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Advances in regenerative therapies for spinal cord injury:a biomaterials approach

丛书名： Current Clinical Practice

2009年

作者： Dawn marcus

来源：畅想之星图书光盘版（南... 评论

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Neural Regeneration Research 2015年第5期10卷 726-742页

作者： Magdalini Tsintou Kyriakos Dalamagkas Alexander marcus Seifalian UCl Centre for Nanotechnology & Regenerative Medicine Division of Surgery and Interventional ScienceUniversity College of London Royal Free london NhS Foundation Trust hospital

Spinal cord injury results in the permanent loss of function, causing enormous personal, social and economic problems. Even though neural regeneration has been proven to be a natural mech- anism, central nervous system repair mechanisms are ineffective due to the imbalance of the inhibitory and excitatory factors implicated in neuroregeneration. Therefore, there is growing re- search interest on discovering a novel therapeutic strategy for effective spinal cord injury repair. To this direction, cell-based delivery strategies, biomolecule delivery strategies as well as scaf- fold-based therapeutic strategies have been developed with a tendency to seek for the answer to a combinatorial approach of all the above. here we review the recent advances on regenerativel neural engineering therapies for spinal cord injury, aiming at providing an insight to the most promising repair strategies, in order to facilitate future research conduction.

关键词： tissue engineering neuroregeneration repair central nervous system biomaterial regenerative medicine nanotechnology spinal cord injury

The Promise of Pharmacogenomics in ReducingToxicity During Acute lymphoblastic leukemiaMaintenance Treatment

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Genomics, Proteomics & Bioinformatics 2017年第2期15卷 82-93页

作者： Shoshana Rudin marcus Marable R. Stephanie huang Biological Sciences Division University of Chicago Chicago IL 60637 USA Department of Medicine University of Chicago Chicago IL 60637 USA

Pediatric acute lymphoblastic leukemia(All) affects a substantial number of children every year and requires a long and rigorous course of chemotherapy treatments in three stages, with the longest phase, the maintenance phase, lasting 2–3 years. While the primary drugs used in the maintenance phase, 6-mercaptopurine(6-MP) and methotrexate(MTX), are necessary for decreasing risk of relapse, they also have potentially serious toxicities, including myelosuppression, which may be life-threatening, and gastrointestinal toxicity. For both drugs, pharmacogenomic factors have been identified that could explain a large amount of the variance in toxicity between patients, and may serve as effective predictors of toxicity during the maintenance phase of All treatment.6-MP toxicity is associated with polymorphisms in the genes encoding thiopurine methyltransferase(TPMT), nudix hydrolase 15(NUDT15), and potentially inosine triphosphatase(ITPA), which vary between ethnic groups. Moreover, MTX toxicity is associated with polymorphisms in genes encoding solute carrier organic anion transporter family member 1B1(SlCO1B1) and dihydrofolate reductase(DhFR). Additional polymorphisms potentially associated with toxicities for MTX have also been identified, including those in the genes encoding solute carrier family 19 member 1(SlC19A1)and thymidylate synthetase(TYMS), but their contributions have not yet been well quantified. It is clear that pharmacogenomics should be incorporated as a dosage-calibrating tool in pediatric All treatment in order to predict and minimize the occurrence of serious toxicities for these patients.

关键词： Acute lymphoblastic leukemia 6-Mercaptopurine Methotrexate Pharmacogenomics Maintenance therapy

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marcus Gunn综合征

中国医科大学学报 1995年第4期24卷 409-410页

作者：英勇高旭光笪宇威王进中国医科大学第一临床学院神经内科锦西市人民医院神经内科

ＭａｒｃｕｓＧｕｎｎ综合征英勇，高旭光，笪宇威王进（中国医科大学第一临床学院神经内科）（锦西市人民医院神经内科）关键词ＭａｒｃｕｓＧｕｎｎ综合征，下颌瞬目现象，联合运动ＭａｒｃｕｓＧｕｎｎ综合征罕见，迄今国内只见３例... 详细信息

ＭａｒｃｕｓＧｕｎｎ综合征英勇，高旭光，笪宇威王进（中国医科大学第一临床学院神经内科）（锦西市人民医院神经内科）关键词ＭａｒｃｕｓＧｕｎｎ综合征，下颌瞬目现象，联合运动ＭａｒｃｕｓＧｕｎｎ综合征罕见，迄今国内只见３例报道￣［１，３］。近年来，我科门诊...

关键词： M-G综合征眼睑下垂病例报告

中国英语学习者对前缀和后缀派生词的识别加工差异

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现代外语 2019年第5期42卷 623-635页

作者：李俊敏 marcus Taft 朱正才张北镇上海交通大学外国语学院上海市200240 浙江大学城市学院新南威尔士大学上海交通大学江苏大学

本研究考查以汉语为母语的高水平英语学习者对前缀与后缀派生词的识别加工是否存在差异。研究含两个实验,实验一采用前掩蔽启动词汇判断任务,考查前缀派生词对其词根(如disagree-AGREE)的判断是否存在促进作用以及后缀派生词对其词根的... 详细信息

本研究考查以汉语为母语的高水平英语学习者对前缀与后缀派生词的识别加工是否存在差异。研究含两个实验,实验一采用前掩蔽启动词汇判断任务,考查前缀派生词对其词根(如disagree-AGREE)的判断是否存在促进作用以及后缀派生词对其词根的启动效应(如sailor-SAIl)是否存在差异,并对比与前后缀相对应的词形相关词对其内镶嵌词(如nuclearClEAR、pillow-PIll)的启动情况。实验二要求被试对带有前缀或后缀的有词素结构假词(如resuit、printful)和相应的无词素结构假词(如lesuit、printfil)进行词汇判断,比较二者的加工差异。结果表明,高水平英语学习者对于前缀与后缀派生词的识别都存在词素分解过程,前缀比后缀更难识别。前缀加工与英语水平有关,而后缀加工与英语水平无关。

关键词：前缀后缀派生词识别加工

干扰素激活基因15作为一种急性和慢性神经损伤的通用标记(英文)

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生理学报 2012年第5期64卷 577-583页

作者：王仁刚 KAUl marcus 张东贤 Del E.Webb神经科学、衰老与干细胞研究中心感染与免疫疾病中心 Sanford-Burnham医学研究所La JollaCA92037美国

在中枢神经系统中干扰素(interferon,IFN)信号系统的激活通常与炎症相关。但是,在肌萎缩性侧索硬化症(amyotrophic lateral sclerosis,AlS)动物模型SOD1(G93A)小鼠的脊髓中,症状前阶段I型IFN激活基因(IFN-stimulated genes,ISGs)的高度激活可在没有明显炎症的情况下发生。为了确定同样的信号系统是否在其它神经损伤中也有增强,我们检测了一种IFN激活基因ISG15在急性和慢性神经损伤的小鼠模型中的蛋白表达水平。我们观察到ISG15蛋白在经受全脑缺血或创伤性脑损伤的小鼠以及过度表达hIV gp120蛋白的转基因小鼠的大脑中显著增加。以上结果提示,ISGs的激活是神经损伤的一种普遍特性,并且ISG15可成为一种适用于检测中枢神经系统神经损伤的生物标志。

关键词：干扰素激活基因15 神经损伤生物标志

Treatment of biliary tract cancer with NVP-AEW541:Mechanisms of action and resistance

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World Journal of Gastroenterology 2010年第2期16卷 156-166页

作者： Samuel Wolf Jana lorenz Joachim Mssner marcus Wiedmann Department of Internal MedicineⅡ University of Leipzig Department of Internal MedicineⅠ St. Mary's Hospital

AIM:To investigate in vitro treatment with NVPAEW541,a small molecule inhibitor of insulin-like growth factor-1 receptor(IGF-1R),in biliary tract cancer (BTC),since this disease is associated with a poor prognosis due to wide resistance to chemotherapeutic agents and ***:Cell growth inhibition by NVP-AEW541 was studied in vitro in 7 human BTC cell lines by automated cell *** addition,the anti-tumoral mechanism of NVP-AEW541 was studied by Western blotting,cell cycle analysis and reverse transcription-polymerase chain reaction(RT-PCR).Anti-tumoral drug effect in combination with gemcitabine,5-fluorouracil(5-FU)and Polo-like kinase 1 inhibitor BI2536 was also studied. RESUlTS:In vitro treatment with NVP-AEW541 suppressed growth in all human BTC cell lines,however response was lower in gallbladder *** withNVP-AEW541 was associated with dephosphorylation of IGF-1R and *** contrast,phosphorylation of p42/p44 and Stat3 and expression of Bcl-xl were inconsistently *** addition,treated cells showed cell cycle arrest at the G1/S-checkpoint and an increase in sub-G1 ***,IGF-1R and its ligands IGF-1 and IGF-2 were co-expressed in RT-PCR,suggesting an autocrine loop of tumor cell *** with gemcitabine,NVP-AEW541 exerted synergistic effects, particularly at low concentrations,while effects of combination with 5-FU or BI 2536 were only additive. CONClUSION:Our findings suggest that NVP-AEW541 is active against BTC in vitro and potentiates the efficacy of gemcitabine.

关键词： Tyrosine kinase inhibitor Cholangiocarcinoma Gemcitabine NVP-AEW541

IMPlEMENTING ThE VIRTUAl PROJECT MANAGEMENT OFFICE :

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2007年

作者： marcus GONCAlVES.

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晚期肿瘤病人的疼痛治疗(英文)

中国临床药理学杂志 1989年第1期 1-4页

作者： marcus M.Reidenberg Cornell University Medical College U.S.A

由于麻醉性镇痛药治疗不当,致使对转移性肿瘤病人的疼痛不能控制,此现象在世界范围内较普遍。对此,世界卫生组织制订出一套逐级治疗方案。该方案采用口服常规给药,并逐步增加麻醉性药物治疗的强度。对疼痛的初始治疗,使用阿斯匹林及其... 详细信息

由于麻醉性镇痛药治疗不当,致使对转移性肿瘤病人的疼痛不能控制,此现象在世界范围内较普遍。对此,世界卫生组织制订出一套逐级治疗方案。该方案采用口服常规给药,并逐步增加麻醉性药物治疗的强度。对疼痛的初始治疗,使用阿斯匹林及其他非甾体类抗炎免疫镇痛药。如不能控制,则加用一种弱的阿片类药物,如可待因。如仍不能控制,此时应给强阿片类药物,如吗啡。另外,采用常规给药,而不是视病人需要给予治疗(疼痛复发或加剧)。使麻醉性药物治疗剂量个体化,代谢迅速的病人给予高剂量后,能获得较好的镇痛效果。

关键词：病人疼痛麻醉性

含酯基和酰胺基支链的苯并菲液晶电荷传输性质的量子化学研究

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化学学报 2008年第7期66卷 738-744页

作者：孙定光丁涪江赵可清四川师范大学化学与材料科学学院成都610066

根据marcus半经典模型,计算了支链中含酰胺基和含酯基的苯并菲盘状液晶化合物C18h6(OC2h5)3(OCh2CO-NhCh3)3和C18h6(OC2h5)3(OCh2COOCh3)3的电荷转移反应的速率常数.这两种化合物的支链都可以对称性分布,也可以非对称性分布.计算表明,... 详细信息

根据marcus半经典模型,计算了支链中含酰胺基和含酯基的苯并菲盘状液晶化合物C18h6(OC2h5)3(OCh2CO-NhCh3)3和C18h6(OC2h5)3(OCh2COOCh3)3的电荷转移反应的速率常数.这两种化合物的支链都可以对称性分布,也可以非对称性分布.计算表明,支链排列的对称性对电荷转移矩阵元和电荷传输速率常数的影响很大,非对称性分子的正电荷传输速率常数和负电荷传输速率常数均大于对称性分子.所以,取代基非对称性排列对增加电荷传输速率常数有利.其原因是支链非对称排列的分子的质量中心与几何中心不重合,当液晶分子绕质量中心旋转的同时形成了分子间的相对平移,从而增大了电荷转移矩阵元.本文为设计、改善液晶分子的电荷传输性能提供了一条新的思路.

关键词：苯并菲盘状液晶电荷转移反应 marcus半经典模型量子化学计算