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白术-木香药对对脾虚腹泻型肠易激综合征大鼠肠道菌群与短链脂肪酸代谢的调节作用

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中国药房 2024年第3期35卷 304-310页

作者：黎豫川张远哲杨元凤陈礼大徐献梅贵州中医药大学第二附属医院药学部贵阳550025 贵州中医药大学基础医学院贵阳550025

目的探讨白术-木香药对对脾虚腹泻型肠易激综合征(IBS-D)大鼠肠道菌群与短链脂肪酸(SCFAs)代谢的调节作用。方法使用番泻叶灌胃联合束缚刺激构建大鼠脾虚IBS-D模型。将造模成功的大鼠分为模型组、阳性对照组(匹维溴铵1.5 mg/kg)和白术... 详细信息

目的探讨白术-木香药对对脾虚腹泻型肠易激综合征(IBS-D)大鼠肠道菌群与短链脂肪酸(SCFAs)代谢的调节作用。方法使用番泻叶灌胃联合束缚刺激构建大鼠脾虚IBS-D模型。将造模成功的大鼠分为模型组、阳性对照组(匹维溴铵1.5 mg/kg)和白术-木香药对低、中、高剂量组(0.7、1.4、2.8 g/kg),每组6只;另取6只健康大鼠作为空白对照组。空白对照组与模型组大鼠灌胃生理盐水,其余各组灌胃相应药液,每天1次,连续14 d。观察大鼠一般状况,并检测粪便含水量;检测大鼠肠道敏感性[以腹壁撤退反射(AWR)阈值评价]和肠道推进率;检测大鼠血清中5-羟色胺(5-HT)、P物质(SP)水平;观察大鼠结肠组织病理变化,检测大鼠结肠组织中5-HT3受体(5-HT3R)、5-HT4受体(5-HT4R)、5-HT转运体(SERT)蛋白表达水平。取空白对照组、模型组和白术-木香药对高剂量组大鼠粪便样本进行16S rRNA测序分析,并检测粪便中乙酸、丙酸、丁酸的含量。结果与模型组比较,白术-木香药对中、高剂量组大鼠给药7、14 d后的体重,粪便含水量,AWR阈值,结肠组织中5-HT4R、SERT蛋白表达水平均显著升高(P<0.05或P<0.01);血清中5-HT、SP水平,肠道推进率(白术-木香药对中剂量组除外),结肠组织中5-HT3R蛋白表达水平均显著降低(P<0.01);腹泻缓解,精神状态恢复,结肠组织部分结构恢复;且白术-木香药对高剂量组大鼠肠道菌群的多样性与物种数量有所减少,粪便中丁酸含量显著降低(P<0.05)。结论白术与木香配伍可以改善脾虚IBS-D模型大鼠的肠道动力及肠道敏感性,并缓解腹泻,这可能与改善肠道菌群结构变化,降低5-HT表达和丁酸含量以及升高5-HT4R、SERT表达有关。

关键词：肠易激综合征白术木香 5-羟色胺肠道菌群短链脂肪酸

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医院制剂益气解毒丸工艺及质量标准研究

中国民族民间医药 2024年第16期33卷 35-41页

作者：陈礼大吴增光黎豫川杨波贵州中医药大学第二附属医院贵州550025

目的:对益气解毒丸的工艺、质量进行研究,优选生产工艺参数,建立质量控制方法。方法:制备工艺从饮片干燥温度、炼蜜等进行参数筛选,以水分、成型、浸出物等内容作为指标成分考察;以三批中试样品进行质量研究,参照丸剂的质量要求,从性状... 详细信息

目的:对益气解毒丸的工艺、质量进行研究,优选生产工艺参数,建立质量控制方法。方法:制备工艺从饮片干燥温度、炼蜜等进行参数筛选,以水分、成型、浸出物等内容作为指标成分考察;以三批中试样品进行质量研究,参照丸剂的质量要求,从性状、鉴别、检查、浸出物等方面对益气解毒丸进行质量研究,采用薄层层析色谱法(TLC)对黄芪、土茯苓、淫羊藿、当归进行制剂的鉴别研究;筛选了浸出物的测定条件。结果:黄芪、土茯苓、淫羊藿、当归的薄层斑点清晰,圆整,阴性制剂无干扰。性状、水分、重量差异、装量、微生物限度均符合要求。浸出物测定条件适宜。结论:该制剂工艺简洁易操作、稳定,可用于制剂生产;质量研究方法稳定可行,重复性好,操作简单、方便,适用于益气解毒丸的质量控制。

关键词：益气解毒丸工艺研究、质量研究薄层色谱浸出物

A unique circular path of moving single bubble sonoluminescence in water

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Chinese Physics B 2011年第7期20卷 252-258页

作者： Rasoul Sadighi-Bonabi Mona Mirheydari Homa Ebrahimi Nastaran Rezaee lida Nikzad Department of Physics Sharif University of TechnologyTehran 11365-91Iran Department of Physics Islamic Azad University Central Tehran BranchTehran 14676-86831Iran Laser and Optics Research School Tehran 14676-86831Iran

Based on a quasi-adiabatic model, the parameters of the bubble interior for a moving single bubble sonoluminescence （m-SBSL） in water are calculated. By using a complete form of the hydrodynamic force, a unique circular path for the m-SBSL in water is obtained. The effect of the ambient pressure variation on the bubble trajectory is also investigated. It is concluded that as the ambient pressure increases, the bubble moves along a circular path with a larger radius and all bubble parameters, such as gas pressure, interior temperature and light intensity, increase. A comparison is made between the parameters of the moving bubble in water and those in N-methylformamide. With fluid viscosity increasing, the circular path changes into an elliptic form and the light intensity increases.

关键词： sonoluminescence bubble trajectory fluid viscosity bremsstrahlung

Electrochemical Reduction of 1,2-Di（p-tolylimino）ethane and 1,2-Di（2,4-dimethylphenylimino）ethane in Dimethylformamide

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Chinese Journal of Chemistry 2007年第10期25卷 1577-1580页

作者： FOTOUHI, lida ZEIENALI, Mahbobeh DEHGHANPOUR, Saeed NEMATOLLAHI, Davood Department of Chemistry Faculty of Science Alzahra University P. O. Box *** Tehran Iran Department of Chemistry Faculty of Sciences Bu-Ali-Sina University P. O. Box 65174 Hamadan Iran

1,2-Di（p-tolylimino）ethane （Ⅰ） and 1,2-Di（2,4-dimethylphenylimino）ethane （Ⅱ） were synthesized and their electrochemical behavior investigated in dimethylformamide using classical voltammetry, differential pulse voltammetry, cyclic voltammetry, chronoamperometry, controlled potential electrolysis and coulometry. Both bis-Schiff base ligands examined show a cathodic irreversible peak which corresponds to one-electron reduction of the substrate to form anion radical. According to the fact obtained from cyclic voltammetry, that the current function （ip/v^1/2） is a decreasing function of the scan rate, it can be concluded that there is a following coupling chemical reaction （EC mechanism）. Thus, the most probable mechanism of electroreduction of both ligands is the coupling of two radicals to form a dimer.

关键词： cyclic voltammetry electrochemistry reduction Schiff base mechanism

新疆托克逊县铜华山-彩华沟地区矿床地质物化探特征与找矿潜力分析

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安徽地质 2024年第2期34卷 115-119页

作者：张利达方雯安邦王伟安徽省勘查技术院安徽合肥230031

铜华山‒彩华沟地区在过去的调查中积累了丰富的地质、物探、化探等资料,相继发现的忠宝钨矿、彩虹铜矿、天彩金矿等及周边的金铜矿床使该区的找矿工作进入到一个新的勘查和开发阶段,成为找矿的一个热点区。本文在充分收集研究以往地质... 详细信息

铜华山‒彩华沟地区在过去的调查中积累了丰富的地质、物探、化探等资料,相继发现的忠宝钨矿、彩虹铜矿、天彩金矿等及周边的金铜矿床使该区的找矿工作进入到一个新的勘查和开发阶段,成为找矿的一个热点区。本文在充分收集研究以往地质资料的基础上,通过1∶50000地面高精度磁测扫面,圈定物探异常,对铜华山‒彩华沟地区内具有重要意义的物探异常进行初步查证,圈定找矿靶区,加强该区成矿地质背景和成矿条件、控矿因素及矿化富集规律的综合研究,对区内的找矿远景进行综合评价,认为铜华山钴多金属矿、彩华沟含铜硫铁矿、天彩金矿成矿地质条件有利,成矿元素组合好,找矿标志明显,有与矿致异常特征相似的物化探异常存在,矿产资源潜力较大。

关键词：铜华山‒彩华沟地区成矿规律矿床特征资源潜力评价

SLM铝合金表面喷射电沉积Ni-MoS_(2)自润滑复合涂层

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热加工工艺 2024年第8期53卷 63-68页

作者：柏华文成海霞陈亚娄桂宾沈理达田宗军南京航空航天大学机电学院江苏南京210016

采用喷射电沉积在SLM铝合金表面制备Ni-MoS_(2)自润滑复合涂层。用摩擦磨损试验机评价镀液中MoS_(2)浓度对Ni-MoS_(2)自润滑复合涂层摩擦磨损性能的影响。结果表明:共沉积MoS_(2)微粒能有效降低Ni-MoS_(2)自润滑复合涂层的摩擦系数和磨... 详细信息

采用喷射电沉积在SLM铝合金表面制备Ni-MoS_(2)自润滑复合涂层。用摩擦磨损试验机评价镀液中MoS_(2)浓度对Ni-MoS_(2)自润滑复合涂层摩擦磨损性能的影响。结果表明:共沉积MoS_(2)微粒能有效降低Ni-MoS_(2)自润滑复合涂层的摩擦系数和磨损率。与纯Ni涂层相比,Ni-MoS_(2)自润滑复合涂层与316L钢球对磨的摩擦系数和磨损率显著降低,摩擦系数从0.51降至0.12,磨损率从0.41 mg/m降至0.11 mg/m,为SLM铝合金表面改善摩擦学性能提供了参考。

关键词： Ni-MoS_(2)自润滑复合涂层喷射电沉积增材制造摩擦磨损

Energy-Aware Scheduling of Parallel Application in Hybrid Computing System

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Chinese Journal of Electronics 2014年第4期23卷 688-694页

作者： MA Yan GONG Bin GUO Zhihong CHEN Yufeng ZOU lida State Grid Shandong Electric Power Research Institute School of Computer Science and Technology Shandong University

Energy management is emerging as an important issue for High performance computing(HPC)owning to high operational cost and low reliability. Compared with low-power architectural approach, energyaware scheduling based on Dynamic voltage scaling(DVS)and Dynamic power management(DPM) is regarded as a promising way since it is practical and low-cost. At present,most studies focus on pure DVS or non-DVS environment, while most high performance computing systems are hybrid non-DVS/DVS platforms. We propose an energyaware scheduling algorithm for parallel application to consider both DVS and non-DVS characteristics of hybrid system. We present the rule of task assignment, make analysis on DVS and DPM technique and give their mathematical formulation, which maintains makespan optimization and energy conservation. The clustering and merging algorithm, and priority computation method consider the situation of resource constraints. The extensive simulations demonstrate that the proposed algorithm has stronger ability of energy saving and time optimization than Heterogeneous earliest finish time(HEFT), Energy-efficient task duplication scheduling(EETDS) and Heterogeneous energy-aware duplication scheduling(HEADUS) algorithm no matter for synthetic workload or realistic workload.

关键词： Energy efficiency Dependent tasks Multiprocessor systems

In-situ deposition of apatite layer to protect Mg-based composite fabricated via laser additive manufacturing

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Journal of Magnesium and Alloys 2023年第2期11卷 629-640页

作者： Youwen Yang Changfu Lu lida Shen Zhenyu Zhao Shuping Peng Cijun Shuai Institute of Bioadditive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Shenzhen Institute of Information Technology Shenzhen 518172China NHC Key Laboratory of Carcinogenesis School of basic Medical ScienceCentral South UniversityChangshaHunan 410013China School of energy and machinery engineering Jiangxi University of Science and TechnologyNanchang 330013China State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China

Biodegradable magnesium(Mg) and its alloy show huge potential as temporary bone substitute due to the favorable biocompatibility and mechanical compatibility. However, one issue deserves attention is the too fast degradation. In this work, mesoporous bioglass(MBG)with high pore volume(0.59 cc/g) and huge specific surface area(110.78 m^(2)/g) was synthesized using improved sol-gel method, and introduced into Mg-based composite via laser additive manufacturing. Immersion tests showed that the incorporated MBG served as powerful adsorption sites, which promoted the in-situ deposition of apatite by successively adsorbing Ca2+and HPO42-. Such dense apatite film acted as an efficient protection layer and enhanced the corrosion resistance of Mg matrix, which was proved by the electrochemical impedance spectroscopy measurements. Thereby, Mg based composite showed a significantly decreased degradation rate of 0.31 mm/year. Furthermore,MBG also improved the mechanical properties as well as cell behavior. This work highlighted the advantages of MBG in the fabrication of Mg-based implant with enhanced overall performance for orthopedic application.

关键词： Laser addictive manufacture Mg-based composite Mesoporous bioglass In-situ deposition Degradation behavior

合金化热镀锌IF钢板表面短白条缺陷产生原因及演变机理研究

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宝钢技术 2024年第5期 41-46页

作者：吕利达陈广兴刘少先宝钢湛江钢铁有限公司广东湛江524000

使用扫描电子显微镜、能谱仪等设备,分析了一种合金化热镀锌IF钢GA外板表面短白条缺陷的产生原因,同时对热卷表面的黑线缺陷、板坯表面的渣孔缺陷进行了分析。结果表明:短白条缺陷形成的直接原因与Al_(2)O_(3)夹杂有关,根本原因为板坯... 详细信息

使用扫描电子显微镜、能谱仪等设备,分析了一种合金化热镀锌IF钢GA外板表面短白条缺陷的产生原因,同时对热卷表面的黑线缺陷、板坯表面的渣孔缺陷进行了分析。结果表明:短白条缺陷形成的直接原因与Al_(2)O_(3)夹杂有关,根本原因为板坯表面的渣孔缺陷。由于炼钢吹氩气泡大,且镇静时间较短,部分携带有Al_(2)O_(3)夹杂的氩气泡来不及上浮至表面,停留在钢中未被去除,在经过轧制延伸并镀锌后,在钢板表面形成短白条缺陷。讨论了该缺陷的演变机理,提出通过改善吹氩方式,采用更多尺寸较小的氩气泡,能更好地去除微小夹杂物,同时降低板坯渣孔的发生率。

关键词：锌铁合金镀层钢板 Al_(2)O_(3)夹杂氩气泡短白条缺陷