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第三心音和第四心音对预测左室功能不全具有低度敏感性和中高度特异性

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英国医学杂志中文版 2006年第2期9卷 117-118页

作者： marcus GM Gerber l McKeown Bh 张学慧

问题：对于因需进行非急诊左心导管插入术而就诊的患者，利用计算机心音描记法测绘第三心音（S3）和第四心音（S4），其诊断左室功能不全的准确性如何？

关键词：左室功能不全第四心音第三心音敏感性左心导管插入术预测描记法计算机

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Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors

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World Journal of Gastroenterology 2008年第23期14卷 3681-3692页

作者： Martin haefner Thilo Bluethner Manuel Niederhagen Christian Moebius Christian Wittekind Joachim Mossner Karel Caca marcus Wiedmann Department of Internal Medicine II University of LeipzigPhilipp-Rosenthal-Str. 27Leipzig 04103Germany Institute of Pathology University of LeipzigLiebigstr. 26Leipzig 04103Germany Department of Surgery II University of LeipzigLiebigstrasse 20aLeipzig 04103Germany Department of Internal Medicine I Klinikum LudwigsburgPosilipostr. 4Ludwigsburg 71640Germany

AIM:To investigate in vitro and in vivo treatment with histone deacetylase inhibitors NVP-lAQ824 and NVP-lBh589 in pancreatic cancer. METhODS:Cell-growth inhibition by NVP-lAQ824 and NVP-lBh589 was studied in vitro in 8 human pancreatic cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide(MTT) assay. In addition,the anti-tumoral effect of NVP-lBh589 was studied in a chimeric mouse model. Anti-tumoral activity of the drugs was assessed by immunoblotting for p21WAF-1,ach4,cell cycle analysis,TUNEl assay,and immunohistochemistry for MIB-1. RESUlTS:In vitro treatment with both compounds significantly suppressed the growth of all cancer cell lines and was associated with hyperacetylation of nucleosomal histone h4,increased expression of p21WAF-1,cell cycle arrest at G2/M-checkpoint,and increased apoptosis. In vivo,NVP-lBh589 alone significantly reduced tumor mass and potentiated the efficacy of gemcitabine. Further analysis of the tumor specimens revealed slightly increased apoptosis and no significant reduction of cell ***:Our findings suggest that NVP-lBh589 and NVP-lAQ824 are active against human pancreatic cancer,although the precise mechanism of in vivo drug action is not yet completely understood. Therefore,further preclinical and clinical studies for the treatment of pancreatic cancer are recommended.

关键词： histone deacetylase inhibitor Pancreatic cancer NVP-lAQ824 NVP-lBh589

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创业投资引导基金补偿机制对创投机构网络位置的影响研究

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管理评论 2020年第1期32卷 107-118页

作者：杨敏利丁文虎郭立宏 marcus W.Feldman 西安理工大学经济与管理学院西安710054 西北大学经济管理学院西安710127 斯坦福大学莫里森人口与资源研究所加利福尼亚94305

随着创投市场的网络化趋势越来越突出,提升网络位置成为创投机构的重要竞争战略之一。论文基于激励视角研究创业投资引导基金(简称引导基金)补偿机制对创投机构网络位置的影响。通过私募通数据库搜集大样本数据构造匹配样本,使用双重差... 详细信息

随着创投市场的网络化趋势越来越突出,提升网络位置成为创投机构的重要竞争战略之一。论文基于激励视角研究创业投资引导基金(简称引导基金)补偿机制对创投机构网络位置的影响。通过私募通数据库搜集大样本数据构造匹配样本,使用双重差分模型,研究结论表明:(1)引导基金参股时为私人资本提供收益补偿、固定收益补偿、或者收益补偿加上固定收益补偿会提升创投机构的网络位置,为私人资本提供亏损补偿、亏损补偿加上固定收益补偿、或者亏损补偿加上收益补偿加上固定收益补偿则不会提升创投机构的网络位置;(2)相比于参股国有背景创投机构而言,引导基金参股非国有背景创投机构时提供收益补偿、固定收益补偿、或者收益补偿加上固定收益补偿对网络位置的提升作用更明显。论文拓宽了创投机构提升网络位置的战略选择,对引导基金主管部门选择补偿机制也有一定的参考意义。

关键词：引导基金参股补偿机制创投机构网络位置

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Inhibition of histone deacetylase for the treatment of biliary tract cancer:A new effective pharmacological approach

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World Journal of Gastroenterology 2007年第35期13卷 4761-4770页

作者： Thilo Bluethner Manuel Niederhagen Karel Caca Frederik Serr helmut Witzigmann Christian Moebius Joachim Mossner marcus Wiedmann Department of Internal Medicine Ⅱ University of LeipzigPhilipp-Rosenthal-Str.27Leipzig 04103Germany Institute of Pathology University of LeipzigLiebigstr.26Leipzig 04103Germany Department of Internal Medicine Ⅰ Klinikum LudwigsburgPosilipostr.4Ludwigsburg 71640Germany Department of Surgery Ⅱ University of LeipzigLiebigstrasse 20a04103 LeipzigGermany

AIM： To investigate in vitro and in vivo therapeutic effects of histone deacetylase inhibitors NVP-lAQ824 and NVP-lBh589 on biliary tract cancer. METhODS： Cell growth inhibition by NVP-lAQ824 and NVP-lBh589 was studied in vitro in 7 human biliary tract cancer cell lines by MTT assay. In addition, the antitumoral effect of NVP-lBh589 was studied in a chimeric mouse model. Anti-tumoral drug mechanism was assessed by immunoblotting for ach4 and p21^WAFl/CIP-1, PARP assay, cell cycle analysis, TUNEl assay, and immunhistochemistry for MIB-1. RESUlTS： In vitro treatment with both compounds significantly suppressed the growth of all cancer cell lines [mean IC50 （3 d） 0.11 and 0.05 μmol/l, respectively], and was associated with hyperacetylation of nucleosomal histone h4, increased expression of p21^WAF-1/CIP-1, induction of apoptosis （PARP cleavage）, and cell cycle arrest at G2/M checkpoint. After 28 d, NVP- lBh589 significantly reduced tumor mass by 66% （bile duct cancer） and 87% （gallbladder cancer） in vivo in comparison to placebo, and potentiated the efficacy of gemcitabine. Further analysis of the tumor specimens revealed increased apoptosis by TUNEl assay and reduced cell proliferation （MIB-1）. CONClUSION： Our findings suggest that NVP-lBh589 and NVP-lAQ824 are active against human biliary tract cancer in vitro. In addition, NVP-lBh589 demonstrated significant in vivo activity and potentiated the efficacy of gemcitabine. Therefore, further clinical evaluation of this new drug for the treatment of biliary tract cancer is recommended.

关键词： histone deacetylase inhibitor Biliary tract cancer Cholangiocarcinoma NVP-lAQ824 NVP-lBh589

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Comparison of a Spectral Bin and Two Multi-Moment Bulk Microphysics Schemes for Supercell Simulation:Investigation into Key Processes Responsible for hydrometeor Distributions and Precipitation

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Advances in Atmospheric Sciences 2024年第5期41卷 784-800页

作者： marcus JOhNSON Ming XUE Youngsun JUNG Center for Analysis and Prediction of Storms University of OklahomaNormanOK 73072USA School of Meteorology University of OklahomaNormanOK 73072USA Office of Science and Technology Integration National Weather ServiceSilver SpringMD 20910USA

There are more uncertainties with ice hydrometeor representations and related processes than liquid hydrometeors within microphysics parameterization(MP)schemes because of their complicated geometries and physical *** supercell simulations are produced using the WRF model coupled with“full”hebrew University spectral bin MP(hU-SBM),and NSSl and Thompson bulk MP(BMP)***-SBM downdrafts are typically weaker than those of the NSSl and Thompson simulations,accompanied by less rain ***-SBM produces more cloud ice(plates),graupel,and hail than the BMPs,yet precipitates less at the *** limiting mass bins(and subsequently,particle size)of rimed ice in hU-SBM and slower rimed ice fall speeds lead to smaller melting-level net rimed ice fluxes than those of the *** from plates in hU-SBM,together with snow–graupel collisions,leads to a greater snow contribution to rain than those of the *** hU-SBM’s fall speeds using the formulations of the BMPs after aggregating the discrete bin values to mass mixing ratios and total number concentrations increases net rain and rimed ice ***,they are smaller in magnitude than bulk rain,NSSl hail,and Thompson graupel net fluxes near the ***,the melting-layer net rimed ice fluxes are reduced when the fall speeds for the NSSl and Thompson simulations are calculated using hU-SBM fall speed formulations after discretizing the bulk particle size distributions(PSDs)into spectral *** results highlight precipitation sensitivity to storm dynamics,fall speed,hydrometeor evolution governed by process rates,and MP PSD design.