the relationship between mass (biomass) and the use of energy. It is compelling because it supports a long standing observation that larger animals appear to use energy more efficiently than smaller ones. For example, an elephant’s weight is 200,000 times of a mouse, but uses only about 10,000 fold energy;thus a cat, having a mass of about 100 times of a mouse, only spends roughly 33 fold energy. In other words, the bigger you are, the less energy per gram of tissue you actually need to stay alive. Many facts pertaining to animal size call for a rational explanation. This paper takes into account that the fascinating relationship between mass and energy use for any living thing is governed strictly by a mathematical universal formula across all living species, operating in the tiniest of bacteria to the biggest of whales and sequoia tress. For the first time, we report a capacity for the mammal eukaryotic cell to split, break or dissociate water molecules through melanin. Even though E = M3/4 was discovered eight decades ago, no proper satisfactory explanation exists. Nevertheless, our multiyear detailed study on the “Human Photosynthesis” or first found in the human retina and later in all eukaryotic cells, may finally unravel this mystery, namely, the bigger you are the more surface area you have to absorb electromagnetic radiation and the more potential exists to use that electromagnetic radiation spectra to perform work. We propose a future application of this theory in the context of human diseases, especially age-related disorders, such as retinopathy, cerebrovascular and Alzheimer disease and these implications may not only foster a better understanding of the pathobiology of these devastating diseases but also develop much more effective therapies in the foreseeable future.

关键词： Human Photosynthesis Kleiber’s Law Geriatrics Gerontology Cardio- and Cerebrovascular Diseases Neurodegeneration Alzheimer Disease Retinopathy

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