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Volumetric Modifications of Metastatic Liver Volumes after Dramatic Responses under Chemotherapy

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Surgical Science 2012年第3期3卷 126-130页

作者： Dominique Elias Léon Maggiori Pascuale Misitano Frederic Deschamps Frédéric dumont Michel Ducreux Diane Goéré Departments of Oncologic Surgery of Interventional Radiology and Medical Oncology Institut Gustave Roussy Villejuif France Departments of Oncologic Surgery of Interventional Radiology and Medical Oncology Institut Gustave Roussy Villejuif France

Objective: To analyze the volumetric modifications of the non tumourous part of the liver when liver metastases (LM) decrease under chemotherapy. Methods: Patients were highly selected based on the following criteria: multiple bilateral large colorectal LM, response of LM attaining at least 85% under chemotherapy. The volumes and ratios of the whole liver, of the LM, and mainly of the non tumourous (normal) part of the liver, were measured on CT scan before and after chemotherapy. Results: Only ten (5%) among 198 treated patients were eligible. Nine of them had received intra-arterial chemotherapy. Metastatic involvement was initially 34% before chemotherapy (range: 13% - 75%), and was 5% (range: 1% - 25%) after chemotherapy. The whole liver volume decreased by 41% (range: 23% - 68%) after chemotherapy. The non metastatic liver (volume and ratio) decreased after chemotherapy in 6 patients and increased in 4 patients. The volume and ratio increased in the 4 patients whose disease initially exhibited the highest metastatic involvement (p = 0.01). Conclusion: The volume of the non metastatic part of the liver varied slightly under standard chemotherapy. Intra-arterial chemotherapy induces dramatic responses, but also liver injury which impairs liver regeneration. However increasing volumes were observed when initial tumour involvement was major.

关键词： Liver Volume Colorectal Metastases Response under Chemotherapy

Oviposition behavior of the mirid Macrolophus pygmaeus under risk of intraguild predation and cannibalism

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Insect Science 2021年第1期28卷 224-230页

作者： Frangois dumont Eric Lucas Oscar Alomar Departement des Sciences Biologiques Universite du Quebec a MontrealCentre VilleMontrealQCCanada Sustainable Plant Protection Programme Institute of Agri food Research and Technology(IRTA)CabrilsCataloniaSpain

Zoophytophagous mirid species,that feed and develop either on prey or plant resources,are often found simultaneously on the same ***,these species can engage in both intraguild predation and cannibalism,which can pose a threat to mirid *** females may respond to such risks of predation on their eggs by reducing the number of eggs laid or selecting safer oviposition *** tested the oviposition behavior of Macrolophus pygmaeus(Rambur)(Hemiptera:Miridae)females under the risk of cannibalism by *** males and intraguild predation by Nesidiocoris tenuis(Reuter)males(Hemiptera:Miridae)under laboratory *** predators and cannibals were introduced during or after the oviposition *** number of eggs laid(using counts of newly hatched nymphs)and their proportion on each part of a tomato plant were both *** results reveal that only cannibalism by *** males after the period of oviposition significantly decreased the number of hatched *** thus represents a greater risk to mirid eggs than intraguild *** *** female responded to the presence of potential intraguild predators(or competitors)by decreasing the nu mber of eggs laid in the upper *** results suggest that *** females avoid competition by ***,by laying fewer eggs on upper *** could regulate zoophytophagous predator populations under prey scarcity conditions and minimize the risk of crop damage associated with those biological control agents.

关键词： antipredator behavior cannibalism intraguild predation Macrolophus pygmaeus',Nesidiocoris tenuis zoophytophagy

Influence of the operating temperature on the ageing and interfaces of double layer polymer electrolyte solid state Li metal batteries

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Nano Research 2023年第6期16卷 8377-8384页

作者： Mikel Arrese-Igor María Martinez-Ibañez Ander Orue Ekaterina Pavlenko Erwan dumont Michel Armand Frédéric Aguesse Pedro López Aranguren Centre for Cooperative Research on Alternative Energies(CIC energiGUNE) Basque Research and Technology Alliance(BRTA)Alava Technology ParkAlbert Einstein 48Vitoria-Gasteiz 01510Spain University of the Basque Country(UPV/EHU) Barrio Sarrienas/nLeioa 48940Spain Saft 111 Boulevard Alfred DaneyBordeaux Cedex 33074France

Solid-state lithium metal batteries(SSLMBs)are considered an auspicious technology to develop high energy density and safe energy storage *** double layer polymer electrolyte(DLPE)is a rational approach for engineering high-performance SSLMBs addressing electrolyte requirements with specifically designed polymers at the positive electrode and as *** this work,SSLMBs were assembled with poly(propylene carbonate)(PPC),offering stability toward oxidation at the positive electrode,and a gel polymer electrolyte with polyethyleneglycol dimethylether(PEGDME)as separator,offering high ionic conductivity at low temperature and sufficient interfacial stability with Li *** electrochemical properties and performance of cells with LiFePO_(4) and Li[Ni_(0.6)Mn_(0.2)Co_(0.2)]O_(2) positive electrodes are thoroughly investigated as function of the operating temperature by using a host of characterization ***-voltage cells with an areal capacity of 0.7 mAh·cm^(−2)cycled at 40℃ exhibit a higher capacity retention than the cells cycled at 70℃.To understand such differences,a three-electrode setup is applied to discriminate anodic processes from cathodic as function of the *** elucidate the ageing and interfacial evolution for DLPE cells with gel polymer electrolytes paving the way for building performance solid state batteries.

关键词： double layer polymer electrolyte solid-state lithium metal battery gel polymer electrolyte high voltage interfacial study

The favorable impact of PIK3CA mutations on survival: an analysis of 2587 patients with breast cancer

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Chinese Journal of Cancer 2012年第7期31卷 327-334页

作者： Amaury G. dumont Sarah N.dumont Jonathan C. Trent Department of Experimental Pediatrics University of Texas-MD Anderson Cancer CenterHouston Texas United States Division of Hematology and Oncology University of Miami-Sylvester Comprehensive Cancer CenterMiami Florida United States

The phosphatidylinositol-3 kinase(PI3K) pathway regulates a number of cellular processes, including cell survival, cell growth, and cell cycle progression. Consequently, this pathway is commonly deregulated in cancer. In particular, mutations in the gene PIK3CA that encodes the p110α catalytic subunit of the PI3K enzymes result in cell proliferation and resistance to apoptosis in vitro and induce breast tumors in transgenic mice. These data underscore the role of this pathway during oncogenesis. Thus, an ongoing, large-scale effort is underway to develop clinically active drugs that target elements of the PI3K pathway. However, conflicting data suggest that gain-of-function PIK3CA mutations may be associated with either a favorable or a poor clinical outcome, compared with the wild-type PIK3CA gene. In the current study, we performed a systematic review of breast cancer clinical studies. Upon evaluation of 2587 breast cancer cases from 12 independent studies, we showed that patients with tumors harboring a PIK3CA mutation have a better clinical outcome than those with a wild-type PIK3CA gene. Importantly, this improved prognosis may pertain only to patients with mutations in the kinase domain of p110α and to postmenopausal women with estrogen receptor-positive breast cancer. We propose three potential explanations for this paradoxical observation. First, PIK3CA mutations may interfere with the metastasis process or may induce senescence, which results in a better outcome for patients with mutated tumors. Secondly, we speculate that PIK3CA mutations may increase early tumor diagnosis by modification of the actin cytoskeleton in tumor cells. Lastly, we propose that PIK3CA mutations may be a favorable predictive factor for response to hormonal therapy, giving a therapeutic advantage to these patients. Ultimately, an improved understanding of the clinical impact of PIK3CA mutations is critical for the development of optimally personalized therapeutics against breast can

关键词：肿瘤患者乳腺癌突变转基因小鼠肌动蛋白细胞骨架磷脂酰肌醇-3 信号通路乳腺肿瘤

Synthesis of hydroxymethylfurfural and furfural from hardwood and softwood pulp using ferric sulphate as catalyst

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Frontiers of Chemical Science and Engineering 2019年第3期13卷 531-542页

作者： Agneev Mukherjee Guillermo Portillo-Perez Marie-Josee dumont Bioresource Engineering Department McGill UniversityQC H9X 3V9Canada

Hydroxymethylfurfural (HMF) and furfural are promising chemicals for the creation of a bio-based economy. The development of an inexpensive catalytic system for converting cellulosic biomass into these chemicals is an important step in this regard. Ferric sulphate is a common, cheap and non-toxic Lewis acid that has been used to catalyse reactions such as wood depolymerisation. In this work, ferric sulphate was used to help the production of HMF and furfural from hardwood and softwood pulps. It was found that for hardwood pulp, the use of ferric sulphate alone gave a maximum HMF yield of 31.6 mol-%. The addition of the ionic liquid [BMIM]Cl or HCl as co-catalysts did not lead to an increase in the yields obtained. A prior decationisation step, however, resulted in HMF yields of 50.4 mol-%. Softwood pulp was harder to depolymerise than hardwood, with a yield of 28.7% obtained using ferric sulphate alone. The maximum HMF yield from softwood, 37.9 mol-%, was obtained using a combination of ferric sulphate and dilute HCl. It was thus concluded that ferric sulphate is a promising catalyst for HMF synthesis from cellulosic biomass.

关键词： 5-hydroxymethylftirfural hardwood softwood ferric sulphate biorefinery

Wheat Ear Segmentation Based on a Multisensor System and Superpixel Classification

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Plant Phenomics 2022年第1期4卷 409-418页

作者： Alexis Carlier Sebastien Dandrifosse Benjamin dumont Benoit Mercatoris Biosystems Dynamics and Exchanges TERRA Teaching and Research CentreGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Plant Sciences TERRA Teaching and Research CentreGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium

The automatic segmentation of ears in wheat canopy images is an important step to measure ear density or extract relevant plant traits separately for the different *** deep learning algorithms appear as promising tools to accurately detect ears in a wide diversity of ***,they remain complicated to implement and necessitate a huge training *** paper is aimed at proposing an easy and quick to train and robust alternative to segment wheat ears from heading to maturity growth stage.

关键词： Wheat heading maturity

Analysis of the microbial communities in soils of different ages following volcanic eruptions

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Pedosphere 2020年第1期30卷 126-134页

作者： Marcela HERNáNDEZ Marcela CALABI Ralf CONRAD Marc G.dumont Max Planck Institute for Terrestrial Microbiology Karl-von-Frisch-Str.10Marburg 35043(Germany) Scientific and Technological Bioresource Nucleus Universidad de La FronteraTemuco(Chile) School of Biological Sciences University of SouthamptonSouthampton SO171BJ(UK)

Volcanism is a primary process of land *** provides a model for understanding soil-forming processes and the role of pioneer bacteria and/or archaea as early colonizers in those new *** objective of this study was to identify the microbial communities involved in soil *** was extracted from soil samples from the Llaima volcano in Chile at sites destroyed by lava in different centuries(1640,1751,and 1957).Bacterial and archaeal 16 S r RNA genes were analyzed using quantitative polymerase chain reaction(q PCR)and Illumina Mi Seq *** showed that microbial diversity increased with soil age,particularly between the 1751 and 1640 *** archaeal communities,Thaumarchaeota was detected in similar abundances in all soils,but Euryarchaeota was rare in the older *** analysis of bacterial 16 S r RNA genes showed high abundances of Chloroflexi(37%),Planctomycetes(18%),and Verrucomicrobia(10%)in the youngest *** and Acidobacteria were highly abundant in the older soils(16%in 1640 and 15%in 1751 for Acidobacteria;38%in 1640 and 27%in 1751 for Proteobacteria).The microbial profiles in the youngest soils were unusual,with a high abundance of bacteria belonging to the order Ktedonobacterales(Chloroflexi)in the 1957 soil(37%)compared with the 1751(18%)and 1640(7%)*** this study,we show that there is a gradual establishment of the microbial community in volcanic soils following an eruption and that specific microbial groups can colonize during the early stages of recovery.

关键词： 16S rRNA gene extreme environment high-throughput sequencing Ktedonobacterales microbial diversity pioneer microbe recolonization soil formation volcanic deposit

Gregarious pupation act as a defensive mechanism against cannibalism and intraguild predation

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Insect Science 2016年第4期23卷 612-620页

作者： Claudia Roberge Bruno Frechette Genevieve Labrie Francois dumont Eric Lucas Universite du Quebec a Montreal Departement des Sciences Biologiques CP 8888 Succ. Centre Ville Montreal Centre de recherche sur les grains Inc (CEROM) 740 chemin Trudeau St-Mathieu-de-Beloeil Quebec J3G OE2 Canada

Coccinellid pupae use an array of defensive strategies against their natural enemies. This study aims to assess the efficiency of gregarious pupation as a defensive mechanism against intraguild predators and cannibals in coccinellid. The study was designed specifically （i） to determine the natural occurrence of gregarious pupation in the field for different coccinellid species, and （ii） to evaluate the adaptive value of gregarious pupation as a defensive mechanism against 2 types of predators （i.e., cannibals and intraguild predators）. In the field, gregarious pupation consisted of a group of 2-5 pupae. The proportion of gregarious pupation observed varied according to species, the highest rate being observed with Harmonia axyridis Pallas （Coccinellidae; 14.17%）. Gregarious pupation had no impact on the probability that intraguild predators and cannibals locate pupae. Intraguild predation occurred more often in site with gregarious pupation, while cannibalism occurred as often in site with gregarious pupation as in site with isolated pupa. However, for a specific pupa, the mortality rate was higher for isolated pupae than for pupae located in a gregarious pupation site both in the presence of intraguild predators and in the presence of cannibals. The spatial location of pupae within the group had no impact on mortality rate. Since it reduces the risk of predation, it is proposed that gregarious pupation act as a defensive mechanism for 11. axyridis pupae.

关键词： attack abatement Coccinellidae dilution effect encounter effect grouping behavior Pentatomidae Selfish herd

Broadband quantum-dot frequency-modulated comb laser

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Light(Science & Applications) 2023年第8期12卷 1696-1707页

作者： Bozhang Dong Mario dumont Osama Terra Heming Wang Andrew Netherton John E Bowers Institute for Energy Efficiency University of CaliforniaSanta BarbaraCAUSA Department of Electrical and Computer Engineering University of CaliforniaSanta BarbaraCAUSA Primary Length and Laser Technology Lab National Institute of StandardsGizaEgypt

Frequency-modulated(FM)laser combs,which offer a quasi-continuous-wave output and a flat-topped optical spectrum,are emerging as a promising solution for wavelength-division multiplexing applications,precision metrology,and ultrafast optical *** generation of FM combs relies on spatial hole burning,group velocity dispersion,Kerr nonlinearity,and four-wave mixing(FWM).While FM combs have been widely observed in quantum cascade Fabry-Perot(FP)lasers,the requirement for a low-dispersion FP cavity can be a challenge in platforms where the waveguide dispersion is mainly determined by the *** we report a 60 GHz quantum-dot(QD)mode-locked laser in which both the amplitude-modulated(AM)and the FM comb can be generated *** high FWM efficiency of-5 dB allows the QD laser to generate FM comb *** also demonstrate that the Kerr nonlinearity can be practically engineered to improve the FM comb bandwidth without the need for GVD *** maximum 3-dB bandwidth that our QD platform can deliver is as large as 2.2 *** study gives novel insights into the improvement of FM combs and paves the way for small-footprint,electrically pumped,and energy-efficient frequency combs for silicon photonic integrated circuits(PICs).

关键词： laser waveguide pumped