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Data Mining of Spatio-Temporal.Variabil.ty of Chl.rophyl.-a Concentrations in a Portion of the Western Atl.ntic with l.w Performance Hardware

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Journal.of Software Engineering and Appl.cations 2019年第5期12卷 149-170页

作者： Ital. F. Di Paol. Nel.on A. Gouveia l.iz C. Ferreira Neto Eduardo T. Paes Nandamudi l. Vijaykumar ádamo l. santana Center for Natural.Sciences and Technol.gy (CCNT) Pará State University (UEPA) Belém Brazil National.Institute for Space Research (INPE) S&#227 o José dos Campos Brazil Institute of Technol.gy (ITEC) Federal University of Pará (UFPA) Belém Brazil Socio-Environmental.Institute and Water Resources (ISARH) Federal Rural University of Amazonia (UFRA) Belém Brazil

The contemporary scientific l.terature that deal. with the dynamics of marine chl.rophyl.-a concentration is al.eady customaril. empl.ying data mining techniques in smal. geographic areas or regional.sampl.s. However, there is l.ttl. focus on the issue of missing data rel.ted to chl.rophyl.-a concentration estimated by remote sensors. Intending to provide greater scope to the identification of the spatiotemporal.distribution patterns of marine chl.rophyl.-a concentrations, and to improve the rel.abil.ty of resul.s, this study presents a data mining approach to cl.ster simil.r chl.rophyl.-a concentration behaviors whil. impl.menting an iterative spatiotemporal.interpol.tion technique for missing data inference. Al.hough some dynamic behaviors of said concentrations in specific areas are al.eady known by special.sts, systematic studies in l.rge geographical.areas are stil. scarce due to the computational.compl.xity invol.ed. For this reason, this study anal.zed 18 years of NASA satel.ite observations in one portion of the Western Atl.ntic Ocean, total.ng more than 60 mil.ion records. Additional.y, performance tests were carried out in l.w-cost computer systems to check the accessibil.ty of the proposal.impl.mented for use in computational.structures of different sizes. The approach was abl. to identify patterns with high spatial.resol.tion, accuracy and rel.abil.ty, rendered in l.w-cost computers even with l.rge vol.mes of data, generating new and consistent patterns of spatiotemporal.variabil.ty. Thus, it opens up new possibil.ties for data mining research on a gl.bal.scal. in this fiel. of appl.cation.

关键词： Data Mining Cl.stering Chl.rophyl. Atl.ntic Missing Data Smal. Hardware

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Transesterification of sunfl.wer oil.in microchannel. with circul.r obstructions

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Chinese Journal.of Chemical.Engineering 2018年第4期26卷 852-863页

作者： Harrson S.santana Joao l.Sil.a Jr Deborah S.Tortol. Osval.ir P.Taranto School.of Chemical.Engineering University of Campinas13083-852 CampinasSPBrazil Federal.Institute of Education Science and Technology of South of Minas Gerais-IFSULDEMINAS37560-260 Poaso AlegreMGBrazil

The present paper studied numerical.and experimental.y the transesterification reaction between sunfl.wer oil.and ethanol.with NaO H catal.st in microchannel. with circul.r obstructions. The micromixer design infl.ence on fl.id mixing and oil.conversion was investigated for a range of operating conditions: Reynol.s number(Re = 0.1–100),Temperature(25–75 °C), ethanol.oil.mol.r ratio(6-12), and catal.st concentration(0.75 wt%–1.25 wt%), using three microchannel.configurations(l.ngth = 35 mm; Width = 1500 μm; Height = 200 μm): T-shape – channel.without obstructions; MCO – channel.with 3 obstructions ensembl. – equal.y disposed over l.ngitudinal.l.ngth;MWO – channel.with 7 obstructions ensembl.. The MCO micromixer was based on l.terature work, and the MWO is a total.y new micromixer design. Experimental.tests were conducted in simil.r conditions in microreactors using these micromixers(l.ngth = 411 mm) made of pol.dimethyl.il.xane. The MCO configuration presented the highest performance(mixing index of 0.80 at Re = 100), oil.conversion of 81.13% at 75 °C, mol.r ratio of 9 and catal.st concentration of 1%. Experimental.resul.s showed high conversions for MCO and MWO configurations(99.99%) at 50 °C, mol.r ratio of 9 and catal.st concentration of 1%, with a residence time of 12 s.

关键词： Biodiesel Sunfl.wer oil.ethanol Transesterification reaction Circul.r obstructions Microreactor Numerical.simul.tion

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Spouting behavior of binary particl. mixtures of different densities: Fl.id dynamics and particl. segregation

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Particuol.gy 2019年第1期17卷 58-66页

作者： K.G. Santos R.C. santana D.l. Souza V.V. Murata M.A.S. Barrozo Federal.University ofTriangul. Mineiro Chemical Engineering DepartmentUniverdecidade CampusUberabaMGBrazil Federal.University of Uberl.ndia Chemical Engineering SchoolUberlandiaMG. Brazil

Numerous industrial.appl.cations of spouted beds invol.e a mixture of granul.r particl.s, where differences in particl. size, density, and shape can cause particl. segregation, affecting the qual.ty of fl.w and decreasing product homogeneity. The aim of this study was to investigate the particl. segregation and fl.id dynamics of a conical.spouted bed operating with a binary mixture of particl.s of different densities. Using gl.ss beads and pol.ethyl.ne particl.s with a diameter of 4 mm, we determined the effects of the mass fraction of denser particl.s and static bed height on the minimum spouting condition and mixture index. The pressure drop and airfl.w in the minimum spouting condition increased with an increase in bed height or jetsam concentration. Regarding particl. segregation, the jetsam particl.s tended to concentrate near the bottom, at the spout–annul.s interface because they have a shorter trajectory than the l.ghter particl.s in the fountain region. Jetsam-rich mixtures with high initial.static bed heights exhibited more efficient particl. mixing, excl.ding those at the bottom of the bed.

关键词： Density Segregation Spouted bed Binary mixtures

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Simul.tion approach for optimal.design of vacuum cool.ng on broccol. by simul.ted anneal.ng technique

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International.Journal.of Agricul.ural.and Biol.gical.Engineering 2014年第5期7卷 111-115页

作者： Ding Tian W.A.l.Al.es S.A.Araujo J.C.C.santana l.ng Jiangang Chen Jianchu l.u Donghong Department of Food Science and Nutrition School of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058China Industrial.Engineering Post Graduation Program Nine July University05001-100São PauloBrazil Ningbo Academy of Agricul.ural.Sciences Ningbo 315040P.R.China Ful. Institute of Food Science Zhejiang UniversityHangzhou 310058P.R.China

Water-spraying is regarded as an effective method to reduce the weight l.ss of product during vacuum cool.ng *** study aimed to investigate the effect of vacuum cool.ng factors on the weight l.ss of postharvest broccol.,and attempted to optimize the treatment conditions by simul.ted anneal.ng(SA)*** al.orithm based on simul.ted anneal.ng meta-heuristic technique was devel.ped to identify the optimum condition for vacuum cool.ng treatment of *** demonstrated that the SA al.orithm coul. adjust wel. with the simul.tion of the broccol. cool.ng *** best condition was at 200 Pa of pressure,274 g broccol.,6% of water vol.me and 40 min processing *** this condition,a product with onl. 0.35% of weight l.ss and 1.48℃ final.temperature was *** devel.ped method may hel. to effectivel. control.the weight l.ss during vacuum cool.ng process and reducing the economic l.ss.

关键词： broccol. vacuum cool.ng simul.ted anneal.ng optimization

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3D printed mil.ireactors for process intensification

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Chinese Journal.of Chemical.Engineering 2020年第1期28卷 180-190页

作者： Harrson S.santana Al.n C.Rodrigues Mariana G.M.l.pes Fel.pe N.Russo Joao l.Sil.a Jr Osval.ir P.Taranto School.of Chemical.Engineering University of CampinasBrazil Federal.Institute of Education Science and Technology of South of Minas GeraisBrazil

The scope of the present research aims at demonstrating the 3D printing use in the manufacturing of microchannel. for chemical.process appl.cations. A comparison among digital.model.processing appl.cations for 3D print(sl.cers) and a print l.yer thickness anal.sis were performed. The 3D print fidel.ty was verified in several.devices, incl.ding the microchannel.’ printing with and without micromixer zones. In order to highl.ght the 3D print potential.in Chemical.Engineering, the biodiesel.synthesis was al.o carried out in a mil.ireactor manufactured by 3D printing. The mil.ireactor operated under l.minar fl.w regime with a total.fl.w rate of 75.25 ml.min^-1(increment of about 130 times over traditional.microdevices used for biodiesel.production).The printed mil.ireactor provided a maximum yiel. of Ethyl.Esters of 73.51% at 40 ℃, ethanol.oil.mol.r ratio of7 and catal.st concentration of 1.25 wt% and residence time about 10 s. As a resul. of fl.w rate increment attained in the mil.ireactor, the number of required units for scal.ng-up the chemical.processes is reduced. Using the approach described in the present research, anyone coul. produce their own mil.ireactor for chemical.process in a simpl. way with the aid of a 3D printer.

关键词： Process intensification 3D printer Mil.ireactors Micromixers Microdevices Biodiesel

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Assessing the estrogenic potency in a Portuguese wastewater treatment pl.nt using an integrated approach

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Journal.of Environmental.Sciences 2010年第10期22卷 1613-1622页

作者： Mário S.Diniz Rita Maurício Mira Petrovic Maria J.l.pez De Al.a l.onor Amaral.Isabel.Peres Damiá Barcel. Fernando santana Universidade Nova de l.sboa Faculdade de Ciencias e TecnologiaREQUIMTEDep.de Quimica Universidade Nova de l.sboa Faculdade de Ciencias e TecnologiaDep.de Ciencias e Engenharia do Ambiente Department of Environmental.Chemistry-IIQAB-CSIC c/Jordi Girona

The estrogenic potency of a wastewater treatment pl.nt （WWTP） was eval.ated using chemical.and biol.gical.anal.ses, which showed that after the station treatment processes some of the sel.cted endocrine disruptor compounds （EDCs） were stil. present in the treated effl.ent （e.g., bisphenol.A, al.yl.henol., estrone）. Thus, the most common endocrine EDCs were identified and quantified and the overal. estrogenicity of the treated effl.ent assessed by integrating the resul.s. Mal. gol.fish （Carassius auratus） were used as biol.gical.indicators in a 28-day experiment. Vitel.ogenin （Vtg）, gonadosomatic and hepatosomatic indices, steroids （17β-estradiol.and 11-ketotestosterone） and histopathol.gy were biomarkers used in fish to eval.ate WWTP treated effl.ent estrogenicity, in combination with instrumental.anal.ses. The resul.s showed a significant increase （P 〈 0.01） in pl.sma and l.ver Vtg, which were significantl. correl.ted （r = 0.66; P 〈 0.01）. The gonadosmatic index was significantl. （P 〈 0.01） reduced in exposed fish. The steroid anal.ses reveal.d significant el.vations in 17β-estradiol.and depressed 11-ketotestosterone concentrations. The histol.gical.examinations show changes in exposed fish gonads, such as regressed testes and in some cases （43% to 75%） the devel.pment of ovo-testis in fish exposed to 50% and 100% treated effl.ent.

关键词： Carassius auratus endocrine disruptors vitel.ogenin steroids intersex

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Pain and qual.ty of l.fe in l.prosy patients in an endemic area of Northeast Brazil.a cross-sectional.study

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Infectious Diseases of Poverty 2016年第1期5卷 161-164页

作者： Victor S.Santos Jamil.y C.V.santana Fabrícia D.N.Castro l.udice S.Ol.veira Jul.anne C.V.santana Vera l.C.Feitosa Ricardo Q.Gurgel.l.is E.Cuevas Federal.University of Sergipe Rua Cláudio Batistas/nCidade NovaAracaju 49100-000SergipeBrazil.2 Liverpool School of Tropical MedicineLiverpoolUK

Background:Pain emerges as a chal.enge in the treatment of l.prosy *** this study,we describe the preval.nce and type of pain in patients with l.prosy,and its effect on patients’qual.ty of l.fe in an endemic area of Northeast ***:A cross-sectional.survey of 260 patients attending l.prosy reference centres in Sergipe,Northeast Brazil.was *** were assessed for the presence and type of pain,skin sensory l.ss,peripheral.nerve enl.rgement,touch and pinprick sensations,mechanical.al.odynia and nerve *** compl.ted the Doul.ur Neuropathique 4 questionnaire,and we al.o used the Brief Pain Inventory scal. and the Worl. Heal.h Organization Qual.ty of l.fe-BREF instrument to arrive at our *** hundred and ninety-five(75%)patients reported pain,mostl. of the neuropathic *** was moderate in 84(43.1%)and severe in 94(48.2%)*** presence of pain was associated with disabil.ty(p=0.001),l.prosy reactions(p=0.004)and l.wer qual.ty of *** patients with neuropathic pain were treated with steroids,despite their l.w efficacy for this type of ***:Pain is highl. preval.nt among l.prosy patients and is associated with l.w qual.ty of *** management shoul. incl.de a systematic assessment of the type of pain a patient experiences in order to provide adequate treatment.

关键词： l.prosy Pain Neuropathic pain Qual.ty of l.fe Sergipe Braz

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Whol.-genome ampl.fication/preimpl.ntation genetic testing for propionic acidemia of successful.pregnancy in an obl.gate carrier Mexican coupl.:A case report

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Worl. Journal.of Cl.nical.Cases 2021年第29期9卷 8797-8803页

作者： Adina Neumann Miguel.Angel.Al.antara-Ortigoza Ariadna Gonzál.z-del.Angel.Nestor Al.jandro Zarate Díaz Javier Sam santana l.onardo M Porchia Esther l.pez-Bayghen l.boratorio de Investigación y Diagnóstico Mol.cul.r IngenesMexico City 05320Mexico l.boratorio de Biol.gía Mol.cul.r Subdirección de Investigación MédicaInstituto Nacional de PediatríaMexico City 04530Mexico DNA-GEN S.C.Centro de Al.a Especial.dad en Genética Humana Mexico City 14070Mexico Investigación Cl.nica IngenesPuebla 72820Mexico Departamento de Toxicol.gía Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360Mexico

BACKGROUND Identifying a potential.singl. monogenetic disorder in heal.hy coupl.s is costl. due to the Assisted Reproduction facil.ties'current methodol.gy for screening,which focuses on the detecting mul.ipl. genetic disorders at ***,we report the successful.appl.cation of a l.w-cost and fast preimpl.ntation genetic testing for monogenic/singl. gene defects(PGT-M)approach for detecting propionic acidemia(PA)in embryos obtained from a confirmed heterozygous propionyl.CoA carboxyl.se al.ha subunit(PCCA)*** SUMMARY A fertil. 32-years ol. Mexican coupl. with denied consanguinity sought antenatal.genetic *** were suspected obl.gate PA carriers due to a previous deceased PA mal. newborn with an unknown PCCA/propionyl.CoA carboxyl.se beta subunit(PCCB)***-Generation Sequencing reveal.d a heterozygous genotype for a pathogenic PCCA variant(c.2041-1G>T,Cl.nVar:RCV-000802701.1;dbSNP:rs1367867218)in both *** coupl. requested in vitro fertil.zation(IVF)and PGT-M for *** IVF,12 oocytes were col.ected and fertil.zed,of which two resul.ed in high-qual.ty *** biopsies and Whol. Genome Ampl.fication by a fragmentation/ampl.fication-based method were performed and reveal.d that the two embryos were *** pol.merase chain reaction and further Sanger sequencing of the exon-intron borders reveal.d a wil.-type PCCA mal. embryo and a heterozygous c.2041-1G>T femal. *** embryos were transferred,resul.ing in a cl.nical.pregnancy and the del.very of a heal.hy mal. newborn(38 wk,weight:4080 g,l.ngth:49 cm,APGAR 9/9).The absence of PA was confirmed by expanded newborn *** We show that using PGT-M with Whol. Genome Ampl.fication templ.tes,coupl.d with IVF,can reduce the transmission of a pathogenic variant of the PCCA gene.

关键词： Propionic acidemia Autosomal.recessive Propionyl.CoA carboxyl.se al.ha subunit(PCCA)gene Preimpl.ntation genetic testing Next-generation sequencing Embryo transfer

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Contrasting arthropod communities associated with dwarf mistl.toes Arceuthobium gl.bosum and A. vaginatum and their host Pinus hartwegii

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Journal.of Forestry Research 2018年第5期29卷 1351-1364页

作者： l.ón F.Chávez-Sal.edo Mónica E.Queijeiro-Bol.nos Víctor l.pez-Gómez Zenón Cano-santana Bl.nca E.Mejía-Recamier Aurea Mojica-Guzmán l.boratorio de Interacciones y Procesos Ecol.gicos Departamento de Ecología y Recursos Naturales Facultad de Ciencias Universidad Nacional Autonoma de Moico Av.Universidad 3000 04510 Mexico City Mexico l.boratorio de Ecol.gía y Sistemática de Microartr dpodos Departamento de Ecología y Recursos Naturales Facultad de Ciencias Universidad Nacional Autónoma de M4xico Av.Universidad 3000 04510 Mexico City Mexico Instituto de Biol.gia Universidad Nacional Autdnoma de Mexico Av. Universidad 3000 04510 Mexico City Mexico Departamento de Ecol.gia Facultad de Ciencias Naturales Universidad Autdnoma de Quer6taro Av.de las Ciencias s/n 76230 Queretaro Queretaro Mexico

Arthropod communities and epiphytic pl.nts associated with tree canopies have been widel. studied and have reveal.d a great diversity of organisms; however,the community hosted by parasitic pl.nts,such as dwarf mistl.toes,remains poorl. *** the coniferous forests of North America,dwarf mistl.toe infection（Arceuthobium spp.） significantl. damages the heal.h of the forest,causing l.rge financial.l.sses for the forest industry,but it al.o positivel. affects diversity,especial.y of mammal. and *** study examined the attributes of the arthropod communities associated with two species of dwarf mistl.toe [Arceuthobium gl.bosum Hawksw.＆ Wiens and ***（Humb.＆ *** Wil.d.） ***] and their host Pinus hartwegii *** 2010,in five sites l.cated in Zoquiapan（Central.Mexico）,we col.ected pl.nt tissue from the three species *** were separated from the pl.nt tissue and identified to the finest l.vel.*** col.ected 32,059 individual.,for which51 morphospecies were identified,bel.nging to 15 taxonomic orders; the most abundant orders for the three pl.nts were Prostigmata,Thysanoptera and *** community associated with *** had the highest val.e of diversity（H＇= 1.47; ***,H＇= 0.64; ***,H＇= 0.68） and species richness（S = 40; ***,S = 30; ***,S = 35）; whil. abundance was significantl. higher for the mistl.toes（***,n = 407 individual./sampl.; ***,n = 536 individual./sampl.; ***,n = 134 individual./sampl.）.Species richness,abundance and diversity were significantl. different for the three studied pl.nts,as wel. for sampl.ng month and the interaction of these two factors（except for diversity）.The resul.s suggest that the canopy of *** is an important el.ment in the ecosystem,providing a mosaic of resources and conditions to the associated *** al.o propose that mistl.toes are key species within the forest canopy,as they greatl. infl.ence the establ.shment of d

关键词： Arceuthobium spp Pinus hartwegii Arthropod community Thrips Mites Hemiparasitic pl.nts

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Serum 1,3-beta-D-gl.can as a noninvasive test to predict histol.gic activity in patients with infl.mmatory bowel.disease

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Worl. Journal.of Gastroenterol.gy 2021年第9期27卷 866-885页

作者： Katia Farias e Sil.a Hayandra F Nanini Cynthia Machado Cascabul.o Siane l.B Rosas Patricia T santana Antonio Joséde V Carneiro El.as Anaissie Marcio Nucci Heitor Siffert Pereira de Souza Department of Cl.nical.Medicine School of MedicineFederal University of Rio de JaneiroRio de Janeiro 21941-913Brazil l.boratory of Innovations in Therapies Education and BioproductsInstituto Oswaldo CruzRio de Janeiro 21040-360Brazil Cl.nical.Trial.and Consul.ing Services CincinnatiOH 45267United States Internal.Medicine D'Or Institute for Research and Education(IDOR)Rio de Janeiro 22281-100Brazil

BACKGROUND 1,3-beta-D-gl.can(BG)is a ubiquitous cel. wal. component of gut *** hypothesized that the serum l.vel. of BG coul. refl.ct active intestinal.infl.mmation in patients with infl.mmatory bowel.*** To determine whether the serum BG concentrations correl.te with intestinal.*** A prospective observational.study was performed in a tertiary referral.center,from 2016 to 2019,in which serum BG was determined in 115 patients with Crohn’s disease(CD),51 with ul.erative col.tis(UC),and 82 control. using a photometric detection *** activity was determined by il.ocol.noscopy,histopathol.gy,magnetic resonance enterography,and biomarkers,incl.ding fecal.cal.rotectin(FC),C-reactive protein,and a panel.of *** abil.ty of BG to detect active vs inactive disease was assessed using the area under the receiver operating characteristic *** subgroup anal.sis,serial.BG was used to assess the response to therapeutic *** The serum BG l.vel. were higher in CD patients than in control.(P=0.0001).The BG l.vel. paral.el.d the endoscopic activity in CD patients and histol.gic activity and combined endoscopic and histol.gic activity in both CD and UC *** area under the curve(AUC)in receiver operating characteristic anal.sis to predict endoscopic activity was 0.694[95%confidence interval.CI):0.60-0.79;P=0.001]in CD,and 0.662(95%CI:0.51-0.81;P=0.066)in UC *** AUC in receiver operating characteristic anal.sis to predict histol.gic activity was 0.860(95%CI:0.77-0.95;Pl.es of BG for both endoscopic and histol.gic activity were 60μg/ml.in CD,and 40μg/ml.in UC *** anal.sis showed that the resul.s based on BG of 40 and 60μg/ml.were more specific for predicting endoscopic activity(71.8%and 87.2%for CD;and 87.5%and 87.5%for UC,respectivel.)than FC(53.3%and 66.7%for CD;and 20%and 80%for UC,respectivel.);and

关键词： Crohn’s disease Ul.erative col.tis Infl.mmatory bowel.disease Beta-gl.can Histol.gic activity Noninvasive test

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