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Science Bulletin 2024年第10期69卷 1458-1471页

作者：马远林高凯孙晓璇王金鑫杨扬武建荧柴安平姚立刘楠郁昊苏怡卢天兰王力芳岳伟华章晓辉徐林张岱李俊 Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Key Laboratory of Mental HealthChinese Academy of Medical SciencesBeijing 100191China The First Affiliated Hospital Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqing 400016China Changping Laboratory Beijing 102206China d Chinese Institute for Brain Research Beijing 102206China Laboratory of Learning and Memory Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China Shenzhen Key Laboratory of Translational Research for Brain Diseases The Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China State Key Laboratory of Cognitive Neuroscience and Learning IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China

Synaptic dysfunction is a core component of the pathophysiology of schizophrenia.However,the genetic risk factors and molecular mechanisms related to synaptic dysfunction are still not fully understood.The Stonin 2(STON2)gene encodes a major adaptor for clathrin-mediated endocytosis(CME)of synaptic vesicles.In this study,we showed that the C-C(307Pro-851Ala)haplotype of STON2 increases the susceptibility to schizophrenia and examined whether STON2 variations cause schizophrenia-like behaviors through the regulation of CME.We found that schizophrenia-related STON2 variations led to protein dephosphorylation,which affected its interaction with synaptotagmin 1(Syt1),a calcium sensor protein located in the presynaptic membrane that is critical for CME.STON2307Pro851Ala knockin mice exhibited deficits in synaptic transmission,short-term plasticity,and schizophrenia-like behaviors.Moreover,among seven antipsychotic drugs,patients with the C-C(307Pro-851Ala)haplotype responded better to haloperidol than did the T-A(307Ser-851Ser)carriers.The recovery of deficits in Syt1 sorting and synaptic transmission by acute administration of haloperidol effectively improved schizophrenia-like behaviors in STON2307Pro851Ala knockin mice.Our findings demonstrated the effect of schizophreniarelated STON2 variations on synaptic dysfunction through the regulation of CME,which might be attractive therapeutic targets for treating schizophrenia-like phenotypes.

关键词： STON2 variations Schizophrenia Synaptic dysfunction Syt1 Haloperidol

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简单的生活、敞亮的记忆(组诗)

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诗刊 2003年第2期 24-25页

作者：柴安平

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谈谈饲料厂的技术档案管理

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饲料工业 1989年第Z1期 24-25页

作者：柴安平山西省饲料公司

饲料厂实行技术档案管理,目的在于更好地利用技术档案的凭证和参考作用,为企业的生产和科研服务。然而有许多饲料厂却忽视了这项重要的管理工作,技术文件材料无专人负责保管,日常工作中形成的技术文件材料四处乱放,残缺不全,使用时到处... 详细信息

饲料厂实行技术档案管理,目的在于更好地利用技术档案的凭证和参考作用,为企业的生产和科研服务。然而有许多饲料厂却忽视了这项重要的管理工作,技术文件材料无专人负责保管,日常工作中形成的技术文件材料四处乱放,残缺不全,使用时到处查找,影响生产和工作。因此,必须加强技术档案管理工作。一、建立管理机构饲料厂应根据本企业的具体情况设置相应的技术档案管理机构,配备专职或兼职管理人员。万吨级饲料厂技术档案,可由生产技术或科研科室来负责管理,配备专职管理人员。万吨以下的饲料厂,可与文书档案统一归档案室,但要分别管理,不能混淆。档案管理人员的职责是整理与保管本厂(公司)的技术档案,提供技术档案为生产和科研服务,帮助科室、车间整理归档的技术文件材料,承办鉴定技术档案和销毁过期的技术档案,兼管技术资料的管理工作。二、建立归档制度饲料厂各科室、车间,要把工作中形成的具有

关键词：技术档案管理车间企业科室企业管理技术文件材料加工厂饲料厂

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