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Current progress and prospects of induced pluripotent stem cells

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Yan Geng~(*+),Yingying Dong~(*+),Ye-Guang Chen~(*),and Wen Ning~(*‖**) +Model Animal Research Center,Nanjing university,Nanjing 210061,china.State Key Laboratory of Biomembrane and Membrane Biotechnology,School of life sciences,Tsinghua university,Beijing 100084,china.‖college of life sciences,nankai university,tianjin 300071,china.

Lung morphogenesis is a well-orchestrated,tightly regulated process through several molecular pathways including TGF/BMP *** of these signaling pathways leads to lung malformation. We herein investigated the role of Follistatin-like 1(Fstl1),a secreted follistatin-module containing glycoprotein,in lung *** of Fstl1 in mice led to postnatal lethality due to respiratory *** of the mutant phenotype showed that Fstl1 is essential for tracheal cartilage formation and alveolar *** of the Fstl1 gene resulted in malformed tracheal rings manifested as discontinued rings and reduced ring ***1 deficient mice displayed septal hypercellularity and end-expiratory atelectasis,which were associated with impaired differentiation of distal alveolar epithelial cells and insufficient production of mature surfactant ***,Fstl1 interacted directly with BMP4,negatively regulated BMP4/Smad 1/5/8 signaling,and inhibited BMP4-induced surfactant gene *** BMP signaling activity by Noggin rescued pulmonary atelectasis of Fstl1 deficient ***,we provide in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation,in part,through BMP4 signaling.

关键词： Fstll respiratory failure tracheal cartilage differentiation of alveolar epithelial cell BMP4

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Science china.life sciences) 2009年第7期52卷 622-636页

作者： CHEN LingYi & Liu Lin Key Laboratory of Bioactive Materials of Ministry of Education,college of life sciences,nankai university,tianjin 300071,china Key Laboratory of Bioactive Materials of Ministry of Education College of Life Sciences Nankai University Tianjin 300071 China

Induced pluripotent stem(iPS) cells are derived from somatic cells by ectopic expression of few transcription *** embryonic stem(ES) cells,iPS cells are able to self-renew indefinitely and to differentiate into all types of cells in the *** cells hold great promise for regenerative medicine,because iPS cells circumvent not only immunological rejection but also ethical *** the first report on the derivation of iPS cells in 2006,many laboratories all over the world started research on iPS cells and have made significant *** paper reviews recent progress in iPS cell research,including the methods to generate iPS cells,the molecular mechanism of reprogramming in the formation of iPS cells,and the potential applications of iPS cells in cell replacement *** problems that need to be addressed and the prospects for iPS research are also discussed.

关键词： induced pluripotent stem(iPS) cells somatic cell reprogramming pluripotency

Totally geodesic submanifolds of maximal rank in symmetric spaces

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Science china.Mathematics 2004年第2期47卷 264-271页

作者： ZHU Fuhai & LIANG KeSchool of Mathematical sciences and LMAM, Peking university, Beijing 100871, china.college of Mathematical sciences and LPMC, nankai university, tianjin 300071, china 1.School of Mathematical sciences and LMAM Peking University 100871 Beijing China 2.College of Mathematical Sciences and LPMC Nankai University 300071 Tianjin China

We gave a complete list of totally geodesic submanifolds of maximal rank in symmetric spaces of noncompact type. The compact cases can be obtained by the duality.

关键词： totally geodesic submanifold, Lie triple system, maximal rank.

Iron-doped Mn-Ce/TiO_2 catalyst for low temperature selective catalytic reduction of NO with NH_3

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Journal of Environmental sciences 2010年第9期22卷 1447-1454页

作者： Boxiong Shen ,Ting Liu,Ning Zhao,Xiaoyan Yang,Lidan Deng college of Environmental Science and Engineering,nankai university,tianjin 300071,china. [a] college of Environmental Science Engineering Nankai University Tianjin 300071 China

The catalysts of iron-doped Mn-Ce/TiO2 （Fe-Mn-Ce/TiO2） prepared by sol-gel method were investigated for low temperature selective catalytic reduction （SCR） of NO with NH3. It was found that the NO conversion over Fe-Mn-Ce/TiO2 was obviously improved after iron doping compared with that over Mn-Ce/TiO2. Fe-Mn-Ce/TiO2 with the molar ratio of Fe/Ti = 0.1 exhibited the highest activity. The results showed that 96.8% NO conversion was obtained over Fe（0.1）-Mn-Ce/TiO2 at 180~C at a space velocity of 50,000 hr-1. Fe-Mn-Ce/TiO2 exhibited much higher resistance to H2O and SO2 than that of Mn-Ce/TiO2. The properties of the catalysts were characterized using X-ray diffraction （XRD）, N2 adsorption, temperature programmed desorption （NH3-TPD and NOx-TPD）, and X- ray photoelectron spectroscopy （XPS） techniques. BET, NH3-TPD and NOx-TPD results showed that the specific surface area and NH3 and NOx adsorption capacity of the catalysts increased with iron doping. It was known from XPS analysis that iron valence state on the surface of the catalysts were in Fe^3＋ state. The doping of iron enhanced the dispersion and oxidation state of Mn and Ce on the surface of the catalysts. The oxygen concentrations on the surface of the catalysts were found to increase after iron doping. Fe-Mn-Ce/TiO2 represented a promising catalyst for low temperature SCR of NO with NH3 in the presence of H20 and SO2.

关键词： low-temperature SCR Fe-Mn-Ce/TiO2 H2O SO2

Electrochemiluminescence from tris(2,2′-bipyridyl) ruthenium (Ⅱ) in the presence of aminocarboxylic acid co-reactants

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Science china.Chemistry 2009年第9期52卷 1394-1401页

作者： YIN XueBo, SHA BeiBei & HE XiWen Research Centre for Analytical sciences, college of Chemistry, nankai university, tianjin 300071, china Research Centre for Analytical sciences College of Chemistry Nankai University Tianjin China

Due to the highly sensitive electrochemiluminescence (ECL), tris(2,2′-bipyridyl) ruthenium(II) (Ru(bpy)32+) is often used in the field of bioarrays with the help of co-reactants. However, the generally used co-reactant, tripropylamine (TPA), is toxic, corrosive and volatile. Therefore, the search for safe, sensitive and economical co-reactants is critical. Herein, three aminocarboxylic acids, ethylenediamine-tetraacetic acid (EDTA), nitrilotriacetic acid (NTA), and 2-hydroxyethylethylene diaminetriacetic acid (HEDTA), have been investigated as potential co-reactants for promoting Ru(bpy)32+ ECL behaviour. A possible ECL mechanism is also presented. The experimental results suggested that the co-reactants have a different ECL behaviour compared to TPA, such as different pH- and surfactant-responses. The detection limits of Ru(bpy)32+ using NTA, EDTA and HEDTA as co-reactants are 1, 60 and 680 fmol·L-1, respectively. The results indicate that NTA has a much higher efficiency than TPA to excite Ru(bpy)3 2+ ECL under their own optimal conditions. NTA could be widely used in many fields because it is less toxic, corrosive and volatile than TPA. Moreover, using Ru(bpy)3 2+ ECL, a sensitive method for the detection of aminocarboxylic acids is also developed. An improvement of four orders of magnitude in detection limits is obtained for EDTA compared to the known Ru(bpy) 3 2+ chemiluminescent methods.

关键词： Ru(bpy)32+ electrochemiluminescence co-reactants aminocarboxylic acids

The molecular characterization of maize B chromosome specific AFLPs

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Cell Research 2002年第1期12卷 63-68页

作者： ZHONG XIA QI, Hui ZENG, Xiu LAN LI, CHENG BIN CHEN, WEN QIN SONG, RUI YANG CHEN The college of life sciences, nankai university, tianjin 300071, china 1The college of life sciences Nankai University Tianjin 300071 China 1The college of life sciences Nankai University Tianjin 300071 China 1The college of life sciences Nankai University Tianjin 300071 China 1The college of life sciences Nankai University Tianjin 300071 China 1The college of life sciences Nankai University Tianjin 300071 China 1The college of life sciences Nankai University Tianjin 300071 China

The origin and evolution of B chromosomes could be explained by the specific DNA sequence on them. But the specific sequences known were quite limited. To investigate maize B chromosome sqicific DNA sequeces, maize genomes with and without B chromosomes were analyzed by AFLP. Only 5 markers were found specific to genomes with B chromosomes among about 2000 AFLP markers. Southern hybridization and sequence analysis revealed that only the sequence of M8-2D was a B chromosome specific sequence. This sequence contained the telomeric repeat unit AGGGTTT conserved in plant chromosome telomeres. In addition, the sequence of M8-2D shared low homology to clones from maize chromosome 4 centromere as well. M8-2D were localized to B chromosome centrorneric and telomeric regions.

关键词： Maize B chromosome AFLP FISH.

Irregular wavelet frames on L^2 (R^n)

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Science china.Mathematics 2005年第2期48卷 277-287页

作者： YANG Deyun & ZHOU Xingwei Department of Information & Technology, nankai university, tianjin 300071, china.Department of Mathematics, nankai university, tianjin 300071, china.Department of Computer Science, Taishan college, Taian 271000, china 1. Department of Information & Technology Nankai University 300071 Tianjin China 2. Department of Mathematics Nankai University 300071 Tianjin China 3. Department of Computer Science Taishan College 271000 Taian China

In this paper, we present the conditions on dilation parameter {sj}j that ensure a discrete irregular wavelet system to be a frame on L2(Rn), and for the wavelet frame we consider the perturbations of translation para... 详细信息

关键词： wavelet transform, frame, wavelet frame, irregular dilation.

On　the　H_∞　Control　for　Linear　Time-Delay　Systems

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Journal of Systems Engineering and Electronics 1998年第3期9卷 23-28页

作者： Chen Wanyi (college of Mathematics, nankai university, tianjin 300071, P. R. china.) college of Marhematics Nankai University Tianjin 300071 P. R. China

In this paper, we study the H∞ control of time-delay linear systems either with some　norm-bounded uncertainties or not with (for systems not in the scope of the nominal systems of the former ones). As linear time-delay systems are infinite dimensional in natural, some new sufficient conditions in Riccati equation form are offered, which extends current related results. We also point out a mistake appeared in a recently published paper.

关键词： Time-delay Uncertainty Stabilization Riccati equation

BIFURCATIONS OF PERIODIC ORBITS IN THREE-WELL DUFFING SYSTEM WITH A PHASE SHIFT

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Journal of Systems Science & Complexity 2011年第3期24卷 519-531页

作者： Jicai HUANG Han ZHANG School of Mathematics and Statistics Central China Normal University Wuhan 430079 China college of Information Technical Science Nankai University Tianjin 300071 China.

Bifurcations of periodic orbits of three-well Duffing system with a phase shift are investigated in detail. The conditions of the existence and bifurcations for harmonics, subharmonics （2-order, 3- order and m-order） and superharmonics under small perturbations are given by using second-order averaging method and Melnikov＇s method. The influence of the phase shift on the dynamics is also obtained.

关键词： Bifurcations Melnikov's method periodic orbits second-order averaging three-well Duffing system.