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中国针灸 1983年第1期 23-24页

作者：王友京张文安王双坤中医研究院针灸研究所

许多研究表明,中枢单胺类神经介质以及内源性吗啡样物质在针刺过程中起重要作用。这两类物质存在着代谢和功能的相关性,因此在进行针刺过程中神经介质作用的研究时,应该进一步探索各

关键词：电针纳洛酮针刺镇痛腹腔注射色胺吲哚镇痛作用内源性吗啡样物质大鼠

Study on the Mechanism of Compound Mistletoe Fluidextract in Relieving Hypertension

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Journal of Traditional Chinese Medicine 2009年第4期29卷 291-295页

作者：叶芳杜广中崔爱庆鹿晓婷王友京(翻译) Qilu Hospital of Shandong University Jinan 250012 China 不详

There are different pathological characteristicsbetween hypertension of age and hypertension of themiddle-age and young people.

关键词：自发性高血压大鼠槲寄生复方科里奥利质量流量计降压作用机制剂量效应管理

针刺镇痛中GABA能系统的作用及其对脑内5-HT代谢的影响

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中国中西医结合杂志 1987年第3期 169-170+191+134页

作者：王友京伍洁王双坤中国中医研究院针灸研究所

电针大鼠双侧"手三里"和"环跳"穴25分钟,随着大鼠痛阈的提高,延桥脑和中脑内5-HT 含量显著升高,5-HIAA 含量无明显变化。但预先腹腔注射 GABA 受体阻断剂荷包牡丹碱不仅能部分阻断电针镇痛效应,也能阻断电针升高大鼠延桥脑和中脑5-HT ... 详细信息

电针大鼠双侧"手三里"和"环跳"穴25分钟,随着大鼠痛阈的提高,延桥脑和中脑内5-HT 含量显著升高,5-HIAA 含量无明显变化。但预先腹腔注射 GABA 受体阻断剂荷包牡丹碱不仅能部分阻断电针镇痛效应,也能阻断电针升高大鼠延桥脑和中脑5-HT 的效应,还可以使电针明显升高纹状体5-HT 的水平。降低下丘脑和皮层内5-HIAA的含量。结果说明,在电针镇痛过程中,GABA 能系统起重要作用,而这种作用可能部分通过中枢5-HT 能系统来实现。

关键词：针刺镇痛电针大鼠 GABA HT 荷包牡丹碱脑内

Effect of Electroacupuncture at Acupoints of the Governor Vessel on Aquaporin-4 in Rat with Experimental Spinal Cord Injury

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Journal of Traditional Chinese Medicine 2006年第2期26卷 148-152页

作者：谢杰方坚冯新送刘庆思王友京 The Third Affiliated Hospital of Guangzhou University of TCM Guangzhou 510360China

This study is to investigate the effects of electroacupuncture at acupoints of the Governor Vessel(GV) onaquaporin-4 (AQP-4) expression and on functions of the hind limbs in the rat of spinal cord injury. Thefunctions of the hind limbs were detected with BBB scale on the 1d,3d,7d and 21d after the spinal cordinjury,respectively,and AQP-4 expression in the spinal cord was determined with immunohistochemicalmethod and analyzed quantitatively with image analyzer. The results indicated that on the ld after the spinalcord injury,increased AQP-4 expression can be seen significantly in both the gray matter and the whitematter of the injured spinal cord,and it reached the peaks on the 3d after the spinal cord injury in both theelectroacupuncture group and the spinal cord injury group. However,AQP-4 express was significantlydecreased in the electroacupuncture group as compared with that in the control group on 7d,14d and 21d(P<0.05 or P<0.01). The decrease of AQP-4 expression almost went with the improvement of theneurological function,which suggested that electroacupuncture at the acupoints of the Governor Vessel caninhibit edema of the spinal cord to alleviate the secondary spinal cord injury by means of decreasing theAQP-4 expression after the spinal cord injury,so as to protect the residual normal spinal cord tissues andpromote the rebuilding of nervous tissues.

关键词：电针治疗穴位实验治疗脊椎损伤

Basic Investigation Effects of Zi Chong Granules on Estradiol Synthesis in the Cultured Ovarian Granular Cells of Mice

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Journal of Traditional Chinese Medicine 2004年第4期24卷 298-302页

作者：陆华高小平尹巧芝王友京 ChangduUniversityofTCM Chengdu6100752China ChengduDi＇aoParmaceuticalGroup Chengdu610041China 不详

To investigate the effect of Zi Chong Granules (资冲颗粒) on estradiol (E2) synthesis in the cultured ovarian granular cells of the mice, so as to probe into the mechanism of the drug in promoting follicular development. Methods: Testosterone (T) with different concentration were added to the cultured ovarian granular cells, and 24 and 48 hours later the enzyme immunoassay (EIA) was used to determine the required concentration of T and time for E2 synthesis; Zi Chong Granules, its active components for tonifying the kidney and removing blood stasis, and the mouse serum containing Zi Chong Granules were respectively added to the medium of the cultured mouse ovarian granular cells and the mixtures were cultured for 48 hours to determine the E2 concentration in various cultures, with insulin growth factor-1(IGF-1), follicle-stimulating hormone (FSH) and Nü Jin Dan (女金丹丸 Golden Pill for Women) as positive control drugs. Results: Zi Chong Granules and Nü Jin Dan (were found to be able to increase the E2 level in the medium of the cultured ovarian granular cells to a certain extent, and the active components for tonifying the kidney or those for removing the blood stasis did not increase the E2 level, but the mouse serum containing Zi Chong Granules could significantly increase the level of·E2. Conclusion: To promote the E2 synthesis in the ovarian granular cells is one of mechanisms of Zi Chong Granules in stimulating follicular development.

关键词：基础调查资冲颗粒 E2 雌二醇女金丹丸卵巢颗粒细胞老鼠

电针镇痛中M型乙酰胆碱受体的作用及其对脑内5-HT代谢的调节

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中国针灸 1988年第6期 31-33页

作者：王友京伍洁王双坤中国中医研究院针灸研究所

我们以往的实验证明,针刺镇痛时大鼠脑内5-羟色胺(5-HT)的代谢发生明显的变化。也有许多报告认为中枢乙酰胆碱(Ach)是加强针刺镇痛的一个重要因素。在本工作中,我们观察了大鼠腹腔注射Ach 毒蕈碱型受体阻断剂阿托品对电针镇痛效应及其脑... 详细信息

我们以往的实验证明,针刺镇痛时大鼠脑内5-羟色胺(5-HT)的代谢发生明显的变化。也有许多报告认为中枢乙酰胆碱(Ach)是加强针刺镇痛的一个重要因素。在本工作中,我们观察了大鼠腹腔注射Ach 毒蕈碱型受体阻断剂阿托品对电针镇痛效应及其脑内5-HT 和它的主要代谢产物5-HIAA 含量变化的影响,以便进一步证明 M 型乙酰胆碱受体在电针镇痛中的作用及其对脑内5-HT 代谢的调节。

关键词： HT 电针镇痛脑内电针刺激大鼠脑阿托品颠茄碱

Effects of Moxibustion Pretreating on SOD and MDA in the Rat of Global Brain Ischemia

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Journal of Traditional Chinese Medicine 2008年第4期28卷 289-292页

作者：华金双李丽萍朱现民王友京(翻译) Henan College of Traditional Chinese Medicine Zhengzhou 450008 China Zhejiang Hospital of TCM Hangzhou 310006 China 不详

Objective: To probe into the mechanism of moxibustion preconditioning in preventive brain-protecting effect. Methods: The global brain ischemia rat model was developed by blocking 4 arteries. Seventy-eight Wistar male rats were randomly divided into 5 groups: a normal control group, a sham-operation group, a brain ischemia group, a brain ischemia preconditioning group, a moxibustion pretreating group. The brains in the 5 groups were taken at 24 h, 48 h, and 72 h after operation respectively. Superoxide dismulase (SOD) activity was determined with xanthine oxidase method and malondialdehyde (MDA) content with thiobarbituric acid method. Results: After the operation, in the moxibustion preconditioning group, SOD activity significantly increased, especially 24 h after moxibustion preconditioning; and MDA content decreased, with a very significant difference as compared with that of the cerebral ischemia group (P<0.01). Conclusion: Moxibustion preconditioning protects the ischemic and anoxic brain tissue by increasing the activity of endogenous antioxidase.

关键词：艾灸脑缺血过氧化物中医

荷包牡丹碱和阿托品对电针大鼠脑内亮-脑啡肽含量的影响

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中国针灸 1985年第5期 28-29页

作者：王友京伍洁王双坤中医研究院针灸研究所

据报道,手针家兔或电针大鼠,痛阈明显升高的同时,纹状体和下丘脑内甲-脑啡肽和亮-脑啡肽含量明显增加;电针也能使大鼠纹状体释放亮-脑啡肽和提高猴侧脑室脑脊液亮-脑啡肽的含量。许多实验还证明了γ-氨基丁酸(GABA)和乙酰胆碱(Ach)不同... 详细信息

据报道,手针家兔或电针大鼠,痛阈明显升高的同时,纹状体和下丘脑内甲-脑啡肽和亮-脑啡肽含量明显增加;电针也能使大鼠纹状体释放亮-脑啡肽和提高猴侧脑室脑脊液亮-脑啡肽的含量。许多实验还证明了γ-氨基丁酸(GABA)和乙酰胆碱(Ach)不同程度参与针刺镇痛过程。为探讨针刺过程中脑内亮-脑啡肽与 GABA或 Ach 系统的功能是否存在一定关系,我们分

关键词：电针荷包牡丹碱阿托品颠茄碱大鼠脑

双枯碱和阿托品对电针大鼠脑内亮-脑啡肽含量的影响

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基础医学与临床 1984年第4期 19-20页

作者：王友京伍洁王双坤中医研究院针灸研究所

据报道,中枢脑啡肽(ENK),γ-氨基丁酸(GABA)和乙酰胆碱(Ach)系统均参与针刺镇痛作用。为了解它们在针刺过程中是否存在一定关系,我们分别观察了腹腔注射GABA受体阻断剂双枯碱(Bicuculline)和Ach毒蕈碱样受体阻断剂阿托品对电针大鼠脑内... 详细信息

据报道,中枢脑啡肽(ENK),γ-氨基丁酸(GABA)和乙酰胆碱(Ach)系统均参与针刺镇痛作用。为了解它们在针刺过程中是否存在一定关系,我们分别观察了腹腔注射GABA受体阻断剂双枯碱(Bicuculline)和Ach毒蕈碱样受体阻断剂阿托品对电针大鼠脑内亮-脑啡肽含量的影响。

关键词：阿托品大鼠脑内颠茄碱电针电针组

EFFECTS OF PHENTOLAMINE AND PROPRANOLOL ON THE CHANGES OF PAIN THRESHOLD AND CONTENTS OF MEK AND LEK IN RAT BRAIN AFTER EA

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Journal of Traditional Chinese Medicine 1989年第3期9卷 210-214页

作者：王友京王双坤 Institute of Acupuncture China Academy of Traditional Chinese Medicine

The contents of Met-enkephalin(MEK)andLeu-enkephalin(LEK)in striatum and MEK in hypo-thalamus of rat increased markedly after electroacu-puncture analgesia(EAA).Intraperitoneal injec-tion of phentolamine,a blocker of a receptor,po-tentiated the EAA and abolished the effects of EAincreasing MEK and LEK contents;while injectionof propranolol,a blocker of β receptor,partially in-hibited the EAA,as well as abolished the effects ofEA increasing MEK and LEK concentrations in thestriatum and the hypothalamus,and also elevatedthe MEK and LEK contents in hippocampus andMEK level in *** results indicate that EA regulates metabo-lism of MEK and LEK,as well as EAA partiallyvia α and β receptors.

关键词： hippocampus cortex blocker analgesia markedly puncture minutes saline partially remarkably