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Fuzzy Difference Equations in Diagnos.s of Glaucoma from Retinal Images Using Deep learning

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Computer modeling in Engineering & sciences 2024年第4期139卷 801-816页

作者： D.Dorathy Prema Kavitha l.Francis Raj sandeep Kautish Abdulaziz s.Almazyad Karam m.sallam Ali Wagdy mohamed Department of mathematics Voorhees CollegeVelloreTamil NaduIndia Chandigarh Group of Colleges JhanjeriMohaliPunjabIndia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Faculty of science and Technology School of IT and SystemsUniversity of CanberraCanberraAustralia Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied science Research Center Applied Science Private UniversityAmman11937Jordan

The intuitive fuzzy set has found important application in decision-making and machine *** enrich and utilize the intuitive fuzzy set,this.study designed and developed a deep neural network-based glaucoma eye detection using fuzzy difference equations in the domain where the retinal images *** image detections are categorized as norm.l eye recognition,s.spected glaucomatous eye recognition,and glaucomatous eye *** degrees associated with weighted values are calculated to determine the level of concentration between the fuzzy partition and the retinal *** proposed model was used to diagnose glaucoma using retinal images and involved utilizing the Convolutional Neural Network(CNN)and deep learning to identify the fuzzy weighted regularization between *** methodology was used to clarify the input images and make them adequate for the process of glaucoma *** objective of this.study was to propose a novel approach to the early diagnos.s of glaucoma using the Fuzzy Expert s.stem(FEs)and Fuzzy differential equation(FDE).The intensities of the different regions in the images and their respective peak levels were *** the peak regions were identified,the recurrence relationships among those peaks were then *** partitioning was done due to varying degrees of sim.lar and dissim.lar concentrations in the *** and dissim.lar concentration levels and spatial frequency generated a threshold image from the combined fuzzy matrix and *** distinguished between a norm.l and abnorm.l eye condition,thus detecting patients with glaucomatous eyes.

关键词： Convolutional Neural Network(CNN) glaucomatous eyes fuzzy difference equation intuitive fuzzy sets image segmentation retinal images

由超拍电子伏特加速器产生的超高能伽马射线气泡

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science Bulletin 2024年第4期69卷 449-457页

作者： lHAAsO Collaboration Zhen Cao Chuandong Gao Cong li Ruo-Yu liu Ruizhi Yang 不详 Key laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary science Shandong UniversityQingdao 266237China school of Astronomy and space science Nanjing UniversityNanjing 210023China University of science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,im.lying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive m.lecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported m.lti-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium star cluster

measuring Impact of lean manufacturing Tools for Continuous Improvement on Economic s.stainability

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Journal of s.stems.science and s.stems Engineering 2024年第4期33卷 452-474页

作者： luis Javier márquez Figueroa Jorge luis García-Alcaraz Ahmed IOsman Alfonso Jes.s Gil lópez Yashar Aryanfar mika sillanpää mamdouh El Haj Assad Department of Electrical Engineering and Computer science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Department of Industrial Engineering and manufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico school of Chemistry and Chemical Engineering Queens UniversityBelfastNorthern IrelandUK Department of Economic and managerial sciences University of La RiojaLa RiojaSpain Department of Chemical Engineering University of JohannesburgJohannesburgSouth Africa Department of s.stainable and Renewable Energy Engineering University of SharjahSharjahUAE

Using lean manufacturing(lm)tools in production process.s is crucial for companies’economic,environmental,and social s.stainability *** study shows a structural equation model(sEm)that shows the relationship between lm Tools like Kaizen(KAI),Gemba(GEm),Value stream mapping(Vsm)and Key Performance Indicator(KPI)with Economic s.stainability(ECs).seven hypothes.s were evaluated with data from 179 respons.s to a questionnaire about the mexican maquiladora industry,showing that these variables are *** a 95%confidence level,the model was evaluated using the partial least squares *** findings indicate that the relationships between KAI and GEm and KAI and Vsm have the strongest relationship,followed by Vsm and ECs;however,Vsm has the strongest effect on *** on these findings,it is recommended that managers adopt a continuous improvement(KAI)approach based on working directly on the shop floor(GEm and Vsm)to support their decisions regarding economic growth(ECs).

关键词： lean manufacturing economic s.stainability structural equation model quality improvement

s、Cl表面吸附及其对γ-Fem(111)(m=Cr、Ni、mn、mo、Cu、Ce)腐蚀的理论研究

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中国腐蚀与防护学报 2024年

作者：董楠秦慰蓉韩培德太原理工大学材料科学与工程学院

采用第一性原理计算方法研究了s、Cl在γ-Fem(111)(m=Cr、Ni、mn、mo、Cu、Ce)表面的吸附及其引起的腐蚀，以及拉、压应力对体系表面结构稳定性的影响。计算结果表明：s、Cl在γ-Fe(111)表面最容易吸附于hcp位和fcc位，s和Cl吸附表面的... 详细信息

采用第一性原理计算方法研究了s、Cl在γ-Fem(111)(m=Cr、Ni、mn、mo、Cu、Ce)表面的吸附及其引起的腐蚀，以及拉、压应力对体系表面结构稳定性的影响。计算结果表明：s、Cl在γ-Fe(111)表面最容易吸附于hcp位和fcc位，s和Cl吸附表面的电子功函数降低，耐蚀性能减弱。合金元素Cr、Ni、mn、mo、Cu、Ce与γ-Fe(111)构成的表面耐Cl腐蚀；mo、Cu和Ce可以同步提高γ-Fe(111)表面的抗s、Cl腐蚀能力。压应力作用下，s、Cl吸附的γ-Fem(111)(m=Cr、Ni、mn、mo、Cu、Ce)表面的电子功函数增大，而拉应力下使得表面电子功函数减小，s、Cl吸附与拉应力共同作用将大大降低体系的耐蚀性。

关键词： γ-Fe 腐蚀介质s、Cl 合金化应力电子功函数第一性原理

Comparative analys.s of microstructure,mechanical,and corrosion properties of biodegradable mg-3Y alloy prepared by selective laser m.lting and spark plasma sintering

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Journal of magnesium and Alloys 2024年第4期12卷 1496-1510页

作者： P.minárik m.Zemková s.Šašek J.Dittrich m.Knapek F.lukáˇc D.Koutný J.Jaroš R.Král Faculty of mathematics and Physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic Research Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of Plasma Physics of the Czech Academy of sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of machine and Industrial Design Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work explored possibilities of biodegradable magnesium alloy mg-3Y preparation by two modern powder metallurgy techniques.spark plasma sintering(s.s)and selective laser m.lting(slm).The powder material was consolidated by both methods utilising optimised parameters,which led to very low porosity(∼0.3%)in the slm material and unmeasurably low porosity in the s.s *** main aim of the study was the thorough microstructure characterisation and interrelation between the microstructure and the functional properties.such as mechanical strength,deformability,and corrosion *** materials.showed comparable strength of∼110 mPa in tension and compression and relatively good deformability of∼9%and∼21%for the slm and s.s materials,*** corrosion res.stance of the s.s material in 0.1 m NaCl solution was.superior to the slm one and comparable to the conventional extruded *** digital image correlation during loading and the cross.section analys.s of the corrosion layers revealed that the residual porosity and large strained grains have the dominant negative effect on the functional properties of the slm *** the other hand,one of the primary outcomes of this.study is that the s.s consolidation method is very effective in the preparation of the W3 biodegradable alloy,resulting in material with convenient mechanical and degradation properties that might find practical applications.

关键词： magnesium Yttrium Powder metallurgy microstructure mechanical strength Corrosion res.stance

高室压大流量姿轨控发动机中高空模拟试验扩压器性能与结构方案设计

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航空动力学报 2024年第08期 170-184页

作者：超力德郭红杰张元徐勇梁国柱北京航空航天大学宇航学院

采用热力计算方法、正激波理论、传热理论以及强度理论等方法，开展了液体姿轨控发动机与圆柱形扩压器性能与结构方案匹配设计和理论分析。从扩压器的性能、主要尺寸、换热方式、强度和稳定性校核等方面，给出了确定其性能与结构方案的... 详细信息

采用热力计算方法、正激波理论、传热理论以及强度理论等方法，开展了液体姿轨控发动机与圆柱形扩压器性能与结构方案匹配设计和理论分析。从扩压器的性能、主要尺寸、换热方式、强度和稳定性校核等方面，给出了确定其性能与结构方案的设计计算方法和流程。计算给出了圆柱形扩压器面积比、燃烧室压力比、真空舱压力比以及燃气等熵指数对扩压器的主要尺寸和工作特性的影响曲线。针对推力为5 000 N的某NTO/mmH液体姿轨控发动机的试验需求，设计了内径为1.1 m、长度为8 m、内壁厚度和冷却夹层厚度均为10 mm的圆柱形扩压器，工作包线显示其具备在发动机燃烧室压强为1～5 mPa、最大流量为1～3 kg/s且模拟工作高度为中高空30～60 km高度范围内开展相关试验的能力。研究表明，在扩压器入流和正激波前后引入燃气热力计算的设计方法可获得更加准确的冷却计算所需的燃气热物性参数，因考虑了高温燃气的化学反应从而获得更合理的性能与结构匹配方案，也便于确定已有扩压器的试验能力范围。

关键词：姿轨控发动机高空模拟试验圆柱形扩压器性能计算方案设计

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2-乙基己基二苯基磷酸酯急性暴露对斑马鱼仔鱼脂质代谢和线粒体功能的影响

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生态毒理学报 2024年第3期19卷 9-21页

作者：李涛岳喜凯余丽琴华中农业大学水产学院武汉430070 湖北省池塘水产养殖工程实验室武汉430070 长江经济带大宗水生生物产业绿色发展教育部工程研究中心武汉430070

2-乙基己基二苯基磷酸酯(2-ethylhexyl diphenyl phosphate,EHDPP)是一种典型的有机磷阻燃剂,该化合物的大量使用导致其在环境基质中被频繁检出。大量离体研究表明EHDPP具有干扰脂质代谢的不良影响,但其是否会引起活体脂质代谢紊乱及潜... 详细信息

2-乙基己基二苯基磷酸酯(2-ethylhexyl diphenyl phosphate,EHDPP)是一种典型的有机磷阻燃剂,该化合物的大量使用导致其在环境基质中被频繁检出。大量离体研究表明EHDPP具有干扰脂质代谢的不良影响,但其是否会引起活体脂质代谢紊乱及潜在的机制尚不明确。本研究将斑马鱼胚胎(2 hours post-fertilization,2 hpf)暴露在环境相关浓度(0、1、10、100、250和500μg·l^(-1))EHDPP中5 d,评估EHDPP对仔鱼脂质代谢和线粒体功能的影响。结果表明,和对照组相比,100、250和500μg·l^(-1)EHDPP暴露显著降低仔鱼孵化率、体长、心率和存活率,畸形率升高,表现出显著的生长发育毒性。结果还显示EHDPP引发脂质紊乱,总胆固醇和甘油三酯的含量在500μg·l^(-1)EHDPP暴露组较对照组显著性降低。EHDPP暴露显著降低仔鱼三磷酸腺苷(adenosine triphosphate,ATP)、超氧化物歧化酶(superoxide dismutase,sOD)和谷胱甘肽(glutathione,GsH)水平,活性氧(reactive oxygen species,ROs)水平显著性升高,这提示EHDPP可能会诱发线粒体功能障碍。进一步发现EHDPP暴露导致仔鱼18rs-rrn基因表达显著性下降,而参与调控线粒体分裂(线粒体动力相关蛋白(drp1)和线粒体分裂蛋白(fis1))、融合(视神经萎缩蛋白(opa1))和自噬(PTEN诱导激酶1(pink1)和FUN14域蛋白1(fundc1))的基因表达显著性升高,表明EHDPP引发线粒体功能障碍。参与脂质合成的基因(脂肪酸合酶基因(fas)和载脂蛋白E基因(apoe))显著性降低,而调控脂质代谢的基因,如过氧化物酶体增殖物激活受体α基因(pparα)、过氧化物酶体增殖物激活受体β基因(pparβ)和酰基辅酶A氧化酶1基因(acox1)显著性升高,这些结果表明EHDPP可能引发斑马鱼线粒体功能障碍进而干扰斑马鱼幼鱼的脂肪酸氧化和脂质合成,总的来说,本研究发现EHDPP可能诱发脂质紊乱,并首次在体内实验中表明EHDPP会引发斑马鱼线粒体功能障碍,为EHDPP的毒性机制的研究提供新的思路。

关键词： 2-乙基己基二苯基磷酸酯斑马鱼脂质紊乱线粒体功能障碍

甘草甜素通过调节PI3K/Akt/GsK3β信号通路对脑卒中偏瘫痉挛状态大鼠的痉挛状态的影响

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中国临床药理学杂志 2024年第12期40卷 1779-1783页

作者：胡斌柴德君齐齐哈尔医学院附属第二医院康复医学科黑龙江齐齐哈尔161000

目的研究甘草甜素(GA)通过调节磷酸肌苷3-激酶(PI3K)/蛋白激酶B(Akt)/糖原合成酶激酶3β(GsK3β)信号通路对脑卒中偏瘫痉挛状态大鼠神经行为学的影响。方法用大脑中动脉闭塞(mCAO)建立脑卒中后痉挛(Pss)大鼠模型。将大鼠分为对照组、假... 详细信息

目的研究甘草甜素(GA)通过调节磷酸肌苷3-激酶(PI3K)/蛋白激酶B(Akt)/糖原合成酶激酶3β(GsK3β)信号通路对脑卒中偏瘫痉挛状态大鼠神经行为学的影响。方法用大脑中动脉闭塞(mCAO)建立脑卒中后痉挛(Pss)大鼠模型。将大鼠分为对照组、假手术组、模型组、低剂量甘草甜素组、高剂量甘草甜素组、巴氯芬组。模型组、假手术组和对照组大鼠每天灌胃等量的0.9%NaCl,高剂量甘草甜素组每天灌胃给予10.8 g·kg^(-1)甘草甜素,低剂量甘草甜素组每天灌胃给予5.4 g·kg^(-1)甘草甜素,巴氯芬组每天灌胃5.4 mg·kg^(-1)巴氯芬,连续4周。用改良Ashworth量表评定肌肉张力,用2,3,5-氯化三苯基四氮唑(TTC)染色法分析脑组织中脑梗死体积,用尼氏染色法和透射电镜观察GA对大鼠脑缺血再灌注损伤后神经元损伤的保护作用,用免疫组化染色法检测脑梗死和脑干周围脑组织中磷酸化PI3K(p-PI3K)、磷酸化Akt(p-Akt)和磷酸化GsK3β(p-GsK3β)的表达水平。结果假手术组、模型组、低剂量甘草甜素组、高剂量甘草甜素组和巴氯芬组大鼠脑梗死体积分别为0、(34.23±1.21)%、(24.12±1.03)%、(18.26±1.08)%和(26.38±1.35)%。对照组、假手术组、模型组、低剂量甘草甜素组、高剂量甘草甜素组的尼氏小体含量分别为(126.23±8.13)%、(131.14±9.62)%、(52.21±6.11)%、(84.29±6.17)%和(112.24±8.21)%。在4周时,假手术组、模型组、低剂量甘草甜素组、高剂量甘草甜素组和巴氯芬组的p-PI3K在脑梗死周围的脑组织中的表达分别为5.45±0.44、4.89±0.34、5.54±0.42、20.59±1.35、25.34±1.46和6.47±0.45,p-PI3K在脑干周围的脑组织中的表达分别为14.47±1.48、10.82±1.24、15.39±1.45、13.51±1.32、25.55±1.49和8.84±0.74,p-Akt在脑梗死周围的脑组织中的表达分别为6.47±0.41、6.18±0.32、5.58±0.51、19.54±1.48、28.56±1.48和14.39±1.56,p-Akt在脑干周围的脑组织中的表达分别为6.45±1.41、8.09±1.32、6.05±1.12、13.63±1.45、16.58±1.61和10.75±1.01,p-GsK3β在脑梗死周围的脑组织中的表达分别为8.64±0.52、5.18±0.61、18.54±1.45、39.56±1.63、43.57±1.59和18.43±1.48,p-GsK3β在脑干周围的脑组织中的表达分别为8.04±1.39、6.91±1.01、6.82±1.16、15.59±1.33、15.65±1.18和5.18±0.47。与模型组相比,低剂量甘草甜素组、高剂量甘草甜素组的大鼠脑梗死和脑干周围脑组织中p-PI3K、p-Akt和p-GsK3β的表达均显著上调(均Pss大鼠痉挛的抑制作用可能与上调PI3K/Akt/GsK3β通路有关。

关键词：甘草甜素脑卒中痉挛脑缺血再灌注损伤磷酸肌苷3-激酶/蛋白激酶B/糖原合成酶激酶3β信号通路神经行为学

失能老人EQ-5D-5l自评与代评生命质量及其影响因素分析

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中国卫生经济 2024年第6期43卷 68-74页

作者：荣艺伍红艳徐程熊尧贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室贵阳561113 贵州医科大学医药卫生管理学院贵阳561113 西南财经大学公共管理学院成都611130 安徽财经大学财政与公共管理学院安徽蚌埠233030

目的:测评成都市60岁及以上失能老人自评与代评生命质量并分析其影响因素,评估2类结果的一致性及代评可行性.方法:使用EQ-5D-5l测量失能老人自评与代评的生命质量,应用加权Kappa和ICC进行一致性检验,使用mann-Whitney/Wilcoxon和Kruskal... 详细信息

目的:测评成都市60岁及以上失能老人自评与代评生命质量并分析其影响因素,评估2类结果的一致性及代评可行性.方法:使用EQ-5D-5l测量失能老人自评与代评的生命质量,应用加权Kappa和ICC进行一致性检验,使用mann-Whitney/Wilcoxon和Kruskal-Wallis检验进行单因素与差异性分析,影响因素分析使用了广义线性模型回归.结果:自评、代评健康效用值与EQ-VAs一致性较好(ICC均大于0.70),各维度一致性为尚可或中等(加权Kappa值约为0.40~0.50).失能老人失能程度、经济状况、户外活动与睡眠、照护者与老人的关系、照护者是否掌握照护相关知识等对失能老人生命质量及自评、代评结果差异有统计学意义(Pl代评结果可考虑作为失能老人自评结果的补充,但个别维度需谨慎应用,需考虑被评价对象的人群特征与个人差异、代理人类型、测量工具等.

关键词：失能老人生命质量量表受访者自己评价代理人评价成都