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影响电针镇痛因素的实验研究概况

针刺研究 1993年第4期18卷 247-252页

作者：王友京中国中医研究院针灸研究所北京100700

本文介绍了有关影响电针镇痛因素的实验研究概况。多数资料表明,电针刺激的强度、频率以及所选择的穴位和时辰不同可产生不同的镇痛作用;不同参数电针刺激的镇痛效应有不同的神经生理和神经生物化学机制。

关键词：电针镇痛电针参数动物实验

不同电针刺激强度和频率对大鼠脑内单胺类神经介质有不同的影响

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基础医学与临床 1983年第5期 30-31页

作者：王友京伍洁张文安王双坤中医研究针炙研究所生化研究室

比较了两种不同电针刺激强度(负载电压峰-峰值3伏,6伏)和频率(10赫兹,200赫兹)对大鼠不同脑区内5-羟色胺(5-HT)及其代谢产物5-羟吲哚乙酸(5-HIAA)、去甲肾上腺素(NA)和多巴胺(DA)水平的影响。70只体重为250克左右的健康雄性大鼠随机分... 详细信息

比较了两种不同电针刺激强度(负载电压峰-峰值3伏,6伏)和频率(10赫兹,200赫兹)对大鼠不同脑区内5-羟色胺(5-HT)及其代谢产物5-羟吲哚乙酸(5-HIAA)、去甲肾上腺素(NA)和多巴胺(DA)水平的影响。70只体重为250克左右的健康雄性大鼠随机分为五个实验组:Ⅰ对照组,Ⅱ低

关键词：电针刺激强度和频脑内大鼠脑纹状体基底神经节

Effects of Wuwei Dilong Decoction on Inflammatory Cells and Cytokines in Asthma Model Guinea Pigs

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Journal of Traditional Chinese Medicine 2009年第3期29卷 220-223页

作者：李祥华涂献玉张德新许甲凤王文英张渊杜亚明王友京 Medical College of Changjiang University

Objective: To explore the effects and the mechanism of Wuwei Dilong Decoction (五味地龙汤 Schisandra Fruit and Earthworm Decoction) for treatment of asthma. Methods: The asthma guinea pig model was established with spray of ovalbumin (OVA). Fifteen days later, the guinea pigs were administered by intra-gastric perfusion of Wuwei Dilong Decoction once a day for 8 consecutive days. Blood samples were taken for testing the total leucocytes, eosinophil (EOS), lymphocytes, interferon-γ (IFN-γ) and leukotriene B4 (LTB4). Results: In the asthma model group, the total leucocytes, EOS and lymphocytes were all increased, with significant differences as compared with the different dosage Wuwei Dilong Decoction groups (P<0.01 or P<0.05). The serum LTB4 in the asthma model group was significantly increased and IFN-γ decreased. After administration of Wuwei Dilong Decoction of the large, medium and small dosages, LTB4 decreased, while IFN-γ increased (P<0.05 or P<0.01). Conclusion: Wuwei Dilong Decoction can inhibit infiltration and diffusion of the inflammatory cells in the asthma model guinea pigs, and regulate LTB4 and IFN-γ, which is probably one of the important mechanisms of Wuwei Dilong Decoction for relieving asthma.

关键词：模型组细胞因子地龙武威哮喘豚鼠白细胞总数干扰素-γ

Effect of Shenqi Compound Formula on PPARγ in White Adipose Tissue of Rats with Macrovascular Lesion in Early Stage of Diabetes

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Journal of Traditional Chinese Medicine 2008年第2期28卷 134-138页

作者：张红敏谢春光陈世伟谢毅强王友京（译） West China Hospital of Sichuan University Chengdu 610041 China Chengdu University of Traditional Chinese Medicine China Food and Drug Administration of Henan China 不详

Objective:To investigate the effect of Shenqi Compound Formula (SCF) on peroxisome proliferators-activated receptor γ (PPARγ) in white adipose tissue of rats with macrovascular lesion in early stage of diabetes. Methods: Corresponding treatment was given to rats in model group, Ramipril group, normal control group, low dosage SCF group and high dosage SCF group respectively for 32 days. The expressions of PPARγ and adiponectin Messenger RNA (mRNA) were detected by real-time reverse transcriptase poly-merase chain reaction. Results: The expressions of PPARγ and adiponectin mRNA increased significantly in both low and high dosage SCF groups as compared with the model group, and a positive linear correlation was found between the expressions of PPARγ and adiponectin mRNA. Conclusions: SCF can prevent macrovascular lesion in early stage of diabetes, which is possibly related with up-regulating expressions of PPARγ and activating PPARγ.

关键词：糖尿病中药过氧化物酶体活性受体

EFFECTS OF ACUPUNCTURE ON PAIN THRESHOLD AND PLASMA CORTICOSTERONE LEVEL AT DIFFERENT TIMES OF THE DAY

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Journal of Traditional Chinese Medicine 1990年第2期10卷 136-140页

作者：曹蔚鸿王友京陆卓珊 Institute of Acupuncture and Moxibustion China Academy of Traditional Chinese Medicine

It is held by traditional Chinese medi-cine that human body is an organismadapting to the environment very well in thenature,and the circulation of“Qi”and“Blood”inside the human body is in har-mony with the outsid... 详细信息

关键词： tradition minutes analgesia Blood outside 子午流注 sensation fluctuation body diurnal

THE NERVE-ROOT-TYPE CERVICAL SPONDYLOPATHY TREATED BY MASSOTHERAPY WITH AN OBSERVATION OF MICROCIRCULATION IN THE AFFECTED LIMB

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Journal of Traditional Chinese Medicine 1999年第4期19卷 292-295页

作者：方存忠樊永新王彤王友京 Institute of Acupuncture and Moxibustion China Academy of Traditional Chinese Medicine Beijing 100700 Institute of Acupuncture and Moxibustion China Academy of Traditional Chinese Medicine

In recent years, great attention has beenpaid to basic theories of microcirculation andits clinical applications both at home andabroad. It has been applied in hematopathy,angiocardiopathy and many other diseases,

关键词：循环检查科技出版社临床手册医药北京

Treatment of Decortical State of Child Encephalitis with Scalp Acupuncture and the Effects on EEG and BEAM

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Journal of Traditional Chinese Medicine 2000年第4期20卷 289-292页

作者：于澎孙领娣林淑静王友京 The First Affiliated Hospital of Harbin University of Medical Sciences HarbinHeilongjiang Province 150001

Electroencephalogram (EEG)-recorded rhythmicelectrophysiologic activity of brain is synchronoussynthesis of postsynaptic potentials of pyramidalcells and their parietal dendrites of the *** changes in EEG and brainelectrical activity mapping (BEAM) appear prior tothat in computed tomography (CT) and nuclearmagnetic resonance (NMR) during the acute stage ofencephalitis,providing a scientific and

关键词：大脑印射脑电描记法针灸治疗孩子,幼儿园去脑状态脑炎人男性头皮

EFFECTS OF NALOXONE ON THE CHANGES OF PAIN THRESHOLD AND CONTENTS OF MONOAMINE NEUROTRANSMITTERS IN RAT BRAIN INDUCED BY EA

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Journal of Traditional Chinese Medicine 1991年第4期11卷 286-290页

作者：王友京王双坤张文安 Institute of Acupuncture China Academy of TCM

5-HT content in medulla oblongata plus pons and DA level in brain stem obviously increased,while NA concentration in telencephalon markedly decreased in EAA.A previous injection ofnaloxone,a blocker of opiate receptor,could partially inhibit the EAA,abolish the effects ofEA’s increasing the 5-HT content in the medulla oblongata plus pons and the DA level in thebrain stem,and decrease the NA level in the diencephalon after *** results indicate thatEA may mediate the metabolism of the central monoamine neurotransmitters partially via opiatereceptor to exert its analgesic effect.

关键词： naloxone analgesic metabolism blocker markedly partially exert inhibit minutes anesthesia

Effects of Electroacupuncture at the Conception Vessel on Proliferation and Differentiation of Nerve Stem Cells in the Inferior Zone of the Lateral Ventricle in Cerebral Ischemia Rats

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Journal of Traditional Chinese Medicine 2008年第1期28卷 58-63页

作者：杨卓欣于海波饶晓丹刘远声皮敏王友京 Shenzhen Municipal Hospital of Traditional Chinese Medicine Guangzhou University of Traditional Chinese Medicine

Objective: To observe the effects of electroacupuncture (EA) at the Conception Vessel on proliferation and differentiation of the nerve stem cells in the inferior zone of the lateral ventricle in cerebral ischemia rats. Methods: The model rats were prepared by occlusion of the middle cerebral artery for 2 hours and then by reperfusion. They were randomly divided into two groups: a control group and an EA group. Changes in differentiation and proliferation of the nerve stem cells were observed 7, 14 and 28 days after successful modeling. Results: As compared with the 7-day control group (C-7d group), there was no significant difference (P>0.05) in the numbers of 5-bromodeoxyuridine (Brdu) positive cells, Brdu/GFAP, Brdu/Nestin and Brdu/Nse double-labeled cells in the inferior zone of the lateral ventricle in the EA group 7 days after modeling. However, in the 14-day EA group (R-14d group) and the 28-day EA group (R-28d group), the numbers of Brdu positive cells and Brdu/GFAP, Brdu/Nestin, Brdu/Nse double-labeled cells significantly increased as compared respectively with the 14-day control (C-14d group) and the 28-day control (C-28d) group (P<0.05 or P<0.01). Conclusions: EA at the Conception Vessel promotes differentiation and proliferation of the nerve stem cells in the inferior zone of the lateral ventricle in the cerebral ischemia rats, and may stimulate differentiation of the proliferous nerve stem cells towards the astrocytes.

关键词：大脑缺血神经干细胞电针刺疗法中医疗效