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Factors Associated to the Presence of Pneumothorax in Cystic Fibrosis Patients in the City of Madrid

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International Journal of Clinical Medicine 2011年第3期2卷 212-217页

作者： Prados Concepción Carpio Carlos Martínez María Teresa Máiz Luis Girón Rosa Barrio Isabel Salcedo Antonio García Hernández Gloria Gómez Carrera Luis álvarez-sala rodolfo Prados Sánchez Concepción Department of Pneumology La Paz University Hospital Madrid

Background: To identify risk factors associated with pneumothorax and to determine the prognosis of cystic fibrosis patients following an episode of pneumothorax in the city of Madrid. Methods: Records of 17 patients (10 males;age 24.4 ± 17.5 years) and 32 controls, and a total of 44 pneumothorax episodes were studied. We have analyzed the characteristics of the pneumothorax, the microbiology, the lung function tests (LFT) and the prognosis of patients. Two controls with cystic fibrosis and without pneumothorax matched for sex and age were selected. Results: Eight male and three female patients with pneumothorax were older than 18 years. The mean age of the first pneumothorax episode was 18.3 years (±9.6). The group with pneumothorax had a mean body mass index of 19.2(±2.42 kg/m2) and in the control group it was 26.5 (±1.98 kg/m2). Pseudomonas aeruginosa was present in fourteen patients (82%) with pneumothorax and in eleven patients (34.4%) in the control group (p = 0.002). Pneumothorax predominantly occurred in the coldest seasons. There was a significant drop in both forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) after the pneumothorax. In the same way, FEV1 and FVC were greater in the control group. Six patients (35.4%) with pneumothorax and two patients in the control group have died (p < 0.05). Conclusions: Patients with pneumothorax are more likely to have P. aeruginosa colonization. LFT drop after an episode of pneumohorax. Patients with pneumothorax have worse LFT than patients without pneumothorax. Mortality is greater in patients with pneumothorax.

关键词： Cystic Fibrosis Pleural Disease Pneumothorax

Experimental test of a building thermal system for preventive maintenance based on thermoeconomic analysis

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Energy Storage and Saving 2024年第1期3卷 42-51页

作者： I.Prol-Godoy A.Picallo-Perez J.M.sala-Lizarraga J.Rey-Martínez Research group ENEDI Department of Thermal EngineeringUniversity of the Basque Country(UPV/EHU)Bilbao48013Spain Research Group Termotecnia University of ValladolidValladolid47002Spain

An analysis of the sectorial structure of energy consumption shows that residential and tertiary sector buildings are the third-highest consumers,responsible for 29.5%of a city’s final energy *** Building Quality Control Laboratory of the Basque Government aims to promote quality,innovation,and sustainability in *** accomplish this goal,it has constructed an experimental facility with different energy generation technologies and a very versatile control system for testing different energy systems and operation *** this study,we tested a facility for supplying domestic hot water and heating for a multi-family house by means of a condensing boiler and an aerothermal heat pump(together with the corresponding control).This installation could reproduce the thermal demands required to be satisfied by the generation equipment through a programmed operation of the installation based on real ***,this installation was analyzed using thermoeconomics(TE)to solve problems unable to be solved using traditional energy analyses based on the First Law of *** problems include:(1)Determining the costs of the products of the installation based on physical criteria,(2)detecting the places where losses actually occur,evaluating their costs,and proposing cost-effective improvements,and(3)diagnosing issues in the *** a result,this paper suggests a solution to the preventive maintenance problems confronting the technical maintenance personnel for thermal installations in buildings by applying TE knowledge and using real data collected from sensors.

关键词： Experimental essay Energy savings in thermal systems Thermoeconomics Thermoeconomic costs Diagnosis

New technologies as a strategy to decrease medication errors: how do they affect adults and children differently?

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世界儿科杂志:英文版 2016年第1期12卷 28-34页

作者： Margarita Ruano Elena Villamañán Ester Pérez Alicia Herrero rodolfo Álvarez-sala Department of Pharmacy La Paz University HospitalMadridSpain Department of Pneumology La Paz University HospitalMadridSpain

Background:Medication error can occur throughout the drug treatment process,with special relevance in children given the risk of adverse effects resulting from a medication error is more prevalent than in *** significance of medication error in children is also greater because small error that would be tolerated in adults can cause significant damage in ***,the likelihood of injury is higher than in *** sources:Based on the data published,most medication errors take place in prescribing and administration stages in both *** in account that child's risk factors are different from those of adults,with some specific causes to pediatrics,we have reviewed available data about new technologies as a strategy to reduce pediatric medication ***:Even though there is a lack of standardized definitions and terminology that makes studies difficult to compare,we checked that new technologies have proven to be effectives in reducing medication errors,mainly computerized physician order entry(CPOE)and platforms to aid ***,we also observed that the use of these informatic tools can also generate new ***:Implementation of CPOE programs for pediatrics,communication improvement between healthcare professionals taking care of admitted children and the knowledge of these programs should be the mayor priorities for the safety of hospitalized children.

关键词： electronic prescribing new technologies pediatric medication errors

针对嗜铬细胞瘤/副神经节瘤患者的左心室力学的荟萃分析

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中华高血压杂志(中英文) 2024年第4期 400-400页

作者： Cuspidi C Gherbesi E Faggiano A sala C Carugo S Grassi G Tadic M 刘青练桂丽

背景:通过测量嗜铬细胞瘤和副神经节瘤(pheochromocytoma and paraganglioma,PPGL)患者的左室射血分数(left ventricular ejection fraction,LVEF)来确定左心室收缩功能的大量研究,要么未能揭示该参数的任何损害,要么发现与原发性高血...

背景:通过测量嗜铬细胞瘤和副神经节瘤(pheochromocytoma and paraganglioma,PPGL)患者的左室射血分数(left ventricular ejection fraction,LVEF)来确定左心室收缩功能的大量研究,要么未能揭示该参数的任何损害,要么发现与原发性高血压或正常血压对照相比,其收缩功能高于正常。为了提供关于PPGL环境下左心室收缩功能障碍的最新信息,研究者对斑点追踪超声心动图(speckle tracking echocardiography,STE)研究进行了荟萃分析,通过整体纵向应变(global lon gitudinal strain,GLS)研究左心室力学,这是一种比LVEF更敏感的左心室收缩功能指标。

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Alexander disease:the road ahead

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Neural Regeneration Research 2023年第10期18卷 2156-2160页

作者： María A.Pajares Elena Hernández-Gerez Milos Pekny Dolores Pérez-sala Department of Structural and Chemical Biology Centro de Investigaciones Biológicas Margarita SalasMadridSpain Laboratory of Astrocyte Biology and CNS Regeneration Center for Brain RepairDepartment of Clinical NeuroscienceInstitute of Neuroscience and PhysiologySahlgrenska Academy at the University of GothenburgGothenburgSweden University of Newcastle NewcastleNSWand the Florey Institute of Neuroscience and Mental HealthParkvilleVICAustralia

Alexander disease is a rare neurodegenerative disorder caused by mutations in the glial fibrillary acidic protein,a type III intermediate filament protein expressed in *** early(infantile or juvenile)and adult onsets of the disease are known and,in both cases,astrocytes present characteristic aggregates,named Rosenthal *** are spread along the glial fibrillary acidic protein sequence disrupting the typical filament network in a dominant *** the presence of aggregates suggests a proteostasis problem of the mutant forms,this behavior is also observed when the expression of wild-type glial fibrillary acidic protein is ***,several isoforms of glial fibrillary acidic protein have been described to date,while the impact of the mutations on their expression and proportion has not been exhaustively ***,the posttranslational modification patterns and/or the protein-protein interaction networks of the glial fibrillary acidic protein mutants may be altered,leading to functional changes that may modify the morphology,positioning,and/or the function of several organelles,in turn,impairing astrocyte normal function and subsequently affecting *** particular,mitochondrial function,redox balance and susceptibility to oxidative stress may contribute to the derangement of glial fibrillary acidic protein mutant-expressing *** study the disease and to develop putative therapeutic strategies,several experimental models have been developed,a collection that is in constant *** fact that most cases of Alexander disease can be related to glial fibrillary acidic protein mutations,together with the availability of new and more relevant experimental models,holds promise for the design and assay of novel therapeutic strategies.

关键词： astrocytes endoplasmic reticulum stress glial fibrillary acidic protein mutants metabolism misassembly misfolding neurodegeneration oxidative stress posttranslational modifications unfolded protein response

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Influence of free fatty acid content and degree of fat saturation on production performance,nutrient digestibility,and intestinal morphology of laying hens

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Animal Nutrition 2023年第2期13卷 313-323页

作者： María Palomar Carlos Garces-Narro Olga Piquer Roser sala Alba Tres Jose AGarcía-Bautista María D.Soler AviFeed Science Department of Animal Production and HealthFacultad de VeterinariaUniversidad CEU Cardenal Herrera e CEU UniversitiesE-46115Alfara de PatriarcaValenciaSpain Animal Nutrition and Welfare Service Department of Animal and Food ScienceFacultat de VeterinariaUniversitat Autonoma de BarcelonaE-08193BellaterraBarcelonaSpain Departament de Nutrici Ciencies de l’Alimentaci i GastronomiaFacultat de Farmacia i Ciencies de l’AlimentaciUniversitat de BarcelonaE-08921Santa Coloma de GramenetBarcelonaSpain

This study was conducted to evaluate the effects of dietary free fatty acid(FFA)content and degree of fat saturation on production performance,lipid and calcium digestibility,and intestinal function of laying *** a 15-week period,a total of 144 laying hens(19 weeks old)were randomly assigned to 8 dietary treatments,which were obtained by gradually replacing crude soybean oil with soybean acid oil(AO),or crude palm oil with palm fatty acid distillate(FAD).Thus,there were 4 soybean and 4 palm diets with 6%added fat varying in their FFA percentage(10%,20%,30%,and 45%),following a 2×4 factorial *** treatment included 6 replicates with 3 birds per *** daily feed intake and final body weight were significantly higher in palm diets(P<0.001),while no differences were found in egg mass and feed conversion *** levels of FFA in soybean diets resulted in lower egg production and higher egg weight(linear,P<0.01).Regarding the degree of fat saturation,hens fed soybean diets presented higher digestibility of ether extract(EE),fatty acids,and calcium than palm diets(P<0.001).The dietary FFA percentage negatively affected the digestibility of EE and calcium(P<0.01),while having little effect on FA *** was a significant interaction in the AME;lower values were reported in soybean diets as the dietary FFA percentage increased(linear,P<0.01),whereas palm diets remained *** experimental diets had little effect on gastrointestinal weight and ***,the jejunum of soybean diets showed higher villus height and higher villus height-to-crypt depth ratio than palm diets(P<0.05),and the dietary FFA percentage increased the crypt depth and decreased the villus height-to-crypt depth ratio(linear,P<0.05).It was concluded that varying dietary FFA content did not affect fat utilization as much as the degree of saturation did,supporting the use of AO and FAD as alternative fat ingredients.

关键词： Acid oil Fat by-product Fatty acid distillate Lipid Calcium

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Large-area Analysis of Soil Erosion and Landslides Induced by Rainfall: A Case of Unsaturated Shallow Deposits

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Journal of Mountain Science 2015年第4期12卷 783-796页

作者： CUOMO Sabatino DELLA sala Maria Department of Civil Engineering University of Salerno

Unsaturated shallow soil deposits may be affected by either superficial soil erosion or shallow landslides in adjacent or overlapping source areas and in different seasons when a different soil suction *** triggering analysis of both these processes is a relevant issue for the hazard analysis while the literature mostly provides specific approaches for erosion or for *** paper proposes a largearea analysis for a case study of Southern Italy,consisting of unsaturated shallow deposits of loose pyroclastic(air-fall) volcanic soils that have been repeatedly affected by erosion and landslides in special *** a past catastrophic event, the simulated source areas of shallow landslides are smaller than those observed in the field while the simulated eroded areas with thickness greater than 5cm are comparable with the in-situ evidences, if the analysis takes into account high rainfall intensity and a spatially variable soil cover *** in general, the results of the paper are consistent with the previous literature and also provide a methodological contribution about the application of distinct tools over large *** added value is that the paper shows how the combination of distinct large-area analyses may help with understanding the dominant slope instability *** once this goal is fully achieved, can specific physically-based analyses be confidently performed at detailed scales and for smaller specific areas.

关键词：浅层滑坡土壤侵蚀降雨强度面积分不饱和沉积物火山碎屑非饱和土壤

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Clustering and classification of energy meter data: A comparison analysis of data from individual homes and the aggregated data from multiple homes

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Building Simulation 2021年第1期14卷 103-117页

作者： Juan sala Rongling Li Morten H.Christensen Department of Civil Engineering Technical University of DenmarkLyngbyDenmark Department of Electrical Engineering Technical University of DenmarkLyngbyDenmark

The transition towards a more sustainable environment requires the development of new control systems on the demand side to integrate renewable energy sources into the energy *** this purpose,energy meter data of homes have been broadly used in modelling,forecast and optimal control of energy ***,usability and reliability of household energy meter data have not been specifically *** this study,we apply commonly used machine learning methods on the heating consumption data of(1)two individual homes in an apartment building and(2)the district heating substation of the apartment building which includes 72 homes,to identify how the characteristics of data affect the result of data *** clustering approaches were applied using the K-means algorithm to group similar heating daily *** the clustering results,different classification algorithms such as logistic regression and random forest were applied to predict the heating consumption level with regards to the weather *** data analysis process showed that the substation data which is the aggregated heating consumption of the 72 homes is more reliable and valid for energy prediction than the data from two individual *** is due to the large variation and uncertainty in the daily energy use of individual homes.

关键词： smart meter data daily profile clustering classification data usability heat substation

High density lipoproteins and atherosclerosis: emerging aspects

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Journal of Geriatric Cardiology 2012年第4期9卷 401-407页

作者： Federica sala Alberico Luigi Catapano Giuseppe Danilo Norata Department of Pharmacological Sciences University of Milan Via Balzaretti 9 Milan 20133 Italy IRCCSMult imedica ViaMilanese 300 Sesto San Giovanni Milan Italy Centro SISAper lo Studio dell’Aterosclerosi Ospedale Bassini Via Gorki50 Cinisello Bal samo Italy The Blizard Institute Barts and the LondonSchool of Medicine & Dentistry Queen Mary University Turner Street London E1 2AD UK

High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis,includingmonocyte-macrophages, B and T ***, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.

关键词： Apolipoprotein High density lipoproteins Immune response Sphingosine-1-phosphate