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Quantification of the Mixture of Hydrothermal and Fresh Water in Tectonic Valleys

Journal of Earth Science 2020年第5期31卷 1007-1015页

作者： Janete Moran-Ramirez Jose Ivan morales-Arredondoc Maria Aurora Armienta-Hernandez Jose Alfredo Ramos-Leal National Council of Science and Technology National Autonomous University of MexicoInstitute of GeophysicsScientific Research CircuitUniversity CityCoyoacan 04150Mexico CityMexico National Autonomous University of Mexico Institute of GeophysicsUniversity CampusMexico CityMexico Potosino Institute for Scientific and Technological Research 78216 San Luis PotosiS.L.P.Mexico

This study was conducted to identify the origin, hydrogeochemical processes and evolution of groundwater in a tectonic valley. This study was carried out with the aim of quantifying the proportions of groundwater flows contributing to the water chemistry abstracted in a zone of convergence favored by the presence of active faults. The study area is located in the Trans-Mexican Volcanic Belt. End members methodology was applied to identify the mixing of hydrothermal with fresh groundwater, where changes in the aquifer geology result in distinct groundwater chemical signatures. Ternary mixing was quantified using conservative elements. Moreover, other evolutionary processes, such as ion exchange and silicate weathering occur due to changes in the geology of the area. In ternary mixing, each of the end members is associated with the lithology through which it circulates. The local flow contributes 70% of the water to the system, the intermediate flow contributes 14%, and the regional flow contributes 16%. Three types of water are produced: Na-HCO3, due to the interaction of water with volcanic rocks of rhyolitic composition, Na-Mg-HCO3, due to the interaction of water with volcanic rocks of basaltic-andesite composition, and Ca-HCO3, due to the interaction of water with sedimentary calcareous rocks.

关键词： hydrogeochemistry ternary mixing end members conservative elements local flow Mexico

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AHORA: a Spanish language tool to identify acute stroke symptoms

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Stroke & Vascular Neurology 2022年第2期7卷 176-178页

作者： Paul Banerjee Helene Koumans Madison Danielle Weech Maricela Wilson Mark Rivera-morales Latha Ganti Fire Rescue Polk County FloridaBartowFloridaUSA Department of Emergency Medicine University of Central Florida College of MedicineOrlandoFloridaUSA Osceola Regional Medical Center KissimmeeFloridaUSA Department of Biology and Medicine Brown UniversityProvidenceRhode IslandUSA Department of Biology University of FloridaGainesvilleFloridaUSA Stroke Community Outreach Seton Healthcare FamilyAustinTexasUSA Department of Neurology University of Central Florida College of MedicineOrlandoFloridaUSA

Objective To develop a Spanish language tool for acute stroke *** A Spanish language translation of the Balance-Eyes-Face-Arm-Speech-Time tool was developed within our emergency medical services *** The authors present a new prehospital stroke tool,Andar,Hablar,Ojos,Rostro and Ambos Brazos o Piernas(AHORA)(which means now in Spanish)to help combat the language barrier and reinforce the necessity to call 9-1-1 as soon as any stroke symptoms are *** AHORA is a Spanish language tool that aims to help Spanish-speaking individuals to identify an acute stroke and obtain prompt help.

关键词： And Spanish prompt

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Receptor of advanced glycation end-products axis and gallbladder cancer:A forgotten connection that we should reconsider

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World Journal of Gastroenterology 2022年第39期28卷 5679-5690页

作者： Armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez Miguel Angel morales Biomedical Research Laboratories Catholic University of MauleTalca 34600000MauleChile Medicine Faculty Catholic University of MauleTalca 34600000MauleChile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000SantiagoChile

Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms,including gallbladder *** this regard,data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products(RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu,thus supporting tumor growth and *** are formed in biological systems or foods,and food-derived AGEs,also known as dietary AGEs are known to contribute to the systemic pool of *** they bind to RAGE,the activation of multiple and crucial signaling pathways are triggered,thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and *** the present review,we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer,and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts.

关键词： Gallbladder cancer Advanced glycation end-products Receptor of advanced glycation end-products Chronic inflammation Nutrition

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Building an interoperable space for smart agriculture

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Digital Communications and Networks 2023年第1期9卷 183-193页

作者： Ioanna Roussaki Kevin Doolin Antonio Skarmeta George Routis Juan Antonio Lopez-morales Ethel Claffey Manuel Mora Juan Antonio Martinez Institute of Communications and Computer Systems AthensGreece Walton Institute WaterfordIreland Department of Information and Communications Engineering University of MurciaMurciaSpain School of Business Waterford Institute of TechnologyWaterfordIreland R&D Department Odin SolutionsMurciaSpain

The digital transformation in agriculture introduces new challenges in terms of data,knowledge and technology adoption due to critical interoperability issues,and also challenges regarding the identification of the most suitable data sources to be exploited and the information models that must be ***(Building an Interoperable,Data-Driven,Innovative and Sustainable European Agri-Food Sector)addresses these challenges by providing an overarching solution that integrates various heterogeneous hardware and software resources(e.g.,devices,networks,platforms)and enables the seamless sharing of data and knowledge throughout the agri-food *** paper introduces the main concepts of DEMETER and its reference architecture to address the data sharing and interoperability needs of farmers,which is validated via two rounds of 20 large-scale pilots along the DEMETER *** paper elaborates on the two pilots carried out in region of Murcia in Spain,which target the arable crops sector and demonstrate the benefits of the deployed DEMETER reference architecture.

关键词： Smart agriculture Internet of things(IoT) DEMETER Reference architecture Interoperability Agricultural information model(AIM) Pilot validation

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Observation of dipolar transport in one-dimensional photonic lattices

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Science Bulletin 2017年第5期62卷 339-344页

作者： Camilo Cantillano Luis morales-Inostroza Bastián Real Santiago Rojas-Rojas Aldo Delgado Alexander Szameit Rodrigo A.Vicencio Departamento de Física MSI-Nucleus on Advanced Opticsand Center for Optics and Photonics(CEFOP)Facultad de CienciasUniversidad de ChileSantiagoChile Center for Optics and Photonics and MSI-Nucleus on Advanced Optics Universidad de ConcepciónCasilla 160-C ConcepcionChile Institute for Physics University of RostockD-18059 RostockGermany

We experimentally study the transport properties of dipolar and fundamental modes on one dimensional(1D) coupled waveguide arrays. By carefully modulating a wide optical beam, we are able to effectively excite dipolar or fundamental modes to study discrete diffraction(single-site excitation) and gaussian beam propagation(multi-site excitation plus a phase gradient). We observe that dipolar modes experience a larger spreading area due to an effective larger coupling constant, which is found to be more than two times larger than the one for fundamental modes. Additionally, we study the effect of non-diagonal disorder and find that while fundamental modes are already trapped on a weakly disorder array, dipoles are still able to propagate across the system.

关键词： Photonic lattices Waveguide arrays Wave propagation Integrated optics

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On Lagrange-Projection Schemes for Shallow Water Flows Over Movable Bottom with Suspended and Bedload Transport

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Numerical Mathematics(Theory,Methods and Applications) 2023年第4期16卷 1087-1126页

作者： Alessia Del Grosso Manuel J.Castro Díaz Christophe Chalons Tomás morales de Luna UniversitéParis-Saclay UVSQCNRSLaboratoire de Mathématiques de Versailles78000VersaillesFrance Dpto.de Análisis Matemático Facultad de CienciasUniversidad de MálagaCampus de Teatinos S/N29081 MálagaSpain

In the present work we aim to simulate shallow water flows over movable bottom with suspended and bedload *** order to numerically approximate such a system,we proceed step by *** start by considering shallow water equations with non-constant density of the mixture ***,the Exner equation is included to take into account bedload sediment ***,source terms for friction,erosion and deposition processes are ***,observe that the sediment particle could go in suspension into the water or being deposited on the *** the numerical scheme,we rely on well-balanced Lagrange-projection *** particular,since sediment transport is generally a slow process,we aim to develop semi-implicit schemes in order to obtain fast *** Lagrange-projection splitting is well-suited for such a purpose as it entails a decomposition of the(fast)acoustic waves and the(slow)material waves of the ***,in subsonic regimes,an implicit approximation of the acoustic equations allows us to neglect the corresponding CFL condition and to obtain fast numerical schemes with large time step.

关键词： Shallow water flows movable bottom erosion-deposition processes Lagrangeprojection schemes implicit-explicit schemes

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Effects of chlorpyrifos on enzymatic systems of Cydia pomonella （Lepidoptera： Tortricidae） adults

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Insect Science 2017年第3期24卷 455-466页

作者： Laura Beatriz Parra morales Raul Adolfo Alzogaray Liliana Cichon Silvina Garrido Jimena Soleno Cristina Monica Montagna Laboratorio de Investigaciones Bioquimicas Quimicas y de Medio Ambiente Facultad de Ingenieria Universidad Nacional del ComahueBuenos Aires 1400 (Q83001BX) Neuquen Facultad de Ciencias del Ambiente y la Salud Universidad Nacional del Comahue Buenos Aires 1400 Neuquen Centro de Investigaciones de Plagas e Insecticidas (CIPEIN-UNIDEFICONICET) Villa Martelli Buenos Aires Instituto de Investigacion e Ingenieria Ambiental (3iA-UNSAM) San Martin Provincia de Buenos Aires Instituto Nacional de Tecnologia Agropecuaria Estacion Experimental Alto Valle General Roca Argentina

The control program of codling moth （Cydia pomonella L.） in the Rio Negro and Neuqu6n Valley is intended to neonate larvae. However, adults may be subjected to sublethal pesticide concentrations generating stress which might enhance both mutation rates and activity of the detoxification system. This study assessed the exposure effects of chlorpyrifos on target enzyme and, both detoxifying and antioxidant systems of surviving adults from both a laboratory susceptible strain （LSS） and a field population （FP）. The results showed that the FP was as susceptible to chlorpyrifos as the LSS and, both exhibited a similar chlorpyrifos-inhibitory concentration 50 （IC50） of acetylcholinesterase （ACHE）. The FP displayed higher carboxylesterase （CarE） and 7-ethoxycoumarine O-deethylase （ECOD） activities than LSS. Both LSS and FP showed an increase on CarE activity after the exposure to low-chlorpyrifos concentrations, followed by enzyme inhibition at higher concentrations. There were no significant differences neither in the activities of glutathione S-transferases （GST）, catalase （CAT） and superoxide dismutase （SOD） nor in the reduced glutathione （GSH） content between LSS and FP. Moreover, these enzymes were unaffected by chlorpyrifos. In conclusion, control adults from the FP exhibited higher CarE and ECOD activities than control adults from the LSS. AChE and CarE activities were the most affected by chlorpyrifos. Control strategies used for C. pomonella, such as rotations of insecticides with different modes of action, will probably delay the evolution of insecticide resistance in FPs from the study area.

关键词： acetylcholinesterase antioxidant system chlorpyrifos codling moth detoxification enzymes

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Stroke care during the COVID-19 outbreak in Spain: the experience of Spanish stroke units

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Stroke & Vascular Neurology 2021年第2期6卷 267-273页

作者： Maria Alonso de Lecinana Mar Castellanos Oscar Ayo-Martin Ana morales the Stroke Group-Spanish Society of Neurology Department of Neurology and Stroke Center Hospital La Paz Institute for Health Research-IdiPAZ.La Paz University Hospital.Universidad Autonoma de MadridMadridSpain Department of Neurology Complexo Hospitalario Universitario A Coruna.Biomedical Research Institute of A CorunaA CorunaSpain Department of Neurology Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Department of Neurology University Clinic Hospital Virgen de la ArrixacaMurciaSpain 不详

Background and purpose Spain has been heavily affected by *** of resources for managing the outbreak might have caused a disruption in stroke *** study analyses the impact on stroke care of reorganising the healthcare system in response to the first COVID-19 outbreak peak in Spain and the strategies adopted by Spanish stroke units to deal with this *** and methods We obtained data from a structured survey sent to the responsible of stroke units across the *** recorded the number of strokes,stroke code activations,intravenous thrombolysis treatments and mechanical thrombectomies during February and March 2019 and *** also collected information on the impact on workflow metrics and on the availability of specialised neurological care and rehabilitation treatments,the characteristics of stroke care for patients with SARS-CoV-2 infection and the impact on human *** compared the activity data between 2019 and 2020 and the information on activity and impact on stroke care between regions classified according to the disease incidence *** Fifty-seven(75%)of all stroke units in Spain responded to the *** was an overall reduction in admissions for all stroke types during the outbreak’s peak and in the number of stroke code activations and intravenous thrombolysis treatments,results that were independent of the COVID-19 incidence *** reported a delay in workflow metrics and a reduction of admissions to stroke units,outpatient clinics and rehabilitation *** pathways and protocols for managing stroke patients with SARS-CoV-2 infection have been *** The COVID-19 outbreak has jeopardised all phases of stroke *** a consequence,some patients with stroke did not receive adequate treatment.

关键词： Spanish consequence outbreak

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Clinical characteristics and surgical treatment of schwannomas of the esophagus and stomach: A case series and systematic review

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World Journal of Gastrointestinal Oncology 2019年第9期11卷 750-760页

作者： Jesús morales-Maza Francisco Ulises Pastor-Sifuentes Germán E Sánchez-morales Emilio Sanchez-Garcia Ramos Oscar Santes Uriel Clemente-Gutiérrez Adriana Simoneta Pimienta-Ibarra Heriberto Medina-Franco Department of Surgery Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

BACKGROUND Gastrointestinal schwannomas are slow-growing benign mesenchymal neoplasms that originate from Schwann cells of the nerve sheath of Auerbach′s plexus or less frequently from Meissner′s *** main differential diagnosis of gastric schwannomas are the gastrointestinal stromal tumors(GISTs),which are classified by their *** treatment of choice for gastric schwannomas is surgery where laparoscopy plays an important *** resection,subtotal or total gastrectomy can be *** its counterpart,esophageal schwannomas are benign tumors of the esophagus that are very uncommon since they comprise less than 2%of all esophageal *** main differential diagnosis is the leiomyoma which corresponds to the most common benign esophageal tumor,followed by *** treatment consists on tumoral enucleation or *** To review the available literature about gastrointestinal schwannomas;especially lesions from de stomach and esophagus,including diagnosis,treatment,and follow up,as well as,reporting our institutional *** A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes *** following databases were used for reviewing process:Pub Med,Ovid,MEDLINE,and *** English language manuscripts were *** gastrointestinal schwannomas specifically located in the esophagus and stomach were *** that did not report long-term follow-up were *** Gastric localization showed a higher prevalence in both,the literature review and our institution:94.95%(n=317)and 83%(n=5)*** a follow-up with disease-free survival greater than 36 mo in most cases:62.01%(n=80)vs66.66%(n=4).In both groups,the median size was>4.1 *** treatment is curative in most cases CONCLUSION Schwannoma must be taken into account in the differential diagnosis of gastrointestinal mesenchymal *** has a good prognosis,and most are benig

关键词： Schwannoma Esophagus Stomach Surgery Systematic review

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Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints

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Cancer Biology & Medicine 2015年第2期12卷 79-86页

作者： Niki Karachaliou Maria Gonzalez Cao Cristina Teixidó Santiago Viteri Daniela morales-Espinosa Mariacarmela Santarpia Rafael Rosell Instituto Oncológico Dr Rosell Quiron Dexeus University Hospital Pangaea Biotech Medical Oncology Unit Human Pathology Department University of Messina Catalan Institute of Oncology Hospital Germans Trias i Pujol Molecular Oncology Research (MORe) Foundation Germans Trias i Pujol Health Sciences Institute and Hospital

Survival rates for metastatic lung cancer, including non-small cell lung cancer （NSCLC） and small cell lung cancer （SCLC）, are poor with S-year survivals of less than 5%. The immune system has an intricate and complex relationship with tumorigenesis; a groundswell of research on the immune system is leading to greater understanding of how cancer progresses and presenting new ways to halt disease progress. Due to the extraordinary power of the immune system-- with its capacity for memory, exquisite specificity and central and universal role in human biology--immunotherapy has the potential to achieve complete, long-lasting remissions and cures, with few side effects for any cancer patient, regardless of cancer type. As a result, a range of cancer therapies are under development that work by turning our own immune cells against tumors. However deeper understanding of the complexity of immunomodulation by tumors is key to the development of effective immunotherapies, especially in lung cancer.

关键词： Lung cancer immunotherapy immune checkpoint program death-ligand 1 (PD -L 1) program death- 1 (PD - i)

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