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unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan u.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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蛋白活化原子层沉积用于超强原油排斥的层级纳米装甲膜（英文）

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Science Bulletin 2024年第2期 218-226页

作者：杨晓彬孙盼温雅洁 Anil u.Mane Jeffrey W.Elam 马军刘少敏 Seth B.Darling 邵路 MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and Environment School of Chemistry and Chemical Engineering Harbin Institute of Technology Chemical Sciences and Engineering Division Argonne National Laboratory Advanced Materials for Energy-Water Systems Energy Frontier Research Center Argonne National Laboratory School of Environment Harbin Institute of Technology Pritzker School of Molecular Engineering University of Chicago Department of Physics University of Illinois at Chicago Applied Materials Division Argonne National Laboratory WA School of Mines: Minerals Energy and Chemical Engineering Curtin University

Atomic layer deposition(ALD) offers unique capabilities to fabricate atomically engineered porous materials with precise pore tuning and multi-functionalization for diverse applications like advanced membrane separations towards sustainable energy-water systems. However, current ALD technique is inhibited on most non-polar polymeric membranes due to lack of accessible nucleation sites. Here, we report a facile method to efficiently promote ALD coating on hydrophobic surface of polymeric membranes via novel protein activation/sensitization. As a proof of concept, TiO2ALD-coated membranes activated by bovine serum albumin exhibit remarkable superhydrophilicity, ultralow underwater crude oil adhesion, and robust tolerance to rigorous environments including acid, alkali, saline, and *** importantly, excellent cyclable crude oil-in-water emulsion separation performance can be achieved. The mechanism for activation/sensitization is rooted in reactivity for a particular set of amino acids. Furthermore, the universality of protein-sensitized ALD is demonstrated using common egg white,promising numerous potential usages in biomedical engineering, environmental remediation, lowcarbon manufacturing, catalysis, and beyond.

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Integrated Approaches of Mechanical Barrier, Insecticide and Botanicals against Mango Mealybug (Drosicha mangiferae)

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Advances in Entomology 2024年第3期12卷 195-202页

作者： N. Akhter M. Z. Alam M. A. Rahaman M. R. u. Miah I. H. Mian M. A. Latif Department of Entomology Faculty of Agriculture Sher-e-Bangla Agricultural University Dhaka Bangladesh Department of Entomology Faculty of Agriculture Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur Bangladesh Department of Plant Pathology Faculty of Agriculture Sher-e-Bangla Agricultural University Dhaka Bangladesh Department of Plant Pathology Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur Bangladesh

An experiment was conducted to test the efficacy of a mechanical barrier around the tree trunk with one spray of Cypermethrin @ 1 ml/l and turmeric powder extract @ 15 g/500ml of water applied in integrated approaches against mango mealybug on mango tree. There were 7 treatments including a control. The treatments were Mechanical barrier, Cypermethrin spray @ 1 ml/l, Turmeric powder spray @ 15 g/500ml of water, Cypermethrin spray + Turmeric spray, Cypermethrin spray + Mechanical barrier, Turmeric + Mechanical barrier and untreated control. Three-year-old mango plants grafted from a 5-year-old mango tree (Variety Amropali) and planted in pots were used in the experiment. The treatment, Cypermethrin spray + Mechanical barrier gave the highest reduction of mango mealybug population 87.06% to 93.90% followed by Turmeric spray + Mechanical barrier and showed 81.13% to 86.04% and Mechanical barrier alone showed 81.13% to 84.59% population reduction. Turmeric powder extract showed only (8.42% to 23.77%) population reduction of mango mealybug which was lowest compared to other treatments.

关键词： Mango Mealybug Integrated Management

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磁性三乙烯四胺/单宁树脂对Cu^(2+)、Pb^(2+)的吸附性能研究

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化学研究与应用 2024年第9期36卷 2087-2094页

作者：金绍娣顾东雅顾晨露盐城工业职业技术学院药品与健康学院江苏盐城224005

利用曼尼希反应将三乙烯四胺(TETA)固化到单宁(TA)基体表面,热溶剂法制得磁性单宁基树脂(MTETA-TA)。通过红外光谱、扫描电镜、比表面积及孔隙度分析仪、振动样品磁强计对M-TETA-TA进行表征,表明M-TETA-TA具有疏水性强、比表面积大的优... 详细信息

利用曼尼希反应将三乙烯四胺(TETA)固化到单宁(TA)基体表面,热溶剂法制得磁性单宁基树脂(MTETA-TA)。通过红外光谱、扫描电镜、比表面积及孔隙度分析仪、振动样品磁强计对M-TETA-TA进行表征,表明M-TETA-TA具有疏水性强、比表面积大的优势,Fe_(3)O_(4)的成功引入有效解决吸附剂回收难的问题。对含Cu^(^(2+))、Pb^(2+)废水溶液进行了静态吸附实验,探讨了其对金属的吸附性能。在pH为5的酸性条件下,吸附效果较好;Cu^(^(2+))和Pb^(2+)吸附动力学均符合准二级反应动力学模型,主要为化学吸附;Cu^(^(2+))的吸附等温线符合Langmuir模型,属单层吸附,理论吸附最大值为173.33 mg·g^(-1);Pb^(2+)的吸附等温线符合Sips模型,属多层吸附,理论吸附最大值为217.14 mg·g^(-1)。推测M-TETA-TA对Pb^(2+)的吸附除了螯合、氧化还原等化学反应,还存在静电和离子交换作用,氨基和酚羟基为主要参与官能团。循环再生5次后,仍有较高的吸附性能和磁性强度。

关键词：三乙烯四胺单宁磁性 Cu^(2+) Pb^(2+) 吸附性能

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General investigation for longitudinal wave propagation under magnetic field effect via nonlocal elasticity

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Applied Mathematics and Mechanics(English Edition) 2015年第10期36卷 1305-1318页

作者： u.GVEN Department of Mechanical Engineering Yildiz Technical University

In this paper, the propagation of longitudinal stress waves under a longitu- dinal magnetic field is addressed using a unified nonlocal elasticity model with two scale coefficients. The analysis of wave motion is mainly based on the Love rod model. The effect of shear is also taken into account in the framework of Bishop＇s correction. This analysis shows that the classical theory is not sufficient for this subject. However, this unified nonlocal elasticity model solely used in the present study reflects in a manner fairly realistic for the effect of the longitudinal magnetic field on the longitudinal wave propagation.

关键词： Rayleigh-Bishop rod nonlocal elasticity magnetic field wave propagation

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Physico-chemical characterization of a farmland affected by wastewater in relation to heavy metals

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Journal of Zhejiang university-Science A(Applied Physics & Engineering) 2008年第3期9卷 366-372页

作者： Emmanuel u. ONWEREMADu Department of Soil Science and Technology Federal university of Technology PMB 1526 Owerri Nigeria

This study investigated selected properties of soils affected by wastewater and its relationship with some heavy metals. A free survey technique involving target sampling was used in siting soil profile pits. Soil samples were collected based on horizon differentiation and analyzed using routine and special analytical techniques. Soil data were subjected to correlation analysis using SAS program. Results show that all heavy metals studied had values above critical limits in the polluted soils using known standards and that these biotoxic metals decreased with soil depths. Highly significant (P=0.01 and 0.05) relationships were established between investigated heavy metals and some soil properties, especially soil pH and organic matter. Further studies involving more edaphic properties, biotoxic metals and their bioaccessibility in crops growing on wastewater soils will surely enhance knowledge and management of these highly anthropogenically influenced soils of the study site.

关键词： Bioavailability Characterization Heavy metals Soil pollution Wastewater

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Semi-solid near-net shape rheocasting of heat treatable wrought aluminum alloys

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Transactions of Nonferrous Metals Society of China 2010年第9期20卷 1719-1724页

作者： u.A.C uRLE Materials Science and Manufacturing Council for Scientific and Industrial Research

Flexibility of the CSIR-RCS, induction stirring with simultaneous air cooling process, in combination with high pressure die casting is successfully demonstrated by semi-solid rheocasting of plates performed on commercial 2024, 6082 and 7075 wrought aluminum alloys. Tensile properties were measured for the above mentioned rheocast wrought aluminum alloys in the T6 condition. The results showed that tensile properties were close to or even in some cases exceeded the minimum specifications. The yield strength and elongation of rheocast 2024-T6 exceeded the minimum requirements of the wrought alloy in the T6 condition but the ultimate tensile strength achieved only 90% of the specification because the Mg content of the starting alloy was below the commercial alloy specification. The strengths of rheocast 6082-T6 exceeded all of the wrought alloy T6 strength targets but the elongation only managed 36% of the required minimum due to porosity, caused by incipient melting during solution heat treatment, and the presence of fine intermetallie needles in the eutectic. The yield strength of rheocast 7075 exceeded the required one and the ultimate tensile strength also managed 97% of the specification; while the elongation only reached 46% of the minimum requirement also due to incipient melting porosity caused during the solution heat treatment process.

关键词： high pressure die casting (HPDC) aluminum alloys as-cast condition T6 treatment incipient melting

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高乙烯含量VAE乳液的研究与生产

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安徽化工 2024年第1期50卷 80-85页

作者：吴尚宋孟璐安徽皖维高新材料股份有限公司安徽巢湖238002

以聚乙烯醇(PVA1788、PVA0588)复配做保护胶体,醋酸乙烯酯及乙烯为单体,采用氧化还原法制备不同乙烯含量的VAE乳液。研究原料、聚合工艺和反应条件及加料方式对VAE乳液乙烯含量、固含量、粘度、玻璃化转变温度和相对分子质量的影响,考... 详细信息

以聚乙烯醇(PVA1788、PVA0588)复配做保护胶体,醋酸乙烯酯及乙烯为单体,采用氧化还原法制备不同乙烯含量的VAE乳液。研究原料、聚合工艺和反应条件及加料方式对VAE乳液乙烯含量、固含量、粘度、玻璃化转变温度和相对分子质量的影响,考查改性PVA对VAE乳液耐水性能的影响。结果表明,最佳初始反应温度为65℃,后期温度为70℃~85℃,最佳乳化剂含量为4%,最佳引发剂用量为2.5%,VAE乳液的乙烯含量为9%~23%,使用疏水基改性PVA代替部分保护胶体,乳液耐水性明显提高。

关键词：醋酸乙烯酯乙烯高乙烯含量VAE乳液改性PVA

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城市与自然之间嘉兴种子艺术中心

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室内设计与装修 2024年第2期 24-27页

作者： B.L.u.E.建筑设计事务所 B.L.u.E.建筑设计事务所

种子艺术中心位于嘉兴市南湖区,距离市中心东侧10 km,处在城市与自然的过渡边界。项目定位为地产配套设施,近期作为附近社区的展示中心与零售空间,未来则活用为周边共享的邻里中心。艺术中心周围一半是农场与公园,一半是住宅与商业街,... 详细信息

种子艺术中心位于嘉兴市南湖区,距离市中心东侧10 km,处在城市与自然的过渡边界。项目定位为地产配套设施,近期作为附近社区的展示中心与零售空间,未来则活用为周边共享的邻里中心。艺术中心周围一半是农场与公园,一半是住宅与商业街,不同方位面向不同的景观与氛围,形成多元、生动的场所感。四周道路交会,人流聚集于此,是整个片区最具活力的核心点位。

关键词：邻里中心场所感嘉兴市南湖区配套设施商业街展示中心项目定位零售空间

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Photoproduction of multi-meson final states–recent results from the Crystal-Barrel/TAPS experiment at ELSA-

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Chinese Physics C 2009年第12期33卷 1105-1112页

作者： u. Thoma HISKP Universitt Bonn Nussallee 14-16 53115 Bonn Germany

Multi-meson final states such as γp →pπ0π0 and γp →pπ0η have been investigated with the Crystal-Barrel/TAPS experiment at ELSA. Baryon cascades via △π and △η and also via higher mass baryon resonances are clearly observed. Based on this data and on data from other reactions a partial wave analysis has been performed from which partial decay widths of various N＊ and △＊ states into the different pπ0π0 and pπ0η decay channels have been determined, leading partly to unexpected results. In addition, polarisation observables have been investigated. The beam asymmetry X has been determined for both reactions and double polarisation data using a longitudinally polarised target and a circularly or linearly polarised photon beam has been taken. Given the angular coverage of the Crystal-Baxrel/TAPS experiment this data covers almost the full angular range and phase space. This data will provide new and important information for the partial wave analyses and bring us one step closer towards a complete experiment.

关键词： baryon spectroscopy photoproduction multi-meson final states polarisation observables

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