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多环芳烃的慢性暴露对人体皮肤微生物菌群的影响

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中华皮肤科杂志 2021年第4期54卷 368-369页

作者： marcus l Xinzhao T Philippe B 不详

多环芳烃(PAhS)是一类可通过吸入、食入和经皮吸收的方式进入体内和血液循环中的有机污染物,常常存在于大气的颗粒物中。虽然已知皮肤对PAhs的慢性暴露可能与皮肤的过早老化、色素沉着、痤疮和皮肤肿瘤有关,但我们对其确切机制仍缺乏了... 详细信息

多环芳烃(PAhS)是一类可通过吸入、食入和经皮吸收的方式进入体内和血液循环中的有机污染物,常常存在于大气的颗粒物中。虽然已知皮肤对PAhs的慢性暴露可能与皮肤的过早老化、色素沉着、痤疮和皮肤肿瘤有关,但我们对其确切机制仍缺乏了解。与此同时,随着皮肤表面微生物菌群对宿主皮肤健康影响的研究不断深人,有研究证实皮肤共生菌群可降解不同的PAhs及与其相关的外源性成分。由于PAhs暴露与皮肤微生态之间可能存在潜在关联,因此有必要进一步探索PAhs对皮肤微生物菌群的影响机制。

关键词：多环芳烃有机污染物微生物菌群皮肤肿瘤皮肤健康血液循环经皮吸收色素沉着

An uncommon cause of gastro-duodenal ulceration

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World Journal of Gastroenterology 2008年第16期14卷 2593-2595页

作者： Sebastian Mallach Uwe Ramp Andreas Erhardt marcus Schmitt Dieter hussinger Klinik für Gastroenterologie Hepatologie und Infektiologie Heinrich-Heine-Universitt Düsseldorf Moorenstr. 5 Düsseldorf D-40225 Germany Institut für Pathologie Heinrich-Heine-Universitt Düsseldorf Moorenstr. 5 Düsseldorf D-40225 Germany

Gastrointestinal ulcers occur frequently and are mainly caused by h pylori infection. In this report, we present a rare case of gastro-duodenal ulcer following selective internal radiation therapy (SIRT). SIRT is a palliative treatment for unresectable liver tumours. During SIRT, 90Y-microspheres are infused into the hepatic artery. Pre- treatment evaluation for the presence of arterial shunts to neighbouring organs should be determined in order to avoid complications of SIRT.

关键词： Selective internal radiation therapy Duodenalulcer Colon carcinoma hepatic metastases Gastroscopy

A Ghz chirped amplitude-modulated laser for high-contrast plasma gratings

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high Power laser Science and Engineering 2024年第1期12卷 74-83页

作者： Michael Valdman Amir hen Gilad marcus Applied Physics Institute Hebrew University of JerusalemJerusalemIsrael

The generation and control of large amplitude plasma gratings and other plasma structures is of paramount importance for the realization of plasma photonics. Autoresonant excitation of such structures by means of chirped amplitude-modulated lasers has been recently discussed and analyzed theoretically. here we discuss the parameter space for the realization of such a scheme and describe the laser system that was built towards this goal. We also expand our earlier theoretical study to account for the more realistic case of a moderately focused laser beam, instead of the simplified plane wave approximation.

关键词： amplitude modulation high-frequency modulation autoresonance ion acoustic wave

A simple method for pulse contrast enhancement via self-focusing

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high Power laser Science and Engineering 2024年第2期12卷 51-61页

作者： Zaharit Refaeli Gilad marcus Yariv Shamir Applied Physics Division Soreq NRCYavneIsrael Applied Physics Institute The Hebrew UniversityThe Edmond J.Safra Campus-Givat RamJerusalemIsrael

here we report on a simple-to-implement and cost-effective approach for laser pulse contrast enhancement,based on the χ(3)nonlinear self-focusing *** intentionally induced and gently controlled self-focusing in a thin glass transforms the time-dependent intensity into variation in beam *** by a spatial discriminating filter,only the strongly focused fraction traverses the setup,at the expense of efficiency.A numerical model,accounting for the pulse and material parameters via a Gaussian ABCD matrix,provides an estimate for the instantaneous beam waist and transmission efficiency,which enables us to evaluate the resulting contrast *** estimated contrast enhancement spans between 0.5 and 2.5 orders of magnitude,in conjunction with approximately 25%–90%estimated efficiency,depending on the pulse *** a preliminary experiment we demonstrated the effect with 10s-μJ sub GW regime with approximately 40%efficiency and a contrast improvement of more than or equal to 20 dB.

关键词： nonlinear optics pulse contrast self-focusing ultrafast laser

Transplantation in autoimmune liver diseases

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World Journal of Gastroenterology 2008年第21期14卷 3388-3395页

作者： marcus Mottershead James Neuberger liver Unit Queen Elizabeth HospitalBirmingham B15 2THUnited Kingdom

liver transplantation remains an effective treatment for those with end-stage disease and with intractable liver-related *** shortage of organs for transplantation has resulted in the need for rationing.A variety of approaches to selection and allocation have been developed and vary from country to *** shortage of donors has meant that new approaches have to be adopted to make maximal use of the available organs;these include splitting grafts,use of extended criteria livers,livers from non-heart-beating donors and from living *** transplantation,most patients will need life-long immunosuppression,although a small proportion can have immunosuppression successfully *** immunosuppressive drugs and different strategies may allow a more targeted approach with a reduction in side-effects and so improve the patient and graft *** autoimmune diseases,transplantation is associated with significant improvement in the quality and length of *** may recur after transplantation and may affect patient and graft survival.

关键词： liver transplantation Autoimmune disease Recurrence Immunosuppression

Scanning probe lithography on calixarene towards single-digit nanometer fabrication

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International Journal of Extreme Manufacturing 2020年第3期2卷 104-124页

作者： marcus Kaestner Ivo W Rangelow Institute of Micro-and Nanoelectronics Nanoscale Systems GroupFaculty of Electrical Engineering and Information TechnologyIlmenau University of TechnologyGustav-Kirchhoff-Str.198693 IlmenauGermany

Cost effective patterning based on scanning probe nanolithography(SPl)has the potential for electronic and optical nano-device manufacturing and other nanotechnological *** of the fundamental advantages of SPl is its capability for patterning and imaging employing the same *** is achieved with self-sensing and self-actuating cantilevers,also known as‘active'*** we used active cantilevers to demonstrate a novel path towards single digit nanoscale patterning by employing a low energy(lectron exposure to thin films of molecular *** tuning the electron energies to the lithographically relevant chemical resist transformations,the interaction volumes can be highly *** method allows for greater control over spatially confined lithography and enhances *** found that at low electron energies,the exposure in ambient conditions required approximately 10 electrons per single calixarene molecule to induce a crosslinking *** sensitivity was 80-times greater than a classical electron beam exposure at 30 *** operating the electro-exposure process in ambient conditions a novel lithographic reaction scheme based on a direct ablation of resist material(positive tone)is presented.

关键词： nanofabrication field-emission scanning probe lithography single nanometer lithography molecular resist

儿童阻塞性睡眠呼吸暂停综合征手术干预后的相关问题

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中国循证儿科杂志 2016年第1期11卷 1-2页

作者： Carole l.marcus 申昆玲许志飞美国宾夕法尼亚大学费城儿童医院呼吸科首都医科大学附属北京儿童医院呼吸科

申昆玲教授很高兴在＂北京国际儿科发展论坛暨呼吸分论坛＂中与美国宾夕法尼亚大学费城儿童医院呼吸科睡眠中心的负责人Carole ***教授相聚,值此荣幸地邀请marcus教授参加儿童阻塞性睡眠呼吸暂停综合征（OSAS）手术干预后的相关问题的... 详细信息

申昆玲教授很高兴在＂北京国际儿科发展论坛暨呼吸分论坛＂中与美国宾夕法尼亚大学费城儿童医院呼吸科睡眠中心的负责人Carole ***教授相聚,值此荣幸地邀请marcus教授参加儿童阻塞性睡眠呼吸暂停综合征（OSAS）手术干预后的相关问题的专家对谈录。OSAS在儿童中较为常见,发病率3%~5%,可引起儿童生长发育落后、心血管和神经认知问题。腺样体、扁桃体肥大是儿童OSAS的主要病因,腺样体、扁桃体切除术是儿童OSAS的一线治疗方法。手术是有创的治疗方法,

关键词：手术干预腺样体费城儿童医院扁桃体肥大神经认知扁桃体切除术睡眠呼吸障碍呼吸科阻塞性呼吸暂停认知功能