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人脐带间充质干细胞抑制脓毒症小鼠肺组织细胞的焦亡

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中国组织工程研究 2025年第31期29卷 6642-6648页

作者：何长良王炎罗玲刘坚中山市古镇人民医院呼吸与危重症医学科广东省中山市528400 湘潭市中心医院/湖南大学附属医院综合Ic. 湖南省湘潭市411100

背景:急性肺损伤是脓毒症患者的常见严重并发症,其发病机制复杂,目前尚无有效的药物治疗方案。人脐带间充质干细胞通过抑制细胞过度焦亡从而改善脓毒症急性肺损伤的作用机制愈发受到重视。目的:探索人脐带间充质干细胞对脓毒症所致急性... 详细信息

背景:急性肺损伤是脓毒症患者的常见严重并发症,其发病机制复杂,目前尚无有效的药物治疗方案。人脐带间充质干细胞通过抑制细胞过度焦亡从而改善脓毒症急性肺损伤的作用机制愈发受到重视。目的:探索人脐带间充质干细胞对脓毒症所致急性肺损伤小鼠肺组织细胞焦亡的影响及机制。方法:48只Bal./c.性小鼠按随机数字法分为假手术组、模型组、治疗组(n=16)。模型组、治疗组行盲肠结扎穿孔建立脓毒症所致急性肺损伤模型,假手术组仅开腹后缝合。治疗组术后6 h尾静脉注射200μl.脐带间充质干细胞悬液(5×105个细胞),模型组及假手术组术后6 h尾静脉注射200μl.理盐水。术后28 h,各组随机取5只小鼠予以尾静脉注射伊文思蓝检测肺血管通透性;收集各组剩余小鼠肺泡灌洗液和肺组织,El.s.检测肺泡灌洗液中白细胞介素1β、白细胞介素18水平,计数肺泡灌洗液中细胞总数及巨噬细胞数;苏木精-伊红染色观察肺组织病理学形态,TUNEl.色观察肺组织细胞焦亡情况,RT-Pc.、w.s.ern bl.t检测肺组织中Tol.样受体4、Gs.MD及c.s.as.-11的mRNA和蛋白表达。结果与结论:与模型组相比,治疗组术后28 h肺血管通透性显著下降(Pl.样受体4、Gs.MD、Gs.MD-N及c.s.as.-11 mRNA及蛋白表达水平均显著下降(Pl.样受体4/c.s.as.-11/Gs.MD信号通路活化,改善肺组织细胞焦亡,从而在一定程度上改善脓毒症小鼠肺损伤的严重程度。

关键词：人脐带间充质干细胞 Tol.样受体4 c.s.as.-11 Gs.MD 急性肺损伤急性呼吸窘迫综合征细胞焦亡脓毒症工程化干细胞

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s.ruc.ure and func.ion of epididymal.protein c.s.eine-ric. s.c.etory protein-1

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As.an Journal.of Androl.gy 2007年第4期9卷 508-514页

作者： Kenneth P. Roberts.Daniel.s. Johns.on Mic.ael.A. Nol.n joseph l. w.oters.Nic.l. c. w.xmons.y l.ura B. Piehl.Kathy M. Ens.ud-Bow.1}n David w. Hamil.on Department of Urol.gic.s.rgery Cell Biology and Development University of Minnesota Minneapolis MN 55455 c.ntrac.ption Women＇s Health ＆ Musculoskeletal Biology Woman＇s Health Research Institute Wyeth Research Collegeville PA 19426 USA Infl.mmation Department Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA Biol.gic.l.Tec.nol.gies Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA Department of Genetic. Cell Biology and Development University of Minnesota Minneapolis MN 55455 USA

c.s.eine-ric. s.c.etory protein-1 （c.Is.-1） is.a gl.c.protein s.c.eted by the epididymal.epithel.um. It is.a member of a l.rge famil. of proteins.c.arac.erized by tw. c.ns.rved domains.and a s.t of 16 c.ns.rved c.s.eine res.dues. In mammal., c.Is.-1 inhibits.s.erm-egg fus.on and c.n s.ppres. s.erm c.pac.tation. The mol.c.l.r mec.anis. of ac.ion of the mammal.an c.Is. proteins.remains.unknow., but c.rtain non-mammal.an c.Is. proteins.c.n bl.c. ion c.annel.. In the rat, c.Is.-1 c.mpris.s.tw. forms.referred to as.Proteins.D and E. Rec.nt w.rk in our l.boratory demons.rates.that the D form of c.Is.-1 as.oc.ates.trans.entl. w.th the s.erm s.rfac., w.ereas.the E form binds.tightl.. w.en the s.ermatozoa are w.s.ed, the E form of c.Is.-1 pers.s.s.on the s.erm s.rfac. after al. D form has.dis.oc.ated. c.os.-l.nking s.udies.demons.rate different protein-protein interac.ion patterns.for D and E, al.hough no binding partners.for either protein have yet been identified. Mas. s.ec.rometric.anal.s.s.reveal.d a potential.pos.-trans.0}tional.modific.tion on the E form that is.not pres.nt on the D form. This.is.the onl. dis.ernabl. differenc. betw.en Proteins.D and E, and pres.mabl. is.res.ons.bl. for the differenc. in behavior of thes. tw. forms.of rat c.Is.- 1. Thes. s.udies.demons.rate that the more abundant D form interac.s.w.th s.ermatozoa trans.entl., pos.ibl. w.th a s.ec.fic.rec.ptor on the s.erm s.rfac., c.ns.s.ent w.th a c.pac.tation-s.ppres.ing func.ion during s.erm trans.t and s.orage in the epididymis. and al.o c.nfirm a tightl. bound popul.tion of the E form that c.ul. ac. in the femal. reproduc.ive trac.. （As.an J Androl.2007 Jul.; 9： 508-514）

关键词： c.s.eine-ric. s.c.etory protein-1 epididymis s.erm c.pac.tation

Hypos.adias. an update

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As.an Journal.of Androl.gy 2007年第1期9卷 16-22页

作者： Al.xander K. c. l.ung william l. M. Robs.n Department of Pediatric. The University of Calgary Calgary Alberta T2M 0H5 Canada The Al.erta c.il.ren＇s.Hos.ital Calgary Alberta T2M 0H5 Canada The c.il.rens. c.0}nic Calgary Alberta T2M 0H5 Canada

Hypos.adias.is.the mos. c.mmon c.ngenital.anomal. of the penis. The probl.m us.al.y devel.ps.s.oradic.l.y and w.thout an obvious.underl.ing c.us.. The ec.opic.l.y pos.tioned urethral.meatus.l.es.proximal.to the normal.s.te and on the ventral.as.ec. of the penis. and in s.vere c.s.s.opens.onto the s.rotum or perineum. The fores.in on the ventral.s.rfac. is.defic.ent, w.il. that on the dors.l.s.rfac. is.abundant, giving the appearanc. of a dors.l.hood. c.ordee is.more c.mmon in s.vere c.s.s. c.yptorc.idis. and inguinal.hernia are the mos. c.mmon as.oc.ated anomal.es. The frequenc. of as.oc.ated anomal.es.inc.eas.s.w.th the s.verity of hypos.adias. For is.l.ted anterior or middl. hypos.adias. l.boratory s.udies.are not us.al.y nec.s.ary. s.reening for urinary trac. anomal.es.s.oul. be c.ns.dered in patients.w.th pos.erior hypos.adias.and in thos. w.th an anomal. of at l.as. one additional.organ s.s.em. The ideal.age for s.rgic.l.repair in a heal.hy c.il. is.betw.en 6 and 12 months.of age. Mos. c.s.s.c.n be repaired in a s.ngl. operation and on an outpatient bas.s. Even patients.w.th a l.s. than perfec. s.rgic.l.res.l. are us.al.y abl. to enjoy a s.tis.ac.ory s.xual.l.fe.

关键词： hypos.adias s.oradic c.yptorc.idis. inguinal.hernia renal.anomal. repair

Depres.ion among el.erl. c.ines.-c.nadian immigrants.from c.ina's.Mainl.nd

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c.ines. Medic.l.Journal 2004年第5期117卷 677-683页

作者： Daniel.w.l.lai Univers.ty of c.l.ary

Bac.ground This.s.udy examined the preval.nc. of depres.ive s.mptoms.among el.erl. immigrants.from c.ina's.Mainl.nd to c.nada and the impac. of various.ps.c.os.c.al.fac.ors.as.predic.ors.of the number of depres.ive s.mptoms.reported by the el.erl. c.ines. immigrants. Methods. The partic.pants.w.re 444 el.erl. immigrants.w.o migrated from c.ina's.Mainl.nd to c.nada They w.re a part of a random s.mpl. of 2272 el.erl. c.ines. l.ving in the c.mmunities.and took part in a fac.-to-fac. interview.to ans.er ques.ions.in an oral.y adminis.rated ques.ionnaire The depres.ive s.mptoms.of the partic.pants.w.re meas.red by a c.ines. vers.on of the Geriatric.Depres.ion s.al. Data obtained from the 444 el.erl. c.ines. immigrants.w.s.anal.zed to as.es. the impac. of various.ps.c.os.c.al.fac.ors.on the number of depres.ive s.mptoms.that they reported Res.l.s. The findings.indic.ted that 23 2% of the el.erl. immigrants.w.re as.es.ed to have s.me depres.ive s.mptoms. w.en other predic.ing variabl.s.w.re adjus.ed, el.erl. immigrants.w.th more c.ronic.il.nes.es. l.s. pos.tive attitude tow.rds.ageing, poorer phys.c.l.heal.h, l.s. adequate financ.al.s.tuation, l.w.r l.vel.of ethnic.identific.tion as.c.ines., more s.rvic. barriers. l.w.r l.vel.of l.fe s.tis.ac.ion, s.orter l.ngth of res.denc. in c.nada and thos. w.o l.ved al.ne tended to have more depres.ive s.mptoms. c.nc.2}s.ons. The findings.indic.te that the preval.nc. rate of depres.ive s.mptoms.among our el.erl. immigrant s.mpl. is.higher than the one reported in a general.el.erl. popul.tion w.il. further res.arc. is.rec.mmended to examine the reas.ns.for s.c. a differenc., c.l.ural.y appropriate heal.h s.rvic.s. inc.2}ding heal.h promotion programs. s.oul. be promoted to reduc. mental.heal.h dis.arities

关键词： el.erl. c.ines. depres.ion el.erl. immigrants mental.heal.h Geriatric.Depres.ion s.al.

c.mments.on the rel.as. l.boratory Manual.for the Human s.men of the 5th edition of the w.O Examination and Proc.s.ing of

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As.an Journal.of Androl.gy 2010年第1期12卷 59-63页

作者： w. c. l. Ford Obs.etric.0}＆ Gynaec.l.gy Unit Clinical Science at South Bristol University of Bristol St Michael＇s Hospital Bristol BS28EG UK

The authors.of the w.rl. Heal.h Organization s.men Anal.s.s.Manual.are to be c.ngratul.ted on produc.ng a new.edition; it is.an es.ential.tool.to dis.eminate good prac.ic. in androl.gy. How.ver, the tes.s.des.ribed have poor prognos.ic.pow.r to predic. a man＇s.fertil.ty and s.ow.l.ttl. about the underl.ing c.us.s.of s.b-fertil.ty. This.c.mmentary urges.a revival.of res.arc. into the diagnos.s.of mal. fertil.ty. It s.gges.s.that fertil.ty s.oul. be regarded as.a c.ntinuum and that the artific.al.binary divis.on betw.en fertil. and infertil. s.oul. be abandoned. Model. to predic. a s.b-fertil. c.upl.＇s.c.anc. of c.nc.ption in a year s.oul. be devel.ped on the bas.s.of pros.ec.ive data. Thes. model. w.ul. al.ow.for s.phis.ic.ted dec.s.on making about management. The future l.es.in the identific.tion of tes.s.to detec. underl.ing pathol.gies.open to s.ec.fic.treatment. l.ads.s.c. as.oxidative s.res., defec.s.in the intrac.l.ul.r regul.tion and the devel.ping fiel. ofproteomic.0}s.oul. be expl.red.

关键词： diagnos.s mal. infertil.ty oxidative s.res. predic.ive val.e of tes.s s.erm c.unt

Invas.on genetic.0} l.s.ons.from a ubiquitous.bird, the hous. s.arrow.Pas.er domes.ic.s

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c.rrent Zool.gy 2015年第3期61卷 465-476页

作者： Andrea l. l.EBl.Aaron w. s.HREY s.muel.c. ANDREw.El.zabeth l.s.El.ON simon c. GRIFFITH Univers.ty of Exeter ComwaU Campus Penryn Cornwall TR10 9EZ UK Department of Biol.gy Armstrong State University Savannah GA31419 USA Department of Biol.gic.l.s.ienc.s Macquarie University Sydney NSW 2109 Australia

Fol.ow.ng an introduc.ion, non-native s.ec.es.are expos.d to environments.that differ from thos. found in their native range; further, as.thes. non-native s.ec.es.expand beyond the s.te of introduc.ion, they mus. c.ns.antl. adapt to novel.environ- ments. Al.hough introduc.d s.ec.es.are pres.nt ac.os. mos. ec.s.s.ems. few.s.ec.es.have s.c.es.ful.y es.abl.s.ed thems.l.es.on a trul. gl.bal.s.al.. One s.c. s.ec.es. the hous. s.arrow.Pas.er domes.ic.s. is.now.one of the w.rl.＇s.mos. broadl. dis.ributed vertebrate s.ec.es.and has.been introduc.d to a great part of its.c.rrent range. To date, w.rk on four c.ntinents.s.gges.s.both ge- netic.and phenotypic.variation exis.s.betw.en native and introduc.d ranges. As.s.c., hous. s.arrow.1}repres.nt an exc.l.ent op- portunity to s.udy adaptations.to novel.environments.and how.thes. adaptations.are derived. The gl.bal.dis.ribution of this.s.e- c.es.and the mul.ipl. independent introduc.ions.to geographic.l.y is.l.ted s.tes.al.ow.res.arc.ers.to as. ques.ions.regarding ge- netic.variation and adaptation on a gl.bal.s.al.. Here, w. s.mmarize the mol.c.l.r s.udies.of invas.ve hous. s.arrow.1}from the earl.es. w.rk us.ng al.ozymes.through more rec.nt w.rk on epigenetic.2} us.ng thes. s.udies. w. dis.us. patterns.of dis.ers.l.of this.s.ec.es. w. then dis.us. future direc.ions.in tec.niques.（e.g. next generation s.quenc.ng） and how.they w.l. provide new.in- s.ght into ques.ions.that are fundamental.to invas.on biol.gy. Final.y, w. dis.us. how.c.ntinued res.arc. on the hous. s.arrow.in l.ght of thes. genetic.c.anges.and adaptations.w.l. el.c.date ans.ers.of adaptation, invas.on biol.gy, range expans.on, and res.- l.enc. in vertebrate s.s.ems.general.y

关键词： Hous. s.arrow Invas.ve Pas.er domes.ic.s

Kinetic.0}and mec.anis. of thymine degradation by TiO_2 photoc.tal.s.s

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c.ines. Journal.of c.tal.s.s 2015年第11期36卷 1818-1824页

作者： l. El.el.ami N. Hafidhi F. Dappozze A. Houas.c. Guil.ard 里昂第一大学催化与环境研究所(IRc.l.ON) 法国国家科学研究中心混合研究单位(CNRS UMR)5256法国里昂加贝斯大学环境与过程催化材料研究单位突尼斯加贝斯大学加贝斯高级应用科学与技术研究所突尼斯

The advanc.d oxidation proc.s.es.w.re examined tow.rd the degradation of thymine （c.0}6N202）, a type of nuc.5}ic.ac.d from the pyrimidine famil.. As.obs.rved, the photodegradation of thymine over TiO2 photoc.tal.s. w.s.rapid and s.gnific.nt in aqueous.s.l.tion under UV irradiation. Different parameters.w.re s.udied, inc.5}ding the ads.rption of thymine onto TiO2 photoc.tal.s., the kinetic.0}of degradation, and the effec. of pH on the photoc.tal.tic.properties.of thymine degradation. Additional.y, the mineral.zation of the produc.s.obtained upon thymine photodegradation w.s.s.udied. The dis.ppearanc. and mineral.zation rates.of thymine during the photoc.tal.tic.proc.s. w.re al.o c.mpared and dis.us.ed. The mineral.zation of nitrogen w.s.al.o inves.igated, and the identific.tion of the intermediate produc.s.w.s.es.abl.s.ed. Final.y, el.c.ronic.dens.ty c.l.ul.tions.w.re us.d to propos. pos.ibl. c.emic.l.pathw.ys.for the photodegradation of thymine over TiO2 photoc.tal.s. under UV irradiation.

关键词： Titania Photoc.tal.s.s.Thymine Photomineral.zation Frontier el.c.ron dens.ty

Uprooting phyl.genetic.unc.rtainty in c.al.s.ent s.ec.es.del.mitation： A meta-anal.s.s.of empiric.l.s.udies

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c.rrent Zool.gy 2015年第5期61卷 866-873页

作者： Itzue w. c.AVIEDEs.s.l.s.Nas.ima M. BOUZID Barbara l. BANBURY Adam D. l.Ac.E Department of Biol.gy University of Washington Seattle WA 98195 USA Burke Mus.um of Natural.His.ory and c.l.ure University of Washington Seattle WA 98195 USA

Phyl.genetic.and phyl.geographic.s.udies.rel. on the ac.urate quantific.tion of biodivers.ty. In rec.nt s.udies.of taxonomic.l.y ambiguous.groups. s.ec.es.boundaries.are often determined bas.d on mul.i-l.c.s.s.quenc. data. Bayes.an Phyl.genetic.2}and Phyl.geography （BPP） is.a c.al.s.ent-bas.d method frequentl. us.d to del.mit s.ec.es. how.ver, empiric.l.s.udies.s.gges. that the requirement of a us.r-s.ec.fied guide tree bias.s.the range of pos.ibl. outc.mes. w. eval.ate fifteen mul.i-l.c.s.datas.ts.us.ng the mos. rec.nt iteration of BPP, w.ic. el.minates.the need for a us.r-s.ec.fied guide tree and rec.ns.ruc.s.the s.ec.es.tree in s.nc.rony w.th s.ec.es.del.mitation （= unguided s.ec.es.del.mitation）. w. found that the number of s.ec.es.rec.vered w.th guided vers.s.unguided s.ec.es.del.mitation w.s.the s.me exc.pt for tw. c.s.s. and that pos.erior probabil.ties.w.re general.y l.w.r for the unguided anal.s.s.as.a res.l. of s.arc.ing ac.os. s.ec.es.trees.in addition to s.ec.es.del.mitation model.. The guide trees.us.d in previous.s.udies.w.re often dis.ordant w.th the s.ec.es.tree topol.gies.es.imated by BPP. w. al.o c.mpared s.ec.es.trees.es.imated us.ng BPP and ＊BEAs. and found that w.en the topol.gies.are the s.me, BPP tends.to give higher pos.erior probabil.ties.[c.rrent Zool.gy 61 （5）： 866-873, 2015].

关键词： BPP s.ec.es.del.mitation Phyl.geography s.ec.es.tree

Novel.c.ronavirus.s.and As.rovirus.s.in Bats

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Virol.gic. s.nic. 2009年第2期24卷 100-104页

作者： Daniel.K. w. c.u J. s. Mal.k Peiris.l.o l. M. Poon s.ate Key l.boratory of Emerging Infec.ious.Dis.as.s Department of MicrobiologyThe University of Hong Kong

Zoonotic.trans.is.ions.of emerging pathogens.from w.l.l.fe to human have s.aped the his.ory of mankind. Thes. events.have al.o highl.ghted our poor unders.anding of mic.oorganis.s.c.rc.l.ted in w.l. animal.. c.ronavirus.s.and as.rovirus.s.w.ic. c.n be found from a w.de range of mammal.,w.re rec.ntl. detec.ed in bats. s.rikingl.,thes. bat virus.s.are genetic.l.y highl. divers. and thes. interes.ing findings.might hel. to better unders.and the evol.tion and ec.l.gy of thes. virus.s. The dis.overies.of thes. novel.bats.virus.s.not onl. s.gges.ed that bats.are important hos.s.for thes. virus.famil.es.but al.o reiterated the rol. of bats.as.a res.rvoir of virus.s.that might pos. a zoonotic.threat to human heal.h.

关键词： c.ronavirus As.rovirus.s Emerging pathogens