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对一种暴发性鳜鱼病的调查

畜禽业 1999年第6期10卷 64-65页

作者：魏文康赖远军方葵张健玲卓越孔德胜曾海燕广东省农科院兽医研究所广东江门市江海区农业发展局广东广州珠海动植物检疫局广东省江门市动植物检疫局

广东省传染性非典型肺炎病原体的分离鉴定及检测结果分析

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华南预防医学 2003年第3期29卷 29-31,T001页

作者：黄吉城林锦炎万卓越郑焕英陈秋霞张欣李晖郑夔鄢心革方苓周惠琼江立敏钟豪杰黄平陈经雕刁丽梅张万里谢韶英柯昌文张勤奋崔金明黄小俊张景强广东省疾病预防控制中心微生物检验所广州510300 中山大学生物防治国家重点实验室

目的　对引起广东省传染性非典型肺炎 (SARS)的病原体进行分离鉴定 ,并分析各市首发病例、死亡病例、各个阶段病例的检测情况 ,为该病的诊断和防治提供依据。方法　对 2 0 0 3年 1～ 5月份采自广州、肇庆、江门、汕头、中山、河源、珠... 详细信息

目的　对引起广东省传染性非典型肺炎 (SARS)的病原体进行分离鉴定 ,并分析各市首发病例、死亡病例、各个阶段病例的检测情况 ,为该病的诊断和防治提供依据。方法　对 2 0 0 3年 1～ 5月份采自广州、肇庆、江门、汕头、中山、河源、珠海等地的SARS病例的咽拭子、咽漱液等标本 ,用Vero E6、Vero、MDCK、Hep 2、传代人胚肺 5种细胞进行分离培养 ,并使用电镜、间接免疫荧光 (IFA)、PCR及基因序列测定等方法对分离物进行鉴定 ,应用ELISA、荧光定量PCR等技术分别对各个阶段SARS病例的血清及咽拭子等标本进行检测。结果　 5种细胞接种上述病人咽拭子标本后 ,均有部分出现细胞病变 ,电镜观察可找到冠状病毒样颗粒。分离物扩增出冠状病毒特异基因片断。分离物与病人恢复期血清抗体发生特异性反应。 1～ 5月的病例标本SARS冠状病毒PCR阳性率分别为 1 0 0 0 0 % (2 / 2 )、76 1 9%(1 6 / 2 1 )、71 74 % (33/ 4 6 )、2 0 0 0 % (1 8/ 90 )、6 36 % (1 1 / 1 73) ;SARS冠状病毒抗体IgG阳性率分别为 1 0 0 0 0 % (2 / 2 )、78 5 7% (1 1 / 1 4 )、5 8 33% (1 4 / 2 4 )、30 3% (1 0 / 33)、1 2 5 0 % (9/ 72 )。河源、佛山、肇庆、中山、东莞、珠海六市首发病例均检测出SARS冠状病毒IgG抗体。 1

关键词：广东传染性非典型肺炎病原体分离鉴定检测严重急性呼吸综合征

SURGICAL TREATMENT OF MITRAL STENOSIS

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Chinese Medical Journal 1955年第4期

作者：蘭錫純馮卓榮黄銘新俞國瑞 Departments of Surgery and Medicine Hung Jen Hospital of Shanghai Second Medical College Shanghai

INTRODUCTIONRheumatic mitral stenosis is a common heart disease frequently seenin youth and middle age. Medical treatment can relieve the distress toa certain extent; but most patients succumb within a few years afterthe first attack of heart failure. Statistically, the average life expectancyof such patients is 30 to 45 years of age (1-3); only 12 to 25 per cent liveto more than 50 years ***, as early as in 1898 had foreseen the possibility of a surgicalapproach. Brunton in 1902 suggested the splitting of the diseasedmitral valve, but it was not until 1923 that Cutler (4) performed the firstoperation on mitral stenosis. Two years later, Souttar (5) successfullyseparated the stenosed mitral valve by finger fracture through the atrial

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Paleoclimatic proxies from global closed basins and the possible beginning of Anthropocene

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Journal of Geographical Sciences 2021年第6期31卷 765-784页

作者： LI Yu HAN Qin HAO Lu ZHANG Xinzhong CHEN Dawei ZHANG Yuxin XU Lingmei YE Wangting PENG Simin LI Yichan FENG Zhuowen LIU Hebin Key Laboratory of Western China's Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesCenter for Hydrologic Cycle and Water Resources in Arid RegionLanzhou UniversityLanzhou 730000China

Global closed basins,occupying almost one fifth of the world's land area,spatially coincide with arid and semiarid *** proxies can indicate basin-wide environmental change and human ***,previous studies have not approached the use of proxies in the same way to reconstruct natural and anthropogenic processes at regional and global *** we present a regional study to investigate the basic processes of paleoclimatic proxies,from a typical closed-basin system in arid *** use multiple paleoclimatic proxies of surface samples and sediments,as well as groundwater and sediment ages to study environmental change and human *** then establish a dataset for paleoclimatic proxies from global closed basins and do a numerical analysis on *** studies verify that human activity greatly impacts paleoclimatic proxies,especially with regard to surface samples,as well as groundwater age,but Holocene sediments are less *** from global studies indicate that the major changing trend of the wet/dry status of closed basins is associated with the movement of the westerly jet streams controlled by long-term changes in winter *** is an abrupt change between 1800 AD and 1900 AD,according to a numerical synthesis of paleoclimatic proxies from global closed basins,which can be linked to human *** suggest this time period can be considered as a start point for the Anthropocene based on the sedimentary evidence of closed basins,globally.

关键词： Anthropocene closed basins paleoclimatic proxies westerly jet streams Asian summer monsoon climate change

自拟中草药配合免疫营养疗法治疗晚期胰腺癌临床体会

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黑龙江医药科学 2004年第3期27卷 70-70页

作者：郭丽曼郭公新韩晶莉于文丽袁晓辉卓越武荣国朱有佳木斯大学第一附属医院黑龙江佳木斯154003

胰腺癌是一种恶性程度高、病情进展快的恶性肿瘤,手术切除率低,预后较差,我们于1996-01～2003-01 收治了10例晚期胰腺癌患者,他们均为体质弱、不能放、化疗而失去手术机会,我们采用中西医结合加上营养免疫疗法的综合治疗,收到了良好的效... 详细信息

胰腺癌是一种恶性程度高、病情进展快的恶性肿瘤,手术切除率低,预后较差,我们于1996-01～2003-01 收治了10例晚期胰腺癌患者,他们均为体质弱、不能放、化疗而失去手术机会,我们采用中西医结合加上营养免疫疗法的综合治疗,收到了良好的效果,现将治疗体会报道如下.

关键词：胰腺癌中药治疗免疫营养疗法

OBSERVATIONS ON MITRAL COMMISSUROTOMY

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Chinese Medical Journal 1957年第10期

作者：蘭錫純黄銘新馮卓荣俞国瑞 Departments of Surgery and Medicine Shanghai Second Medical College Shanghai

1. An analysis is made of 159 cases of mitral surgery performed inour college hospital within a period of two years since February *** hundred and twenty-two cases have been followed up for from sixmonths to two years and are classified into excellent 18.9 per cent, im-proved 67.2 per cent, unimproved 9 per cent and worse 4.9 per *** were 3 deaths, the mortality rate being less than 2 per cent.2. On the basis of operative findings coupled with clinical observa-tion, we venture to re-classify the pathological changes of the majorvalve into two main types, namely diaphragmatic and funnel. Thediaphragmatic is divided into three subtypes: 1. fibrotic-edges, 2. fibroticvalve and 3. diaphragmatic funnel.3. In preoperative preparation, attention should be directed towardthe possibility of postoperative hyponatremia.4. The technique of commissurotomy is described. The unglovedfinger method is advocated for the separation of valvular adhesions.5. Postoperative icterus and acute hepatic congestion are ascribed topericardial effusion. A window made in the pericardium behind thephrenic nerve for adequate drainage efficiently prevents this complica-tion. 6. There were 33 cases of postoperative auricular fibrillation (22.1per cent). The preoperative and postoperative administration of quini-dine had no prophylactic value. Our present method of management isdescribed.7. The operative failures and mortalities are analyzed with sug-gestions for improvement.

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牛心包瓣代替心脏瓣膜的早期观察

上海医学 1980年第3期 1-5页

作者：王一山冯卓荣叶椿秀朱洪生范关荣吴国良朱晓萍郑道声陆慧华孙大金武晋鸿陆瑞昶上海第二医学院附属第三人民医院胸外科上海第二医学院附属第三人民医院心内科上海第二医学院附属第三人民医院麻醉科上海第二医学院附属第三人民医院超声心动图室上海第二医学院针麻研究室

本文报告牛心包瓣代替心脏瓣膜11例,其中风湿性二尖瓣关闭不全伴狭窄10例,主动脉瓣关闭不全1例,心代偿功能Ⅳ级者4例,Ⅲ级者7例。手术死亡2例.9例存活者随访3～9月,临床症状大部分消失,二尖瓣区杂音均消失,X线胸片示心影明显缩小,肺充... 详细信息

本文报告牛心包瓣代替心脏瓣膜11例,其中风湿性二尖瓣关闭不全伴狭窄10例,主动脉瓣关闭不全1例,心代偿功能Ⅳ级者4例,Ⅲ级者7例。手术死亡2例.9例存活者随访3～9月,临床症状大部分消失,二尖瓣区杂音均消失,X线胸片示心影明显缩小,肺充血减轻.7例超声心动图示心脏各房室内径均明显缩小,而主动脉内径都明显增大,人工瓣膜开放和关闭线条清晰.6例心阻抗图测定显示心脏排血功能明显改善.心电图改变不明显.

关键词：牛心包瓣房室环术前生物瓣二尖瓣僧帽瓣心瓣膜主动脉瓣关闭不全停搏液换置早期观察架脚低排综合征瓣环

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拔牙术前后类杆菌及梭杆菌变化的临床意义

中国微生态学杂志 1996年第2期8卷 35-35页

作者：马淑霞李丽秋卓越杨景云郑建金吴双燕刘成君张宏伟佳木斯医学院微生物教研室佳木斯医学院附属口腔医院

拔牙术破坏了口腔的正常生理结构，改变了口腔内环境，使菌群失调。未实验对１７名拔牙的患者进行了拔牙术前术后类杆菌、梭杆菌的培养，结果表明，无论是类杆菌还是梭杆菌在拔牙前后都发生了明显的变化，尤其是梭杆菌拔牙后明显高于拔... 详细信息

拔牙术破坏了口腔的正常生理结构，改变了口腔内环境，使菌群失调。未实验对１７名拔牙的患者进行了拔牙术前术后类杆菌、梭杆菌的培养，结果表明，无论是类杆菌还是梭杆菌在拔牙前后都发生了明显的变化，尤其是梭杆菌拔牙后明显高于拔牙前。

关键词：拔牙术类杆菌梭杆菌

Synthesis of poly(amidoamine)-poly(ethyleneglycol)-poly(amidoamine) and preparation of its hydrogel solution containing doxorubicin

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Journal of Chinese Pharmaceutical Sciences 2019年第5期28卷 316-328页

作者： Zhantao Li Ai Liao Man Liu Shuang Zhang Zhenhan Feng Guangxue Wang Jingru Wang Meiqi Xu Zhuoyue Li Xiaochuan Duan Yanli Hao Xiuchai Zheng Hui Li Qin Na Hua Zhang Bilin Liu Xuan Zhang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Department of Pharmaceulics School of Pharmaceutical SciencesPeking University Healuh Science CenterBeijing 100191China Key Laboratory of Xinjiang Phytomedicine Resources and Utilization of Ministry of Education. School of Pharmacy. Shihezi University Shihezi 832000China College of Pharmaceutical Engineering Chongging Chemical Industry Vocational College. Chongging 401228China

Many pH-and temperature-responsive polymers have been designed for preparing *** the present study,in order to decrease the pH sensitivity of reported poly(amidoamine)-poly(ethyleneglycol)-poly(amidoamine)(PAA1580-PEG4600-PAA1580),we designed and synthesized poly(amidoamine)-poly(ethyleneglycol)-poly(amidoamine)(PAA-PEG-PAA)with shorter length of PAA chain by decreasing reaction temperature for preparing PAA-PEG-PAA hydrogel solution containing doxorubicin(DOX).The PAA-PEG-PAA was synthesized via the Michael-addition *** characteristic of PAA-PEG-PAA was *** PAA-PEG-PAA hydrogel solution was prepared and ***-loaded PAA-PEG-PAA hydrogel solution was prepared,and its in vitro DOX release and in vitro anti-tumor activity were *** results indicated that the viscosity of PAA-PEG-PAA hydrogel solution was concentration-and *** sol-gel transition temperature of PAA-PEG-PAA hydrogel solution(12%,w/w)ranged from 35 to 29℃,and its pH ranged from 6.0 to *** released DOX from DOX-loaded PAA-PEG-PAA hydrogel showed sustained release *** in vitro anti-tumor activity of DOX-loaded PAA-PEG-PAA hydrogel was confirmed in B16 F10 cell *** the acidic tumor microenvironment,this DOX-loaded PAA-PEG-PAA hydrogel solution would be easy in situ administration for intra-tumor injection or para-tumor injection forming hydrogel at body *** suggested that this DOX-loaded PAA-PEG-PAAhydrogel solution,if containing photothermal conversion agents,would have a potential further use for photothermal therapy.

关键词： Poly(amidoamine)-poly(ethyleneglycol)-poly(amidoamine)(PAA-PEG-PAA) pH-and temperature-responsive polymer Hydrogel Doxorubicin(DOX) B16F10 cells