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Changes in Dietary Patterns and Certain Nutrition-related Diseases in Urban and Rural Residents of jiangsu Province,china,During the 1990s

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Biomedical and Environmental Sciences 2002年第4期15卷 271-276页

作者： WANG CAN-NAN , LIANG ZHI , WEI PING , LIU PEI , YD JiA-Xr, ZHANG DAN-MEI, AND MA FENG-LOUFaculty of Public Health, Xuzhou medical College, Xuzhou, jiangsu 221002, china Bureau ofHealth, jiangsu Provincial Government, nanjing, jiangsu 210008, china Statistical Bureauof jiangsu Provincial Government nanjing, jiangsu 210026, china Health andAnti-epidemic Station of Xuzhou, Xuzhou. jiangsu 221002, china ’ school of publichealth, nanjing medical university, nanjing, jiangsu 210029, china Faculty of Public Health Xuzhou Medical College 江苏 Xuzhou 221002 Bureau of Health Jiangsu Provincial Government 江苏 Nanjing 210008 Faculty of Public Health Xuzhou Medical Colleg 江苏 Xuzhou 221002 Health and Anti-epidemic Station of Xuzhou 江苏 Xuzhou 221002 school of Public Health Nanjing Medical University 江苏 Nanjing 210029

Objective To investigate into the changes of dietary patterns and their impacts on health of urban and rural residents in jiangsu Province, china during the 1990s. Methods On the basis of the results of food consumption survey, the calorie intake was calculated according to the balanced diet method and the quality of diet was assessed by scores of desirable dietary pattern (DDP). Results It was found that food consumption and dietary patterns changed remarkably during the 1990s. Grain consumption was decreasing year by year, but the consumption of animal food was markedly increasing. Although the score of desirable dietary pattern (DDP) in urban residents was more than 90, the deducted score due to over-consumption of animal food increased. The mortality from infectious diseases evidently decreased in the whole province, while the death rates of some chronic diseases, such as diabetes, hypertension, colorectal cancer and breast cancer, were increasing rapidly in urban areas. Conclusions Sufficient attention should be paid to the negative effects of change in dietary patterns on people's health, especially in the urban residents.

关键词： Dietary patterns Nutrition-related diseases

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Mitochondrial uncoupling protein 2 expression in colon cancer and its clinical significance

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World Journal of Gastroenterology 2010年第45期16卷 5773-5778页

作者： Xiao-Yi Kuai, Ze-Yu Ji, Hong-Jie Zhang,Department of Gastroenterology, First Affiliated Hospital of nanjing medical university, nanjing 210029, jiangsu Province, china Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road Nanjing 210029 Jiangsu Province China.

AIM: To detect the expression of mitochondrial uncoupling protein 2 (UCP2) in colon cancer and analyze the relation between UCP2 expression and clinical pathological features of colon ***: Fifteen colon tissue samples and 15 its adjacent tissue samples were obtained from colon cancer patients during surgical interventions. UCP2 expression was detected with immunohistochemical method in 10 normal controls, 10 hyperplastic polyp patients, 20 tubular adenoma patients and 78 colon cancer patients. Patients with rectal cancer were excluded. Quantitative reverse transcription polymerase chain reaction and Western blotting were used to detect UCP2 expressions in colon cancer tissue samples and its adjacent tissue samples. Relation between UCP2 expression and clinical pathological features of colon cancer was also analyzed. RESULTS: The UCP2 mRNA expression level was fourfold higher in colon cancer tissue samples than in its adjacent tissue samples. The UCP2 protein expression level was three-fold higher in colon cancer tissue samples than in its adjacent normal tissue samples. The UCP2 was mainly expressed in cytoplasm. The UCP2 was not expressed in normal colon mucosa. Strong positive staining for UCP2 with a diffuse distribution pattern was identified throughout the mucosa in colon cancer tissue samples with a positive expression rate of 85.9%. The UCP2 expression level was higher in colon cancer tissue samples at clinical stages Ⅲ and Ⅳ than in those at stageⅠ+ Ⅱ. Univariate analysis showed that the high UCP2 expression level was significantly correlated to colon cancer metastasis (hazard ratio = 4.321, confidence interval = 0.035-0.682, P = 0.046). CONCLUSION: UCP2 is highly expressed in human colon cancer tissue and may be involved in colon cancer metastasis.

关键词： Mitochondrial uncoupling protein 2 Colon cancer Uncoupling protein 2 Clinicopathologic characteristics

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QP-FREE,TRUNCATED HYBRID METHODS FOR LARGE-SCALE NONLINEAR CONSTRAINED OPTIMIZATION

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Journal of Computational Mathematics 1997年第1期15卷 36-54页

作者： Q. Ni(school of Science, nanjing university of Aeronautics and Astronautics, nanjing, china) 南京航空航天大学研究生院江苏南京

In this paper, a truncated hybrid method is proposed and developed for solving sparse large-scale nonlinear programming problems. In the hybrid method, a symmetric system of linear equations, instead of the usual quadratic programming subproblems, is solved at iterative process. In order to ensure the global convergence, a method of multiplier is inserted in iterative process. A truncated solution is determined for the system of linear equations and the unconstrained subproblems are solved by the limited memory BFGS algorithm such that the hybrid algorithm is suitable to the large-scale problems. The local convergence of the hybrid algorithm is proved and some numerical tests for medium-sized truss problem are given.

关键词： QP-FREE,TRUNCATED HYBRID METHODS FOR LARGE-SCALE NONLINEAR CONSTRAINED OPTIMIZATION II

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On consensus protocols for high-order multiagent systems

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控制理论与应用（英文版） 2010年第4期8卷 406-412页

作者： Jing KUANG,Jiandong ZHU (school of Mathematical Sciences,nanjing Normal university,nanjing jiangsu 210097,china) school of Mathematical Sciences Nanjing Normal University Nanjing Jiangsu China

In this paper,the static consensus problem and the dynamic consensus problem are considered for a class of high-order multiagent *** the proposed consensus protocols,necessary and sufficient conditions for the consensus problems are *** the static consensus protocol,the desired consensus speed can be achieved by adjusting feedback *** show the effectiveness of the proposed consensus protocols.

关键词： Consensus Multiagent systems Graph theory

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A local probability exponential inequality for the large deviation of an empirical process indexed by an unbounded class of functions and its application

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Science china Mathematics 2004年第6期47卷 821-830页

作者： ZHANG DixinDepartment of Finance, Business school, nanjing university, nanjing 210093, china Department of Finance Business School Nanjing University Nanjing China

A local probability exponential inequality for the tail of large deviation of an empirical process over an unbounded class of functions is proposed and studied. A new method of truncating the original probability space and a new symmetrization method are given. Using these methods, the local probability exponential inequalities for the tails of large deviations of empirical processes with non-i.i.d. independent samples over unbounded class of functions are established. Some applications of the inequalities are discussed. As an additional result of this paper, under the conditions of Kolmogorov theorem, the strong convergence results of Kolmogorov on sums of non-i.i.d. independent random variables are extended to the cases of empirical processes indexed by unbounded classes of functions, the local probability exponential inequalities and the laws of the logarithm for the empirical processes are obtained.

关键词： empirical process large deviation unbounded class of functions local probability exponential inequality

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Effect of Excipients on Stability and Structure of rhCuZn-SOD Encapsulated in PLGA Microspheres

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Chemical Research in Chinese Universities 2004年第3期20卷 323-327页

作者： LIU Ling 1,2 ,GE Yu 1 and YUAN Qin-sheng 1 1. State Key Laboratory of Bioreactor Engineering and Institute of Biochemistry,East china university of Science and Technology,Shanghai 200237,P. R. china 2. Public Health school,nanjing medical university,nanjing 210029,P. R. china State Key Laboratory of Bioreactor Engineering and Institute of Biochemistry East China University of Science and Technology 生物反应器工程国家重点实验室上海 200237

When a protein is encapsulated into poly( DL -lactide-co-glycolide)(PLGA) microspheres by means of the double-emulsion method,the harsh microspheres formation process including ultrasonification,exposure to an organic solvent and a polymer may cause the denaturation of the protein. In this study,we investigated the enzymatic activity change and the effect of the excipients on the stability of recombinant human Cu,Zn-superoxide dismutase(rhCu,Zn-SOD) during the emulsification. The specific activity recovery was found to be concentration dependent and the excipients involved such as PEG 600 and Tween 20,and trehalose were shown to increase the stability of rhCu,Zn-SOD. The protein structural integrity within the microspheres was analyzed by FTIR. The structure of rhCu,Zn-SOD within PLGA microspheres containing trehalose was found to be similar to that of the native solid state,whereas the protein encapsulated during the preparation in the absence of any excipient changed due to the possible hydrophobic interaction with the polymer. The results suggest that a rational stability strategy for protein to be encapsulated into microspheres should aim at different processes.

关键词： Poly( DL -lactide-co-glycolide)(PLGA) microsphere Recombinant human Cu Zn-superoxide dismutase(rhCu Zn-SOD) Fourier transform infrared(FTIR) spectroscopy Protein stability Excipient

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The Optimum Dosage Regimen of Intravenous Infusion for Drugs Obeying Parallel First-order and Michaelis-Menten Elimination Kinetics

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生物数学学报 1996年第4期11卷 6-11页

作者： Ding Yong（Department of Biomathematics，nanjing medical university，nanjing 210029）

For drugs obeying parallel first-order and Michaelis-Menten elimination kinetics,mathematical analysis concerning the optimum dosage regimen of intravenous infusion is conducted and following equations are derived:where Xo is the intravenous loading dose,Cb the plasma concentration level desired in clinical therapy,V the apparent distribution volume,k0 the rate constant of intravenouns infusion,K the first－order elimination rate constant,Vm the theoretical maximum rate of the Michaelis－Menten elimination process,Km the Michaelis *** this dosage regimen,plasma level maintains a constant Cb during the administration *** K=0 the dosage regimen above is also suitable for drugs obeying Michaelis-Menten elimination kinetics.

关键词： Intravenous infusion Optimum dosage regimen Michaelis-Menten elimination kinetics Mathematical analysis

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Association of the MTHFR C677T polymorphism and bone mineral density in postmenopausal women:a meta-analysis

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The Journal of Biomedical Research 2010年第6期24卷 417-423页

作者： Donghua Li,Jie Wu Department of Obstetrics and Gynecology,the First Affiliated Hospital of nanjing medical university,nanjing 210029,jiangsu Province,china Department of Obstetrics and Gynecology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China

Osteoporosis is a condition characterized by low bone mineral density （BMD） and micro-architectural changes in the bone *** risk of osteoporosis is partly determined by genetic *** role of C677T polymorphism of methylenetetrahydrofolate reductase （MTHFR） gene has been investigated in postmenopausal ***,the relationship between MTHFR polymorphism and BMD is still *** carried out a meta-analysis of 5,833 subjects to evaluate the association of MTHFR and BMD in postmenopausal *** of MEDLINE,Web of Science,Scopus and CNKI were retrieved for all publications relating to MTHFR polymorphism and BMD in postmenopausal *** eligible studies were selected for *** these articles studied the association of MTHFR polymorphism and BMD of the femoral neck and lumbar spine in postmenopausal *** analysis suggested that postmenopausal women with the TT genotype had lower femoral neck BMD than the women with the CC/CT genotype,and the weighted mean difference （WMD） was-0.01 g/cm 2 [95% confidence interval （CI）：（-0.01,-0.01）,P 0.01].However,BMD of the lumbar spine of postmenopausal women with the TT genotype was not significantly different from that of women with the CC/CT *** the random effects model,the WMD between the TT and TC/CC genotype was-0.01 g/cm 2 [95% CI：（-0.04,0.01）,P=0.32].The C677T polymorphism of the MTHFR gene is associated with BMD of the femoral neck in postmenopausal *** with the TT genotype of the MTHFR gene have lower BMD,suggesting that the TT genotype may be a risk factor for postmenopausal osteoporosis.

关键词： methylenetetrahydrofolate reductase postmenopausal women bone mineral density meta-analysis

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Retrieval of dislodged coronary stent from left renal artery by gooseneck snare

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The Journal of Biomedical Research 2010年第6期24卷 479-482页

作者： Chunjian Li,Zhijian Yang,Kejiang Cao Department of Cardiology,the First Affiliated Hospital of nanjing medical university,nanjing,jiangsu 210029,china Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China.

A rapamycin-eluting stent was dislodged during attempt of implantation at the proximal right coronary artery,which was found by fluoroscopy to have migrated into the anterior trunk of the left renal *** chose a 5 mm d... 详细信息

关键词： percutaneous coronary intervention complications stent gooseneck snare renal artery

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Potential Role of NO in Modulation of COX-2 Expression and PGE2 Production in Pancreatic β-cells

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Acta Biochimica et Biophysica Sinica 2005年第2期37卷 139-146页

作者： Jia-Jian LING Yu-Jie SUN Dong-Ya ZHU Qi CHEN Xiao HAN The Key Laboratory of Human Functional Genomics of jiangsu Province,nanjing medical university,nanjing 210029,china school of Pharmacy,nanjing medical university,nanjing 210029,china TheKeyLaboratoryofHumanFunctionalGenomicsofjiangsuProvince NanjingMedicalUniversityNanjing210029China

Cytokines have been implicated in pancreatic β-cell destruction leading to type 1 *** to interleuken-1β（IL-1β）of pancreatic β-cells induces expression of inducible nitric oxide syn-thase（iNOS）and cyclooxygenase-2（COX-2）.Subsequent formation of nitric oxide（NO）and prostaglandinE2（PGE2）may impair β-cell *** NOS inhibitor NG-monomethyl-L-arginine（L-NMMA）,wehave further investigated the relation between NO formation and COX-2 ***-1β stimulated theformation of NO and PGE2 by pancreatic β-cells.L-NMMA completely inhibited IL-1β-induced NO forma-tion and attenuated PGE2 ***-2 gene transcription level and protein expression were deter-mined by real-time PCR,Western blot and luciferase analysis.L-NMMA inhibited IL-1β-induced promoteractivity,gene transcription and protein expression of COX-2 in pancreatic β-***,we concludedthat NO-affected COX-2 activity is directly linked to COX-2 gene transcription and protein expression inpancreatic β-*** identification of a novel interaction of NO on the COX signaling pathway in β-cellsprovides a strategy of intervention for further evaluating the role of NO and PGE2 in autoimmune diabetes.

关键词： nitric oxide cyclooxygenase-2 pancreatic β-cell prostaglandin E2

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