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Diet and microbiome in the beginning of the sequence of gut inflammation

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World Journal of Clinical Cases 2021年第36期9卷 11122-11147页

作者： Daniel Ceballos A hernández-Camba Laura Ramos Department of Gastroenterology Hospital Universitario de Gran Canaria Doctor NegrinLas Palmas 35019CanariasSpain Department of Gastroenterology Hospital Universitario Nuestra Señora de La CandelariaSanta Cruz de Tenerife 38010CanariasSpain Department of Gastroenterology Hospital Universitario de CanariasSan Cristóbal de La Laguna 38320CanariasSpain

Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract due,at least partially,to an aberrant and excessive mucosal immune response to gut bacteria in genetically-predisposed individuals under certain environmental *** incidence of IBD is rising in western and newly industrialized countries,paralleling the increase of westernized dietary patterns,through new antigens,epithelial function and permeability,epigenetic mechanisms(e.g.,DNA methylation),and alteration of the gut *** in the composition and functionality of the gut microbiome(including bacteria,viruses and fungi)seems to be a nuclear pathogenic *** microbiome itself is dynamic,and the changes in food quality,dietary habits,living conditions and hygiene of these western societies,could interact in a complex manner as modulators of dysbiosis,thereby influencing the activation of immune cells’promoting *** microbiome produces diverse small molecules via several metabolic ways,with the fiber-derived short-chain fatty acids(i.e.,butyrate)as main elements and having anti-inflammatory *** metabolites and some micronutrients of the diet(i.e.,vitamins,folic acid,beta carotene and trace elements)are regulators of innate and adaptive intestinal immune *** excessive and unhealthy consumption of sugar,animal fat and a low-vegetable and-fiber diet are risk factors for IBD ***,metabolism of nutrients in intestinal epithelium and in gut microbiota is altered by inflammation,changing the demand for nutrients needed for *** role of food and a reduced gut microbial diversity in causing IBD might also have a prophylactic or therapeutic role for *** relationship between dietary intake,symptoms,and bowel inflammation could lead to dietary and lifestyle recommendations,including diets with abundant fruits,vegetables,olive oil and oily fish,which have anti-inflammatory effects and could pre

关键词： Diet Microbiome Inflammatory bowel disease Pathogenia

Design of multilayer hybrid sol-gel coatings with bifunctional barrier-bioactive response on the Elektron 21 magnesium alloy for biomedical applications

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Journal of Magnesium and Alloys 2021年第6期9卷 2097-2112页

作者： K.S.Durán N.hernández L.M.Rueda C.A.hernández-Barrios A.E.Coy F.Viejo Grupo de Investigación en Desarrollo y Tecnología de Nuevos Materiales(GIMAT) Universidad Industrial de Santander9 Cra.27Colombia Grupo de Investigación de las Ciencias de las Ingenierías(GICI) Universidad de San BuenaventuraCartagenaCalle Real de TerneraDiagonal 32#30-966Colombia

The present study aims to develop multilayer barrier-bioactive hybrid sol-gel coatings from a mixture of the silane precursors tetraethylorthosilicate(TEOS)and glycidoxypropyltriethoxysilane(GPTMS)deposited on the Elektron 21 magnesium *** purpose of the inner layer(barrier coating)was to provide corrosion protection to the magnesium alloy,whereas the outer layer(bioactive coating)was doped with different Ca and Mg contents to produce a bioactive *** coatings were characterised using scanning electron microscopy(SEM)and their corrosion behaviour was evaluated by anodic polarisation and electrochemical impedance spectroscopy after immersion in simulated body fluid(SBF)at 37±0.5°*** experimental results showed that the multilayer coatings increased the corrosion resistance of the alloy up to three orders of magnitude during immersion in SBF *** the other hand,the presence of Ca and Mg in the bioactive coating promoted the growth of apatite-like ***,an increment of salt content favoured the formation of porous coatings,which allowed the access of the electrolyte to the substrate leading to their rapid *** the latter,this research endorses the premise that the TEOS-GPTMS hybrid system represents a promising alternative to produce bifunctional barrier-bioactive coatings.

关键词： Magnesium bioactivity coating sol-gel EIS corrosion

Cooperating CoScheduling:A Coscheduling Proposal Aimed at Non-Dedicated Heterogeneous NOWs

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Journal of Computer Science & Technology 2007年第5期22卷 695-710页

作者： Francesc Giné Francesc Solsona Mauricio Hanzich Porfidio hernández Emilio Luque Department of Computer Science Universitat de Lleida Spain Department of Computer Architecture & Operating Systems Universitat Autònoma de Barcelona Spain

Implicit coscheduling techniques applied to non-dedicated homogeneous Networks Of Workstations （NOWs） have shown they can perform well when many local users compete with a single parallel job. Implicit coscheduling deals with minimizing the communication waiting time of parallel processes by identifying the processes in need of coscheduling through gathering and analyzing implicit runtime information, basically communication events. Unfortunately, implicit coscheduling techniques do not guarantee the performance of local and parallel jobs, when the number of parallel jobs competing against each other is increased. Thus, a low efficiency use of the idle computational resources is achieved. In order to solve these problems, a new technique, named Cooperating CoScheduling （CCS）, is presented in this work. Unlike traditional implicit coscheduling techniques, under CCS, each node takes its scheduling decisions from the occurrence of local events, basically communication, memory, Input/Output and CPU, together with foreign events received from cooperating nodes. This allows CCS to provide a social contract based on reserving a percentage of CPU and memory resources to ensure the progress of parallel jobs without disturbing the local users, while coscheduling of communicating tasks is ensured. Besides, the CCS algorithm uses status information from the cooperating nodes to balance the resources across the cluster when necessary. Experimental results in a non-dedicated heterogeneous NOW reveal that CCS allows the idle resources to be exploited efficiently, thus obtaining a satisfactory speedup and provoking an overhead that is imperceptible to the local user.

关键词： job scheduling non-dedicated and heterogeneous NOW computing resource allocation

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Seeing better-Evidence based recommendations onoptimizing colonoscopy adenoma detection rate

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World Journal of Gastroenterology 2016年第5期22卷 1767-1778页

作者： Javier Aranda-hernández Jason Hwang Gabor Kandel Division of Gastroenterology University of TorontoTherapeutic Endoscopy and Endoscopic OncologySt.Michael’s HospitalTorontoOntario M5B 1W8Canada

Colorectal cancer is one of the three most frequent causes of cancer deaths in men and women in Europe and North America. Diagnosis and resection of adenomas has convincingly demonstrated its utility in diminishing colorectal cancer incidence. Therefore, colonoscopy is now the gold standard for colorectal cancer screening. But it is also known that colonoscopy effectiveness varies among endoscopists. Among different quality indicators, the most used is the adenoma detection rate(ADR) which is the percentage of average-risk patients for colorectal cancer who are found to have at least one adenoma or adenocarcinoma during a screening colonoscopy. There is compelling evidence supporting an inverse correlation between ADR and interval colorectal cancer(cancer found after a screening colonoscopy). Many factors such as quality of precolonoscopy preparation, additional observers, manoeuvres with the endoscope(second view, retroflexion, water inflation rather than air), time spent during withdrawal, changes in patient position, foldflattener devices, new imaging or endoscopic modalities and use of intravenous or through the scope sprayed drugs, have been studied and developed with the aim of increasing the ADR. This reviews discusses these factors, and the current evidence, to "see better" in the colon and optimize ADR.

关键词： Adenoma Detection Colonoscopy Cancer Screening

Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: Involvement of perisinusoidal stellate cells

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World Journal of Gastroenterology 2005年第47期11卷 7480-7485页

作者： Raquel hernández Esther Martínez-Lara Ana Cauelo Ma Luisa del Moral Santos Blanco Eva Siles Ana Jiménez Juan ngel Pedrosa Ma ngeles Peinado Department of Experimental Biology University of JaénParaje Las Lagunillas s/nE-23071 JaénSpain

AIM： To analyze the relationship between perisinusoidal stellate cell （PSC） activation and the dietary fat quantity and composition in the treatment of hepatic steatosis. METHODS： Using an experimental rat model of steatosis based on the intake of a hyperlipidic diet （14% fat as olive oil or sunflower oil, HL-O and HL-S, respectively）, we analyzed the liver＇s capability of recovery after the treatment with a normal-lipidic diet （5% fat as olive oil or sunflower oil, NL-O and NL-S, respectively） by immunoo/tochemical and Western blot analysis of glial fibrillary acidic protein （GFAP） expression in PSCs, collagen quantification and serum aminotransferase determination. RESULTS： The fatty infiltration in the steatotic livers decreased after the treatment with both NL diets, indicating liver recovery. This decrease was accompanied with a lower collagen deposition and aminotransferase level as well as changes in the PSC population that increased the GFAP expression. The above-mentioned effects were more pronounced in animals fed on NL-O based diet. CONCLUSION： Treatment with a balanced diet enriched in olive oil contributes to the liver recovery from a steatotic process. The PSC phenotype is a marker of this hepatic-recovery model.

关键词： PSCs GFAP Steatosis Collagen, Hyperlipidic diet Liver recovery Olive oil

Onto the sense of smell in macaws, amazons and toucans: can they use volatile cues of fruits to make foraging decisions?

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Integrative Zoology 2023年第4期18卷 762-771页

作者： M.Carmen hernÁndez Ana María VILLADA Isabel BARJA Unidad Zoología Departamento de BiologíaUniversidad Autónoma de MadridCampus Universitario de CantoblancoMadridSpain Toucan Rescue Ranch HerediaCosta Rica Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM)Universidad Autónoma de Madrid MadridSpain

Over the past decades,empirical evidence has been accumulated indicating that olfactory information plays a fundamental role in bird life ***,many aspects of avian olfaction remain poorly *** purpose was to broaden the knowledge about the importance of the sense of smell in some neglected bird groups:psittaciformes and ramphastids,and to compare how the response varied between the *** of the lack of information about the use of chemical cues for locating food in fruit-eating species,we also aimed to delve into this *** conducted a 3-choice(water/vinegar/papaya and banana juice)scent test in 5 Costa Rican native species:scarlet macaw(Ara macao),red-lored amazon(Amazona autumnalis),yellow-naped amazon(Amazona auropalliata),keel-billed toucan(Ramphastos sulfuratus),and yellow-throated toucan(Ramphastos ambiguus).Results revealed that macaws and toucans allocated signiﬁcantly more time to interacting with the fruit scent container,indicating that these species can perceive the volatile chemicals emitted by ripe fruits and that they can use this information to make foraging ***,amazons did not dedicate more time to interact with the fruit *** research provides theﬁrst evidence of the ability to exploit chemical volatile cues in macaws and toucans.

关键词： avian olfaction bird senses frugivorous birds psittaciformes ramphastids scent test

Litterfall production modeling based on climatic variables and nutrient return from stands of Eucalyptus grandis Hill ex Maiden and Pinus taeda L.

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Journal of Forestry Research 2024年第5期35卷 26-36页

作者： Andrés Baietto Andrés Hirigoyen Jorge hernández Amabelia del Pino Forest Department Faculty of AgronomyUniversity of the Republic12900 MontevideoUruguay National Research Program of Forest Production National Agriculture Research InstituteINIA97000 TacuarembóUruguay Soil and Water Department Faculty of AgronomyUniversity of the Republic12900 MontevideoUruguay

Native grasslands in the Pampas of South America are increasingly being replaced by Eucalyptus and Pinus *** short rotation regimes used for the stands require high nutrient levels,with litterfall being a major source of nutrient *** model the litterfall production using climatic variables and assess the nutrient return in 14-year-old Eucalyptus grandis and Pinus taeda stands,we measured litter production over 2 years,using conical litter traps,and monitored climatic *** temperature,accumulated precipitation,and mean maximum vapor pres-sure deficit at the seasonal level influenced litterfall produc-tion by ***;seasonal accumulated precipitation and mean maximum temperature affected litterfall by *** regression tree modeling based on these climatic vari-ables had great accuracy and predictive power for ***(N=33;MAE(mean absolute error)=0.65;RMSE(root mean square error)=0.91;R^(2)=0.71)and ***(N=108;MAE=1.50;RMSE=1.59;R^(2)=0.72).The nutrient return followed a similar pattern to litterfall deposition,as well as the order of importance of macronutrients(***:Ca>N>K>Mg>P;***:N>Ca>K>Mg>P)and micronutrients(*** and ***:Mn>Fe>Zn>Cu)in both *** study constitutes a first approximation of factors that affect litterfall and nutrient return in these systems.

关键词： Afforestation Litterfall Nutrient recycling Climate modeling Myrtaceae Pinaceae

Glial cells in the center of future ischemic stroke treatments

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Neural Regeneration Research 2022年第12期17卷 2659-2660页

作者： IvóH.hernández Maria JoséPérez-Álvarez Genomic Instability Group Spanish National Cancer Research Centre(CNIO)MadridSpain Departamento de Biología(Fisiología Animal)Facultad de Ciencias Universidad Autónoma de Madridand Instituto de Biología Molecular-CBMSOUAM/CSICMadridSpain

In the last century,increasing knowledge about glial cells has revealed their importance in brain physiology and disease and an exciting potential target for new therapeutic interventions(hernández et al.,2021).Ischemic stroke is the most common of all types of *** the second leading cause of disability and mortality,ischemic stroke is a serious socio-economic burden *** it has been strongly associated with aging,during 2020 COVID-19 emerged as a new risk factor for ischemic stroke in younger patients(Cagnazzo et al.,2021).The only therapy or intervention currently available for humans is early reperfusion after the onset of the first ***,due to the high risk of brain hemorrhage,these treatments are suitable for only a small percentage of ***,reperfusion does not prevent post-injury neurodegeneration,hence the importance of finding new therapeutic alternatives to ameliorate ischemic damage and improve post-stroke quality of life.

关键词： mortality treatment younger