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Analysis of GC×GC fingerprints from medicinal materials using a novel contour detection algorithm:A case of Curcuma wenyujin

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Journal of Pharmaceutical Analysis 2024年第4期14卷 542-551页

作者： Xinyue Yang Yingyu sima Xuhuai Luo Yaping Li Min He Department of Pharmaceutical Engineering School of Chemical EngineeringXiangtan UniversityXiangtanHunan411105China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha410082China Department of Quality Control Xiangtan Central HospitalXiangtanHunan411100China

This study introduces an innovative contour detection algorithm,PeakCET,designed for rapid and efficient analysis of natural product image fingerprints using comprehensive two-dimensional gas chromatogram(GC×GC).This method innovatively combines contour edge tracking with affinity propagation(AP)clustering for peak detection in GC×GC fingerprints,the first in this *** edge tracking signif-icantly reduces false positives caused by“burr”signals,while AP clustering enhances detection accuracy in the face of false *** efficacy of this approach is demonstrated using three medicinal products derived from Curcuma *** not only performs contour detection but also employs inter-group peak matching and peak-volume percentage calculations to assess the compositional similarities and differences among various ***,this algorithm compares the GC×GC fingerprints of Radix/Rhizoma Curcumae Wenyujin with those of products from different botanical *** findings reveal that genetic and geographical factors influence the accumulation of secondary metabolites in various plant *** sample exhibits unique characteristic components alongside common ones,and vari-ations in content may influence their therapeutic *** research establishes a foundational data-set for the quality assessment of Curcuma products and paves the way for the application of computer vision techniques in two-dimensional(2D)fingerprint analysis of GC×GC data.

关键词： GC×GC Image fingerprints Contour detection Clustering of mass spectra Curcuma products

MicroRNAs in thyroid cancer with focus on medullary thyroid carcinoma:potential therapeutic targets and diagnostic/prognostic markers and web based tools

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Oncology Research 2024年第6期32卷 1011-1019页

作者： ELHAM SHAKIBA SETI BOROOMAND sima KHERADMAND KIA MEHDI HEDAYATI Department of Biochemistry Faculty of Biological SciencesNorth Tehran BranchIslamic Azad UniversityTehran***Iran Department of Pathology and Laboratory Medicine Vancouver General HospitalVancouverV5Z 1M9Canada Department of Blood Cell Research Laboratory for Red Blood Cell DiagnosticsSanquinAmsterdam1006 ANThe Netherlands Cellular and Molecular Endocrine Research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehran***Iran

This review aimed to describe the inculpation of microRNAs(miRNAs)in thyroid cancer(TC)and its subtypes,mainly medullary thyroid carcinoma(MTC),and to outline web-based tools and databases for bioinformatics analysis of miRNAs in ***,the capacity of miRNAs to serve as therapeutic targets and biomarkers in TC management will be *** review is based on a literature search of relevant articles on the role of miRNAs in TC and its subtypes,mainly ***,web-based tools and databases for bioinformatics analysis of miRNAs in TC were identified and *** can perform as oncomiRs or antioncoges,relying on the target mRNAs they *** replacement therapy using miRNA mimics or antimiRs that aim to suppress the function of certain miRNAs can be applied to correct miRNAs aberrantly expressed in diseases,particularly in *** are involved in the modulation of fundamental pathways related to cancer,resembling cell cycle checkpoints and DNA repair *** are also rather stable and can reliably be detected in different types of biological materials,rendering them favorable diagnosis and prognosis biomarkers as *** have emerged as promising tools for evaluating medical outcomes in TC and as possible therapeutic *** contribution of miRNAs in thyroid cancer,particularly MTC,is an active area of research,and the utility of web applications and databases for the biological data analysis of miRNAs in TC is becoming increasingly important.

关键词： Thyroid cancer MicroRNAs Biomarker Bioinformatics analysis Medullary thyroid carcinoma(MTC) OncomiRs Antioncoges

The Fascinating Chinese Character Family

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China Book International 2024年第1期 22-25页

作者： Lord sima Miao Lingnan Fine Arts Publishing House

This series is an engaging read about Chinese characters,explaining their origins and the logic behind their *** allows readers to grasp the essence of Chinese character culture and appreciate the ancient art of character *** series is divided into eight mini-volumes,each focusing on eight major categories of common everyday *** introduces over 260 key characters studied in elementary school and more than 200 practical idioms for elementary students.

关键词： everyday elementary character

Robust tube-based MPC with smooth computation for dexterous robot manipulation

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Science China(Information Sciences) 2024年第11期67卷 252-268页

作者： Yu LUO Tianying JI Fuchun SUN Qie sima Huaping LIU Mingxuan JING Jianwei ZHANG Department of Computer Science and Technology Tsinghua University Science & Technology on Integrated Information System Laboratory Institute of Software Chinese Academy of Sciences Department of Informatics University of Hamburg

Dexterous robot manipulation has shone in complex industrial scenarios, where multiple manipulators, or fingers, cooperate to grasp and manipulate objects. When encountering multi-objective optimization with system constraints in such scenarios, model predictive control(MPC) has demonstrated exceptional performance in complex multi-robot manipulation tasks involving multi-objective optimization with system constraints. However, in such scenarios, the substantial computational load required to solve the optimal control problem(OCP) at each triggering instant can lead to significant delays between state sampling and control application, hindering real-time performance. To address these challenges, this paper introduces a novel robust tube-based smooth MPC approach for two fundamental manipulation tasks: reaching a given target and tracking a reference trajectory. By predicting the successor state as the initial condition for imminent OCP solving, we can solve the forthcoming OCP ahead of time, alleviating delay effects. Additionally,we establish an upper bound for linearizing the original nonlinear system, reducing OCP complexity and enhancing response speed. Grounded in tube-based MPC theory, the recursive feasibility and closed-loop stability amidst constraints and disturbances are ensured. Empirical validation is provided through two numerical simulations and two real-world dexterous robot manipulation tasks, which shows that the seamless control input by our methods can effectively enhance the solving efficiency and control performance when compared to conventional time-triggered MPC strategies.

关键词： dexterous robot manipulation model predictive control smooth computation

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珠穆朗玛峰北坡桤木属大气花粉传输路径与来源

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地球科学进展 2024年第4期39卷 419-428页

作者：程久菊吕新苗朱立平马庆峰 HUMAGAIN sima PAUDAYAL N KHUM 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室北京100101 中国科学院大学北京100049 Central Department of Geology Tribhuvan UniversityKathmandu 44600Nepal

认识区域大气花粉组成及其形成条件有利于明确不同类型花粉组合的气候与环境意义。利用布卡大气花粉采样器在珠穆朗玛峰北坡开展了连续2年(2012—2013年)的大气花粉观测研究。基于后向轨迹和潜在来源区域模型,探讨了秋季主要组分桤木属... 详细信息

认识区域大气花粉组成及其形成条件有利于明确不同类型花粉组合的气候与环境意义。利用布卡大气花粉采样器在珠穆朗玛峰北坡开展了连续2年(2012—2013年)的大气花粉观测研究。基于后向轨迹和潜在来源区域模型,探讨了秋季主要组分桤木属花粉的传输路径与潜在来源区域,分析了桤木属花粉与其植物分布和大气环流的关系及气候指示意义。结果显示:(1)桤木属花粉季气团传输路径主要来自于采样点西南方向;(2)桤木属花粉潜在来源区域与其气团传输路径基本一致,主要是喜马拉雅山脉中段,包括尼泊尔中部和东部以及西藏南部等地区;(3)桤木属花粉数量、传输路径和来源区域的年际变化与大气环流有关,受高空西风影响的西南气团对桤木属花粉影响更大。研究结果可以为认识珠穆朗玛峰北坡外来花粉的气候意义提供科学依据。

关键词：桤木属花粉传输路径来源区域后向轨迹模拟青藏高原

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铜基载氧体催化电厂烟气脱氧研究

燃料化学学报（中英文） 2024年第6期52卷 839-849页

作者：司马皓王雪峰邓存宝太原理工大学安全与应急管理工程学院山西太原030024

电厂烟气主要成分为N_(2)、CO_(2)和部分O_(2),将电厂烟气注入矿井采空区可实现CO_(2)封存,并替代注氮气防治遗煤自燃,但是烟气中的O_(2)是造成遗煤自燃的因素之一。因此,亟待开发一种经济有效的催化剂来脱除电厂烟气中的O_(2)。本研究... 详细信息

电厂烟气主要成分为N_(2)、CO_(2)和部分O_(2),将电厂烟气注入矿井采空区可实现CO_(2)封存,并替代注氮气防治遗煤自燃,但是烟气中的O_(2)是造成遗煤自燃的因素之一。因此,亟待开发一种经济有效的催化剂来脱除电厂烟气中的O_(2)。本研究采用共沉淀法,通过调变载体和负载量可控制备了铜基催化剂和系列xCuO/CeO_(2)催化剂,利用BET、XRD、ICP、TEM、H_(2)-TPR和XPS等手段对催化剂进行了表征,并建立催化剂结构与催化电厂烟气脱氧性能之间的构效关系。结果表明,CeO_(2)的加入提高了CuO的分散性、增加了催化剂的氧空位,提高了催化剂的活性和还原氧化性能,Cu-Ce界面结构的协同效应促进了还原氧化过程,表现出良好的活性和循环稳定性。30CuO/CeO_(2)由于其CuO颗粒尺寸最小、分散性最高、氧空位浓度最高,表现出较优的催化电厂烟气脱氧性能。本研究为开发低成本可循环使用、高活性和高稳定性的脱氧催化剂提供了参考。

关键词：化学链燃烧 CuO/CeO_(2) 氧化还原界面结构氧空位

面向历史风貌的中心城区精细化城市管控策略研究——以墨尔本中心城区为例

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现代城市研究 2024年第8期39卷 60-66页

作者：李翔司马艺娜厦门大学建筑与土木工程学院宁波诺丁汉大学理工学院建筑与建筑环境系

在历史城区风貌保护中,我国存在城区特色风貌指引不明、管控要素划分不够细致、元素之间缺乏整体统筹等问题,需要构建精细化城市管控体系来维护历史风貌、增强城市吸引力。文章从墨尔本维护历史城区特色风貌的精细化城市管控策略入手,... 详细信息

在历史城区风貌保护中,我国存在城区特色风貌指引不明、管控要素划分不够细致、元素之间缺乏整体统筹等问题,需要构建精细化城市管控体系来维护历史风貌、增强城市吸引力。文章从墨尔本维护历史城区特色风貌的精细化城市管控策略入手,深入分析其在历史城区风貌保持、建设开发强度管控、特色空间人性化提升和户外广告风格约束等4个层面的策略。在此基础上,结合我国历史城区保护现状,从层级体系建设、特色风貌指引、要素控制协调、管理语言传导、多方团队协作等方面归纳墨尔本精细化城市管控的思路和经验,并对我国精细化城市管控转型提出建议。

关键词：历史风貌中心城区精细化管理城市规划与设计管控墨尔本

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珠峰北坡桤木属大气花粉传输路径与来源

地球科学进展 2024年

作者：程久菊吕新苗朱立平马庆峰 HUMAGAIN sima KHUM PAUDAYAL N 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室 Central Department of Geology Tribhuvan University 中国科学院大学

认识区域大气花粉组成及其形成条件有利于明确不同类型花粉组合的气候与环境意义。利用布卡大气花粉采样器在珠峰北坡开展了连续2年（2012—2013年）的大气花粉观测研究。基于后向轨迹和潜在来源区域模型，探讨了占秋季主要组分的桤木... 详细信息

认识区域大气花粉组成及其形成条件有利于明确不同类型花粉组合的气候与环境意义。利用布卡大气花粉采样器在珠峰北坡开展了连续2年（2012—2013年）的大气花粉观测研究。基于后向轨迹和潜在来源区域模型，探讨了占秋季主要组分的桤木属花粉传输路径与潜在来源区域，分析了桤木属花粉与其植物分布和大气环流的关系及气候指示意义。结果显示：(1)桤木属花粉季气团传输路径主要来自于采样点西南方向；(2)桤木属花粉潜在来源区域与其气团传输路径基本一致，主要是喜马拉雅中段，包括尼泊尔中部和东部以及西藏南部等地区；(3)桤木属花粉数量、传输路径和来源区域的年际变化与大气环流有关，受高空西风影响的西南气团对桤木属花粉影响更大。研究结果为认识珠峰北坡外来花粉的气候意义提供科学依据。

关键词：桤木属花粉传输路径来源区域后向轨迹模拟青藏高原

敷设分层梯度声学覆盖层的加肋圆柱壳声辐射特性研究

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船舶力学 2024年第2期28卷 294-308页

作者：俞白兮李凯张峰司马灿中国船舶科学研究中心江苏无锡214082 深海技术科学太湖实验室江苏无锡214082

单壳体潜艇敷设声学覆盖层应具有机械噪声、水动力噪声和声目标强度控制的多功能特性,为此需要解决两个基本问题:其一,提高机械噪声低频控制效果;其二,实现覆盖层的多功能兼容性。本文从降低机械激励壳体声辐射角度出发,采用模态叠加法... 详细信息

单壳体潜艇敷设声学覆盖层应具有机械噪声、水动力噪声和声目标强度控制的多功能特性,为此需要解决两个基本问题:其一,提高机械噪声低频控制效果;其二,实现覆盖层的多功能兼容性。本文从降低机械激励壳体声辐射角度出发,采用模态叠加法,建立无限大理想水介质中分层梯度声学覆盖层与有限长加肋圆柱壳的声振耦合及声辐射模型,基于声学覆盖层模态传递函数特性,计算分析声学覆盖层分层梯度分布及厚度、层数等参数对加肋圆柱壳辐射噪声影响的特征和规律,给出分层梯度声学覆盖层的特征声阻抗渐变参数分布并与敷设均匀声学覆盖层降噪特性比较。研究结果表明:加肋圆柱壳敷设内层至外层声阻抗逐渐递增,各分层取慢波速的声学覆盖层,具有比均匀声学覆盖层更有效地降低外表面振动位移的特性,可明显增加降噪效果,并扩展低频降噪范围。声学覆盖层的优化应增加声阻抗的内分层失配和外分层适配的效应,有利于降低加肋圆柱壳低频声辐射,并可兼顾降低声目标强度。

关键词：分层梯度声学覆盖层加肋圆柱壳声辐射