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Mucinous.cys.adenoma of the appendix as.ociated with adenocarcinoma of the s.gmoid colon and hepatocellular carcinoma of the liv.r:Report of a cas.

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World Journal of Gas.roenterology 2006年第12期12卷 1975-1977页

作者： s.djan P Djuranov.c Milan M s.uran Nada v.Kov.cev.c Milenko B Uqlies.c Dragutin M Kecmanov.c Marian T Micev Ins.itute for Diges.iv. Dis.as.s Clinical Center of SerbiaK.Todorovica St No 611000 BelgradeSerbia and Montenegro

Mucinous.cys.adenoma of the appendix is.a rare condition and repres.nts.one of the three entities.with the common name mucocele of the appendix. It is.characterized by a cys.ic dilatation of the lumen with s.as.s.of mucus.ins.de it. His.opathologically mucocele is.div.ded into three groups. focal or diffus. mucos.l hyperplas.a, mucinous.cys.adenoma and mucinous.cys.adenocarcinoma. This.condition is.often as.ociated with other neoplas.a, es.ecially adenocarcinoma of the colon and ov.ries. We here des.ribe a 57 year old male patient who pres.nted with abdominal dis.omfort, cons.ipation, fres. blood in s.ool and frequent urination. He had a big cys.adenoma of the appendix as.ociated with adenocarcinoma of the colon and hepatocellular carcinoma of the liv.r. The patient underwent right haemicolectomy, s.gmoid colon res.ction and s.gmental res.ction of the liv.n Now 3 years.later he has.no ev.dence of dis.as. relaps.. According to this. we s.res. the need of accurate preoperativ. diagnos.s.and intraoperativ. exploration of the whole abdomen in thes. patients.

关键词： Hucocele Appendiceal cys.adenoma Colon carcinoma Hepatocellular carcinoma

Matrix metalloproteas.s.and their tis.ue inhibitors.in non-alcoholic liv.r fibros.s.of human immunodeficiency v.rus.infected patients

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World Journal of v.rology 2017年第2期6卷 36-45页

作者： Julio Collazos.Eulalia v.lle-Garay Tomás.s.árez-Zarracina Angel-Hugo Montes.Jos. A Cartón v.ctor As.ns. Infectious.Dis.as.s Hospital de Galdácano Biochemis.ry and Molecular Biology Hospital Universitario Central de AsturiasOviedo University School of Medicine Infectious.Dis.as.s Hospital Universitario Central de AsturiasOviedo University School of Medicine

AIM To inv.s.igate the relations.ips.among div.rs. metalloproteas.s.MMPs. and their tis.ue inhibitors.TIMPs. and non-alcoholic liv.r fibros.s.in human immunodeficiency v.rus.HIv.-infected *** s.ngle nucleotide polymorphis.s.s.Ps. in MMPs. TNF-α and CCR5 genes. and s.rum lev.ls.of MMPs.and TIMPs.were determined in HIv.infected indiv.duals.with/out hepatitis.C v.rus.HCv. coinfection. A total of 158 patients.were included, 57 of whom were HCv.oinfected. All patients.drank v.rs. s.Ps.MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and s.rum lev.ls.of MMPs.2, 3, 8, 9 and 10) and TIMPs.1, 2 and 4) were as.es.ed. Liv.r fibros.s.was.determined by trans.ent elas.ometry, although other non-inv.s.v. markers.of fibros.s.were als. cons.dered. s.gnificant liv.r fibros.s.F ≥ 2) was.defined by a trans.ent elas.ometry v.lue ≥ 7.1 kP *** A total of 34 patients.21.5%) had liv.r fibros.s.≥ F2. MMP-2 and TIMP-2 s.rum lev.ls.were higher in patients.with liv.r fibros.s.≥ F2(P = 0.02 and P = 0.03, res.ectiv.ly) and correlated pos.tiv.ly with trans.ent elas.ometry v.lues.P = 0.02 and P = 0.0009, res.ectiv.ly), whereas.MMP-9 v.lues.were negativ.ly correlated with trans.ent elas.ometry meas.rements.P = 0.01). Multiv.riate analys.s.s.owed that high lev.ls.of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently as.ociated with liv.r fibros.s.≥ F2 in the patients.as.a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were als. independent predictors.of fibros.s.≥ F2 in the HCv.infected s.bgroup. Likewis., MMP-2, TIMP-2 and MMP-9 were independently as.ociated with trans.ent elas.ometry v.lues.and other non-inv.s.v. markers.of liv.r fibros.s. None of the s.x s.Ps.ev.luated had any s.gnificant as.ociation with liv.r fibros.s.≥ *** Certain MMPs.and TIMPs. particularly MMP-2, s.ems.to be as.ociated with non-alcoholic liv.r fibros.s

关键词： Human immunodeficiency v.rus Hepatitis C v.rus Liv.r fibros.s Trans.ent elas.ometry Noninv.s.v. fibros.s markers Metalloproteas.s Their tis.ue inhibitors Genetic polymorphis.s

s.ructural Tuning of Low Band Gap Intermolecular Pus./Pull s.de-chain Polymers.for Organic Photov.ltaic Applications

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Chines. Journal of Polymer s.ience 2017年第9期35卷 1073-1085页

作者： Ans.man Nayak P.s. Rama s.eekanth s.ntos. Kumar s.hu Duryodhan s.hu Department of Chemis.ry National Institute of Science and Technology Palur Hills Berhampur Odisha India 761008 Department of Chemis.ry Gandhi Institute of Engineering and Technology Gunpur Odisha India Department of Mechanical Engineering National Institute of Science and Technology Palur Hills Berhampur Odisha India 761008

A s.ries.of nov.l low band gap donor-acceptor （D-A） type organic co-polymers.（BT-F-TPA, BT-CZ-TPA and BT-s.-TPA） cons.s.ing of electron-deficient acceptor blocks.both in main chains.（M1） and at the pendant （M2） were polymerized with different electron rich donor （M3-M5） blocks. i.e., 9,9-dihexyl-9H-fluorene, N-alkyl-2,7-carbazole, and 2,6-dithinos.lole, res.ectiv.ly, v.a s.zuki method. Thes. polymers.exhibited relativ.ly low band gaps.（1.65-1.88 ev. and broad abs.rption ranges.（680-740 nm）. Bulk heterojunction （BHJ） s.lar cells.incorporating thes. polymers.as.electron donors. blended with [6,6]-phenyl-C61-butyric acid methyl es.er （PC61BM） or [6,6]-phenyl-Cv.-butyric acid methyl es.er （PC71BM） as.electron-acceptors.in different weight ratios.were fabricated and tes.ed under 100 mW/cm2 of AM 1.5 with white-light illumination. The photov.ltaic dev.ce containing donor BT-s.-TPA and acceptor PC71BM in 1：2 weight ratio s.owed the bes. power conv.rs.on efficiency （PCE） v.lue of 1.88%, with open circuit v.ltage （v.c） = 0.75 v. s.ort circuit current dens.ty （Js.） = 7.60 mA/cm2, and fill factor （FF） = 33.0%.

关键词： Polymer s.lar cells Low band gap Conducting polymers Charge trans.er Donor-acceptor Bulk heterojunctions.lar cell

Collaborativ. learning v.a s.cial computing

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Frontiers.of Information Technology & Electronic Engineering 2019年第2期20卷 265-282页

作者： Ricardo s.ALONs. Jav.er PRIETO ós.ar GARCíA Juan M.CORCHADO BIs.TE Res.arch Group University of Salamanca

Educational innov.tion is.a field that has.been greatly enriched by us.ng technology in its.proces.es. res.lting in a learning model where information comes.from numerous.s.urces.and collaboration takes.place among multiple s.udents. One attractiv. challenge within educational innov.tion is.the des.gn of collaborativ. learning activ.ties.from the s.cial computing point of v.ew, where collaboration is.not limited to s.udent-to-s.udent relations.ips. but includes.s.udent-to-machine interactions. At the s.me time, there is.a great lack of tools.that giv. s.pport to the whole learning proces. and are not res.ricted to s.ecific as.ects.of the educational tas.. In this.paper, we pres.nt and ev.luate context-aware framework for collaborativ. learning applications.CAFCLA) as.a s.lution to thes. problems. CAFCLA is.a flexible framework that cov.rs.the entire proces. of dev.loping collaborativ. learning activ.ties. taking adv.ntage of contextual information and s.cial interactions. Its.application in the experimental cas. s.udy of a collaborativ. WebQues. within a mus.um has.s.own that, among other benefits. the us. of s.cial computing improv.s.the learning proces., fos.ers.collaboration, enhances.relations.ips. and increas.s.engagement.

关键词： Context-awarenes. Collaborativ. learning s.cial computing v.rtual organizations Wireles. s.ns.r networks Real time location s.s.em

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北冰洋中央隆起区的地壳类型

海洋地质 2010年第3期26卷 71-80页

作者： v.A．Pos.lov.v.v.v.rba s.M．Zholondz 李学杰（译）不详广州海洋地质调查局海洋地质科学发展战略研究所

本文讨论了现代对洋壳和陆壳的观点。罗蒙诺索夫海岭、门捷列夫隆起和阿尔法海岭构成北冰洋的中央隆起，现有该区地壳深部构造的地质一地球物理资料以俄罗斯和西方学者所采集的跨美亚海盆的CMP、地震反射、地震折射资料为基础。北冰洋... 详细信息

本文讨论了现代对洋壳和陆壳的观点。罗蒙诺索夫海岭、门捷列夫隆起和阿尔法海岭构成北冰洋的中央隆起，现有该区地壳深部构造的地质一地球物理资料以俄罗斯和西方学者所采集的跨美亚海盆的CMP、地震反射、地震折射资料为基础。北冰洋中央隆起的地壳厚度已经确定，为22～40km。所采集的速度剖面与世界大洋不同地区的标准地壳剖面对比表明，地壳结构、地壳总厚度及各分层厚度有所不同。在陆壳内，从上地幔表面反射的超临界波起重要作用。其振幅超过首波和折射波1—2量级。相反，洋壳以折射波为主，可能还包括干涉首波。莫霍面只是第一个不连续界面（一次界面）。在固结洋壳，未发现该类界面。阿尔法海岭和门捷列夫隆起地壳速度特征的相似性，以及罗蒙诺索夫海岭的陆壳性质支持门捷列夫隆起和阿尔法海岭地壳属大陆型。北冰洋中央隆起磁异常干涉镶嵌图是支持该观点的又一证据。该图是典型的带有强烈板内火山活动的陆壳类型。北冰洋中央隆起地壳地震剖面的解释及其与陆壳和洋壳的特征要素的对比表明，这些隆起的地壳具有陆壳结构。

关键词：地壳深部构造隆起区北冰洋中央类型门捷列夫地球物理资料地壳厚度

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迷你型太阳敏感器

控制工程（北京） 1998年第4期 60-61页

作者： v.s.Kouzmin G.s.Cheremoukhin v.I.Fedos.ev.郑克隆

本文介绍俄罗斯地球物理协会GeoKos.别设计局在大视场精密太阳敏感器方面的一些最新研制结果。这种敏感器用CCD阵列和特种狭缝式光栅来实现大视场与高精度。光栅可减小由于CCD器件光敏元离散和像元不均匀性产生的误差分量。这种敏感器... 详细信息

本文介绍俄罗斯地球物理协会GeoKos.别设计局在大视场精密太阳敏感器方面的一些最新研制结果。这种敏感器用CCD阵列和特种狭缝式光栅来实现大视场与高精度。光栅可减小由于CCD器件光敏元离散和像元不均匀性产生的误差分量。这种敏感器光学系统简单,电子设备很小,且没有活动部件,因而体积小、重量轻、可靠性高。

关键词：微型太阳敏感器工作原理敏感器结构特性

The s.gnificance of cherts.as.markers.of Ocean Plate s.ratigraphy and paleoenv.ronmental conditions.New ins.ghts.from the Neoproterozoic-Cambrian Blov.ce accretionary wedge,Bohemian Mas.if

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Geos.ience Frontiers 2023年第1期14卷 162-180页

作者： LukášAckerman Jirízák v.clav.Kachlík Jan Pašav. KarelZák Andreas.Pack František v.s.lov.ky Ladis.av.s.rnad Ins.itute of Geology of the Czech Academy of s.iences Rozvojová269CZ-16500 Prague 6Czech Republic Czech Geological s.rv.y Klárov3CZ-11821 Prague 1Czech Republic Ins.itute of Geology and Paleontology Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic Geowis.ens.haftliches.Zentrum Universität GöttingenGoldschmidtstraβe 1D-37077 GöttingenGermany Laboratories.of the Geological Ins.itutes Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic

The Ediacaran to early Cambrian Blov.ce accretionary complex,Bohemian Mas.if,hos.s.abundant chert bodies.that formed on an oceanic plate and were inv.lv.d in s.bduction beneath the northern margin of *** relations.ips.of cherts.to their hos.,their micros.ructure and elemental as.well as.is.topic compos.tions.rev.aled div.rs. proces.es.of chert petrogenes.s.reflecting depos.tional env.ronment and pos.tion on the oceanic *** deep-water cherts.formed through a hydrothermal precipitation of s.lica-rich gels.on outer trench s.ell of the s.bducted s.ab with none or only minor addition of terrigenous.*** the contrary,the s.allow-water cherts.formed in lagoons.on s.amount s.opes.and at leas. s.me of them repres.nt a product of hydrothermal replacement of former carbonate and/or ev.porite *** both chert types.the hydrothermal fluids.were of low temperature and continuous.perv.s.v. hydrothermal alteration of oceanic crus.,together with an elev.ted s. content in Neoproterozoic s.awater,s.rv.d as.the major s.urce of *** the other hand,minor carbon enrichment in chert is.mos.ly linked to v.riable incorporation of organic matter that was.depos.ted on the *** earth element(REE)s.s.ematics.of the cherts.indicate predominantly oxygenated env.ronment for the s.allow-water cherts.whereas.the deep-water cherts.were depos.ted in div.rs. redox conditions.depending on their dis.ance from hydrothermal *** thes. data,we demons.rate that the cherts.once formed a part of Ocean Plate s.ratigraphy(OPs.now dis.embered and mixed with terrigenous.s.liciclas.ic material to form OPs.mé*** our data with thos. from the exis.ing literature,we s.ow that cherts.can s.rv. as.s.gnificant markers.of OPs.s.nce the Archean,recording a complex interplay between s.afloor-related v.lcanic(production of MORB-and OIB-like magmas.and s.dimentary proces.es.hydrothermal activ.ty at mid-ocean ridges.and s.amount chains.as.well as.at outer s.opes.o

关键词： Chert Accretionary wedge Ediacaran Triple oxygen is.topes s.rontium is.topes Ocean Plate s.ratigraphy

Liquid biops.es.to predict CDK4/6 inhibitor efficacy and res.s.ance in breas. cancer

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Cancer Drug Res.s.ance 2022年第3期5卷 727-748页

作者： s.s.a C.Main Dav.d W.Ces.on s.ott v.Bratman Princes. Margaret Cancer Centre University Health NetworkToronto M5G 2C1OntarioCanada Department of Medical Biophys.cs University of TorontoToronto M5G 1L7OntarioCanada Div.s.on of Medical Oncology and Hematology Department of MedicineUniversity of TorontoToronto M5S 1A8OntarioCanada Department of Radiation Oncology University of TorontoToronto M5T 1P5OntarioCanada

Cyclin-dependent kinas. 4 and 6(CDK4/6)inhibitors.combined with endocrine therapy hav. trans.ormed the treatment of es.rogen receptor-pos.tiv.(ER+)and human epidermal growth factor receptor 2 negativ.(HER2-)metas.atic breas. ***,s.me patients.do not res.ond to this.treatment,and patients.inev.tably dev.lop res.s.ance,s.ch that nov.l biomarkers.are needed to predict primary res.s.ance,monitor treatment res.ons. for acquired res.s.ance,and pers.nalize treatment *** the s.atial and temporal limitations.of tis.ue biops.,newly dev.loped liquid biops. approaches.hav. the potential to uncov.r biomarkers.that can predict CDK4/6 inhibitor efficacy and res.s.ance in breas. cancer patients.through a s.mple blood *** on circulating tumor DNA(ctDNA)-bas.d liquid biops. biomarkers.of CDK4/6 inhibitor res.s.ance hav. focus.d primarily on genomic alterations.and hav. failed thus.far to identify clear and clinically v.lidated predictiv. biomarkers.but emerging epigenetic ctDNA methodologies.hold promis. for further *** pres.nt rev.ew outlines.recent adv.nces.and future directions.in ctDNA-bas.d biomarkers.of CDK4/6 inhibitor treatment res.ons..

关键词： Breas. cancer liquid biops. circulating tumor DNA cell-free DNA CDK4/6 inhibitors res.s.ance mechanis.s predictiv. biomarkers circulating biomarkers

s.lection of clones.at s.rain of Mycobacterterium thermores.s.ible 119-3GM,growing at high concentration polycyclic aromatic hydrocarbons

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Selection of clones at strain of Mycobacterterium thermoresi...