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Associations between polymorphis.s in leptin and leptin receptor genes and colorectal cancer survival

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Cancer Biology & medicine 2023年第6期20卷 438-451页

作者： meizhi Du Yu Wang Jillian Vallis matin shariati Patrick s.Parfrey John R.m.laughlin Peizhong Peter Wang Yun Zhu Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjin 300070China Division of Community Health and Humanities Faculty of MedicineMemorial University of NewfoundlandSt.John's A1B 3V6Canada Clinical Epidemiology Unit Faculty of MedicineMemorial University of NewfoundlandSt.John's A1B 3V6Canada Dalla lana school of Public Health University of TorontoToronto M5T 3M7Canada Beatrice Hunter Cancer Institute Halifax B3H 4R2Canada Centre for New Immigrant Wellbeing Markham L3R 9V1Canada

Objective:leptin(lEP)is an obesity-associated adipokine associated with tumor cell *** examined the relevance of genetic variants of lEP and leptin receptor(lEPR)to colorectal cancer(CRC)survival by using data from the Newfoundland Fam.lial Colorectal Cancer ***:A total of 532 patients newly diagnosed with CRC between 1997 and 2003 were followed up until April *** on their demographics and lifestyles were collected via *** of blood sam.les was performed with the Illumina Human Omni-Quad Bead *** Cox models were used to ass.ss the relationships of 35 tag single-nucleotide polymorphis.s(sNPs)in lEP and lEPR with overall survival(Os),disease-free survival(DFs),and CRC-specific ***:At the gene level,lEP was associated with DFs(P=0.017),and lEPR was associated with both DFs(P=0.021)and CRCspecific survival(P=0.013)in patients with *** single-sNP analys.s,lEP rs11763517,lEPR rs9436301,and lEPR rs7602 were associated with DFs after adjustment for m.ltiple *** lEPR haplotypes G-C-T(rs7534511-rs9436301-rs1887285)and A-A-G(rs7602-rs970467-rs9436748)were associated with prolonged Os among patients with CRC overall(G-C-T:HR,0.63;95%CI,0.43–0.93;A-A-G:HR,0.59;95%CI,0.38–0.91)and those diagnosed with colon cancer(G-C-T:HR,0.54;95%CI,0.34–0.86;A-A-G:HR,0.49;95%CI,0.29–0.83).sim.lar results were observed for ***,significant interactions were found among lEPR rs7602(A vs.G),lEPR rs1171278(T vs.C),red meat intake,and BmI status:the associations between these variants and prolonged DFs were limited to patients with below-median red meat consumption and body mass index(BmI)lymorphic variations in the lEP and lEPR genes were associated with survival of patients after CRC *** lEP/lEPR-CRC survival association was modified by participants’red meat intake and BmI.

关键词： colorectal cancer intake

Thermodynamic study of CN^- ion inhibition of Jack bean urease using the extended solvation theory

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Chinese Chemical letters 2009年第11期20卷 1389-1392页

作者： G.Rezaei Behbehani A.A.saboury m.mohebbian s.Tahmasbi sarvestani m.Poorheravi Chemistry Department Imam Khomeini International UniversityQazvinIran Institute of Biochemistry and Biophysics University of TehranTehranIran Chemistry Department Payame Noor University(PNU)AbharIran

Cyanide ion was.studied as an inhibitor of Jack bean urease at 300 K in 30 mm.l/l tris buffer, pH 7. The inhibition was investigated by isotherm.l titration calorimetry （ITC）. The extended solvation model was used for CN^- ＋ JBU interaction over the whole range of CN^- concentrations. The binding parameters recovered from the solvation model were attributed to the cyanide ion interaction. It was found that cyanide ion acted as a non-cooperative inhibitor ofurease, and there is a set of 12 ± 0.12 identical and independent binding sites for CN- ions. The dissociation equilibrium constant is 749.99 um.l/l. The m.lar enthalpy of binding is AH= -13.60 kJ m.l^-1.

关键词： Jack bean urease Cyanide ion Isotherm.l titration calorimetry Binding parameters Inhibitor

Audi公司新一代1.8l增压燃油分层喷射汽油机(第1部分)——基础发动机及其热管理

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汽车与新动力 2012年第5期 14-19页

作者： Eiser A Doerr J Jung m Adam s 范明强

Audi公司已成功将EA888型4缸汽油机系列的第3代机型,即1.8 l增压燃油分层喷射汽油机投放市场。鉴于日趋严格的二氧化碳排放限值和未来的欧6排放标准,对该机型进行了全面改进,应用了众多的创新技术(例如,集成在气缸盖中的整体式废气冷却)... 详细信息

Audi公司已成功将EA888型4缸汽油机系列的第3代机型,即1.8 l增压燃油分层喷射汽油机投放市场。鉴于日趋严格的二氧化碳排放限值和未来的欧6排放标准,对该机型进行了全面改进,应用了众多的创新技术(例如,集成在气缸盖中的整体式废气冷却),使用了缸内直接喷射和进气道喷射的双重喷油系统,以及采用双凸轮轴相位调节器的可变气门机构(Audi可变气门升程机构)。同时,运用新颖的全电动冷却液调节,使实施创新的热管理成为可能。介绍了这种新一代汽油机的基础发动机及其热管理。

关键词：燃油分层增压热管理降低排放双重喷油系统可变气门升程机构

synchronous optimization of strengths, ductility and corrosion res.stances of bulk nanocrystalline 304 stainless.steel

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Journal of materials.science & Technology 2020年第2期37卷 161-172页

作者： s.G.Wang m.sun s.Y.liu X.liu Y.H.Xu C.B.Gong K.long Z.D.Zhang shenyang National laboratory for materials.science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

structural materials usually suffer from several attacks during their service,such as tension,fatigue and *** is necessary to synchronously improve these properties for their lightweight and longlifetime,but corrosion res.stance and ductility are generally inverse correlation with strength,it is very difficult to sim.ltaneously optimize all three ***,bulk nanocrystalline 304 stainless.steel(BN-304ss)produced by severe rolling technology poss.ssed the larger yield and ultimate tensile strengths with sufficient elongation(>40%)during tensile test,the larger saturation stress and longer lifetime during low-cycle fatigue,the enhanced uniform and pitting corrosion res.stances during fiveday immersion test in 6 m.l/l HCl,the lowered stress corrosion cracking(sCC)s.sceptibility with larger yield(~2.40 GPa)and ultimate tensile(~2.66 GPa)strengths,and enough elongation(>30%)during stress corrosion in comparison with conventional polycrystalline 304 stainless.steel(CP-304 ss)*** uniform and pitting corrosion res.stances of fractured BN-304ss were enhanced in comprsion with those of fractured CP-304 ss during seven-day immersion test in 1 m.l/l *** results demonstrated the strengths,ductility and corrosion res.stances of BN-304ss can be sim.ltaneously optimized by severe rolling *** improved results of BN-304ss in different disciplines were understood by its valence electron configurations rather than traditional microstructural parameters.

关键词： stainless steel Pitting corrosion stress corrosion Tensile properties low-cycle fatigue severe rolling technology

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提高工业废水中总铁的分析准确度

广东化工 2016年第19期43卷 172-173页

作者：伍治群中国石油化工股份有限公司广州分公司广东广州510700

介绍分光光度法分析工业废水中的总铁,采集样品前大约500 m.l水样加入2 m.l浓盐酸,分析时加显色液之前用0.45μm的滤膜抽滤,滤液加显色剂邻菲罗啉比色分析。这样操作大大降低浊度、颗粒物对吸光度的影响,提高分析准确度。

关键词：废水分析总铁抽滤

A high voltage Bi-CmOs compatible buffer super-junction lDmOs with an N-type buried layer

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Journal of semiconductors 2014年第1期35卷 65-69页

作者：伍伟张波方健罗小蓉李肇基 state Key laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China

A novel buffer super-junction （s J） lateral double-diffused mOsFET （lDmOs） with an N-type buried layer （NB） is proposed. An N- buffer layer is im.lemented under the sJ region and an N-type layer is buried in the P substrate. Firstly, the new electric field peak introduced by the p-n junction of the P substrate and the N-type buried layer modulates the surface electric field distribution. secondly, the N-buffer layer suppress.s the substrate ass.sted depletion effect. Both of them improve the breakdown voltage （BV）. Finally, because of the shallow depth of the sJ region, the NB buffer sJ-lDmOs is compatible with Bi-CmOs technology. sim.lation results indicate that the average value of the surface lateral electric field strength of the NB buffer sJ-lDmOs reaches 23 V/μm at 15/μm drift length which results in a BV of 350 V and a specific on-res.stance of 21 mΩ·cm2.

关键词： N-type buried layer breakdown voltage electric field modulation lateral double-diffusion mOsFET super-junction

A study on Risk Factors for Venous Thromboembolism and the Requirement of Thromboprophylaxis in Pregnancy and Postpartum Period in a Tertiary Care Centre in south Asian Country: A Cross.sectional study

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Open Journal of Obstetrics and Gynecology 2023年第3期13卷 403-413页

作者： P. l. A. sirisena s. N. samarakkody B. subhani D. Gunawardana m. A. K. Perera C. Rathnayake De soysa Hospital for Women Colombo Sri Lanka Colombo south Teaching Hospital Colombo Sri Lanka National Hospital of sri lanka Colombo Sri Lanka Provincial Department of Health services Central Province Kandy Sri Lanka Department of Obstetrics and Gynaecology University of Peradeniya Kandy Sri Lanka

Introduction: Thrombos.s is a major cause of maternal death worldwide. During pregnancy, the risk of venous thromboembolism (VTE) increas.s fourfold to five-fold and contributes towards maternal morbidity and mortality. sri lanka does not have a proper ass.ssment tool to detect and manage it in the antenatal care. Objectives: To identify ris.s factors for VTE among pregnant mothers, postpartum mothers according to RCOG (Royal College of Obstetricians) risk categorization and to ass.ss the requirement of thromboprophylaxis. method: A cross.sectional study was conducted at the antenatal clinics and obstetrics and gynaecology wards (ward 2, 5, 8) of De soysa Hospital for Women in 2021. Obstetric thromboprophylaxis risk ass.ssment tool recommended by the RCOG was used for the risk ass.ssment of pregnant mothers during the antenatal and postpartum period. Results: In antenatal period, obesity (BmI > 35), age more than 35 years and parity more than 3 were the commonest risk factors. Out of 404 mothers, 67.33% did not have any risk factors. Among others, 18.56%, 0.40%, 2.72%, 0.99% had a score of 1, 2, 3 and 4 respectively. Patients with intermediate (0.99%) and high risk (2.72%) were commenced on thromboprophylaxis from 28 weeks. The low-risk category was not started on any treatment (28.96%, n = 97). Approximately 96% of mothers did not require any thromboprophylaxis during antenatal period. Another 404 postnatal mothers were recruited for the study group. Elective caesarean section and caesarean section during labour were the main ris.s identified other than pre-existing antenatal ris.s. 39.95 % of mothers did not have any risk factors and 37.22% of mothers had a score of 1. Conclusions: VTE risk ass.ssment tool can be im.lemented at national level to detect patients at risk of VTE and improve maternal care.

关键词： Venous Thromboembolism Postpartum Thromboprophylaxis Cross.sectional study maternal morbidity and mortality

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高效液相色谱测定龙眼核中多酚含量方法优化

广州化工 2023年第22期51卷 61-64页

作者：徐小云伍舒华赖敏成廖延智吴文欧纯宜广东轻工职业技术学院广东广州510030

采用色谱柱C_(18)[Gensial C_(18),5 mm,250 mm×4.6 mm,***1852546],流动相是甲醇∶水=10∶90,流速0.200 ml/min,检测波长254 nm,PDA检测器,建立一个龙眼核多酚高效液相色谱(HPlC)测定方法。样品经甲醇溶解,0.45μm有机滤膜过滤,可知多酚0.5~5μg/μl范围内线性方程为y=100738x,相关系数R=0.9998,呈良好的线性关系,平均回收率为97.8%,相对标准偏差RsD=0.00%。该方法简便快速,操作稳定,重现性好,不仅适用于龙眼核中多酚测定,而且为多酚产品中多酚含量的测定提供技术参考。

关键词： HPlC法龙眼核多酚纯化方法优化

复方扶芳藤合剂影响免疫抑制小鼠CD11b^(+)单核细胞CD69的表达

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海南医学院学报 2023年第23期29卷 1774-1779页

作者：丁健陈果李建明李开奇杨晨一伍月榕广西中医药大学、广西高发传染病中西医结合转化医学重点实验室、广西特色实验动物病证模型重点实验室广西南宁530200 湖北省中医院脾胃病科湖北武汉430060

目的:探讨复方扶芳藤合剂(compound fufangteng mixture,CFm)对免疫抑制小鼠脾及外周血CD11b^(+)单核细胞表面活化分子CD2、CD69及耗竭分子PD-1、CD95表达水平的影响。方法:将30只sPF级Balb/c雄性小鼠随机分为空白组(Control组)、免疫... 详细信息

目的:探讨复方扶芳藤合剂(compound fufangteng mixture,CFm)对免疫抑制小鼠脾及外周血CD11b^(+)单核细胞表面活化分子CD2、CD69及耗竭分子PD-1、CD95表达水平的影响。方法:将30只sPF级Balb/c雄性小鼠随机分为空白组(Control组)、免疫抑制模型组(CTX组)、复方扶芳藤合剂高、中、低剂量干预组(CTX+CFm-H组、CTX+CFm-m组、CTX+CFm.l组)、黄芪(astragalus particles,AP)干预组(CTX+AP组)。各组小鼠连续3 d腹腔注射环磷酰胺(CTX)70 mg/kg,遂按照分组方案分别给药10 d,末次给药24 h后取材。流式细胞术检测小鼠外周血CD11b^(+)单核细胞表面活化分子(CD2、CD69)和耗竭分子(PD-1、CD95)的表达。结果:与Control组相比,CTX+CFm-H组、CTX+CFm-m组、CTX+CFm.l组脾CD11b^(+)CD69表达水平均有改善趋势,并随着复方扶芳藤合剂剂量梯度降低。结论:复方扶芳藤合剂可调节免疫抑制小鼠脾CD11b^(+)细胞CD69的免疫功能。

关键词：复方扶芳藤合剂免疫抑制 CD69 CD95