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Phase separating Rho:a widespread regulatory function of disordered regions in proteins revealed in bacteria

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signal Transduction and Targeted Therapy 2023年第7期8卷 3203-3205页

作者： Eric schumbera Pablo Mier Miguel A.Andrade-navarro Institute of Organismic and Molecular Evolution Faculty of BiologyJohannes Gutenberg University of Mainz55128 MainzGermany

A recent study published in science by Krypotou et *** the role of an intrinsically disordered region(IDR)in the transcription termination Rho protein from Bacteroides thetaiotaomicron:in response to starvation Rho phase separated,which triggered an increase in Rho activity and expression changes.1 These results demonstrate that a highly conserved protein can acquire new regulatory properties in evolution by gaining an IDR that leads to protein phase separation.

关键词： al. disordered separating

Mating Disruption of striped Rice stem Borer: Importance of Early Deployment of Dispensers and Impact on Airborne Pheromone Concentration

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Rice science 2021年第6期28卷 525-528,I0027-I0029页

作者： Aitor GAVARA sandra VACAs Jaime PRIMO Vicente navarro-LLOPIs Centre for Agricultural Chemical Ecology Mediterranean Agroforestry InstitutePolytechnic University of ValenciaBuilding 6CCamino de Vera s/n46022 ValenciaSpain

Mating disruption(MD)is an effective environmentally-friendly control method against the striped rice stem borer(RsB),Chilo suppressalis(Lepidoptera:Crambidae).In this study,the current MD dispensers release the pheromone exponentially,with higher initial release rates that decrease throughout the *** adjust the timing of dispensers'deployment and evaluate the importance of controlling the early first or the second male flight,field trials were carried out to test the efficacy of two strategies:the early dispenser deployment prior to the first male flight(May)and the late deployment prior to the second flight(June).The early dispenser deployment was more effective in reducing plant damage inflicted by RsB when assessed at ***,neither of these strategies was able to inhibit the male catches of the third flight due to the dispensers5 *** to the airborne pheromone concentrations obtained,around 1.60 ng/m3 were capable to inhib社*** male flight effectively.

关键词： release Impact adjust

Analysis of doping control test results in individual and team sports from 2003 to 2015

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Journal of sport and Health science 2020年第2期9卷 160-169页

作者： Millan Aguilar-navarro Jesus Munoz-Guerra Maria del Mar Plara Juan Del Cosoa Exercise Physiology Laboratory Camilo Jose Cela UniversityMadrid28692Spain Faculty of Education Francisco de Vitoria UniversityMadrid28223Spain Department for Doping Control Spanish Agency for Health Protection in SportMadrid28016Spain Department of Education Spanish Agency for Health Protection in SportMadrid28016Spain

Background:Determining the prevalence of doping in sport might be useful for anti-doping authorities to gauge the effectiveness of anti-doping policies implemented to prevent positive attitudes toward *** questionnaires and personal interviews,previous investigations have found that the prevalence of doping might be different among different sports disciplines;however,there is no sport-specific information about the proportion of adverse and atypical findings(AAF) in samples used for doping *** aim of the present investigation was to assess the differences in the frequency of adverse analytical and atypical findings among sports using the data made available by the World Anti-Doping ***:The data included in this investigation were gathered from the Testing Figures Reports made available annually from 2003 to 2015 by the World Anti-Doping *** Testing Figures Reports include information about the number of samples analyzed,the number of AAFs reported,and the most commonly found drugs in the urine and blood samples analyzed.A total of 1,347,213 samples were analyzed from the individual sports selected for this investigation,and 698,371 samples were analyzed for disciplines catalogued as team ***:In individual sports,the highest proportions of AAF were 3.3%±1.0% in cycling,3.0%±0.6% in weightlifting,and 2.9%±0.6% in *** team sports,the highest proportions of AAF were 2.2%±0.5% in ice hockey,2.0%±0.5% in rugby,and 2.0%±0.5% in *** and skating had the lowest proportions at(≤1.0%) for individual sports,and field hockey,volleyball and football had the lowest proportions for team sports(≤1.4%).Conclusion:As suggested by the analysis,the incidence of AAF was not uniform across all sports disciplines,with the different proportions pointing to an uneven use of banned substances depending on the *** information might be useful for increasing the strength and efficacy of anti-doping policies in those s

关键词： Anti-doping Attitude Banned drugs Elite athlete Type of sport

Does forest restoration influence soil infiltrability? A case study in the restored woodland of sierra de ávila(Central spain)

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Journal of Mountain science 2021年第7期18卷 1778-1793页

作者： MONGIL-MANsO Jorge navarro-HEVIA Joaquín sAN MARTÍN Roberto Hydrology and Conservation Research Group Catholic University“Santa Teresa de Jesús”ofÁvilaÁvila 05005Spain Forest Water and Soil Research GroupPalencia 34004Spain Department of Agricultural and Forestry Engineering University of ValladolidPalencia 34004Spain Department of statistics and Operations Research University of ValladolidPalencia 34004Spain

Infiltration,as a major component of the hydrological cycle,plays an important role in ecosystems,river flooding,and soil ***,this process has been studied on different soils,with different vegetation cover,and under different climate ***,it is still necessary to know how infiltration rates depend on land degradation,vegetation cover,forest management,and forest restoration,since soil infiltration is related to soil hydrological function and hydrological ecosystem *** aim of our study is to analyze the way reforestation and check dam construction have helped to improve soil infiltration rates in comparison with old,degraded land,different soils and vegetation covers in Central ***,three infiltration tests were carried out by means of a simple methacrylate infiltrometer ring,in four sampling plots,for five types of land use:(i) native holm oak forest,(ii) 60-year-old reforested pine wood,(iii) shrubs,(iv) sediment wedges of check dams,and(v) gullies and degraded *** results show much higher infiltration rates in the soil of 60-yearold pine reforestation sites(1198.00 mm·h^(-1)),and in the sediment wedges of check dams(1088.00 mm·h^(-1)),than in those of degraded hillslopes(365.00 mm·h^(-1)) and shrubland(420.80 mm·h^(-1)).The rates were also shown to be close to those from the remaining patches of native holm oak woodland(770.40 mm·h^(-1)).We also found that organic matter,humus and litter depth,and height of vegetation and cover,all improve soil infiltration rates,while slope degree,presence of coarse elements,stoniness,clay content,bulk density,and electric conductivity inhibit the *** was additionally seen that pine reforestation and check dam construction caused degraded land to recover its hydrological conditions to a level that is quite close to that of the ancient oak holm native forest,alongside ameliorating the hydrological cycle in the *** information will be very useful for decisi

关键词： soil hydrology Permeability Runoff Reforestation Land restoration

Deforestation and fragmentation trends of seasonal dry tropical forest in Ecuador: impact on conservation

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Forest Ecosystems 2021年第3期8卷 615-627页

作者： Carlos A.Rivas JoséGuerrero-Casado Rafael M.navarro-Cerillo Instituto de Ciencias Básicas Universidad Técnica de ManabíPortoviejoManabíEcuador Department of Forest Engineering Laboratory of DendrochronologySilviculture and Global Change–DendrodatLab–ERSAFUniversity of CordobaCampus de RabanalesCrta.IVkm.396E-14071 CordobaSpain Departamento de Medicina Veterinaria Facultad de Ciencias VeterinariasUniversidad Técnica de ManabíPortoviejoManabíEcuador Department of Zoology University of CordobaCampus de Rabanales14071 CordobaSpain

Background:Fragmentation and deforestation are one of the greatest threats to forests,and these processes are of even more concern in the tropics,where the seasonal dry forest is possibly one of the most threatened ecosystems with the least remaining surface ***:The deforestation and fragmentation patterns that had occurred in Ecuadorian seasonal dry forests between 1990 and 2018 were verified,while geographic information systems and land cover shapes provided by the Ecuadorian Ministry of the Environment were employed to classify and evaluate three types of seasonal dry forests:deciduous,semi-deciduous,and *** study area was tessellated into 10 km2 hexagons,in which six fragmentation parameters were measured:number of patches,mean patch size,median patch size,total edge,edge density and reticular fragmentation index(RFI).The RFI was also measured both outside and inside protected natural areas(unprotected,national protected areas and protected forest).Moreover,the areas with the best and worst conservation status,connectivity and risk of disappearance values were identified by means of a Getis-Ord Gi*statistical ***:The deforestation of seasonal dry forests affected 27.04%of the original surface area still remaining in 1990,with an annual deforestation rate of−1.12%between 1990 and *** RFI has increased by 11.61%as a result of the fact that small fragments of forest have tended to disappear,while the large fragments have been fragmented into smaller *** semi-deciduous forest had the highest levels of fragmentation in *** three categories of protection had significantly different levels of fragmentation,with lower RFI values in national protected areas and greater values in protected ***:The seasonal dry forest is fragmenting,deforesting and disappearing in some *** increased protection and conservation of the Ecuadorian seasonal dry forest is,therefore,necessary owing to the fact that not all prot

关键词： Deciduous forest semi-deciduous forest Remnant forest Patch isolation Habitat loss Protected areas

Non-technical approach to the challenges of ecological architecture： Learning from Van der Laan

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Frontiers of Architectural Research 2016年第2期5卷 202-212页

作者： Maria-Jesus Gonzalez-Diaz Justo Garcia-navarro Department of Agroforestry Engineering Construction Unit Universidad Politécnica de Madrid Madrid 28040 Spain

Up to now, ecology has a strong influence on the development of technical and instrumental aspects of architecture, such as renewable and efficient of resources and energy, COz emissions, air quality, water reuse, some social and economical aspects. These concepts define the physical keys and codes of the current ＇sustainable＇ architecture, normally instrumental but rarely and insufficiently theorised. But is not there another way of bringing us to nature？ We need a theoretical referent. This is where we place the Van der Laan＇s thoughts： he considers that art completes nature and he builds his theoretical discourse on it, trying to better understand many aspects of architecture. From a conceptual point of view, we find in his works sense of timelessness, universality, special attention on the ＇locus＇ and a strict sense of proportions and use of materials according to nature. Could these concepts complement our current sustainable architecture？ How did Laan apply the current codes of ecology in his architecture？ His work may help us to get a theoretical interpretation of nature and not only physical. This paper develops this idea through the comparison of thoughts and works of Laan with the current technical approach to ＇sustainable＇ architecture.

关键词： Nature Architecture Van-der-Laan Ecology Ethics Environment

Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease

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World Journal of Gastroenterology 2008年第40期14卷 6224-6227页

作者： Guilherme Eduardo Gonalves Felga Fernando Marcuz silva Ricardo Correa Barbuti Tomás navarro-Rodriguez schlioma Zaterka Jaime Natan Eisig Department of Gastroenterology University of So PauloSchool of Medicine

AIM: To establish the efficacy and safety of a 7-d therapeutic regimen using omeprazole,bismuth subcitrate,furazolidone and amoxicillin in patients with peptic ulcer disease who had been previously treated with other therapeutic regimens without ***: Open cohort study which included patients with peptic ulcer who had previously been treated unsuccessfully with one or more eradication *** therapeutic regimen consisted of 20 mg omeprazole,240 mg colloidal bismuth subcitrate,1000 mg amoxicillin,and 200 mg furazolidone,taken twice a day for 7 *** were considered as eradicated when samples taken from the gastric antrum and corpus 12 wk after the end of treatment were negative for Helicobacter pylori (H pylori) (rapid urease test and histology).safety was determined by the presence of adverse ***: Fifty-one patients were *** eradication rate was 68.8% (31/45).Adverse effects were reported by 31.4% of the patients,and these were usually considered to be slight or moderate in the majority of the *** patients had to withdraw from the treatment due to the presence of severe adverse ***: The association of bismuth,furazolidone,amoxicillin and a proton-pump inhibitor is a valuable alternative for patients who failed to respond to other eradication *** is an effective,cheap and safe option for salvage therapy of positive patients.

关键词： Gastric ulcer Duodenal ulcer Helicobacter pylori Retreatment Furazolidone

Identification of human papillomavirus in esophageal squamous papillomas

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World Journal of Gastroenterology 2008年第46期14卷 7107-7111页

作者： Olga L Bohn Leticia navarro Jesus saldivar sergio sanchez-sosa Department of Pathology UPAEP University Hospital

AIM： To investigate the presence of human papillomavirus （HPV） in esophageal squamous papilloma （EsP） and determine p16, p53 and Ki67 expression in a Mexican cohort. METHODs： Nineteen cases diagnosed as EsP, corresponding to 18 patients were reviewed; nineteen cases of normal esophageal mucosa were used as negative controls. HPV detection was performed by ,amplified chromogenic in situ hybridization （ACIsH） using a wide spectrum-cocktail probe and PCR. REsULTs： The average age at presentation was 46.3 years （range 28-72 years）. Patients included four （22.22%） males and 14 （77.77%） females. The most frequent location was upper third （11 cases）, followed by middle third （3 cases） and unknown site （5 cases）. Immunohistochemistry （IHC） revealed basal and focal p53 expression in 17 cases （89%）; p16 was expressed in eight cases （42.10%） and the Ki67 index ranged from 10% to 30%. HPV was detected in 14 out of 16 cases （87.5%） by ACIsH： Twelve showed diffuse nuclear patterns and two showed granular patterns. HPV DNA was identified by PCR in 12 out of 14 cases （85.7%）. Low-risk HPV types were detected in the most of the cases. CONCLUsION： This study provides identification of HPV infection in almost 80% of EsP using either ACIsH or PCR; overall, all of these lesions show low expression of cell-cycle markers. We suggest ACIsH as an alternative diagnostic tool for HPV detection in EsR .

关键词： Human papillomavirus Esophageal papilloma Papillomatosis Esophageal neoplasm Immunohistochemistry Cell cycle

History of pseudomyxoma peritonei from its origin to the first decades of the twenty-first century

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World Journal of Gastrointestinal surgery 2019年第9期11卷 358-364页

作者： Francisco J Morera-Ocon Clara navarro-Campoy Department of General surgery Hospital General de RequenaValencia 46340Spain Department of Gynecology and Obstetrics Hospital 9 OctubreValencia 46340Spain

Pseudomyxoma peritonei(PMP)is a disease surrounded by misunderstanding and *** about the etymology of pseudomyxoma is useful to remove the ambiguity around that *** word pseudomyxoma derives from pseudomucin,a type of *** was first described in a case of a woman alleged to have a ruptured pseudomucinous cystadenoma of the ovary,a term that has disappeared from today’s classifications of cystic ovarian *** is known today that in the majority of cases,the origin for PMP is an appendiceal neoplasm,often of low histological ***,ovarian tumors are wrongly being considered a significant recognized etiology of *** classification continues to be under discussion,and experts’panels strive for *** is also under discussion,and it is shown in this review that there is a long-standing historical reason for *** is the main tool in the treatment armamentarium for PMP,and the only therapy with potential curative option.

关键词： Pseudomyxoma peritonei Pseudomucin Appendiceal neoplasm Hyperthermic intraperitoneal chemotherapy