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Comparison of mismatch repair and immune checkpoint protein profile with histopathological parameters in pancreatic,periampullary/ampullary,and choledochal adenocarcinomas

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 875-882页

作者： arzu Hazal Aydın nesrin Turhan Department of Pathology Aksaray University Aksaray Training and Research HospitalAksaray 68200Turkey Department of Pathology University of Health Sciences Ankara City HospitalAnkara 06800Turkey

BACKGROUnD Pancreatic,periampullary/ampullary,and choledochal adenocarcinomas are aggressive malignancies with a poor *** checkpoint blockade is a promising treatment option for several tumor types.H long terminal repeatassociating 2(HHLA2),which is analogous to programmed death-ligand 1(PDL1),is a recently discovered member of the B7/cluster of differentiation 28 family and is expressed in many *** To analyze the expression of HHLA2 and its association with the pathologic biomarkers that predict sensitivity to *** ninety-two adenocarcinoma cases located in the pancreas,ampulla,and distal common bile duct were *** study assessed 106 pancreaticoduodenectomy and distal/total pancreatectomy samples that were delivered to Ankara City Hospital between 2019 and *** was conducted to examine the expression of DnA mismatch repair(MMR),PD-L1,and HHLA2 *** Patients with high HHLA2 expression had a higher mean age than those with low *** HHLA2 expression was associated with high perineural ***2 expression was low in pathological stage T3(pT)3 cases and high in pathological stage T1,T2,and T4 *** was no correlation between HHLA2 expression and the expression of MMR proteins and *** Evaluation of HHLA2 expression in microsatellite stable and PD-L1-negative tumors may be useful for predicting the response of individuals to immunotherapy and may serve as a novel therapeutic target for immunotherapy in advanced-stage disease.

关键词： H long terminal repeat-associating 2 Programmed death-ligand 1 Adenocarcinoma Pancreas Ampulla of Vater Distal common bile duct

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Impact of sex on the outcomes of deceased donor liver transplantation

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World Journal of Transplantation 2024年第1期14卷 120-129页

作者： Oya M Andacoglu Isabel S Dennahy nicole C Mountz Luisa Wilschrey arzu Oezcelik Division of Transplantation and Advanced Hepatobiliary Surgery University of UtahSalt Lake CityUT 84112United States Department of Surgery University of EssenEssen D-45122Germany Department of Surgery The University of Oklahoma Health Sciences CenterOklahoma CityOK 73117United States Department of Surgery University of Oklahoma College of MedicineOklahoma CityOK 73117United States

BACKGROUnD Data examining the impact of sex on liver transplant(LT)outcomes are *** is clear that further research into sex-related differences in transplant patients is necessary to identify areas for *** of these differences may help to identify specific areas of focus to improve on the organ matching process,as well as the peri-and post-operative care of these *** To utilize data from a high-volume Eurotransplant center to compare characteristics of male and female patients undergoing liver transplant and assess association between sex-specific variables with short-and long-term post-transplant *** A retrospective review of the University of Essen’s transplant database was performed with collection of baseline patient characteristics,transplant-related data,and short-term *** of these data were made with Shapiro-Wilk,Mann-Whitney U,χ2 and Bonferroni tests applied where appropriate.A P value ofnts,261(33.5%)were *** patients suffered higher incidences of acute liver failure and lower incidences of alcohol-related or viremic liver disease(P=0.001).Female patients were more likely to have received an organ from a female donor with a higher donor risk index score,and as a high urgency offer(all Pne characteristics of male and female recipients were also significantly *** multivariate hazard regression analysis,recipient lab-Model for End-Stage Liver Disease score and donor cause of death were associated with long-term outcomes in ***-operative diagnosis of hepatocellular carcinoma,age at time of listing,duration of surgery,and units transfused during surgery,were associated with long-term outcomes in *** of complications was associated with long-term outcomes in both *** survival was similar in both males and females;however,when stratified by age,females<50 y

关键词： Liver transplant Outcomes Survival Peri-and post-operative care

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Thermal Efficiency for Each Zone of a Solar Pond

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Chinese Physics Letters 2011年第10期28卷 281-283页

作者： BEZİR CİCEK nalan ŞahinŞencan arzu Department of Physics Faculty of ScienceSuleyman Demirel UniversityTurkey Department of Mechanical Education Technical Education FacultySüleyman Demirel UniversityTurkey

A salt gradient solar pond with a surface area of 3.5×3.5 m^(2) and a depth of 2 m is *** collapsible covers are used to reduce thermal energy loss from the surface of the solar pond during the night and to increase the thermal efficiency of the pond solar energy harvesting during *** covers can be rotated between 0 and 180°by a controlled electric motor and has insulation and reflection *** thermal efficiency for each solar pond zone is investigated theoretically and experimentally.

关键词： properties insulation harvesting

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再也没有安塔基亚？土耳其地震下的古城之殇

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环球人文地理 2024年第15期 92-99页

作者：李桓 mehmetkrc Cenk arzu Tayfun Gunerkaya Koraysa Mete Caner Arican Tarik GOK flickr

2023年，土耳其发生7.8级大地震。当世界将目光投向灾区时，人们才渐渐回忆起，废墟下古城安塔基亚的千年故事与蹊跷奇闻……安塔基亚，哈塔伊省省会，位于土耳其南部边陲。它曾是庞大帝国的王都，与君士坦丁堡齐名，却天灾不断，是战...

2023年，土耳其发生7.8级大地震。当世界将目光投向灾区时，人们才渐渐回忆起，废墟下古城安塔基亚的千年故事与蹊跷奇闻……安塔基亚，哈塔伊省省会，位于土耳其南部边陲。它曾是庞大帝国的王都，与君士坦丁堡齐名，却天灾不断，是战争中的炮灰，数次被夷为平地。人们说，安塔基亚似乎被诅咒了，只有死神常驻于此……

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Exact Solutions of Fisher and Generalized Fisher Equations with Variable Coefficients

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Acta Mathematicae Applicatae Sinica 2007年第4期23卷 563-568页

作者： arzu ■ün Cevat Kart Department of Mathematics Faculty of SciencesAnkara University06100 Tando■an-Ankara Turkey

In this work, we consider a Fisher and generalized Fisher equations with variable coefficients. Using truncated Painleve expansions of these equations, we obtain exact solutions of these equations with a constraint on... 详细信息

关键词： nonlinear evolution equations fisher equation generalized fisher equation backlund transformation painleve property

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Fixing an illusion–an empirical assessment of correction methods for the terrain reversal effect in satellite images

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International Journal of Digital Earth 2020年第10期13卷 1135-1150页

作者： Gianna Hartung arzu Çöltekin Department of Geography University of ZurichZurichSwitzerland FHnW University of Applied Sciences and Arts northwestern ZurichSwitzerland

Identifying land forms and land cover classes are important tasks in image ***,a phenomenon called terrain reversal effect(TRE)causes an inverted perception of 3D *** this inversion occurs,valleys appear as ridges and vice *** the TRE can severely impair the ability to identify 3D land forms,‘correcting’for the TRE in imagery can introduce new ***,one of most commonly-proposed methods–shaded relief map(SRM)overlay–appears to impair the ability to identify land cover *** this paper,we report a comparative empirical evaluation of an SRM overlay solution,and its‘enhanced’versions supported by various other cues(stereopsis,motion,labels).In response to the different solutions,we measure the effectiveness,efficiency,confidence and preferences of our participants in land form and land cover identification *** examined methods significantly improve the ability to detect land forms accurately,but they also impair the ability to identify the land cover classes to different ***,participants’visualization preferences contradict their performance with them,calling for reflection on the visual effects of the applied correction *** on the study,recommendations concerning the correction of the TRE are drawn,and gaps are identified.

关键词： Terrain reversal effect satellite images correction methods shaded relief map stereoscopy motion

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Comparing the terrain reversal effect in satellite images and in shaded relief maps:an examination of the effects of color and texture on 3D shape perception from shading

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International Journal of Digital Earth 2019年第4期12卷 442-459页

作者： arzu Çöltekin Julien Biland Department of Geography University of ZurichZurichSwitzerland Department of Geography University of BernBernSwitzerland

Terrain reversal effect(TRE)causes reversed 3D shape perception in satellite images and shaded relief maps(SRMs),and introduces difficulties in identifying landforms such as valleys and *** this paper,in a controlled laboratory experiment,we compare how well 27 participants could identify valleys and ridges over 33 locations using SRMs,color satellite images and grayscale satellite *** main depth cue is shadow both in vertical-view images and ***,the presence of texture and color in images also affect 3D shape *** our participants experience the illusion strongly:with the SRMs,it is very severe(2%accuracy),with grayscale images low but considerably better than SRMs(17.6%accuracy),and slightly worse with color imagery(15.3%accuracy).These differences between SRMs and imagery suggest that the participants who are able to bypass the illusion consciously or subconsciously interpret the photographic *** support this observation further with a cue-strength ***,we provide exploratory analyses of the effects of expertise,global convexity bias,and bistable *** original empirical observations serve towards a better understanding of this visual illusion,and contribute towards nuanced and appropriate solutions to correcting for TRE differently for satellite images and SRMs.

关键词： Terrain reversal relief inversion false topographic perception phenomenon photo interpretation visual illusion user study bistable perception global convexity bias

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Mathematical Modelling and 3D FEM Analysis of the Influence of Initial Stresses on the ERR in a Band Crack’s Front in the Rectangular Orthotropic Thick Plate

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Computers, Materials & Continua 2017年第3期53卷 249-270页

作者： arzu Turan Dincel Surkay DAkbarov Yildiz Technical University Department of Mathematical EngineeringDavutpasa Campus34220EsenlerIstanbul-Turkey Yildiz Technical University Faculty of Mechanical EngineeringDepartment of Mechanical EngineeringYildiz Campus34349BesiktasIstanbul-Turkey Institute of Mathematics and Mechanics of the national Academy of Science of Azerbaijan 37041BakuAzerbaijan

This paper deals with the mathematical modelling and 3D FEM study of the energy release rate(ERR)in the band crack’s front contained in the orthotropic thick rectangular plate which is stretched or compressed initially before the loading of the crack's edge *** initial stretching or compressing of the plate causes uniformly distributed normal stress to appear acting in the direction which is parallel to the plane on which the band crack is *** the appearance of the initial stress in the plate it is assumed that the crack's edge planes are loaded with additional uniformly distributed normal forces and the ERR caused with this additional loading is *** corresponding boundary value problem is formulated within the scope of the so-called 3D linearized theory of elasticity which allows the initial stress on the values of the ERR to be taken into *** results on the influence of the initial stress,anisotropy properties of the plate material,the crack’s length and its distance from the face planes of the plate on the values of the ERR,are presented and *** particular,it is established that for the relatively greater length of the crack’s band,the initial stretching of the plate causes a decrease,but the initial compression causes an increase in the values of the ERR.

关键词： Band crack energy release rate stress intensity factor initial stress orthotropic material rectangular plate 3D FEM

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In vitro antibacterial and antitumor activities of some medicinal plant extracts, growing in Turkey

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Asian Pacific Journal of Tropical Medicine 2013年第8期6卷 616-624页

作者： arzu Birinci Yildirim Fatma Pehlivan Karakas arzu Ucar Turker Department of Biology Abant Izzet Baysal University

Objective: To investigate antibacterial and antitumor activities of 51 different extracts prepared with 3 types of solvents (water, ethanol and methanol) of 16 different plant species (Ajuga reptans (A. reptans) L., Phlomis pungens (P. pungens) Willd., Marrubium astracanicum (M. astracanicum) Jacq., nepeta nuda (n. nuda) L., Stachys annua (S. annua) L., Genista lydia (G. lydia) Boiss., nuphar lutea (n. lutea) L., nymphaea alba (n. alba) L., Vinca minor (V. minor) L., Stellaria media (S. media) L., Capsella bursa-pastoris (C. bursa-pastoris) L., Galium spurium (G. spurium) L., Onosma heterophyllum (O. heterophyllum) Griseb., Reseda luteola (R. luteola) L., Viburnum lantana (V. lantana) L. and Mercurialis annua (M. annua) L.) grown in Turkey was conducted. Methods: Antibacterial activity was evaluated with 10 bacteria including Streptococcus pyogenes (S. pyogenes), Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), Escheria coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Salmonella typhimurium (S. typhimurium), Serratia marcescens (S. marcescens), Proteus vulgaris (P. vulgaris), Enterobacter cloacae (E. cloacea), and Klebsiella pneumoniae (K. pneumoniae) by using disc diffusion method. Antitumor activity was evaluated with Agrobacterium tumefaciens (A. tumefaciens)-induced potato disc tumor assay. Results: Best antibacterial activity was obtained with ethanolic extract of P. pungens against S. pyogenes . Ethanolic and methanolic extract of n. alba and ethanolic extract of G. lydia also showed strong antibacterial activities. Results indicated that alcoholic extracts especially ethanolic extracts exhibited strong antibacterial activity against both gram-positive and gram-negative bacteria. Best antitumor activity was obtained with methanolic extracts of n. alba and V. lantana (100% tumor inhibition). Ethanolic extract of n. alba , alcoholic extracts of n. lutea , A. reptans and V. minor flowers, methanolic extracts of G. lydia and O

关键词： Bioassays Antibacterial Antitumor Medicinal plants

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Prevalence of the terrain reversal effect in satellite imagery

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International Journal of Digital Earth 2015年第8期8卷 640-655页

作者： Miguel-Angel Bernabé-Poveda arzu Çöltekin Universidad de las Fuerzas Armadas–ESPE Departamento de Ciencias de la Tierra y de la ConstrucciónSangolquíPichinchaEcuador Geographic Information Visualization and Analysis Group Department of GeographyUniversity of ZurichSwitzerland

The terrain reversal effect is a perceptual phenomenon which causes an illusion in various 3D geographic visualizations where landforms appear inverted,*** perceive valleys as ridges and vice *** that such displays are important for spatio-visual analysis,this illusion can lead to critical mistakes in interpreting the ***,it is currently undocumented how commonly this effect is *** this paper,we study the prevalence of the terrain reversal effect in satellite imagery through a two-stage online user *** experiment was conducted with the participation of a diverse and relatively large population(n=535).Participants were asked to identify landforms(valley or ridge?)or judge a 3D spatial relationship(is A higher than B?).When the images were rotated by 180°,the results were *** a control task with‘illusion-free’original images,people were successful in identifying landforms,yet a very strong illusion occurred when these images were rotated 180°.Our findings demonstrate that the illusion is acutely present;thus,we need a better understanding of the problem and its ***,the results caution us that in an interactive environment where people can rotate the display,we might be introducing a severe perceptual problem.

关键词： terrain reversal relief inversion false topographic perception phenomenon photo interpretation visual illusion user study

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