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Thermosensitive and Wound-Healing Gelatin-Alginate Biopolymer Hydrogels Modified with Humic Acids

Journal of Renewable Materials 2024年第10期12卷 1691-1713页

作者： Denis Miroshnichenko Vladimir Lebedev Katerina Lebedeva Аnna Cherkashina Sergey Petrushenko Olena Bogoyavlenska аnzhela olkhovska Ihor Hrubnyk Liudmyla Maloshtan Natalja Klochko The Department of Oil Gas and Solid Fuel Refining TechnologiesNational Technical University«Kharkiv Polytechnic Institute»Kharkiv61002Ukraine The Department of Plastics and Biologically Active Polymers Technology National Technical University«Kharkiv Polytechnic Institute»Kharkiv61002Ukraine Faculty of Physics V.N.Karazin Kharkiv National UniversityKharkiv61000Ukraine Technical University of Liberec Liberec46117Czech Republic The Department of Organizations and Management Healthcare and Social Medicine National Technical University«Kharkiv Polytechnic Institute»Kharkiv61002Ukraine The Common Pharmacy Department National Technical University«Kharkiv Polytechnic Institute»Kharkiv61002Ukraine Department of Micro-and Nanoelectronics National Technical University«Kharkiv Polytechnic Institute»Kharkiv61002Ukraine

The main goal of the article is the creation and study of thermosensitive and wound-healing gelatin-alginate bio-polymer hydrogels modiﬁed with humic *** rheological properties,swelling and contraction behavior were experimentally investigated,elucidated using Fourier transform infrared spectroscopy and used to achieve the physiological melting point,which is necessary for successful drug *** has been shown that in the gelatin-alginate-humic acid biopolymer hydrogels systems,it is possible to obtain a gel-sol transition temperature close to the physiological temperature of 37°C,which is important for drug delivery in the treatment of *** changing the type and concentration of humic acids in the gelatin-alginate hydrogel,it turned out to be achiev-able to regulate the softening time of the gel on the human body in the range from 6 to 20 min,which provides the possibility of controlled prolonged delivery of *** on the study of the inﬂuence of calcium ions on the properties of humic acids and ion exchange,as well as the interaction of humic acids,sodium alginate and gelatin with the formation of tighter gel networks,approaches to regulate the rate of softening of hydrogels at physiological temperature and their swelling,which simulates the absorption of exudate,were proposed and *** addition,low shrinkage of the hydrogel surface due to cross-linking of gelatin-alginate networks when modiﬁed with humic acids was experimentally conﬁrmed,which is important for avoiding problems of wound contracture and contour deformations when using dressings for wound ***,the developed opti-mized innovative biopolymer hydrogels synergistically combine the outstanding properties of natural molecular polymers and humic acids and are promising for the creation of effective medicines for wound healing.

关键词： Gelatin-alginate hydrogel humic acids wound healing rheological properties swelling thermosensitivity contraction

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