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Immune regulatory properties of multipotent mesenchymal stromal cells:Where do we stand?

World Journal of Stem Cells 2011年第1期3卷 1-8页

作者： ênio josé bassi Carlos Alberto Mayora Aita Niels Olsen Saraiva Camara Laboratory of Transplantation Immunobiology Department of Immunology Universidade of So Paulo Centro de Ciências Biológi-cas e da Saúde Pontifícia Universidade Católica do Paraná

Multipotent mesenchymal stromal cells (MSC) can be isolated and efficiently expanded from almost every single body tissue and have the ability of self-renewal and differentiation into various mesodermal cell lineages. Moreover, these cells are considered immunologically privileged, related to a lack of surface expression of costimulatory molecules required for complete T cell activation. Recently, it has been observed that MSC are capable of suppressing the immune response by inhibiting the maturation of dendritic cells and suppressing the function of T lymphocytes, B lymphocytes and natural killer cells in autoimmune and inflammatory diseases as a new strategy for immunosuppression. The understanding of immune regulation mechanisms by MSC is necessary for their use as immunotherapy in clinical applications for several diseases.

关键词： Immunosuppression Mesenchymal stem cell Immune system Inflammation Autoimmune disease

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An integrated approach for increasing breeding efficiency in apple and peach in Europe

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Horticulture Research 2018年第1期5卷 825-838页

作者： Francois Laurens Maria joséAranzana Pere Arus Daniele bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg IRHS INRAAgrocampus-OuestUniversitéd’AngersSFR 4207 QuaSaVUniversitéBretagne Loire42 rue Georges MorelBeaucouzé49071France IRTA(Institut de Recerca i Tecnologia Agroalimentàries) BarcelonaSpain Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB Campus UABBellaterraBarcelonaSpain Universitàdegli Studi di Milano-DiSAA Via Celoria 2Milan20133Italy Biometris Wageningen University and ResearchDroevendaalsesteeg 1Wageningen6708PBThe Netherlands IRTA-Mas Badia Mas BadiaLa Tallada17134Spain Parco Tecnologico Padano Via EinsteinLoc.Cascina CodazzaLodi26900Italy Dipartimento di Scienze Agrarie Alma Mater Studiorum-Universitàdi BolognaBolognaItaly UMR AGAP INRAMontpellier34398France GAFL INRAMontfavet84143France Agroscope Research Division Plant BreedingSchloss 1Wädenswil8820Switzerland Julius Kühn-Institute(JKI) Federal Research Centre for Cultivated Plants Institute for Breeding Research on Fruit CropsPillnitzer Platz 3aDresden01326Germany Research and Innovation Center Fondazione Edmund MachSan Michele all’AdigeTrentoItaly CREA-VE Center of Viticulture and Enologyvia XXVIII Aprile 26Conegliano(TV)31015Italy Plant Breeding Wageningen University and ResearchDroevendaalsesteeg 1P.O.Box 386Wageningen6700AJThe Netherlands Hendrix Genetics Research Technology&ServicesBoxmeer5830 ACThe Netherlands

Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and *** bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private *** complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for *** breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank *** also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection *** FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the *** review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond.

关键词： breeding germplasm breed

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Qualitative Assessment of Knowledge, Attitude, and Practice of Contraceptives among Women Attending Postnatal Care in a Health Facility in jos, Plateau State, Nigeria

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Open Journal of Obstetrics and Gynecology 2022年第8期12卷 706-718页

作者： Kingsley Chinedu Okafor Lucy Ochanya Idoko Emmanuel Unubi Ochuma Anne Inyangobong Effiong David Victor Omeiza Amos Paul bassi Department of Community Medicine & Primary Health Care Bingham University Karu Nigeria Community Health and Primary Health Care Bingham University Karu Nigeria

Background: Contraceptive acceptance and utilization in society has been a huge challenge for communities in developing countries. There is a need to support the increase in the utilization of contraception and family planning services. In all this, good knowledge and practice of contraception services will enable women to select the best methods. The study seeks to qualitatively assess the knowledge, attitude, and practice of contraceptive use among women attending postnatal care in a health facility in jos, Plateau State, Nigeria. Methods: This qualitative study was conducted in Bingham University Teaching Hospital, jos, Plateau State in September 2019. This study utilized Focus Group Discussions among 36 women recruited using the purposive sampling technique. There were four (4) sessions involving nine (9) women per session. Findings: Of the 36 women, a majority (88.9%) had positive perception regarding contraception, all agreed that contraception and family planning is beneficial to families and communities. A majority felt that communities are yet to accept contraception. Most (83.3%) of the women had good knowledge of contraception. Three-quarters (77.8%) of the women have used contraception in the past, and about half (41.7%) are using it currently. Attitude towards adoption of contraceptives after current pregnancy was generally good. About half (52.7%) of the participants stated they required spousal approval before they adopt a method of contraception. Conclusion: There is a need for health agencies, development partners, and government to continue the health education, community sensitization, and support towards making contraception and family planning commodities available and accessible.

关键词： Contraception Family Planning Knowledge Practice Women

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Attitude, Practice, and Factors Affecting Contraceptive Use among Women Attending Postnatal Care in a Tertiary Health Facility in jos North LGA, Plateau State, Nigeria

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Open Journal of Obstetrics and Gynecology 2022年第8期12卷 814-831页

作者： Kingsley Chinedu Okafor David Victor Omeiza Lucy Ochanya Idoko Effiong Anne Inyangobong Ochuma Emmanuel Unubi Amos Paul bassi Department of Community Medicine & Primary Health Care Bingham University Karu Nigeria Community Health and Primary Health Care Bingham University Karu Nigeria

The high population growth rate has been associated with the increased level of poverty, morbidity, mortality, and decreased life expectancy. Modern contraception is an important factor in controlling fertility through prevention of unintended and unwanted pregnancies. Contraception (birth control) prevents pregnancy by interfering with the normal process of ovulation, fertilization, and implantation. Contraceptive use is still very low in Nigeria and Sub-Saharan Africa (SSA), where the levels of fertility and unmet need for family planning are high. The attitude of women toward contraception will usually affect the practice and utilization of contraceptives. The objective of this study is to assess the attitude, prevalence, and factors affecting contraceptive use among women attending Postnatal care in a tertiary health facility in jos North L. G. A Plateau State, Nigeria. There was a descriptive cross-sectional study done between September to October 2019, with a sample size of 250 women. Respondents were determined using a multi-stage sampling method. Data collection was done using an interviewer-administered, pre-tested, structured questionnaire. The data was collected, entered, and analyzed using IBM Statistical package for social sciences (SPSS) version 20.0. Most women have a positive attitude 162 (64.8%) toward contraception while 88 (35.2%) had negative attitude toward contraception. Three quarters (75.2%) of women are willing to use contraception. The prevalence of contraceptive use among respondents was 35.6% while the prevalence of previous use of contraceptives among the respondents was 71.2%. Fifty (27.9%) used condom (barrier method), 40 (22.9%) used withdrawal method. Majority of the other respondents were spread across OCPs, injectables and implants. Major factors affecting the use of contraceptives were majorly attributed to informed choice with 60.1%, Partner’s decision (44.1%) and mild or no adverse reaction (12.8%). While major factors preventin

关键词： Attitude Contraception Postnatal Women

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