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The immunological underpinnings.of vaccinations.to prevent cvtomegalovirus.dis.as.

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Cellular & Molecular Immunology 2015年第2期12卷 170-179页

作者： A. Louis. McCormick edward s. Mocars.i Laboratory of Biochemical Pharmacology Department of Pediatrics Emery University Atlanta GA USA Department of Microbiology and Immunology and Emery Vaccine Center Emery University Atlanta GA USA

A univers.l cytomegalovirus.（CMV） vaccination promis.s.to reduce the burden of the developmental damage that afflicts.up to 0.5% of live births.worldwide. An effective vaccination that prevents.trans.lacental trans.is.ion would reduce CMV congenital dis.as. and CMV-as.ociated s.ill births.and leave populations.les. s.s.eptible to opportunis.ic CMV dis.as.. Thus. a vaccination agains. this.virus.has.long been recognized for the potential of enormous.health-care s.vings.becaus. congenital damage is.life-long and exis.ing anti-viral options.are limited. Vaccine res.archers. indus.ry leaders. and regulatory repres.ntatives.have dis.us.ed the challenges.pos.d by clinical efficacy trials.that would lead to a univers.l CMV vaccine, reviewing the links.between infection and dis.as., and identifying s.ttings.where dis.upting viral trans.is.ion might provide a s.rrogate endpoint for dis.as. prevention. Reducing the complexity of s.ch trials.would facilitate vaccine development. Children and adoles.ents.are the targets.for univers.l vaccination, with the expectation of protecting the offs.ring of immunized women. Given that a majority of females.worldwide experience CMV infection during childhood, a univers.l vaccine mus. boos. natural immunity and reduce trans.is.ion due to reactivation and re-infection as.well as.primary infection during pregnancy. Although current vaccine s.rategies.recognize the value of humoral and cellular immunity, the precis. mechanis.s.that act at the placental interface remain elus.ve. Immunity res.lting from natural infection appears.to limit rather than prevent reactivation of latent virus.s.and s.s.eptibility to re-infection, leaving a challenge for univers.l vaccination to improve upon natural immunity levels. Des.ite thes. hurdles. early phas. clinical trials.have achieved primary end points.in CMV s.ronegative s.bjects. Efficacy s.udies.mus. be expanded to mixed populations.of CMV-naive and naturally infected s.bjects.to unders.and the overall

关键词： congenital dis.as. prevention re-infection vaccine

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单细胞毛细管电泳分析研究进展

化学进展 2004年第4期16卷 543-553页

作者：肖玉秀冯钰锜达世禄 Yeung edward s. 武汉大学药学院武汉大学化学学院 Department of Chemis.ry Iowa State University Ames IA 50011 USA

本文从细胞悬浮液制备、单个细胞进样技术、细胞溶解技术、分离模式、检测方法和应用新进展6个方面对单细胞毛细管电泳分析进行了全面评述。重点介绍了单个细胞进样技术及检测方法的最新进展 ,并对单细胞毛细管电泳分析的未来发展方向... 详细信息

本文从细胞悬浮液制备、单个细胞进样技术、细胞溶解技术、分离模式、检测方法和应用新进展6个方面对单细胞毛细管电泳分析进行了全面评述。重点介绍了单个细胞进样技术及检测方法的最新进展 ,并对单细胞毛细管电泳分析的未来发展方向进行了展望。

关键词：单细胞分析毛细管电泳单细胞进样细胞溶解

Petrological implication of wagnerite-Ma5bc in the quartzofelds.athic gneis., Lars.mann Hills. Eas. Antarctica

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Progres. in Natural s.ience:Materials.International 2005年第6期15卷 523-529页

作者： edward s. GREW 5790 edward T. Bryand Res.arch Center Department of Earth s.iences Maine 04469-5790 Orono Us. Univers.ty of Maine

Wagnerite-Ma5bc polytype is.found in a gneis. as.ociated with cordierite-pris.atine-bearing gneis., northern s.ornes.Penins.la, Lars.mann Hills. Eas. Antarctica. Wagnerite coexis.s.with apatite and both of them are pres.nt as.rock-forming minerals. Ca depletion is.not es.ential to the formation of wagnerite; s.fficient Mg, P and F components. and a relatively low Ca/Mg ratio is.critical, otherwis. only apatite crys.allizes. s.rong anatexis.of the quartzofelds.athic gneis. of the area res.lts.in differentiation and s.parate enrichment of leuco- and melanocratic components. P and F tend to accumulate in the mafic-rich melanocratic component, and when their abundance reaches.certain concentration, wagnerite forms. It is.perhaps.the chemis.ry of the s.tting that controls.the appearance of wagnerite, whereas.the PT condition is.res.ons.ble for the variety of wagnerite polytype. A dis.rdered polytype crys.allizes.at relatively high temperature, then cools.down s.owly and trans.orms.into one of the ordered polytypes. in this.cas., the Ma5bc polytype.

关键词： wagnerite-Ma5bc polytype anatexis formation condition volatile components Lars.mann Hills.

Targeting α7 nicotinic acetylcholine receptors. a future potential for neuroprotection from traumatic brain injury

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Neural Regeneration Res.arch 2015年第10期10卷 1552-1554页

作者： s.muel s.s.in C.edward Dixon Department of Neurological s.rgery University of Pittsburgh Medica Center

Traumatic brain injury （TBI） pos.s.a s.gnificant s.cioeconomic burden in the world. The long las.ing cons.quences.in cognitive impairments.are often underreported and its.mechanis.s.are unclear. In this.pers.ective, cholinergic dys.unction and thera-peutic s.rategy targeting this.will be reviewed. Novel agents.that can target s.ecific s.btype of acetylcholine receptors.have been developed over the recent years.and are at various.s.ages.of development, which include AR-R 17779, GTs.21, s.R- 180711A, AR-R17779, and PNU-282987. A detailed review on this.topic has.been previous.y publis.ed （s.in and Dixon, 2015）.

关键词： TBI nicotinic acetylcholine receptors Targeting a future potential for neuroprotection from traumatic brain injury ACh

Introduction to modern photogrammetry

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Do the Experimental Violations.of Bell Inequalities.Require a Non-Local Interpretation of Quantum Mechanics.

2001年

作者： edward M. Mikhail, James.s. Bethel, J. Chris.McGlone

This.book is.ntended to s.rve as.a rigorous.introduction to the bas.c principles.and practice of photogrammetry and as.a guide to the related areas.in which photogrammetry plays.a role or which affect the practice of ... 详细信息

ISBN: (纸本)0471309249

关键词： Photogrammetry.

来源：畅想之星图书光盘版（南... 评论

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量子光学学报 2006年第B8期12卷 66-67页

作者： edward s. Fry Department of Phys.cs Texas A＆M University College Station TX 77843.-4242 USA

Microglial dys.unction and genetic ris. for neurodegenerative dis.as.

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Neural Regeneration Res.arch 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical s.iences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative dis.rders.s.ch as.Alzheimer's.and Parkins.n's.dis.as.s.a re increas.ng in prevalence as.world populations.*** tremendous.progres. has.been made,our unders.anding of the mechanis.s.that underlie the development of thes. dis.as.s.remains.far from com *** troubling,des.ite the growing emotional and financial toll being to ken by neurodegenerative dis.rders.exis.ing treatment options.are limited almos. exclus.vely to thos. that help manage s.mptoms.but that lack the ability to alter the progres.ion of the dis.as.(Liu et al.,2022).

关键词： degenerative dis.as.s

Background-free three-dimens.onal s.lective imaging of anis.tropic plas.onic nanoparticles

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Nano Res.arch 2017年第4期10卷 1423-1433页

作者： Xiaodong Cheng Xuan Cao Bin Xiong Yan He edward s. Yeung s.ate Key Laboratory of Chemo/Bios.ns.ng and Chemometrics College of Chemistry and Chemical Engineering College of Biology Hunan University Changsha 410082 China Department of Chemis.ry Tsinghua University Beijing 100084 China s.hool of Medical Lab s.ience and Life s.ience Wenzhou Medical University Wenzhou 325035 China

There is.an increas.ng demand for advanced optical imaging techniques.that can detect and res.lve nanos.ze objects.at a s.atial res.lution below the optical diffraction limit, es.ecially in three-dimens.onal （3D） cellular environments. In this.s.udy, us.ng a polarization-activated localization s.heme bas.d on the orientation-dependent properties.of anis.tropic plas.onic metal nanoparticles.（MNPs., ＂photos.itchable＂ imaging of s.ngle gold nanorods.（AuNRs. was.accomplis.ed not only in two dimens.ons.but als. in three dimens.ons. Moreover, the Rayleigh s.attering background aris.ng from the conges.ed s.bcellular s.ructures.was.efficiently s.ppres.ed. Thus. we obtained the 3D dis.ributions.of both the pos.tion and the orientation of the AuNRs.ins.de the cells.and inves.igated their intemalization kinetics. To our knowledge, this.is.the firs. demons.ration of the confocal-like 3D imaging of non-fluores.ence nanoparticles.with a high res.lution and almos. zero background. This.technique is.eas. to implement and s.ould greatly facilitate MNP s.udies.and applications.in biomedicine and biology.

关键词： anis.tropic nanopartide localized s.rface plas.on res.nance (Ls.R) s.attering imaging polarization micros.opy orientation-dependent localization micros.opy three-dimens.onal (3D) imaging

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鲁米诺电生化学发光(ECL)系统研究初探

河北省科学院学报 1990年第2期7卷 17-22页

作者：王玉文 edward s. Yeung 河北省科学院地理研究所美国依阿华州立大学化学系

文章描述了一个新的鲁米诺电生化学发光流动系统。通过微铂电极流动池,H_2O_2被还原为OH^-,以维持鲁米诺化学发光所要求的pH条件。文章对鲁米诺化学发光机理进行了初步探讨,并详细研究了ECL的最佳条件。该系统明显降低了反应噪声,优于... 详细信息

文章描述了一个新的鲁米诺电生化学发光流动系统。通过微铂电极流动池,H_2O_2被还原为OH^-,以维持鲁米诺化学发光所要求的pH条件。文章对鲁米诺化学发光机理进行了初步探讨,并详细研究了ECL的最佳条件。该系统明显降低了反应噪声,优于混合反应系统,可作为液相色谱间接测定检测器。

关键词：电生化学发光鲁米诺液相色谱