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Real-time fluorescence image-guided gastrointestinal oncologic surgery:Towards a new era

World Journal of Gastrointestinal Oncology 2021年第9期13卷 1029-1042页

作者： Elías Martínez-López Aleix Martínez-Pérez sergio navarro-Martínez Juan Carlos sebastián-Tomás Nicola de'Angelis Eduardo García-Granero Department of surgery University of ValenciaValencia 46010Spain Department of General and Digestive surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health sciences Valencian International UniversityValencia 46002Spain Minimally Invasive and Robotic Digestive surgery Unit Miulli HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive surgery Hospital Universitario y Politécnico La FeValencia 46026Spain

Technological improvements are crucial in the evolution of ***-time fluorescence-guided surgery(FGs)has spread worldwide,mainly because of its usefulness during the intraoperative decision-making *** success of any gastrointestinal oncologic resection is based on the anatomical identification of the primary tumor and its regional lymph *** allows also to evaluate the blood perfusion at the gastrointestinal stumps after colorectal or esophageal ***,a reduction on the anastomotic leak rates has been postulated as one of the foreseeable benefits provided by the use of FGs in these *** the use of fluorescence in lymph node detection was initially described in breast cancer surgery,the technique is currently applied in gastric or splenic flexure cancers,as they both present complex and variable lymphatic *** allows also to perform intraoperative lymphograms or sentinel lymph node *** applications of FGs are being developed to assist in the detection of peritoneal metastases or in the evaluation of the tumor resection *** present review aims to provide a general overview of the current status of real-time FGs in gastrointestinal oncologic *** put a special focus on the different applications of FGs,discussing the main findings and limitations found in the contemporary literature and also the promising near future applications.

关键词： surgery Colorectal cancer Esophageal cancer Fluorescence Image-guided surgery Anastomotic leak Lymph node

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In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

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Acta Pharmaceutica sinica B 2021年第4期11卷 989-1002页

作者： Ana LMartínez-López Carlos JGonzález-navarro Paula Aranaz JoséLVizmanos Juan MIrache NANO-VAC Research Group Department of Chemistry and Pharmaceutical TechnologySchool of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Center for Nutrition Research School of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Department of Biochemistry&Genetics School of ScienceUniversity of NavarraPamplona 31080Spain Navarra Institute for Health Research(IdisNA) Pamplona 31080Spain

The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral administration of *** nanocarriers,based on the coating of zein nanoparticles with a polymer conjugate containing PEG,displayed a size of 260 nm with a negative surface charge and an insulin payload of 77 mg/*** intestinal pig mucus,the diffusivity of these nanoparticles(PPA-NPs)was found to be 20-fold higher than bare nanoparticles(NPs).These results were in line with the biodistribution study in rats,in which NPs remained trapped in the mucus,whereas PPA-NPs were able to cross this layer and reach the epithelium *** therapeutic effcacy was evaluated in Caenorhabditis elegans grown under high glucose *** this model,worms treated with insulin-loaded in PPA-NPs displayed a longer lifespan than those treated with insulin free or nanoencapsulated in *** finding was associated with a signifcant reduction in the formation of reactive oxygen species(ROs)as well as an important decrease in the glucose and fat content in *** effects would be related with the mucus-permeating ability of PPA-NPs that would facilitate the passage through the intestinal peritrophic-like dense layer of worms(similar to mucus)and,thus,the absorption of insulin.

关键词： Nanoparticles Oral delivery Mucus-permeating Biodistribution Insulin Caenorhabditis elegans ROs

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Quality Characteristics of Dark Muscle from Yellowfin Tuna Thunnus albacares to Its Potential Application in the Food Industry

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Food and Nutrition sciences 2011年第1期2卷 22-30页

作者： Elena sánchez-Zapata Mahassine Amensour Rosa Oliver Evangélica Fuentes-Zaragoza Casilda navarro Juana Fernández-López Esther sendra Estrella sayas José Angel Pérez-Alvarez 不详

Dark muscle from yellowfin tuna is an important edible fish by-product. However, it has a low commercial value, and it is underutilized. The present study was conducted to establish the characteristic of this by-product. Myoglobin concen- tration in tuna dark muscle is high (9650.12 mg/kg). Total iron in tuna muscle was 32.11 mg/kg, higher than other animal foods like veal or pork, and heme iron concentration was 23.56 mg/kg (73.38% of the total iron), indicating a high bioavailability of heme iron in dark muscle from yellowfin tuna, which is a nutritional advantage. As for the techno- logical properties, yellowfin tuna dark muscle had a water holding capacity of 8.37 g water/g and oil holding capacity of 8.11 g oil/g. This indicates that tuna dark muscle has possible applications to elaborate products, such as emulsion- ated foods or cooked products, so its industrialization is possible.

关键词： Dark Muscle Tuna Fish Haemopigments Myoglobin Heme Iron Physicochemical Properties

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Thermal preference, tolerance and temperature-dependent respiration in the California sea hare <i>Aplysia californica</i>

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Agricultural sciences 2013年第6期4卷 46-52页

作者： Ana Denisse Re Fernando Díaz Alfredo salas-Garza Marco Gonzalez Victor Cordero Clara E. Galindo-sanchez Edna sanchez-Castrejon Adolfo sánchez Zamora Alexei Licea-navarro Instituto de Investigaciones Oceanológicas Universidad Autónoma de Baja California Ensenada Baja California México Laboratorio de Biología Celular y Molecular Departamento de Biotecnología Marina Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE) Ensenada Baja California México Laboratorio de Ecofisiología de Organismos Acuáticos Departamento de Biotecnología Marina Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE) Ensenada Baja California México Laboratorio de Ecofisiología de Organismos Acuáticos Departamento de Biotecnología Marina Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE) Ensenada Baja California México Laboratorio de Genómica Funcional Departamento de Biotecnología Marina Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE) Ensenada Baja California México Unidad Multidisciplinaria de Docencia e Investigación Facultad de Ciencias Universidad Autónoma de México Sisal México

The thermoregulatory behavior of sea hare Aplysia californica was determined in a horizontal thermal gradient;with a preferred temperature (PT) of 18.3°C for the day cycle and 20.8°C for the night cycle. The displacement velocity demonstrated an initial rate of 30 cm·hˉ1 and gradually the velocity diminished to 18 cm·hˉ1 with several fluctuations mainly at 02:00 am. Critical Temperature Maxima (CTMax refers to the temperature point where at least 50% of the experimental group have a loss of attachment) was measured at three acclimation temperatures (16°C, 19°C and 22°C). At the lowest acclimation temperature (16°C), 50% of the experimental group had an attachment loss at CTMax 32.7°C, and in a higher acclimation temperature (22°C) CTMax was 36.2°C. The Oxygen Consumption Rate (OCR) was closely correlated to acclimation temperature, and at 16°C and 19°C sea hare had a relatively stable metabolic rate, with OCR increasing to 9 mg O2 hˉ1·kgˉ1 w.w. in a higher acclimation temperature.

关键词： Thermoregulatory Behavior CTMax Oxygen Consumption Aplysia californica

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Fast and reliable identification of atomically thin layers of Tase2 crystals

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Nano Research 2013年第3期6卷 191-199页

作者： Andres Castellanos-Gomez Efren navarro-Moratalla Guillermo Mokry Jorge Quereda Elena Pinilla-Cienfuegos Nicolas Agrait Herre s. J. van der Zant Eugenio Coronado Gary A. steele Gabino Rubio-Bollinger Kavli Institute of Nanoscience Delft University of Technology Lorentzweg 1 2628 CJ Delft The Netherlands Instituto Ciencia Molecular (ICMol) Univ. Valencia C/Catedrdtico Jose Beltrdn 2 E-46980 Paterna Spain Departamento de Fisica de la Materia Condensada (C-III). UniversidadAutonoma de Madrid Campus de Cantoblanco 28049 Madrid Spain Instituto Madrileno de Estudios Avanzados en Nanociencia IMDEA-Nanociencia E-28049 Madrid Spain

Deposition of clean and defect-free atomically thin two-dimensional crystalline flakes on surfaces by mechanical exfoliation of layered bulk materials has proven to be a powerful technique, but it requires a fast, reliable and non-destructive way to identify the atomically thin flakes among a crowd of thick flakes. In this work, we provide general guidelines to identify ultrathin flakes of Tase2 by means of optical microscopy and Raman spectroscopy. Additionally, we determine the optimal substrates to facilitate the optical identification of atomically thin Tase2 crystals. Experimental realization and isolation of ultrathin layers of Tase2 enables future studies on the role of the dimensionality in interesting phenomena such as superconductivity and charge density waves.

关键词： atomically thin layer metal dichalcogenide layered superconductor Tase2 optical microscopy Raman spectroscopy

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Prevalence of occult hepatitis B virus infection

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World Journal of Gastroenterology 2011年第12期17卷 1538-1542页

作者： Maria Luisa Gutiérrez-García Conrado M Fernandez-Rodriguez Jose Luis Lledo-navarro Ingrid Buhigas-Garcia service of Gastroenterology Hospital Universitario Fundación AlcorcónAv Budapest-128922 AlcorcónMadridSpain

Occult hepatitis B virus(HBV) infection(OBI) is characterized by the persistence of HBV DNA in the liver tissue in individuals negative for the HBV surface *** prevalence of OBI is quite variable depending on the level of endemic disease in different parts of the world,the different assays utilized in the studies,and the different populations *** studies have been carried out on OBI prevalence in different areas of the world and categories of *** studies show that OBI prevalence seems to be higher among subjects at high risk for HBV infection and with liver disease than among individuals at low risk of infection and without liver disease.

关键词： Occult hepatitis B virus infection Hepatitis B virus DNA Anti-HBc Hepatitis B virus seronegative Hepatitis C Crytogenetic hepatitis Dialysis Human immunodeficiency virus Blood donors

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Limphocutaneous sporotrichosis Due to sporothrix schenckii var schenckii: A Relapsing Case after Treatment with Potassium Iodide in Elderly

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Advances in Microbiology 2022年第4期12卷 192-197页

作者： Eder R. Juárez-Durán sabrina Escandón-Pérez Fritz Cajuste-sequeira Luis M. sánchez-navarro Carlos A. Barrera-Ochoa Rigoberto Hernández-Castro Roberto Arenas General Hospital Mexico City Mexico ángeles Lomas Hospital Mexico City Mexico La Habana University Havana Cuba Dermatologist General Hospital Oaxaca Mexico General Hospital Mexico City Mexico Pathogen Ecology Department General Hospital Mexico City Mexico

sporotrichosis is a subcutaneous mycosis caused by the sporothrix schenckii complex. It has three classic clinical variants: fixed, lymphangitic, and systemic. Treatment in most cases has been itraconazole or potassium iodide. The aim of this paper is to communicate an unusual relapsing case treated with IK. We report a 73-year-old woman with lymphangitic sporotrichosis, adequate response to treatment with potassium iodide, and recurrence 15 months after. A molecular test was performed through the amplification of a 331 bp fragment of the calmodulin gene. In both infections, the same specie was isolated. The effects of potassium iodide are briefly discussed, and we conclude that the same treatment can be prescribed, if no side effects are observed.

关键词： sporotrichosis Lymphangitic sporotrichosis sporothrix schenckii Recurrence Potassium Iodide

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sex differences in Alzheimer's disease:an urgent research venue to follow

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Neural Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel Jiménez-Herrera Ana Contreras Juan D.navarro-López Lydia Jiménez-Díaz Neurophysiology&Behavior Lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

Due to increasing life expectancy,the amount of people with dementia worldwide is expected to experience a substantial rise,with estimates indicating a growth from 55 million in 2019 to a staggering 139 million by the... 详细信息

关键词： Alzheimer predominant estimates

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甲酸乙酯与二氧化碳混合熏蒸可食用鲜切花

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粮油食品科技 2024年第3期32卷 30-38页

作者： Hagit navarro shlomo navarro Nadav INBARI 李燕羽(译) 默多克大学环境和生命科学学院澳大利亚珀斯WA 6150 绿色储藏有限公司以色列里雄莱锡安7570905 国家粮食和物资储备局科学研究院粮食储运研究所

西花蓟马(缨翅目)是蓟马类中一种具有代表性的植物害虫,是一种能够对作物生产造成不利影响的多食性物种。因此,在欧盟,这些蓟马物种被作为检疫生物进行管理。西花蓟马以易感植物为食,并会传播几种导致严重植物疾病的病毒,从而对这些植... 详细信息

西花蓟马(缨翅目)是蓟马类中一种具有代表性的植物害虫,是一种能够对作物生产造成不利影响的多食性物种。因此,在欧盟,这些蓟马物种被作为检疫生物进行管理。西花蓟马以易感植物为食,并会传播几种导致严重植物疾病的病毒,从而对这些植物造成非常大的损害。以色列的供应占欧洲新鲜草本市场的50%,被认为是可食用鲜切花的主要供应市场。然而,在过去的十年中,由于没有可选的处理方法来控制检疫害虫而导致植物检疫失败,大大减少了出口量。目前尚无有效的采后杀虫处理方法。众所周知,熏蒸剂甲基溴(MB)具有植物毒性,尤其是对叶类产品和叶片,且与臭氧层的损耗有关。目前甲基溴仅能用作检疫和装运前熏蒸。甲酸乙酯(EF)被建议作为甲基溴的替代品,药效快、价格低廉、哺乳动物无毒性、环境无害、分解迅速,残留量极少或无残留。在以色列进行的30 g/m^(3)甲酸乙酯与二氧化碳(1∶1.6)混合处理不同花种的实验中,在10和15℃条件下分别处理1和1.5 h,对西花蓟马各虫态均有较好的防治效果。在15℃暴露2 h,可杀死全部害虫,对花或其保质期没有不良影响。因此甲酸乙酯熏蒸可作为一种检疫处理方法,也是甲基溴(MB)的可行替代方法。

关键词：食用鲜切花甲酸乙酯甲基溴代替品检疫处理

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Grafting effects on bioactive compounds,chemical and agronomic traits of‘Corbarino’tomato grown under greenhouse healthy conditions

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Horticultural Plant Journal 2023年第2期9卷 273-284页

作者： Mario Parisi Alfonso Pentangelo Antonietta D’Alessandro Giovanna Festa Gianluca Francese Alejandra navarro Vincenzo Onofaro sanajà Giuseppe Mennella CREA Research Centre for Vegetable and Ornamental Crops Via Cavalleggeri 25PontecagnanoSA 84098Italy

In tomatoes,grafting onto resistant rootstocks represents an effective strategy to control several soil-borne diseases that reduce crop profitability,especially for landraceswith little or no resistance tomultiple pathogens/*** this study,the high-value‘Corbarino’tomato landrace was grafted onto seven commercial solanum interspecific rootstocks to evaluate graft compatibility,yield performance,and qualitative characteristics under greenhouse healthy *** rootstocks were themost effective in improving fruit yield without negatively affecting the carpometric,technological,and health-related traits of the traditional tomato.‘Dinafort’rootstock increased fresh and dry yield,harvest index,and fruit/clusters,while mean fruit weight,shape index,total and soluble solid content,simple sugars,organic acids,flavonoids,ascorbic acid,and trans-lycopene content did not differ with respect to the ungrafted‘Corbarino’.‘Interpro’rootstock also showed promising results for the overall yield and quality traits,although it reduced the trans-lycopene content in the fruit.‘silex’rootstock showed the highest harvest index as result of decreased *** fruit quality induced by‘silex’was satisfactory and high levels of simple sugars,flavonoids,ascorbic acid,and trans-lycopene were also ***,graft success,especially for‘Dinafort’and‘silex’,needs to be improved by investigating more suitable methods for seedling production,grafting,acclimatization,etc.

关键词： solanum lycopersicum L Local variety Yield Graft compatibility sugars Organic acids Health-related compounds

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