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Continuous long-term albendazole therapy in intraabdominal cystic echinococcosis

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Chinese Medical Journal 2000年第9期113卷 59-64页

作者：刘约翰王小根吴景全 Institute of Infectious and Parasitic Diseases Department of Radiology Chongqing University of Medical Sciences

To assess the therapeutic effects of long-term albendazole therapy in intraabdominal cystic echinococcosis Methods Fifteen patients with a total of 45 cysts were treated with albendazole with dosage regimen of 20 *!mg·kg -1 ·d -1 for an average of 2 5 years Repeated CT and ultrasound scannings (US) were performed after the end of therapy The duration of follow-up was 3 6 years on average The number, size and morpiology of cysts were compared before and after treatment Results The hydatid cysts were classified according to location and CT patterns into hepatic simple cysts, hepatic cysts with daughter cysts, hepatic/abdominal cysts and splenic cysts The hepatic simple cysts responded most favorably to albendazole therapy, with an overall cure rate of 88 7% The disappearance of cysts was observed in 43 0% of cases (15/35) Sixteen cysts (45 7%) became solidified or calcified, among which 8 cysts were completely calcified, 6 showed egg shell-like calcification of the cystic walls, and 2 showed solidification and calcification of cyst contents Four patients had large hepatic cysts containing daughter cysts; the daughter cysts all disappeared after treatment, but one patient relapsed with the reappearance of daughter cysts at 4-year follow-up Two splenic cysts also calcified Two patients had peritoneal cysts; one calcified and the other one reduced in size Among 15 patients treated, 9 were cured and 6 were improved There was no serious toxic reactions with continuous long-term therapy in a small series of patients Conclusions Continuous long-term albendazole treatment of intraabdominal cystic echinococcosis is safe and effective in the treatment of hepatic simple cysts, and some daughter cysts, peritoneal secondary cysts and splenic cysts No serious toxic reactions were found

关键词： cystic echinococcosis albendazole computed tomography

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基于遗传算法的网络教学资源共享优化调度

电化教育研究 2006年第10期27卷 46-48页

作者：王小根江南大学教育学院江苏无锡214122

网络教学资源的不断建设和发展,给教学过程中共享网络教学资源提供了方便。当前基于通用搜索引擎的网络教学资源搜索,在高效优质满足教师和学生要求方面还存在一定的问题,借助遗传算法对搜索到的网络教学资源信息进行优化,可以提供教师... 详细信息

网络教学资源的不断建设和发展,给教学过程中共享网络教学资源提供了方便。当前基于通用搜索引擎的网络教学资源搜索,在高效优质满足教师和学生要求方面还存在一定的问题,借助遗传算法对搜索到的网络教学资源信息进行优化,可以提供教师和学生优质的网络教学资源信息。同时,本文提出了网络教学资源信息优化的方法,并对遗传算法与通用搜索引擎结合进行网络教学资源信息优化的过程进行了阐述。

关键词：网络教学资源遗传算法网络教学资源共享

基于Flow理论的小学数学游戏故事情节设计

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电化教育研究 2011年第10期32卷 103-106,120页

作者：王小根江南大学教育技术系江苏无锡214122

游戏的故事情节设计决定了游戏设计的方向,好的故事情节能够增强游戏的沉浸感。当前的小学数学教育游戏故事情节不够突出,难以吸引学生。本文在Flow理论的基础上,分析游戏故事情节中增强沉浸感的要素,并结合具体事例来探讨小学数学教育... 详细信息

游戏的故事情节设计决定了游戏设计的方向,好的故事情节能够增强游戏的沉浸感。当前的小学数学教育游戏故事情节不够突出,难以吸引学生。本文在Flow理论的基础上,分析游戏故事情节中增强沉浸感的要素,并结合具体事例来探讨小学数学教育游戏故事情节设计。

关键词： Flow理论小学数学教育游戏故事情节设计

PRELIMINARY OBSERVATION OF CONTINUOUS ALBENDAZOLE THERAPY IN ALVEOLAR ECHINOCOCCOSIS

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中华医学杂志(英文版) 1991年第11期104卷 930-933页

作者：刘约翰王小根陈雅棠 630042 Chongqing Research Institute of Infectious and Parasitic Diseases Chongqing University of Medical Sciences

Fifteen cases of alveolar hydatid disease were treated with albendazole in the dosage of 20 mg/kg/d×30 days for 12-60 courses. All cases were followed up 1-5 years (average 38 months) by ultrasonic scanning of liver and chest X-ray films. One patient whose hepatic lesion was converted into fibro-calcific after treatment was apparently cured. Twelve patients were symptomatically improved: jaundice (4 cases) and hemoptysis (2 cases) disappeared, with reduction in size of lesions in the liver and lung. Two patients in the late stage of disease with huge and extensive nodular masses in both lobes of the liver were not improved. Evidently, albendazole is effective in the treatment of alveolar hydatid disease. Early diagnosis and early treatment are to be emphasized.

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一种基于资源状态预测的资源调度模型

上海理工大学学报 2006年第2期28卷 149-152,158页

作者：王小根须文波江南大学师范学院无锡214122 江南大学信息工程学院无锡214122

网格资源管理系统在进行任务请求与资源的匹配调度时,应考虑资源的网格环境以及资源的当前工作状态的问题.提出了一种基于资源状态预测的资源调度模型,结合资源状态和距离计算资源的共享开销,并作为任务资源匹配调度的依据,从而为任务... 详细信息

网格资源管理系统在进行任务请求与资源的匹配调度时,应考虑资源的网格环境以及资源的当前工作状态的问题.提出了一种基于资源状态预测的资源调度模型,结合资源状态和距离计算资源的共享开销,并作为任务资源匹配调度的依据,从而为任务请求分配“最好”的共享资源.

关键词：网格计算资源状态预测 PageRank算法

Triclabendazole in the treatment of Paragonimiasis skrjabini

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Chinese Medical Journal 2003年第11期116卷 1683-1686页

作者：高劲松刘约翰王小根胡鹏 Daan Gene Diagnostic Center Sun Yat-sen University Guangzhou 510089 China Department of Infectious Disease First Affiliated Hospital Chongqing University of Medical Sciences Chongqing 400016 China

Objective To observe triclabendazole effect on Paragonimus skrjabini in experimentally infected rats, and to develop a new drug for treating paragonimiasis.Methods Metacercariae of Paragonimus skrjabini were isolated from crabs (Sinopotamon) collected from endemic area. Wistar rats were infected intraperitoneally. One and two months after infection, they were treated with triclabendazole at the dosage of 300 mg · kg -1 · 2d-1, 450 mg ·kg -1 · 3d -1 and 600 mg · kg-1 · 3d-1 respectively. Five patients with Paragonimus skrjabini were treated, with Triclabendazole dosage of 10 mg/kg bid x3 days.Results The worm reduction rates were 50. 3%, 80. 8% and 86. 7% respectively one month after completion of treatment. Dead worms of sesame size recovered from muscles, liver, abdominal cavity, chest cavity and lung were greatly diminished in size and weight in comparison with that of the control group. Many large (about 1 cm) black-colored distended worm cysts were found in the lungs of the control rats. Usually there were two adult worms pairs with numerous eggs in each worm cyst. Most worm cysts in the treated groups of rats were changed into hemorrhagic-necrotic patches. All five patients were cured.Conclusion Triclabendazole was highly active against Paragonimus skrjabini in rats experimentally infected and patients.

关键词： Paragonimus skrjabini ·triclabendazole praziquantel helminthic larva migrans

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丙硫苯咪唑长期连续治疗泡型包虫病的观察

中华内科杂志 1992年第12期31卷 761-763页

作者：刘约翰王小根 630042，重庆医科大学传染病寄生虫病研究所

15例肝泡蚴病患者采用丙硫苯咪唑治疗，剂量为20mg·kg-1/d，分2次口服，30天为一疗程，平均25.8疗程。治疗后平均4年（1～7年）复查结果：所有患者右上腹痛、4例梗阻性黄疸与2例因肺转移病灶而咯血均消失。肝脏B超复查：13例肝内肿块... 详细信息

15例肝泡蚴病患者采用丙硫苯咪唑治疗，剂量为20mg·kg-1/d，分2次口服，30天为一疗程，平均25.8疗程。治疗后平均4年（1～7年）复查结果：所有患者右上腹痛、4例梗阻性黄疸与2例因肺转移病灶而咯血均消失。肝脏B超复查：13例肝内肿块显著缩小。9例CT检查：5例肝内病变全部或大部钙化；3例病变区外界有钙化圈形成；仅一例晚期患者无效。在长期连续疗法中未发生严重不良反应。

关键词：棘球蚴病丙硫苯咪唑药物疗法

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移动教育在课程教学中的实践和思考

教学与管理（理论版） 2005年第11期 52-53页

作者：王小根江南大学师范学院

一、引言什么是移动教育?总的来说移动教育是指在移动计算设备如手机的帮助下,借助无线移动网和国际互联网,方便教师和学生在任意时间和地点开展教学的教学活动.从这里可以看出,借助移动计算设备的和移动通信网络系统的帮助,是开展移动... 详细信息

一、引言什么是移动教育?总的来说移动教育是指在移动计算设备如手机的帮助下,借助无线移动网和国际互联网,方便教师和学生在任意时间和地点开展教学的教学活动.从这里可以看出,借助移动计算设备的和移动通信网络系统的帮助,是开展移动教育的基本要求.摆脱教学在时间和地点上的约束,提高教学灵活性和效果是移动教育的最终目标.本文分析了移动教育的特点,并在课程教学中利用移动教育方式进行了初步的实践,最后对当前开展移动教育提出了一些思考.

关键词：移动教育课程教学实践通信网络系统移动计算国际互联网教学活动最终目标教育方式移动网

阿苯达唑连续治疗肝泡球蚴病伴梗阻性黄疸的临床观察

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中华内科杂志 1996年第4期35卷 261-264页

作者：王小根刘约翰余登高重庆医科大学传染病寄生虫病研究所

为观察阿苯达唑连续治疗肝泡球蚴病伴梗阻性黄疸的临床疗效，对６例患者采用阿苯达唑每日每公斤体重２０ｍｇ连续治疗。结果黄疸均于治疗后１～２．５个月消退，血清胆红质逐渐降至正常。治疗前Ｂ超或（和）ＣＴ检查均显示肝内不均质实... 详细信息

为观察阿苯达唑连续治疗肝泡球蚴病伴梗阻性黄疸的临床疗效，对６例患者采用阿苯达唑每日每公斤体重２０ｍｇ连续治疗。结果黄疸均于治疗后１～２．５个月消退，血清胆红质逐渐降至正常。治疗前Ｂ超或（和）ＣＴ检查均显示肝内不均质实质性病变，肝门区模糊，胆总管或右叶胆管未显影，肝内胆管明显扩张。１例伴有胆总管与胰管扩张，脾静脉增粗，脾显著肿大。２例分别于停药后９年和３年复查时，肝内病变几乎完全钙化，可能治愈。４例仍在治疗中。治疗１年时复查，６例肝内病变明显好转，肝内胆管扩张消失。肝功能复查，除２例球蛋白升高外，均转为正常。表明阿苯达唑治疗肝泡球蚴病伴梗阻性黄疸有较好效果，长期连续治疗未见明显毒副反应。

关键词：阿苯达唑黄疸泡球蚴病肝泡球蚴病药物疗法